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Protein

Low-density lipoprotein receptor-related protein 12

Gene

Lrp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 12
Short name:
LRP-12
Gene namesi
Name:Lrp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2443132. Lrp12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 492ExtracellularSequence analysisAdd BLAST460
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Topological domaini514 – 858CytoplasmicSequence analysisAdd BLAST345

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001734033 – 858Low-density lipoprotein receptor-related protein 12Add BLAST826

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76By similarity
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi103 ↔ 122By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Disulfide bondi215 ↔ 232By similarity
Disulfide bondi222 ↔ 245By similarity
Disulfide bondi239 ↔ 254By similarity
Disulfide bondi259 ↔ 285By similarity
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi375 ↔ 388By similarity
Disulfide bondi382 ↔ 401By similarity
Disulfide bondi395 ↔ 410By similarity
Glycosylationi409N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi420 ↔ 439By similarity
Disulfide bondi433 ↔ 448By similarity
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi451 ↔ 463By similarity
Disulfide bondi458 ↔ 476By similarity
Disulfide bondi470 ↔ 485By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BUJ9.
PRIDEiQ8BUJ9.

PTM databases

iPTMnetiQ8BUJ9.
PhosphoSitePlusiQ8BUJ9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022305.
CleanExiMM_LRP12.
GenevisibleiQ8BUJ9. MM.

Interactioni

Subunit structurei

May interact with RACK1, ZFYVE9 and NMRK2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022916.

Structurei

3D structure databases

ProteinModelPortaliQ8BUJ9.
SMRiQ8BUJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 159CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini214 – 255LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST42
Domaini259 – 372CUB 2PROSITE-ProRule annotationAdd BLAST114
Domaini374 – 411LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini412 – 449LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini450 – 486LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 5 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPT2. Eukaryota.
ENOG410YUIT. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG103190.
InParanoidiQ8BUJ9.
KOiK20050.
OMAiISFQDFD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiQ8BUJ9.
TreeFamiTF332149.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 4 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 5 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BUJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARRWSTKES QRRGSAWLLL FLAGVYGNGA LAELSENVHI SGVSTACGES
60 70 80 90 100
PEQIRAPSGI ITSPGWPSDY PAQVNCSWLI RANPGEIITI SFQDFDIQGS
110 120 130 140 150
RRCTLDWLTI ETYKNIESYR ACGSTIPPPY ISSQDHVWIR FHSDDSVSRK
160 170 180 190 200
GFRLAYFSGK SEQPDCACDQ FRCGNGKCIP EAWKCNSMDE CGDSSDEEVC
210 220 230 240 250
ASDAHPPTTT AFQPCAYNQF QCLSRFTKVY TCLPESLKCD GNIDCLDLGD
260 270 280 290 300
EIDCDMPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
310 320 330 340 350
FTDFKLDGTG YGDYVKIYDG LEENPRKLLR VLTAFDSHAP LTVVSSSGQI
360 370 380 390 400
RVHFCADKVN AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH
410 420 430 440 450
CPNGRDEINC TMCQKEEFPC SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF
460 470 480 490 500
CQPGNFHCKN NRCVFESWVC DSQDDCGDGS DEENCPVIVP TRVITAAVIG
510 520 530 540 550
SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL LRREAPPSYG
560 570 580 590 600
QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS IRLPMTGRSS
610 620 630 640 650
NIWNRIFNFA RSRHSGSLAL VSGDGDEVVP SQSSSRETER SRPHRSLFSV
660 670 680 690 700
ESDDTDTENE RRDTAGASGG VAAPLPQKVP PTTAVEATVG SGGNSSAQST
710 720 730 740 750
RGGHADGREV SSVEAPSVSP ARHQLTSALS RMTQGLRWVR FTLGRSSSTT
760 770 780 790 800
QNRSPLRQLD TAVSGREDDD DVEMLIPVSD GASDIDANDC SRPLLDLASD
810 820 830 840 850
QVQGFRQPHS AGNPGVRTSN RDGPCERCGI VHTAQIPDTC LEATVKTETS

DDEALLLC
Length:858
Mass (Da):94,551
Last modified:April 13, 2004 - v2
Checksum:iB6E4AC8C2B69798C
GO
Isoform 2 (identifier: Q8BUJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-45: Missing.

Note: No experimental confirmation available.
Show »
Length:839
Mass (Da):92,714
Checksum:iDF761D18D823AF0E
GO

Sequence cautioni

The sequence BAC39247 differs from that shown. Reason: Frameshift at position 854.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00982127 – 45Missing in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050512 mRNA. Translation: BAC34299.1.
AK084675 mRNA. Translation: BAC39247.1. Sequence problems.
BC058345 mRNA. Translation: AAH58345.1.
CCDSiCCDS27446.1. [Q8BUJ9-1]
RefSeqiNP_766402.1. NM_172814.3. [Q8BUJ9-1]
XP_006520967.1. XM_006520904.3. [Q8BUJ9-2]
UniGeneiMm.39874.

Genome annotation databases

EnsembliENSMUST00000022916; ENSMUSP00000022916; ENSMUSG00000022305. [Q8BUJ9-1]
ENSMUST00000110305; ENSMUSP00000105934; ENSMUSG00000022305. [Q8BUJ9-2]
GeneIDi239393.
KEGGimmu:239393.
UCSCiuc007vom.1. mouse. [Q8BUJ9-1]
uc007von.1. mouse. [Q8BUJ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050512 mRNA. Translation: BAC34299.1.
AK084675 mRNA. Translation: BAC39247.1. Sequence problems.
BC058345 mRNA. Translation: AAH58345.1.
CCDSiCCDS27446.1. [Q8BUJ9-1]
RefSeqiNP_766402.1. NM_172814.3. [Q8BUJ9-1]
XP_006520967.1. XM_006520904.3. [Q8BUJ9-2]
UniGeneiMm.39874.

3D structure databases

ProteinModelPortaliQ8BUJ9.
SMRiQ8BUJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022916.

PTM databases

iPTMnetiQ8BUJ9.
PhosphoSitePlusiQ8BUJ9.

Proteomic databases

PaxDbiQ8BUJ9.
PRIDEiQ8BUJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022916; ENSMUSP00000022916; ENSMUSG00000022305. [Q8BUJ9-1]
ENSMUST00000110305; ENSMUSP00000105934; ENSMUSG00000022305. [Q8BUJ9-2]
GeneIDi239393.
KEGGimmu:239393.
UCSCiuc007vom.1. mouse. [Q8BUJ9-1]
uc007von.1. mouse. [Q8BUJ9-2]

Organism-specific databases

CTDi29967.
MGIiMGI:2443132. Lrp12.

Phylogenomic databases

eggNOGiENOG410IPT2. Eukaryota.
ENOG410YUIT. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG103190.
InParanoidiQ8BUJ9.
KOiK20050.
OMAiISFQDFD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiQ8BUJ9.
TreeFamiTF332149.

Miscellaneous databases

PROiQ8BUJ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022305.
CleanExiMM_LRP12.
GenevisibleiQ8BUJ9. MM.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 4 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 5 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 2 hits.
PS50068. LDLRA_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRP12_MOUSE
AccessioniPrimary (citable) accession number: Q8BUJ9
Secondary accession number(s): Q8BWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.