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Protein

Sentrin-specific protease 7

Gene

Senp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).By similarity

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei847By similarity1
Active sitei979By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC48.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 7 (EC:3.4.22.68)
Alternative name(s):
SUMO-1-specific protease 2
Sentrin/SUMO-specific protease SENP7
Gene namesi
Name:Senp7
Synonyms:Kiaa1707, Susp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913565. Senp7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676091 – 1037Sentrin-specific protease 7Add BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei13PhosphoserineBy similarity1
Modified residuei25PhosphoserineBy similarity1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BUH8.
MaxQBiQ8BUH8.
PaxDbiQ8BUH8.
PeptideAtlasiQ8BUH8.
PRIDEiQ8BUH8.

PTM databases

iPTMnetiQ8BUH8.
PhosphoSitePlusiQ8BUH8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052917.
CleanExiMM_SENP7.
ExpressionAtlasiQ8BUH8. baseline and differential.
GenevisibleiQ8BUH8. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-60609N.
STRINGi10090.ENSMUSP00000086779.

Structurei

3D structure databases

ProteinModelPortaliQ8BUH8.
SMRiQ8BUH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni747 – 1037ProteaseBy similarityAdd BLAST291

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
HOGENOMiHOG000015333.
HOVERGENiHBG079864.
InParanoidiQ8BUH8.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiQ8BUH8.
TreeFamiTF350136.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLS
60 70 80 90 100
KLRGSECWWT RSLRNKVICL DHKKPKAARG CPPKGLPKRH LRVMLTNVLW
110 120 130 140 150
TDLGREFRKT LPRKDANLCA PSKVQSDSLP STSVDSIETC QRLDPLHQSL
160 170 180 190 200
NLSERTPRVI LTDIRQTELG RKYLKIPPVT EASLSDTANL KSEQLSSSSD
210 220 230 240 250
GSLESCQSVN HHKSFLSESG PKPSRTGDVP AKEAACGGQK QGDDGGVTPE
260 270 280 290 300
MAAPHPKDFN TGNKGCDYLE EGTSNKNTSY SYSEMDHTPV SRKRKKRGRS
310 320 330 340 350
NFHDSHNSKT SLDKPTEHTK EEENDSSVSR KLEESGEDSH QDPAPPEGLA
360 370 380 390 400
PESLESEATN LRSFAAGQEP DASAASGRAS SPNKSLESSA SSEVSENSSV
410 420 430 440 450
AVKGEALTLK EASPPGGSSE ESQLLISAEP IVVSSDEEGP VEHKNSVILK
460 470 480 490 500
LQPPHEIMSE NQGTSDPQLS ELTLGACESV QVTSELFPYN PDVENISCIK
510 520 530 540 550
SNSEMDLKLD FIFTCVYIGK IKGTPKGCVT FTKKYIKIPF QVSTNEISLT
560 570 580 590 600
VDTARLKRFG LWESKDEDHS KRSHAILFLW LSSDYLQDIQ TQLENPMLSQ
610 620 630 640 650
QSKANEFIFL ELNSSISQRE ELKLKDIMME ISTKNGNLHL SCPLPWVQAL
660 670 680 690 700
PLFQDLSPQE ISFLHYYYAS ASALPTAAGA DMKKKSVSQP SNSDTIKPTY
710 720 730 740 750
TFLHKQSSGC YSLSITSSPE EEWQEVRNTG PVQKLIVYPP PPTKGGLGVT
760 770 780 790 800
NEDLECLEEG EFLNDVIIDF YLKYLLLEKA SDELVERSHI FSSFFYKCLT
810 820 830 840 850
RKENNLTEDN PDLSVAQRRH RRVRTWTRHI NIFNKDYIFV PVNESSHWYL
860 870 880 890 900
AVICFPWLEE AVYEDCPQTV SQQFQGQQSQ HDHKMTDNDP HTTSTVSTSA
910 920 930 940 950
EDSQSTEVNM SVPKKMCKRP CILILDSLKA ASIQNTVQNL REYLEVEWEV
960 970 980 990 1000
KRKTHREFSK TNMVDLCPKV PKQDNSSDCG VYLLQYVESF FQDPIVNFEL
1010 1020 1030
PIHLEKWFPR HVIKTKREDI RELILKLHLQ QQKGGSC
Length:1,037
Mass (Da):116,346
Last modified:March 1, 2003 - v1
Checksum:i35CAC29F61A293C5
GO

Sequence cautioni

The sequence BAC65824 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122542 mRNA. Translation: BAC65824.1. Different initiation.
AK085060 mRNA. Translation: BAC39352.1.
BC058593 mRNA. Translation: AAH58593.1.
CCDSiCCDS28222.1.
RefSeqiNP_079759.2. NM_025483.4.
XP_011244296.1. XM_011245994.2.
UniGeneiMm.255784.

Genome annotation databases

EnsembliENSMUST00000089362; ENSMUSP00000086779; ENSMUSG00000052917.
GeneIDi66315.
KEGGimmu:66315.
UCSCiuc007zmi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122542 mRNA. Translation: BAC65824.1. Different initiation.
AK085060 mRNA. Translation: BAC39352.1.
BC058593 mRNA. Translation: AAH58593.1.
CCDSiCCDS28222.1.
RefSeqiNP_079759.2. NM_025483.4.
XP_011244296.1. XM_011245994.2.
UniGeneiMm.255784.

3D structure databases

ProteinModelPortaliQ8BUH8.
SMRiQ8BUH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60609N.
STRINGi10090.ENSMUSP00000086779.

Protein family/group databases

MEROPSiC48.009.

PTM databases

iPTMnetiQ8BUH8.
PhosphoSitePlusiQ8BUH8.

Proteomic databases

EPDiQ8BUH8.
MaxQBiQ8BUH8.
PaxDbiQ8BUH8.
PeptideAtlasiQ8BUH8.
PRIDEiQ8BUH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089362; ENSMUSP00000086779; ENSMUSG00000052917.
GeneIDi66315.
KEGGimmu:66315.
UCSCiuc007zmi.2. mouse.

Organism-specific databases

CTDi57337.
MGIiMGI:1913565. Senp7.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
HOGENOMiHOG000015333.
HOVERGENiHBG079864.
InParanoidiQ8BUH8.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiQ8BUH8.
TreeFamiTF350136.

Miscellaneous databases

ChiTaRSiSenp7. mouse.
PROiQ8BUH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052917.
CleanExiMM_SENP7.
ExpressionAtlasiQ8BUH8. baseline and differential.
GenevisibleiQ8BUH8. MM.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSENP7_MOUSE
AccessioniPrimary (citable) accession number: Q8BUH8
Secondary accession number(s): Q6P398, Q80TA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.