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Protein

Thioredoxin-like protein 4B

Gene

Txnl4b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Gene namesi
Name:Txnl4b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443724. Txnl4b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182901 – 149Thioredoxin-like protein 4BAdd BLAST149

Proteomic databases

EPDiQ8BUH1.
MaxQBiQ8BUH1.
PaxDbiQ8BUH1.
PRIDEiQ8BUH1.

PTM databases

iPTMnetiQ8BUH1.
PhosphoSitePlusiQ8BUH1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031723.
CleanExiMM_TXNL4B.
GenevisibleiQ8BUH1. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034159.

Structurei

3D structure databases

ProteinModelPortaliQ8BUH1.
SMRiQ8BUH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiKOG3414. Eukaryota.
ENOG4111FE6. LUCA.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ8BUH1.
OMAiMSLFLPK.
OrthoDBiEOG091G0QHA.
TreeFamiTF332397.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SMARTiSM01410. DIM1. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSA
60 70 80 90 100
DLSKMAAIYL VDVDHTPVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNVP KYDLLYQDI
Length:149
Mass (Da):17,020
Last modified:September 18, 2013 - v2
Checksum:iA9DA3896F5F28758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → G in BAC39394 (PubMed:16141072).Curated1
Sequence conflicti61V → G in BAC39394 (PubMed:16141072).Curated1
Sequence conflicti92V → G in BAC39394 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085226 mRNA. Translation: BAC39394.1.
AC125162 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11422.1.
BC094379 mRNA. Translation: AAH94379.1.
BC132373 mRNA. Translation: AAI32374.1.
BC138333 mRNA. Translation: AAI38334.1.
CCDSiCCDS40469.1.
RefSeqiNP_783577.2. NM_175646.4.
UniGeneiMm.37667.

Genome annotation databases

EnsembliENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723.
ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723.
GeneIDi234723.
KEGGimmu:234723.
UCSCiuc012gkh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085226 mRNA. Translation: BAC39394.1.
AC125162 Genomic DNA. No translation available.
CH466525 Genomic DNA. Translation: EDL11422.1.
BC094379 mRNA. Translation: AAH94379.1.
BC132373 mRNA. Translation: AAI32374.1.
BC138333 mRNA. Translation: AAI38334.1.
CCDSiCCDS40469.1.
RefSeqiNP_783577.2. NM_175646.4.
UniGeneiMm.37667.

3D structure databases

ProteinModelPortaliQ8BUH1.
SMRiQ8BUH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034159.

PTM databases

iPTMnetiQ8BUH1.
PhosphoSitePlusiQ8BUH1.

Proteomic databases

EPDiQ8BUH1.
MaxQBiQ8BUH1.
PaxDbiQ8BUH1.
PRIDEiQ8BUH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034159; ENSMUSP00000034159; ENSMUSG00000031723.
ENSMUST00000178445; ENSMUSP00000137524; ENSMUSG00000031723.
GeneIDi234723.
KEGGimmu:234723.
UCSCiuc012gkh.1. mouse.

Organism-specific databases

CTDi54957.
MGIiMGI:2443724. Txnl4b.

Phylogenomic databases

eggNOGiKOG3414. Eukaryota.
ENOG4111FE6. LUCA.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ8BUH1.
OMAiMSLFLPK.
OrthoDBiEOG091G0QHA.
TreeFamiTF332397.

Miscellaneous databases

PROiQ8BUH1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031723.
CleanExiMM_TXNL4B.
GenevisibleiQ8BUH1. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SMARTiSM01410. DIM1. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTXN4B_MOUSE
AccessioniPrimary (citable) accession number: Q8BUH1
Secondary accession number(s): Q52KF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: September 18, 2013
Last modified: November 30, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.