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Protein

Beta-Ala-His dipeptidase

Gene

Cndp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107Zinc 2By similarity1
Active sitei109By similarity1
Metal bindingi140Zinc 1By similarity1
Metal bindingi140Zinc 2By similarity1
Active sitei174Proton acceptorBy similarity1
Metal bindingi175Zinc 1By similarity1
Metal bindingi203Zinc 2By similarity1
Metal bindingi453Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • peptide catabolic process Source: GO_Central
  • proteolysis Source: MGI
  • regulation of cellular protein metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM20.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-Ala-His dipeptidase (EC:3.4.13.20)
Alternative name(s):
CNDP dipeptidase 1
Carnosine dipeptidase 1
Gene namesi
Name:Cndp1
Synonyms:Cn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2451097. Cndp1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505301 – 492Beta-Ala-His dipeptidaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BUG2.
PaxDbiQ8BUG2.
PeptideAtlasiQ8BUG2.
PRIDEiQ8BUG2.

PTM databases

PhosphoSitePlusiQ8BUG2.

Expressioni

Tissue specificityi

Detected exclusively in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000056162.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8BUG2. 1 interactor.
MINTiMINT-4112586.
STRINGi10090.ENSMUSP00000069699.

Structurei

3D structure databases

ProteinModelPortaliQ8BUG2.
SMRiQ8BUG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2276. Eukaryota.
COG0624. LUCA.
HOGENOMiHOG000216709.
HOVERGENiHBG051103.
InParanoidiQ8BUG2.
KOiK05604.
PhylomeDBiQ8BUG2.
TreeFamiTF300633.

Family and domain databases

CDDicd05676. M20_dipept_like_CNDP. 1 hit.
Gene3Di3.30.70.360. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR017153. CNDP/DUG1.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037242. CNDP_dipeptidase. 1 hit.
PROSITEiPS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSAHSGLL EKLFHYIDLH QDEFVQTLKE WVAIESDSVQ PVPRLRQKLF
60 70 80 90 100
QMMALAADKL RNLGAGVESI DLGSQQMPDG QSLPIPPILL AELGSDPEKP
110 120 130 140 150
TVCFYGHLDV QPAQKDDGWL TDPYTLTEVD GKLYGRGATD NKGPVLAWIN
160 170 180 190 200
AVSTFRALQQ DLPVNIKFIL EGMEEAGSIA LEELVMREKD HFFSSVDYIV
210 220 230 240 250
ISDNLWLSQR KPALTYGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD
260 270 280 290 300
LVALLGSLVD SSGHILIPGI YDQMAPITEG EKTMYKNIDM DLEEYQNINQ
310 320 330 340 350
VEKFLFDTKE ELLMHLWRYP SLSIHGIEGA FDEPGTKTVI PGRVLGKFSI
360 370 380 390 400
RLVPTMSPSV VEKQVTQHLE AVFSKRNSFN KMAVSMVLGL HPWTANVNDT
410 420 430 440 450
QYLAAQRTIK TVFGVNPDMI RDGSTIPIAK IFQAITQKSV MMLPLGAVDD
460 470 480 490
GEHSQNEKIN RWNYIQGSKL FAAFFLELSK QHSGHQMPSS VY
Length:492
Mass (Da):55,090
Last modified:March 1, 2003 - v1
Checksum:i5A3E3F984CBF4567
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168F → L in AAH43305 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085308 mRNA. Translation: BAC39417.1.
BC043305 mRNA. Translation: AAH43305.1.
CCDSiCCDS29382.1.
RefSeqiNP_803233.2. NM_177450.4.
UniGeneiMm.23278.

Genome annotation databases

GeneIDi338403.
KEGGimmu:338403.
UCSCiuc008fur.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085308 mRNA. Translation: BAC39417.1.
BC043305 mRNA. Translation: AAH43305.1.
CCDSiCCDS29382.1.
RefSeqiNP_803233.2. NM_177450.4.
UniGeneiMm.23278.

3D structure databases

ProteinModelPortaliQ8BUG2.
SMRiQ8BUG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BUG2. 1 interactor.
MINTiMINT-4112586.
STRINGi10090.ENSMUSP00000069699.

Protein family/group databases

MEROPSiM20.006.

PTM databases

PhosphoSitePlusiQ8BUG2.

Proteomic databases

MaxQBiQ8BUG2.
PaxDbiQ8BUG2.
PeptideAtlasiQ8BUG2.
PRIDEiQ8BUG2.

Protocols and materials databases

DNASUi338403.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi338403.
KEGGimmu:338403.
UCSCiuc008fur.2. mouse.

Organism-specific databases

CTDi84735.
MGIiMGI:2451097. Cndp1.

Phylogenomic databases

eggNOGiKOG2276. Eukaryota.
COG0624. LUCA.
HOGENOMiHOG000216709.
HOVERGENiHBG051103.
InParanoidiQ8BUG2.
KOiK05604.
PhylomeDBiQ8BUG2.
TreeFamiTF300633.

Miscellaneous databases

PROiQ8BUG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056162.

Family and domain databases

CDDicd05676. M20_dipept_like_CNDP. 1 hit.
Gene3Di3.30.70.360. 1 hit.
InterProiIPR001261. ArgE/DapE_CS.
IPR017153. CNDP/DUG1.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037242. CNDP_dipeptidase. 1 hit.
PROSITEiPS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNDP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUG2
Secondary accession number(s): Q80XP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

In contrast to human counterpart, it lacks a signal sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.