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Protein

Beta-Ala-His dipeptidase

Gene

Cndp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

In contrast to human counterpart, it lacks a signal sequence.Curated

Catalytic activityi

Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi107Zinc 2By similarity1
Active sitei109By similarity1
Metal bindingi140Zinc 1By similarity1
Metal bindingi140Zinc 2By similarity1
Active sitei174Proton acceptorBy similarity1
Metal bindingi175Zinc 1By similarity1
Metal bindingi203Zinc 2By similarity1
Metal bindingi453Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: MGI
  • regulation of cellular protein metabolic process Source: MGI

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM20.006

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-Ala-His dipeptidase (EC:3.4.13.20)
Alternative name(s):
CNDP dipeptidase 1
Carnosine dipeptidase 1
Gene namesi
Name:Cndp1
Synonyms:Cn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2451097 Cndp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505301 – 492Beta-Ala-His dipeptidaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8BUG2
PaxDbiQ8BUG2
PeptideAtlasiQ8BUG2
PRIDEiQ8BUG2

PTM databases

PhosphoSitePlusiQ8BUG2

Expressioni

Tissue specificityi

Detected exclusively in kidney.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ8BUG2, 1 interactor
MINTiQ8BUG2
STRINGi10090.ENSMUSP00000069699

Structurei

3D structure databases

ProteinModelPortaliQ8BUG2
SMRiQ8BUG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2276 Eukaryota
COG0624 LUCA
HOGENOMiHOG000216709
HOVERGENiHBG051103
InParanoidiQ8BUG2
KOiK05604
PhylomeDBiQ8BUG2
TreeFamiTF300633

Family and domain databases

CDDicd05676 M20_dipept_like_CNDP, 1 hit
InterProiView protein in InterPro
IPR001261 ArgE/DapE_CS
IPR017153 CNDP/DUG1
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
PIRSFiPIRSF037242 CNDP_dipeptidase, 1 hit
PROSITEiView protein in PROSITE
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BUG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSAHSGLL EKLFHYIDLH QDEFVQTLKE WVAIESDSVQ PVPRLRQKLF
60 70 80 90 100
QMMALAADKL RNLGAGVESI DLGSQQMPDG QSLPIPPILL AELGSDPEKP
110 120 130 140 150
TVCFYGHLDV QPAQKDDGWL TDPYTLTEVD GKLYGRGATD NKGPVLAWIN
160 170 180 190 200
AVSTFRALQQ DLPVNIKFIL EGMEEAGSIA LEELVMREKD HFFSSVDYIV
210 220 230 240 250
ISDNLWLSQR KPALTYGTRG NCYFTVEVKC RDQDFHSGTF GGILNEPMAD
260 270 280 290 300
LVALLGSLVD SSGHILIPGI YDQMAPITEG EKTMYKNIDM DLEEYQNINQ
310 320 330 340 350
VEKFLFDTKE ELLMHLWRYP SLSIHGIEGA FDEPGTKTVI PGRVLGKFSI
360 370 380 390 400
RLVPTMSPSV VEKQVTQHLE AVFSKRNSFN KMAVSMVLGL HPWTANVNDT
410 420 430 440 450
QYLAAQRTIK TVFGVNPDMI RDGSTIPIAK IFQAITQKSV MMLPLGAVDD
460 470 480 490
GEHSQNEKIN RWNYIQGSKL FAAFFLELSK QHSGHQMPSS VY
Length:492
Mass (Da):55,090
Last modified:March 1, 2003 - v1
Checksum:i5A3E3F984CBF4567
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti168F → L in AAH43305 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085308 mRNA Translation: BAC39417.1
BC043305 mRNA Translation: AAH43305.1
CCDSiCCDS29382.1
RefSeqiNP_803233.2, NM_177450.4
UniGeneiMm.23278

Genome annotation databases

GeneIDi338403
KEGGimmu:338403
UCSCiuc008fur.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCNDP1_MOUSE
AccessioniPrimary (citable) accession number: Q8BUG2
Secondary accession number(s): Q80XP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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