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Q8BUE7

- MUC20_MOUSE

UniProt

Q8BUE7 - MUC20_MOUSE

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Protein

Mucin-20

Gene

Muc20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity).By similarity

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. hepatocyte growth factor receptor signaling pathway Source: MGI
  3. positive regulation of apoptotic process Source: UniProtKB
  4. protein homooligomerization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198517. O-linked glycosylation of mucins.
REACT_198575. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-20
Short name:
MUC-20
Gene namesi
Name:Muc20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2385039. Muc20.

Subcellular locationi

Secreted Curated. Apical cell membrane By similarity. Basolateral cell membrane By similarity. Cell projectionmicrovillus membrane By similarity

GO - Cellular componenti

  1. basal plasma membrane Source: MGI
  2. cell projection Source: UniProtKB-KW
  3. cytosol Source: UniProtKB
  4. extracellular region Source: UniProtKB-KW
  5. mitochondrial outer membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 656635Mucin-20PRO_0000317470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ8BUE7.

PTM databases

PhosphoSiteiQ8BUE7.

Expressioni

Tissue specificityi

Highly expressed in kidney. Up-regulated in renal tissues during renal injury.1 Publication

Gene expression databases

BgeeiQ8BUE7.
CleanExiMM_MUC20.
ExpressionAtlasiQ8BUE7. baseline and differential.
GenevestigatoriQ8BUE7.

Interactioni

Subunit structurei

Interacts with MET; oligomerization increases affinity for MET.By similarity

Protein-protein interaction databases

BioGridi230247. 1 interaction.
STRINGi10090.ENSMUSP00000110769.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati180 – 18891
Repeati189 – 19792
Repeati198 – 20693
Repeati210 – 21894
Repeati219 – 22795

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 22748Approximate repeatsAdd
BLAST
Regioni399 – 603205Involved in oligomerizationBy similarityAdd
BLAST
Regioni604 – 65653Interaction with METBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi331 – 34818Ser-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG84731.
GeneTreeiENSGT00730000111453.
HOGENOMiHOG000036067.
HOVERGENiHBG108160.
InParanoidiQ8BUE7.
PhylomeDBiQ8BUE7.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BUE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSVWGLAVP LLVFCWKVGV SVSSPGLDIS RSVPLVTTNN MEVSTFTQRD
60 70 80 90 100
RPSSERAFQT TNLIQYVPLD TQTLSTESAS NALSATSISS EVNSRDTQTT
110 120 130 140 150
SFVTKTRKTH TTTPAASSLE AQTTSPNLST LNIQITSPIA SSLDAQTIFP
160 170 180 190 200
VSLSLSTQTT SPAPSFLDTQ TTSPEPSSLT TSPAPSSLIT SPTPSSLTTS
210 220 230 240 250
PAPSFLDTQT TSPAPSSLTT SPAPSSLDTQ TISPIELTLK TQTISTVTET
260 270 280 290 300
RTVSIRIPSD LTVMHTIPTE TLAPSNSPRT GMSTVQTGTV WDSIEAVFDT
310 320 330 340 350
LCTDDSSEEA RKITVDLLTL AHTSTEVEYL SSESSSSSDS SAGVLSSSRV
360 370 380 390 400
LGPDSATPAK GLVAFNITHI KLSNCITEIE TTITISGAPG ASLSPTEATA
410 420 430 440 450
ALFTSEILTL PPPTEAKPIF PETTSLSGIL STAGTPALAT TLEGTVSTSA
460 470 480 490 500
ITESETAVAQ TLTSVGTSVT VRRNPLENTS TLSIETQSHT EVLGTITVPM
510 520 530 540 550
VAGSTMGEAA SFVSFTALDS SSLSVVVTTE SSATSETLTT GNTTNSSFLT
560 570 580 590 600
ESHPPFSIYS TTASTSKNPN ITLTKTTASP KPPTHPTTSA STAWIRKTTK
610 620 630 640 650
HDPGEDGGFL LVRLTVASPK DLTEHNAREK LMNQLRRELH ARMPLVHMSF

LSIRRG
Length:656
Mass (Da):68,720
Last modified:March 1, 2003 - v1
Checksum:i5A0BECDE6F3297DA
GO

Sequence cautioni

The sequence AAH26367.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991T → A in BAD06719. (PubMed:14565953)Curated
Sequence conflicti199 – 1991T → I in BAD06719. (PubMed:14565953)Curated
Sequence conflicti215 – 2151P → L in BAD06719. (PubMed:14565953)Curated
Sequence conflicti219 – 2191T → A in BAD06719. (PubMed:14565953)Curated
Sequence conflicti262 – 2621T → K in BAD06719. (PubMed:14565953)Curated
Sequence conflicti273 – 2731A → T in BAD06719. (PubMed:14565953)Curated
Sequence conflicti293 – 2931S → P in BAD06719. (PubMed:14565953)Curated
Sequence conflicti297 – 2971V → I in BAD06719. (PubMed:14565953)Curated
Sequence conflicti329 – 3291Y → H in BAD06719. (PubMed:14565953)Curated
Sequence conflicti374 – 3741N → T in BAD06719. (PubMed:14565953)Curated
Sequence conflicti391 – 3911A → V in BAD06719. (PubMed:14565953)Curated
Sequence conflicti509 – 5091A → T in BAD06719. (PubMed:14565953)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB098732 mRNA. Translation: BAD06719.1.
AK085640 mRNA. Translation: BAC39492.1.
AK165477 mRNA. Translation: BAE38212.1.
BC026367 mRNA. Translation: AAH26367.1. Different initiation.
CCDSiCCDS49830.1.
RefSeqiNP_001139346.1. NM_001145874.1.
NP_666183.2. NM_146071.2.
UniGeneiMm.153301.
Mm.484124.

Genome annotation databases

EnsembliENSMUST00000041123; ENSMUSP00000041221; ENSMUSG00000035638.
GeneIDi224116.
KEGGimmu:224116.
UCSCiuc007yzi.2. mouse.

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB098732 mRNA. Translation: BAD06719.1 .
AK085640 mRNA. Translation: BAC39492.1 .
AK165477 mRNA. Translation: BAE38212.1 .
BC026367 mRNA. Translation: AAH26367.1 . Different initiation.
CCDSi CCDS49830.1.
RefSeqi NP_001139346.1. NM_001145874.1.
NP_666183.2. NM_146071.2.
UniGenei Mm.153301.
Mm.484124.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 230247. 1 interaction.
STRINGi 10090.ENSMUSP00000110769.

PTM databases

PhosphoSitei Q8BUE7.

Proteomic databases

PRIDEi Q8BUE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041123 ; ENSMUSP00000041221 ; ENSMUSG00000035638 .
GeneIDi 224116.
KEGGi mmu:224116.
UCSCi uc007yzi.2. mouse.

Organism-specific databases

CTDi 200958.
MGIi MGI:2385039. Muc20.

Phylogenomic databases

eggNOGi NOG84731.
GeneTreei ENSGT00730000111453.
HOGENOMi HOG000036067.
HOVERGENi HBG108160.
InParanoidi Q8BUE7.
PhylomeDBi Q8BUE7.

Enzyme and pathway databases

Reactomei REACT_198517. O-linked glycosylation of mucins.
REACT_198575. Termination of O-glycan biosynthesis.

Miscellaneous databases

NextBioi 377095.
PROi Q8BUE7.
SOURCEi Search...

Gene expression databases

Bgeei Q8BUE7.
CleanExi MM_MUC20.
ExpressionAtlasi Q8BUE7. baseline and differential.
Genevestigatori Q8BUE7.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney."
    Higuchi T., Orita T., Nakanishi S., Katsuya K., Watanabe H., Yamasaki Y., Waga I., Nanayama T., Yamamoto Y., Munger W., Sun H.-W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T., Saito Y., Nakamura M.
    J. Biol. Chem. 279:1968-1979(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
    Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H., Yamamoto T., Saito Y., Nakamura M.
    Mol. Cell. Biol. 24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MET.

Entry informationi

Entry nameiMUC20_MOUSE
AccessioniPrimary (citable) accession number: Q8BUE7
Secondary accession number(s): Q76I84, Q8R0X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3