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Q8BUE7

- MUC20_MOUSE

UniProt

Q8BUE7 - MUC20_MOUSE

Protein

Mucin-20

Gene

Muc20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. hepatocyte growth factor receptor signaling pathway Source: MGI
    3. positive regulation of apoptotic process Source: UniProtKB
    4. protein homooligomerization Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_198517. O-linked glycosylation of mucins.
    REACT_198575. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-20
    Short name:
    MUC-20
    Gene namesi
    Name:Muc20
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2385039. Muc20.

    Subcellular locationi

    Secreted Curated. Apical cell membrane By similarity. Basolateral cell membrane By similarity. Cell projectionmicrovillus membrane By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. basal plasma membrane Source: MGI
    3. cytosol Source: UniProtKB
    4. extracellular region Source: UniProtKB-SubCell
    5. microvillus membrane Source: UniProtKB-SubCell
    6. mitochondrial outer membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 656635Mucin-20PRO_0000317470Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ8BUE7.

    PTM databases

    PhosphoSiteiQ8BUE7.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney. Up-regulated in renal tissues during renal injury.1 Publication

    Gene expression databases

    ArrayExpressiQ8BUE7.
    BgeeiQ8BUE7.
    CleanExiMM_MUC20.
    GenevestigatoriQ8BUE7.

    Interactioni

    Subunit structurei

    Interacts with MET; oligomerization increases affinity for MET.By similarity

    Protein-protein interaction databases

    BioGridi230247. 1 interaction.
    STRINGi10090.ENSMUSP00000110769.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati180 – 18891
    Repeati189 – 19792
    Repeati198 – 20693
    Repeati210 – 21894
    Repeati219 – 22795

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 22748Approximate repeatsAdd
    BLAST
    Regioni399 – 603205Involved in oligomerizationBy similarityAdd
    BLAST
    Regioni604 – 65653Interaction with METBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi331 – 34818Ser-richAdd
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG84731.
    GeneTreeiENSGT00730000111453.
    HOGENOMiHOG000036067.
    HOVERGENiHBG108160.
    PhylomeDBiQ8BUE7.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BUE7-1 [UniParc]FASTAAdd to Basket

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    MGSVWGLAVP LLVFCWKVGV SVSSPGLDIS RSVPLVTTNN MEVSTFTQRD    50
    RPSSERAFQT TNLIQYVPLD TQTLSTESAS NALSATSISS EVNSRDTQTT 100
    SFVTKTRKTH TTTPAASSLE AQTTSPNLST LNIQITSPIA SSLDAQTIFP 150
    VSLSLSTQTT SPAPSFLDTQ TTSPEPSSLT TSPAPSSLIT SPTPSSLTTS 200
    PAPSFLDTQT TSPAPSSLTT SPAPSSLDTQ TISPIELTLK TQTISTVTET 250
    RTVSIRIPSD LTVMHTIPTE TLAPSNSPRT GMSTVQTGTV WDSIEAVFDT 300
    LCTDDSSEEA RKITVDLLTL AHTSTEVEYL SSESSSSSDS SAGVLSSSRV 350
    LGPDSATPAK GLVAFNITHI KLSNCITEIE TTITISGAPG ASLSPTEATA 400
    ALFTSEILTL PPPTEAKPIF PETTSLSGIL STAGTPALAT TLEGTVSTSA 450
    ITESETAVAQ TLTSVGTSVT VRRNPLENTS TLSIETQSHT EVLGTITVPM 500
    VAGSTMGEAA SFVSFTALDS SSLSVVVTTE SSATSETLTT GNTTNSSFLT 550
    ESHPPFSIYS TTASTSKNPN ITLTKTTASP KPPTHPTTSA STAWIRKTTK 600
    HDPGEDGGFL LVRLTVASPK DLTEHNAREK LMNQLRRELH ARMPLVHMSF 650
    LSIRRG 656
    Length:656
    Mass (Da):68,720
    Last modified:March 1, 2003 - v1
    Checksum:i5A0BECDE6F3297DA
    GO

    Sequence cautioni

    The sequence AAH26367.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti99 – 991T → A in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti199 – 1991T → I in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti215 – 2151P → L in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti219 – 2191T → A in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti262 – 2621T → K in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti273 – 2731A → T in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti293 – 2931S → P in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti297 – 2971V → I in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti329 – 3291Y → H in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti374 – 3741N → T in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti391 – 3911A → V in BAD06719. (PubMed:14565953)Curated
    Sequence conflicti509 – 5091A → T in BAD06719. (PubMed:14565953)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB098732 mRNA. Translation: BAD06719.1.
    AK085640 mRNA. Translation: BAC39492.1.
    AK165477 mRNA. Translation: BAE38212.1.
    BC026367 mRNA. Translation: AAH26367.1. Different initiation.
    CCDSiCCDS49830.1.
    RefSeqiNP_001139346.1. NM_001145874.1.
    NP_666183.2. NM_146071.2.
    UniGeneiMm.153301.
    Mm.484124.

    Genome annotation databases

    EnsembliENSMUST00000041123; ENSMUSP00000041221; ENSMUSG00000035638.
    GeneIDi224116.
    KEGGimmu:224116.
    UCSCiuc007yzi.2. mouse.

    Cross-referencesi

    Web resourcesi

    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB098732 mRNA. Translation: BAD06719.1 .
    AK085640 mRNA. Translation: BAC39492.1 .
    AK165477 mRNA. Translation: BAE38212.1 .
    BC026367 mRNA. Translation: AAH26367.1 . Different initiation.
    CCDSi CCDS49830.1.
    RefSeqi NP_001139346.1. NM_001145874.1.
    NP_666183.2. NM_146071.2.
    UniGenei Mm.153301.
    Mm.484124.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230247. 1 interaction.
    STRINGi 10090.ENSMUSP00000110769.

    PTM databases

    PhosphoSitei Q8BUE7.

    Proteomic databases

    PRIDEi Q8BUE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041123 ; ENSMUSP00000041221 ; ENSMUSG00000035638 .
    GeneIDi 224116.
    KEGGi mmu:224116.
    UCSCi uc007yzi.2. mouse.

    Organism-specific databases

    CTDi 200958.
    MGIi MGI:2385039. Muc20.

    Phylogenomic databases

    eggNOGi NOG84731.
    GeneTreei ENSGT00730000111453.
    HOGENOMi HOG000036067.
    HOVERGENi HBG108160.
    PhylomeDBi Q8BUE7.

    Enzyme and pathway databases

    Reactomei REACT_198517. O-linked glycosylation of mucins.
    REACT_198575. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    NextBioi 377095.
    PROi Q8BUE7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BUE7.
    Bgeei Q8BUE7.
    CleanExi MM_MUC20.
    Genevestigatori Q8BUE7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney."
      Higuchi T., Orita T., Nakanishi S., Katsuya K., Watanabe H., Yamasaki Y., Waga I., Nanayama T., Yamamoto Y., Munger W., Sun H.-W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T., Saito Y., Nakamura M.
      J. Biol. Chem. 279:1968-1979(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    4. "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
      Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H., Yamamoto T., Saito Y., Nakamura M.
      Mol. Cell. Biol. 24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MET.

    Entry informationi

    Entry nameiMUC20_MOUSE
    AccessioniPrimary (citable) accession number: Q8BUE7
    Secondary accession number(s): Q76I84, Q8R0X0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3