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Q8BUE7 (MUC20_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucin-20
Short name=MUC-20
Gene names
Name:Muc20
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length656 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression By similarity.

Subunit structure

Interacts with MET; oligomerization increases affinity for MET By similarity. Ref.4

Subcellular location

Secreted Potential. Apical cell membrane By similarity. Basolateral cell membrane By similarity. Cell projection › microvillus membrane By similarity.

Tissue specificity

Highly expressed in kidney. Up-regulated in renal tissues during renal injury. Ref.1

Sequence caution

The sequence AAH26367.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 656635Mucin-20
PRO_0000317470

Regions

Repeat180 – 18891
Repeat189 – 19792
Repeat198 – 20693
Repeat210 – 21894
Repeat219 – 22795
Region180 – 22748Approximate repeats
Region399 – 603205Involved in oligomerization By similarity
Region604 – 65653Interaction with MET By similarity
Compositional bias331 – 34818Ser-rich

Amino acid modifications

Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation5701N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict991T → A in BAD06719. Ref.1
Sequence conflict1991T → I in BAD06719. Ref.1
Sequence conflict2151P → L in BAD06719. Ref.1
Sequence conflict2191T → A in BAD06719. Ref.1
Sequence conflict2621T → K in BAD06719. Ref.1
Sequence conflict2731A → T in BAD06719. Ref.1
Sequence conflict2931S → P in BAD06719. Ref.1
Sequence conflict2971V → I in BAD06719. Ref.1
Sequence conflict3291Y → H in BAD06719. Ref.1
Sequence conflict3741N → T in BAD06719. Ref.1
Sequence conflict3911A → V in BAD06719. Ref.1
Sequence conflict5091A → T in BAD06719. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BUE7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5A0BECDE6F3297DA

FASTA65668,720
        10         20         30         40         50         60 
MGSVWGLAVP LLVFCWKVGV SVSSPGLDIS RSVPLVTTNN MEVSTFTQRD RPSSERAFQT 

        70         80         90        100        110        120 
TNLIQYVPLD TQTLSTESAS NALSATSISS EVNSRDTQTT SFVTKTRKTH TTTPAASSLE 

       130        140        150        160        170        180 
AQTTSPNLST LNIQITSPIA SSLDAQTIFP VSLSLSTQTT SPAPSFLDTQ TTSPEPSSLT 

       190        200        210        220        230        240 
TSPAPSSLIT SPTPSSLTTS PAPSFLDTQT TSPAPSSLTT SPAPSSLDTQ TISPIELTLK 

       250        260        270        280        290        300 
TQTISTVTET RTVSIRIPSD LTVMHTIPTE TLAPSNSPRT GMSTVQTGTV WDSIEAVFDT 

       310        320        330        340        350        360 
LCTDDSSEEA RKITVDLLTL AHTSTEVEYL SSESSSSSDS SAGVLSSSRV LGPDSATPAK 

       370        380        390        400        410        420 
GLVAFNITHI KLSNCITEIE TTITISGAPG ASLSPTEATA ALFTSEILTL PPPTEAKPIF 

       430        440        450        460        470        480 
PETTSLSGIL STAGTPALAT TLEGTVSTSA ITESETAVAQ TLTSVGTSVT VRRNPLENTS 

       490        500        510        520        530        540 
TLSIETQSHT EVLGTITVPM VAGSTMGEAA SFVSFTALDS SSLSVVVTTE SSATSETLTT 

       550        560        570        580        590        600 
GNTTNSSFLT ESHPPFSIYS TTASTSKNPN ITLTKTTASP KPPTHPTTSA STAWIRKTTK 

       610        620        630        640        650 
HDPGEDGGFL LVRLTVASPK DLTEHNAREK LMNQLRRELH ARMPLVHMSF LSIRRG

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney."
Higuchi T., Orita T., Nakanishi S., Katsuya K., Watanabe H., Yamasaki Y., Waga I., Nanayama T., Yamamoto Y., Munger W., Sun H.-W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T., Saito Y., Nakamura M.
J. Biol. Chem. 279:1968-1979(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Kidney.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[4]"MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H., Yamamoto T., Saito Y., Nakamura M.
Mol. Cell. Biol. 24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MET.
+Additional computationally mapped references.

Web resources

Mucin database

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB098732 mRNA. Translation: BAD06719.1.
AK085640 mRNA. Translation: BAC39492.1.
AK165477 mRNA. Translation: BAE38212.1.
BC026367 mRNA. Translation: AAH26367.1. Different initiation.
IPIIPI00395071.
RefSeqNP_001139346.1. NM_001145874.1.
NP_666183.2. NM_146071.2.
UniGeneMm.153301.
Mm.484124.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000110769.

PTM databases

PhosphoSiteQ8BUE7.

Proteomic databases

PRIDEQ8BUE7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041123; ENSMUSP00000041221; ENSMUSG00000035638.
GeneID224116.
KEGGmmu:224116.
UCSCuc007yzi.2. mouse.

Organism-specific databases

CTD200958.
MGIMGI:2385039. Muc20.

Phylogenomic databases

eggNOGNOG84731.
GeneTreeENSGT00620000088126.
HOGENOMHOG000036067.
HOVERGENHBG108160.
OrthoDBEOG4BRWM6.

Gene expression databases

ArrayExpressQ8BUE7.
BgeeQ8BUE7.
CleanExMM_MUC20.
GenevestigatorQ8BUE7.

Family and domain databases

ProtoNetSearch...

Other

NextBio377095.
SOURCESearch...

Entry information

Entry nameMUC20_MOUSE
AccessionPrimary (citable) accession number: Q8BUE7
Secondary accession number(s): Q76I84, Q8R0X0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents