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Protein

Mucin-20

Gene

Muc20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity).By similarity

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • hepatocyte growth factor receptor signaling pathway Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB
  • protein homooligomerization Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-8851805. MET activates RAS signaling.
R-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-20
Short name:
MUC-20
Gene namesi
Name:Muc20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2385039. Muc20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000031747022 – 656Mucin-20Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi366N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BUE7.
PRIDEiQ8BUE7.

PTM databases

iPTMnetiQ8BUE7.
PhosphoSitePlusiQ8BUE7.

Expressioni

Tissue specificityi

Highly expressed in kidney. Up-regulated in renal tissues during renal injury.1 Publication

Gene expression databases

BgeeiENSMUSG00000035638.
CleanExiMM_MUC20.
ExpressionAtlasiQ8BUE7. baseline and differential.
GenevisibleiQ8BUE7. MM.

Interactioni

Subunit structurei

Interacts with MET; oligomerization increases affinity for MET.By similarity

Protein-protein interaction databases

BioGridi230247. 1 interactor.
STRINGi10090.ENSMUSP00000110769.

Structurei

3D structure databases

ProteinModelPortaliQ8BUE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati180 – 18819
Repeati189 – 19729
Repeati198 – 20639
Repeati210 – 21849
Repeati219 – 22759

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 227Approximate repeatsAdd BLAST48
Regioni399 – 603Involved in oligomerizationBy similarityAdd BLAST205
Regioni604 – 656Interaction with METBy similarityAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi331 – 348Ser-richAdd BLAST18

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IVUU. Eukaryota.
ENOG4111Y2D. LUCA.
GeneTreeiENSGT00730000111453.
HOGENOMiHOG000036067.
HOVERGENiHBG108160.
InParanoidiQ8BUE7.
PhylomeDBiQ8BUE7.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BUE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVWGLAVP LLVFCWKVGV SVSSPGLDIS RSVPLVTTNN MEVSTFTQRD
60 70 80 90 100
RPSSERAFQT TNLIQYVPLD TQTLSTESAS NALSATSISS EVNSRDTQTT
110 120 130 140 150
SFVTKTRKTH TTTPAASSLE AQTTSPNLST LNIQITSPIA SSLDAQTIFP
160 170 180 190 200
VSLSLSTQTT SPAPSFLDTQ TTSPEPSSLT TSPAPSSLIT SPTPSSLTTS
210 220 230 240 250
PAPSFLDTQT TSPAPSSLTT SPAPSSLDTQ TISPIELTLK TQTISTVTET
260 270 280 290 300
RTVSIRIPSD LTVMHTIPTE TLAPSNSPRT GMSTVQTGTV WDSIEAVFDT
310 320 330 340 350
LCTDDSSEEA RKITVDLLTL AHTSTEVEYL SSESSSSSDS SAGVLSSSRV
360 370 380 390 400
LGPDSATPAK GLVAFNITHI KLSNCITEIE TTITISGAPG ASLSPTEATA
410 420 430 440 450
ALFTSEILTL PPPTEAKPIF PETTSLSGIL STAGTPALAT TLEGTVSTSA
460 470 480 490 500
ITESETAVAQ TLTSVGTSVT VRRNPLENTS TLSIETQSHT EVLGTITVPM
510 520 530 540 550
VAGSTMGEAA SFVSFTALDS SSLSVVVTTE SSATSETLTT GNTTNSSFLT
560 570 580 590 600
ESHPPFSIYS TTASTSKNPN ITLTKTTASP KPPTHPTTSA STAWIRKTTK
610 620 630 640 650
HDPGEDGGFL LVRLTVASPK DLTEHNAREK LMNQLRRELH ARMPLVHMSF

LSIRRG
Length:656
Mass (Da):68,720
Last modified:March 1, 2003 - v1
Checksum:i5A0BECDE6F3297DA
GO

Sequence cautioni

The sequence AAH26367 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99T → A in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti199T → I in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti215P → L in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti219T → A in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti262T → K in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti273A → T in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti293S → P in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti297V → I in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti329Y → H in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti374N → T in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti391A → V in BAD06719 (PubMed:14565953).Curated1
Sequence conflicti509A → T in BAD06719 (PubMed:14565953).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098732 mRNA. Translation: BAD06719.1.
AK085640 mRNA. Translation: BAC39492.1.
AK165477 mRNA. Translation: BAE38212.1.
BC026367 mRNA. Translation: AAH26367.1. Different initiation.
CCDSiCCDS49830.1.
RefSeqiNP_001139346.1. NM_001145874.1.
NP_666183.2. NM_146071.2.
UniGeneiMm.153301.
Mm.484124.

Genome annotation databases

EnsembliENSMUST00000041123; ENSMUSP00000041221; ENSMUSG00000035638.
GeneIDi224116.
KEGGimmu:224116.
UCSCiuc007yzi.2. mouse.

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098732 mRNA. Translation: BAD06719.1.
AK085640 mRNA. Translation: BAC39492.1.
AK165477 mRNA. Translation: BAE38212.1.
BC026367 mRNA. Translation: AAH26367.1. Different initiation.
CCDSiCCDS49830.1.
RefSeqiNP_001139346.1. NM_001145874.1.
NP_666183.2. NM_146071.2.
UniGeneiMm.153301.
Mm.484124.

3D structure databases

ProteinModelPortaliQ8BUE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230247. 1 interactor.
STRINGi10090.ENSMUSP00000110769.

PTM databases

iPTMnetiQ8BUE7.
PhosphoSitePlusiQ8BUE7.

Proteomic databases

PaxDbiQ8BUE7.
PRIDEiQ8BUE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041123; ENSMUSP00000041221; ENSMUSG00000035638.
GeneIDi224116.
KEGGimmu:224116.
UCSCiuc007yzi.2. mouse.

Organism-specific databases

CTDi200958.
MGIiMGI:2385039. Muc20.

Phylogenomic databases

eggNOGiENOG410IVUU. Eukaryota.
ENOG4111Y2D. LUCA.
GeneTreeiENSGT00730000111453.
HOGENOMiHOG000036067.
HOVERGENiHBG108160.
InParanoidiQ8BUE7.
PhylomeDBiQ8BUE7.

Enzyme and pathway databases

ReactomeiR-MMU-8851805. MET activates RAS signaling.
R-MMU-913709. O-linked glycosylation of mucins.
R-MMU-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

PROiQ8BUE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035638.
CleanExiMM_MUC20.
ExpressionAtlasiQ8BUE7. baseline and differential.
GenevisibleiQ8BUE7. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMUC20_MOUSE
AccessioniPrimary (citable) accession number: Q8BUE7
Secondary accession number(s): Q76I84, Q8R0X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.