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Protein

G-protein coupled receptor 4

Gene

Gpr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.By similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI

GO - Biological processi

  • angiogenesis involved in wound healing Source: MGI
  • glomerular mesangial cell development Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of angiogenesis Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: GO_Central
  • positive regulation of Rho protein signal transduction Source: GO_Central
  • response to acidic pH Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 4
Gene namesi
Name:Gpr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2441992. Gpr4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 55CytoplasmicSequence analysis10
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 135CytoplasmicSequence analysisAdd BLAST20
Transmembranei136 – 156Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini157 – 179ExtracellularSequence analysisAdd BLAST23
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 226CytoplasmicSequence analysisAdd BLAST26
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 273ExtracellularSequence analysisAdd BLAST26
Transmembranei274 – 291Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini292 – 365CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003795191 – 365G-protein coupled receptor 4Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BUD0.
PeptideAtlasiQ8BUD0.
PRIDEiQ8BUD0.

PTM databases

PhosphoSitePlusiQ8BUD0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044317.
GenevisibleiQ8BUD0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061243.

Structurei

3D structure databases

ProteinModelPortaliQ8BUD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ8BUD0.
KOiK04312.
OMAiLYCFVNE.
OrthoDBiEOG091G0CEX.
PhylomeDBiQ8BUD0.
TreeFamiTF331803.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BUD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSTGTGEG CHVDSRVDHL FPPSLYIFVI GVGLPTNCLA LWAAYRQVRQ
60 70 80 90 100
HNELGVYLMN LSIADLLYIC TLPLWVDYFL HHDNWIHGPG SCKLFGFIFY
110 120 130 140 150
SNIYISIAFL CCISVDRYLA VAHPLRFARL RRVKTAVAVS SVVWATELGA
160 170 180 190 200
NSAPLFHDEL FRDRYNHTFC FEKFPMERWV AWMNLYRVFV GFLFPWALML
210 220 230 240 250
LCYRGILRAV QSSVSTERQE KVKIKRLALS LIAIVLVCFA PYHALLLSRS
260 270 280 290 300
AVYLGRPWDC GFEERVFSAY HSSLAFTSLN CVADPILYCL VNEGARSDVA
310 320 330 340 350
KALHNLLRFL ASNKPQEMAN ASLTLETPLT SKRSTTGKSS GAVWAVPPTA
360
QGDQVPLKVL LPPAQ
Length:365
Mass (Da):41,105
Last modified:March 1, 2003 - v1
Checksum:i20D9F8128DE0EA37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085829 mRNA. Translation: BAC39547.1.
CH466639 Genomic DNA. Translation: EDL23124.1.
BC099398 mRNA. Translation: AAH99398.1.
CCDSiCCDS20893.1.
RefSeqiNP_783599.1. NM_175668.4.
XP_006540111.1. XM_006540048.3.
UniGeneiMm.135984.

Genome annotation databases

EnsembliENSMUST00000060225; ENSMUSP00000061243; ENSMUSG00000044317.
GeneIDi319197.
KEGGimmu:319197.
UCSCiuc009flb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK085829 mRNA. Translation: BAC39547.1.
CH466639 Genomic DNA. Translation: EDL23124.1.
BC099398 mRNA. Translation: AAH99398.1.
CCDSiCCDS20893.1.
RefSeqiNP_783599.1. NM_175668.4.
XP_006540111.1. XM_006540048.3.
UniGeneiMm.135984.

3D structure databases

ProteinModelPortaliQ8BUD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061243.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8BUD0.

Proteomic databases

PaxDbiQ8BUD0.
PeptideAtlasiQ8BUD0.
PRIDEiQ8BUD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060225; ENSMUSP00000061243; ENSMUSG00000044317.
GeneIDi319197.
KEGGimmu:319197.
UCSCiuc009flb.2. mouse.

Organism-specific databases

CTDi2828.
MGIiMGI:2441992. Gpr4.

Phylogenomic databases

eggNOGiENOG410IH5V. Eukaryota.
ENOG410Z8KI. LUCA.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000004801.
InParanoidiQ8BUD0.
KOiK04312.
OMAiLYCFVNE.
OrthoDBiEOG091G0CEX.
PhylomeDBiQ8BUD0.
TreeFamiTF331803.

Enzyme and pathway databases

ReactomeiR-MMU-373076. Class A/1 (Rhodopsin-like receptors).
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiGpr4. mouse.
PROiQ8BUD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044317.
GenevisibleiQ8BUD0. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002276. GPR4_orph.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01147. GPR4RECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR4_MOUSE
AccessioniPrimary (citable) accession number: Q8BUD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.