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Protein

Uronyl 2-sulfotransferase

Gene

Ust

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • establishment of cell polarity Source: MGI
  • regulation of axonogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-MMU-2022923. Dermatan sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Uronyl 2-sulfotransferase (EC:2.8.2.-)
Gene namesi
Name:Ust
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2442406. Ust.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini71 – 407LumenalSequence analysisAdd BLAST337

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076821 – 407Uronyl 2-sulfotransferaseAdd BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8BUB6.
PRIDEiQ8BUB6.

PTM databases

PhosphoSitePlusiQ8BUB6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047712.
CleanExiMM_UST.
GenevisibleiQ8BUB6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052017.

Structurei

3D structure databases

ProteinModelPortaliQ8BUB6.
SMRiQ8BUB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3922. Eukaryota.
ENOG410XTA1. LUCA.
GeneTreeiENSGT00530000063408.
HOGENOMiHOG000059649.
HOVERGENiHBG086208.
InParanoidiQ8BUB6.
KOiK03193.
OMAiRPHFFIP.
OrthoDBiEOG091G0VTJ.
TreeFamiTF315238.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BUB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKQQQHPG GGTDPWPHGA PVGGAPPCLG SCKRRIPLLP FLRFSLRDYG
60 70 80 90 100
FCMATLLVFC LGSLFYQLSG GPPRFLLDLR QYLGNSTYLD DHGPPPSKVL
110 120 130 140 150
PFPSQVVYNR VGKCGSRTVV LLLRILSEKH GFNLVTSDIH NKTRLTKNEQ
160 170 180 190 200
MELIKNISTA EQPYLFTRHV HFLNFSRFGG DQPVYINIIR DPVSRFLSNY
210 220 230 240 250
FFRRFGDWRG EQNHMIRTPS MRQEERYLDI NECILENYPE CSNPRLFYII
260 270 280 290 300
PYFCGQHPRC REPGEWALER AKLNVNENFL LVGILEELED VLLLLERFLP
310 320 330 340 350
HYFKGVLSIY KDPEHRKLGN MTVTVRKTVP SPEAVQILYQ RMRYEYEFYH
360 370 380 390 400
YVREQFHLLK RKLGLKSRVS GPPVRPQFFI PTPLETEEPI DDEEQDDEKW

LEDIYKR
Length:407
Mass (Da):47,730
Last modified:July 27, 2011 - v3
Checksum:i5DE77416709B9DC6
GO

Sequence cautioni

The sequence BAC39625 differs from that shown. Reason: Frameshift at position 318.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57L → V in BAC39625 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086181 mRNA. Translation: BAC39625.1. Frameshift.
BC138155 mRNA. Translation: AAI38156.1.
CCDSiCCDS35835.1.
RefSeqiNP_796361.2. NM_177387.3.
UniGeneiMm.41163.

Genome annotation databases

EnsembliENSMUST00000061601; ENSMUSP00000052017; ENSMUSG00000047712.
GeneIDi338362.
KEGGimmu:338362.
UCSCiuc007eit.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK086181 mRNA. Translation: BAC39625.1. Frameshift.
BC138155 mRNA. Translation: AAI38156.1.
CCDSiCCDS35835.1.
RefSeqiNP_796361.2. NM_177387.3.
UniGeneiMm.41163.

3D structure databases

ProteinModelPortaliQ8BUB6.
SMRiQ8BUB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052017.

PTM databases

PhosphoSitePlusiQ8BUB6.

Proteomic databases

PaxDbiQ8BUB6.
PRIDEiQ8BUB6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061601; ENSMUSP00000052017; ENSMUSG00000047712.
GeneIDi338362.
KEGGimmu:338362.
UCSCiuc007eit.1. mouse.

Organism-specific databases

CTDi10090.
MGIiMGI:2442406. Ust.

Phylogenomic databases

eggNOGiKOG3922. Eukaryota.
ENOG410XTA1. LUCA.
GeneTreeiENSGT00530000063408.
HOGENOMiHOG000059649.
HOVERGENiHBG086208.
InParanoidiQ8BUB6.
KOiK03193.
OMAiRPHFFIP.
OrthoDBiEOG091G0VTJ.
TreeFamiTF315238.

Enzyme and pathway databases

ReactomeiR-MMU-2022923. Dermatan sulfate biosynthesis.

Miscellaneous databases

ChiTaRSiUst. mouse.
PROiQ8BUB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047712.
CleanExiMM_UST.
GenevisibleiQ8BUB6. MM.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
[Graphical view]
PfamiPF03567. Sulfotransfer_2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUST_MOUSE
AccessioniPrimary (citable) accession number: Q8BUB6
Secondary accession number(s): B2RR02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.