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Protein

Solute carrier family 26 member 9

Gene

Slc26a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate.2 Publications

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: MGI
  • bicarbonate transport Source: MGI
  • chloride transmembrane transport Source: GO_Central
  • chloride transport Source: MGI
  • positive regulation of gene expression Source: MGI
  • regulation of intracellular pH Source: GO_Central
  • regulation of membrane potential Source: GO_Central
  • regulation of pH Source: MGI
Complete GO annotation...

Protein family/group databases

TCDBi2.A.53.2.10. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 26 member 9
Alternative name(s):
Anion transporter/exchanger protein 9
Gene namesi
Name:Slc26a9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444594. Slc26a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei332 – 352HelicalSequence analysisAdd BLAST21
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003244931 – 790Solute carrier family 26 member 9Add BLAST790

Proteomic databases

PaxDbiQ8BU91.
PRIDEiQ8BU91.

PTM databases

PhosphoSitePlusiQ8BU91.

Expressioni

Tissue specificityi

Expressed in stomach and trachea. Abundantly expressed in the apical domain of the surface epithelial cells and the deep cells in the gastric gland. Also expressed in heart, brain, lung and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000042268.
CleanExiMM_SLC26A9.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036916.

Structurei

3D structure databases

ProteinModelPortaliQ8BU91.
SMRiQ8BU91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini519 – 737STASPROSITE-ProRule annotationAdd BLAST219

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 293Poly-Val4

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ8BU91.
KOiK14706.
PhylomeDBiQ8BU91.
TreeFamiTF313784.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BU91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPRPRYVV DRAAYSLSLF DDEFEKKDRA YPVGEKLRNT FRCSSAKFKA
60 70 80 90 100
FVFGLLPVLS WLPKYKIKDY IIPDLLGGLS GGCIQVPQGM AFALLANLPA
110 120 130 140 150
VNGLYSSFFP LLTYFFLGGI HQMVPGTFAV ISILVGNICL QLAPESKFQI
160 170 180 190 200
FNNVTNETYV DTAAMEAERL HVSATLACLT AVIQMALGFM QFGFVAIYLS
210 220 230 240 250
ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT FIDICKNLPH
260 270 280 290 300
TNIASLIFAL VSGVFLVLVK ELNARYMHKI HFPIPTEMIV VVVATAISGS
310 320 330 340 350
CKMPKKYHMQ IVGEIRQGFP TPVAPMVSQW KGMVGTAFSL AIVGYVINLA
360 370 380 390 400
MGRTLASKHG YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA
410 420 430 440 450
GGKSQVASLC VSLVVMITML VLGSYLYPLP KAVLGALIAV NLKNSLKQLT
460 470 480 490 500
DPYYLWRKSK LDCCVWVVSF LSSFFLSLPY GVAVGVAFSI LVVIFQTQFR
510 520 530 540 550
NGSTLAQVMD TDIYVNPKTY NRAQEIAGVK IVTYCSPLYL ANSEIFRQKV
560 570 580 590 600
IAKTGMDPQK VLLAKQKYLR KQEKRTAIPT QQRKSLFMKT KTVSLQELQQ
610 620 630 640 650
DFESAPSTDP NNNQAPAAEA HISYITFSPD ASTAAACELP ASTRSPQEAS
660 670 680 690 700
DTLASVPPFV TFHTLILDMS GVSFVDLMGI KALAKLSSTY EKIGVQIFLV
710 720 730 740 750
NIHAQVYNDI SHGGVFEDGC VQRSHVFPSI HDAVLFAQAN AREAPDRNFH
760 770 780 790
GAPGDTEFSL YDSEEEGPSY WDLEQEMFGT MFHTETLTAL
Length:790
Mass (Da):86,852
Last modified:March 1, 2003 - v1
Checksum:i4D473330D4D94DCD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332G → D in AAK54448 (Ref. 1) Curated1
Sequence conflicti332G → D in BAC37482 (PubMed:16141072).Curated1
Sequence conflicti540L → F in AAK54448 (Ref. 1) Curated1
Sequence conflicti540L → F in BAC37482 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034145 mRNA. Translation: AAK54448.1.
AK078966 mRNA. Translation: BAC37482.1.
AK086815 mRNA. Translation: BAC39749.1.
CCDSiCCDS15273.1.
RefSeqiNP_796217.2. NM_177243.4.
XP_006529763.1. XM_006529700.2.
UniGeneiMm.482704.

Genome annotation databases

GeneIDi320718.
KEGGimmu:320718.
UCSCiuc007cns.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY034145 mRNA. Translation: AAK54448.1.
AK078966 mRNA. Translation: BAC37482.1.
AK086815 mRNA. Translation: BAC39749.1.
CCDSiCCDS15273.1.
RefSeqiNP_796217.2. NM_177243.4.
XP_006529763.1. XM_006529700.2.
UniGeneiMm.482704.

3D structure databases

ProteinModelPortaliQ8BU91.
SMRiQ8BU91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036916.

Protein family/group databases

TCDBi2.A.53.2.10. the sulfate permease (sulp) family.

PTM databases

PhosphoSitePlusiQ8BU91.

Proteomic databases

PaxDbiQ8BU91.
PRIDEiQ8BU91.

Protocols and materials databases

DNASUi320718.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi320718.
KEGGimmu:320718.
UCSCiuc007cns.1. mouse.

Organism-specific databases

CTDi115019.
MGIiMGI:2444594. Slc26a9.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000006546.
HOVERGENiHBG000639.
InParanoidiQ8BU91.
KOiK14706.
PhylomeDBiQ8BU91.
TreeFamiTF313784.

Miscellaneous databases

PROiQ8BU91.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042268.
CleanExiMM_SLC26A9.

Family and domain databases

Gene3Di3.30.750.24. 2 hits.
InterProiIPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR030306. SLC26A9.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 2 hits.
PTHR11814:SF17. PTHR11814:SF17. 2 hits.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 2 hits.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS26A9_MOUSE
AccessioniPrimary (citable) accession number: Q8BU91
Secondary accession number(s): Q8BVC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.