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Protein

BPI fold-containing family B member 6

Gene

Bpifb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
BPI fold-containing family B member 6
Alternative name(s):
Bactericidal/permeability-increasing protein-like 3
Gene namesi
Name:Bpifb6
Synonyms:Bpil3, Gm119
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684965. Bpifb6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001716919 – 449BPI fold-containing family B member 6Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 172By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BU51.
PRIDEiQ8BU51.

PTM databases

iPTMnetiQ8BU51.
PhosphoSitePlusiQ8BU51.

Expressioni

Gene expression databases

BgeeiENSMUSG00000068009.
ExpressionAtlasiQ8BU51. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ8BU51.
SMRiQ8BU51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110772.
HOGENOMiHOG000231740.
HOVERGENiHBG095916.
InParanoidiQ8BU51.
OMAiMTITGKS.
OrthoDBiEOG091G048N.
TreeFamiTF315617.

Family and domain databases

InterProiView protein in InterPro
IPR017943. Bactericidal_perm-incr_a/b_dom.
IPR032942. BPI/LBP/Plunc.
IPR032948. BPIFB6.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017942. Lipid-bd_serum_glycop_N.
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF99. PTHR10504:SF99. 1 hit.
PfamiView protein in Pfam
PF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
SMARTiView protein in SMART
SM00329. BPI2. 1 hit.
SUPFAMiSSF55394. SSF55394. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BU51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCSLSLVLC GLLAGTRADP GGLLRLGMDI MNHEVQSAME ESHILEKMAA
60 70 80 90 100
EASNPQPGGK AIKGLSNMKV KDVLEPVITL NFVPGVGISQ CVSTGMTITG
110 120 130 140 150
KSFTGGNMEI NVVLNITATD RLLQDEEAGT PVFRSEGCEV ILVSVKTNLP
160 170 180 190 200
NNKAINKFVD STLRKVLPGL MCPAIDAVLE YVNKKWAKLT DPMPVDKMGT
210 220 230 240 250
VKYALTSPPA TTASHIQVDF SPVVQLQEGQ LIQLATDGSL PEFPEGSAKD
260 270 280 290 300
SQLLLSATFL TAELALLQKS LEVKLKDKRV GKLPQNTRTL AGFIPQVAKT
310 320 330 340 350
YHKPKPLLIK VKINKPPKVT MKAGKSLMHL HGSLEMFAAR RHGKHPKSLF
360 370 380 390 400
RLETHIGLEI HYSVQDNRLQ MVTSMDSLLS LARESSSVGD FHEAELTGFI
410 420 430 440
TDYLQKAYIP VVNDVLHVGL PLPDLLAINY NLAELDIVED ALVLGLKTE
Length:449
Mass (Da):48,781
Last modified:July 27, 2011 - v3
Checksum:iEF5EFCB3D4401DC3
GO

Sequence cautioni

The sequence BAC39978 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti385 – 386SS → FF in AAH48083 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833803 Genomic DNA. Translation: CAM18459.1.
BC048083 mRNA. Translation: AAH48083.1.
AK087711 mRNA. Translation: BAC39978.1. Different initiation.
CCDSiCCDS16920.1.
RefSeqiNP_955007.2. NM_199303.2.
XP_017173296.1. XM_017317807.1.
UniGeneiMm.137570.

Genome annotation databases

EnsembliENSMUST00000088955; ENSMUSP00000086347; ENSMUSG00000068009.
GeneIDi228796.
KEGGimmu:228796.
UCSCiuc008nio.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiBPIB6_MOUSE
AccessioniPrimary (citable) accession number: Q8BU51
Secondary accession number(s): A2APD0, Q80ZU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: July 27, 2011
Last modified: July 5, 2017
This is version 101 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families