Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetolactate synthase-like protein

Gene

Ilvbl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity
  • thiamine diphosphateBy similarityNote: Binds 1 thiamine pyrophosphate per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Thiamine pyrophosphateBy similarity1
Metal bindingi521MagnesiumBy similarity1
Metal bindingi547MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
LigandMagnesium, Metal-binding, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Acetolactate synthase-like protein (EC:2.2.1.-)
Alternative name(s):
IlvB-like protein
Gene namesi
Name:Ilvbl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1351911 Ilvbl

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148261 – 632Acetolactate synthase-like proteinAdd BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei369PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BU33
PaxDbiQ8BU33
PeptideAtlasiQ8BU33
PRIDEiQ8BU33

PTM databases

iPTMnetiQ8BU33
PhosphoSitePlusiQ8BU33

Expressioni

Gene expression databases

BgeeiENSMUSG00000032763
CleanExiMM_ILVBL
ExpressionAtlasiQ8BU33 baseline and differential
GenevisibleiQ8BU33 MM

Interactioni

Protein-protein interaction databases

BioGridi229702, 1 interactor
IntActiQ8BU33, 3 interactors
MINTiQ8BU33
STRINGi10090.ENSMUSP00000101023

Structurei

3D structure databases

ProteinModelPortaliQ8BU33
SMRiQ8BU33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni470 – 550Thiamine pyrophosphate bindingBy similarityAdd BLAST81

Sequence similaritiesi

Belongs to the TPP enzyme family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1185 Eukaryota
COG0028 LUCA
GeneTreeiENSGT00530000063412
HOGENOMiHOG000010642
HOVERGENiHBG108004
InParanoidiQ8BU33
KOiK11259
OMAiFRPLCKF
OrthoDBiEOG091G057K
PhylomeDBiQ8BU33
TreeFamiTF354221

Family and domain databases

InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR029061 THDP-binding
IPR012000 Thiamin_PyroP_enz_cen_dom
IPR012001 Thiamin_PyroP_enz_TPP-bd_dom
IPR000399 TPP-bd_CS
IPR011766 TPP_enzyme-bd_C
PfamiView protein in Pfam
PF02775 TPP_enzyme_C, 1 hit
PF00205 TPP_enzyme_M, 1 hit
PF02776 TPP_enzyme_N, 1 hit
SUPFAMiSSF52467 SSF52467, 2 hits
SSF52518 SSF52518, 2 hits
PROSITEiView protein in PROSITE
PS00187 TPP_ENZYMES, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BU33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METSAAAASA GGFFPSFLLL AFGTLVAAVL GVAHRLGLFY QLMHKVDKTS
60 70 80 90 100
IRHGGESVAA VLRAHGVRFV FTLVGGHISP LLVACEKLGI RVVDTRHEVT
110 120 130 140 150
AVFAADAVAR LTGTVGVAAV TAGPGLTNTV TAVKNAQVAQ SPVLLLGGAA
160 170 180 190 200
STLLQKRGAL QAIDQMSLFR PLCKFCASVR RVRDIVPTLR TAIAAAQSGT
210 220 230 240 250
PGPVFVELPL DVLYPYFMVE KEMIPTKLPN SLMGRVVVWY LQNCLANLFV
260 270 280 290 300
GAWEPRPEGP LPLDIPQASP QQVQRCVEIL SRAKRPLLVL GSQALLPPTP
310 320 330 340 350
ANKLRAAVET LGVPCFLGGM SRGLLGRNHP LHIRQNRSAA LKKADVVVLA
360 370 380 390 400
GAVCDFRLSY GRVLNRKSSI IIVNRNRDDL LLNSDIFWKP QEAVQGDVGS
410 420 430 440 450
FMIKLVEGLQ GQMWSSDWAE ELRKADQQKE QTYRDKALMP VLQHLNPVWV
460 470 480 490 500
LQQVEETLPD NALLVVDGGD FVATAAYLVQ PRGPLRWLDP GAFGTLGVGA
510 520 530 540 550
GFALGAKLCQ PEAEVWCLFG DGAFGYSLIE FDTFVRHKVP VIALVGNDAG
560 570 580 590 600
WTQISREQVP RLGSDVACSL AYTDYHKAAM GLGAQGLILS RDNKDQVVKV
610 620 630
LREGQQLCQD GHAVVVNILI GRTDFRDGSI SV
Length:632
Mass (Da):68,156
Last modified:March 1, 2003 - v1
Checksum:i02B5C5ED36ECDE89
GO
Isoform 2 (identifier: Q8BU33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-416: DVGSFMIKLVEGLQGQMWSS → ECTPRDPTMCMVSSSCLCCI
     417-632: Missing.

Note: No experimental confirmation available.
Show »
Length:416
Mass (Da):44,550
Checksum:i2F6AF90E9154B5DC
GO
Isoform 3 (identifier: Q8BU33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-401: GDVGSF → AGPASP
     402-632: Missing.

Note: No experimental confirmation available.
Show »
Length:401
Mass (Da):42,812
Checksum:i66B7E30E903AE2B0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030392396 – 401GDVGSF → AGPASP in isoform 3. 1 Publication6
Alternative sequenceiVSP_030393397 – 416DVGSF…QMWSS → ECTPRDPTMCMVSSSCLCCI in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_030394402 – 632Missing in isoform 3. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_030395417 – 632Missing in isoform 2. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087956 mRNA Translation: BAC40057.1
AK133553 mRNA Translation: BAE21720.1
AK143918 mRNA Translation: BAE25603.1
AK146075 mRNA Translation: BAE26879.1
BC056459 mRNA Translation: AAH56459.1
CCDSiCCDS23966.1 [Q8BU33-1]
RefSeqiNP_776112.1, NM_173751.4 [Q8BU33-1]
XP_011241702.1, XM_011243400.2 [Q8BU33-1]
XP_011241703.1, XM_011243401.1
UniGeneiMm.2644

Genome annotation databases

EnsembliENSMUST00000105384; ENSMUSP00000101023; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000218271; ENSMUSP00000151480; ENSMUSG00000032763 [Q8BU33-3]
ENSMUST00000218885; ENSMUSP00000151263; ENSMUSG00000032763 [Q8BU33-1]
ENSMUST00000220430; ENSMUSP00000151674; ENSMUSG00000032763 [Q8BU33-2]
GeneIDi216136
KEGGimmu:216136
UCSCiuc007fxv.2 mouse [Q8BU33-1]
uc007fxw.1 mouse [Q8BU33-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiILVBL_MOUSE
AccessioniPrimary (citable) accession number: Q8BU33
Secondary accession number(s): Q3UNZ4, Q3UZY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health