Reviewed,
UniProtKB/Swiss-Prot Q8BU33 (ILVBL_MOUSE)
Last modified
June 16, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acetolactate synthase-like protein EC=2.2.1.- Alternative name(s): IlvB-like protein | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 632 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Cofactor | Binds 1 magnesium ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the TPP enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Transmembrane |
| Ligand | Magnesium Metal-binding Thiamine pyrophosphate |
| Molecular function | Transferase |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW thiamin pyrophosphate bindingInferred from electronic annotation. Source: InterPro transferase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8BU33-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8BU33-2) The sequence of this isoform differs from the canonical sequence as follows: 397-416: DVGSFMIKLVEGLQGQMWSS → ECTPRDPTMCMVSSSCLCCI 417-632: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q8BU33-3) The sequence of this isoform differs from the canonical sequence as follows: 396-401: GDVGSF → AGPASP 402-632: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 632 | 632 | Acetolactate synthase-like protein | PRO_0000314826 | |||||
Regions | |||||||||
| Transmembrane | 13 – 33 | 21 | Potential | ||||||
| Region | 470 – 550 | 81 | Thiamine pyrophosphate binding By similarity | ||||||
Sites | |||||||||
| Metal binding | 521 | 1 | Magnesium By similarity | ||||||
| Metal binding | 547 | 1 | Magnesium By similarity | ||||||
| Binding site | 98 | 1 | Thiamine pyrophosphate By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 396 – 401 | 6 | GDVGSF → AGPASP in isoform 3. | VSP_030392 | |||||
| Alternative sequence | 397 – 416 | 20 | DVGSF…QMWSS → ECTPRDPTMCMVSSSCLCCI in isoform 2. | VSP_030393 | |||||
| Alternative sequence | 402 – 632 | 231 | Missing in isoform 3. | VSP_030394 | |||||
| Alternative sequence | 417 – 632 | 216 | Missing in isoform 2. | VSP_030395 | |||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6J and NOD. Tissue: Kidney, Liver, Pituitary and Thymus. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK087956 mRNA. Translation: BAC40057.1. AK133553 mRNA. Translation: BAE21720.1. AK143918 mRNA. Translation: BAE25603.1. AK146075 mRNA. Translation: BAE26879.1. BC056459 mRNA. Translation: AAH56459.1. | |
| IPI | IPI00225209. IPI00881209. IPI00881346. |
| RefSeq | NP_776112.1. |
| UniGene | Mm.2644 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1OZH based on UniProtKB P27696. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8BU33. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000032763. Mus musculus. [Contig view] |
| GeneID | 216136. |
| KEGG | mmu:216136. |
Organism-specific databases | |
| MGI | MGI:1351911. Ilvbl. |
Phylogenomic databases | |
| HOGENOM | Q8BU33. |
| HOVERGEN | Q8BU33. |
| OMA | Q8BU33. SLFRPLC. |
Gene expression databases | |
| Bgee | Q8BU33. |
| CleanEx | MM_ILVBL. |
Family and domain databases | |
| InterPro | IPR000399. TPP_bd_CS. IPR012001. TPP_bd_enzyme_N. IPR011766. TPP_enzyme_bd_C. IPR012000. TPP_enzyme_M. [Graphical view] |
| Pfam | PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view] |
| PROSITE | PS00187. TPP_ENZYMES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 374994. |
| SOURCE | Search... |
Entry information
| Entry name | ILVBL_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8BU33 Secondary accession number(s): Q3UNZ4, Q3UZY5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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