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Protein

Ras-related protein Rap-2c

Gene

Rap2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi116 – 119GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • establishment of endothelial intestinal barrier Source: MGI
  • negative regulation of cell migration Source: MGI
  • positive regulation of protein autophosphorylation Source: MGI
  • Rap protein signal transduction Source: UniProtKB
  • regulation of protein tyrosine kinase activity Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-2c
Gene namesi
Name:Rap2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919315 Rap2c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi176C → G: Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-177. 1 Publication1
Mutagenesisi177C → G: Loss of association with the recycling endosome membranes and loss of TNIK activation; when associated with C-176. 1 Publication1
Mutagenesisi180C → A: Loss of association with membranes. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000302231 – 180Ras-related protein Rap-2cAdd BLAST180
PropeptideiPRO_0000030224181 – 183Removed in mature form1 Publication3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi176S-palmitoyl cysteine1 Publication1
Lipidationi177S-palmitoyl cysteine1 Publication1
Modified residuei180Cysteine methyl ester1 Publication1
Lipidationi180S-geranylgeranyl cysteine1 Publication1

Post-translational modificationi

Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiQ8BU31
MaxQBiQ8BU31
PaxDbiQ8BU31
PeptideAtlasiQ8BU31
PRIDEiQ8BU31

PTM databases

iPTMnetiQ8BU31
PhosphoSitePlusiQ8BU31
SwissPalmiQ8BU31

Expressioni

Gene expression databases

BgeeiENSMUSG00000050029
CleanExiMM_RAP2C
GenevisibleiQ8BU31 MM

Interactioni

Protein-protein interaction databases

BioGridi215127, 1 interactor
STRINGi10090.ENSMUSP00000058391

Structurei

3D structure databases

ProteinModelPortaliQ8BU31
SMRiQ8BU31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ8BU31
KOiK07839
OMAiEPDEHIC
OrthoDBiEOG091G0OOG
PhylomeDBiQ8BU31
TreeFamiTF313014

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BU31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP
60 70 80 90 100
SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI
110 120 130 140 150
VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK
160 170 180
SMVDELFAEI VRQMNYSSLP EKQDQCCTTC VVQ
Length:183
Mass (Da):20,745
Last modified:March 1, 2003 - v1
Checksum:i6763385F76638324
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83S → N in AAH27363 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087971 mRNA Translation: BAC40066.1
AK146057 mRNA Translation: BAE26866.1
AK146956 mRNA Translation: BAE27564.1
AK147015 mRNA Translation: BAE27609.1
BC027363 mRNA Translation: AAH27363.3
BC050056 mRNA Translation: AAH50056.2
BC064814 mRNA Translation: AAH64814.2
BC094890 mRNA Translation: AAH94890.1
CCDSiCCDS30121.1
RefSeqiNP_766001.1, NM_172413.2
XP_006541608.1, XM_006541545.2
XP_006541609.1, XM_006541546.2
UniGeneiMm.43152

Genome annotation databases

EnsembliENSMUST00000053593; ENSMUSP00000058391; ENSMUSG00000050029
GeneIDi72065
KEGGimmu:72065
UCSCiuc009tds.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAP2C_MOUSE
AccessioniPrimary (citable) accession number: Q8BU31
Secondary accession number(s): Q504Q0
, Q6P1Y7, Q810J4, Q8R2P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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