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Q8BU27

- PPM1M_MOUSE

UniProt

Q8BU27 - PPM1M_MOUSE

Protein

Protein phosphatase 1M

Gene

Ppm1m

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (02 Feb 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi71 – 711Manganese 1By similarity
    Metal bindingi71 – 711Manganese 2By similarity
    Metal bindingi72 – 721Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi330 – 3301Manganese 2By similarity
    Metal bindingi387 – 3871Manganese 2By similarity

    GO - Molecular functioni

    1. CTD phosphatase activity Source: UniProtKB
    2. manganese ion binding Source: UniProtKB
    3. phosphoprotein phosphatase activity Source: MGI

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1M (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 2C isoform eta
    Short name:
    PP2C-eta
    Short name:
    PP2CE
    Gene namesi
    Name:Ppm1m
    Synonyms:Ppm1e
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1915155. Ppm1m.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Protein phosphatase 1MPRO_0000057757Add
    BLAST

    Proteomic databases

    PRIDEiQ8BU27.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in testis and lower levels in lung, kidney and brain.1 Publication

    Gene expression databases

    CleanExiMM_PPM1E.
    MM_PPM1M.
    GenevestigatoriQ8BU27.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BU27.
    SMRiQ8BU27. Positions 62-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 299240PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000251606.
    HOVERGENiHBG105802.
    InParanoidiQ8BU27.
    KOiK17507.
    PhylomeDBiQ8BU27.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 3 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8BU27-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYVPPRTSLR VWPMLCGIRV INAEKSEFNE DQAACGKLCI RRCEFGIEED    50
    QEWLTVCPEE FLTGHYWALF DGHGGPAAAI LAANTLHSCL RRQLEAVVEG 100
    MIAPQPPMHL SGRCVCPSDP QFVEEKGIQA EDLVIGALEN AFQECDDVIG 150
    RELEASGQVG GCTALVAVFL QGKLYVANAG DSRAILVRRH EIRQLSSEFT 200
    PETERQRIQQ LAFTYPELLA GEFTRLEFPR RLKGDDLGQK VLFRDHHMRG 250
    WSYKRVEKSD LKYPLIHGQG RQARLLGTLA VSRGLGDHQL RVLDTDIQLK 300
    PFLLSIPQVT VLDVHQLAVQ EEDVVVMATD GLWDVLSNEQ VALLVRSFLT 350
    GNQKDDPHRF SELAKMLIHN TQGKDNGATG EGQVSYDDVS VFVIPLHSQA 400
    QEGSGH 406
    Length:406
    Mass (Da):45,273
    Last modified:February 2, 2004 - v2
    Checksum:iAE82D1B601C2CDF4
    GO
    Isoform 2Curated (identifier: Q8BU27-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-100: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:306
    Mass (Da):34,054
    Checksum:iFA5CDCC368C624FE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti102 – 1021I → M in AAR01612. (PubMed:14654243)Curated
    Sequence conflicti102 – 1021I → M in BAC40085. (PubMed:16141072)Curated
    Sequence conflicti156 – 1561S → L in BAB30649. (PubMed:16141072)Curated
    Sequence conflicti223 – 2231F → L in BAB30649. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 100100Missing in isoform 2. 1 PublicationVSP_050658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY332616 mRNA. Translation: AAR01612.1.
    AK013149 mRNA. Translation: BAB28679.2.
    AK017245 mRNA. Translation: BAB30649.1.
    AK046387 mRNA. Translation: BAC32699.1.
    AK087999 mRNA. Translation: BAC40085.1.
    CCDSiCCDS23471.1. [Q8BU27-1]
    RefSeqiNP_945149.2. NM_198931.3.
    UniGeneiMm.23018.

    Genome annotation databases

    GeneIDi67905.
    KEGGimmu:67905.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY332616 mRNA. Translation: AAR01612.1 .
    AK013149 mRNA. Translation: BAB28679.2 .
    AK017245 mRNA. Translation: BAB30649.1 .
    AK046387 mRNA. Translation: BAC32699.1 .
    AK087999 mRNA. Translation: BAC40085.1 .
    CCDSi CCDS23471.1. [Q8BU27-1 ]
    RefSeqi NP_945149.2. NM_198931.3.
    UniGenei Mm.23018.

    3D structure databases

    ProteinModelPortali Q8BU27.
    SMRi Q8BU27. Positions 62-396.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8BU27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 67905.
    KEGGi mmu:67905.

    Organism-specific databases

    CTDi 132160.
    MGIi MGI:1915155. Ppm1m.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000251606.
    HOVERGENi HBG105802.
    InParanoidi Q8BU27.
    KOi K17507.
    PhylomeDBi Q8BU27.

    Miscellaneous databases

    NextBioi 325910.
    PROi Q8BU27.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PPM1E.
    MM_PPM1M.
    Genevestigatori Q8BU27.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family."
      Komaki K., Katsura K., Ohnishi M., Li M.G., Sasaki M., Watanabe M., Kobayashi T., Tamura S.
      Biochim. Biophys. Acta 1630:130-137(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: EmbryoImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J and NOD.
      Tissue: Corpora quadrigemina, Head and Thymus.

    Entry informationi

    Entry nameiPPM1M_MOUSE
    AccessioniPrimary (citable) accession number: Q8BU27
    Secondary accession number(s): Q9CSD6, Q9CU88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: February 2, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3