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Q8BU27

- PPM1M_MOUSE

UniProt

Q8BU27 - PPM1M_MOUSE

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Protein

Protein phosphatase 1M

Gene

Ppm1m

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi71 – 711Manganese 1By similarity
Metal bindingi71 – 711Manganese 2By similarity
Metal bindingi72 – 721Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi330 – 3301Manganese 2By similarity
Metal bindingi387 – 3871Manganese 2By similarity

GO - Molecular functioni

  1. CTD phosphatase activity Source: UniProtKB
  2. manganese ion binding Source: UniProtKB
  3. phosphoprotein phosphatase activity Source: MGI

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1M (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 2C isoform eta
Short name:
PP2C-eta
Short name:
PP2CE
Gene namesi
Name:Ppm1m
Synonyms:Ppm1e
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915155. Ppm1m.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Protein phosphatase 1MPRO_0000057757Add
BLAST

Proteomic databases

PRIDEiQ8BU27.

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis and lower levels in lung, kidney and brain.1 Publication

Gene expression databases

CleanExiMM_PPM1E.
MM_PPM1M.
GenevestigatoriQ8BU27.

Structurei

3D structure databases

ProteinModelPortaliQ8BU27.
SMRiQ8BU27. Positions 62-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 299240PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000251606.
HOVERGENiHBG105802.
InParanoidiQ8BU27.
KOiK17507.
PhylomeDBiQ8BU27.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8BU27-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYVPPRTSLR VWPMLCGIRV INAEKSEFNE DQAACGKLCI RRCEFGIEED
60 70 80 90 100
QEWLTVCPEE FLTGHYWALF DGHGGPAAAI LAANTLHSCL RRQLEAVVEG
110 120 130 140 150
MIAPQPPMHL SGRCVCPSDP QFVEEKGIQA EDLVIGALEN AFQECDDVIG
160 170 180 190 200
RELEASGQVG GCTALVAVFL QGKLYVANAG DSRAILVRRH EIRQLSSEFT
210 220 230 240 250
PETERQRIQQ LAFTYPELLA GEFTRLEFPR RLKGDDLGQK VLFRDHHMRG
260 270 280 290 300
WSYKRVEKSD LKYPLIHGQG RQARLLGTLA VSRGLGDHQL RVLDTDIQLK
310 320 330 340 350
PFLLSIPQVT VLDVHQLAVQ EEDVVVMATD GLWDVLSNEQ VALLVRSFLT
360 370 380 390 400
GNQKDDPHRF SELAKMLIHN TQGKDNGATG EGQVSYDDVS VFVIPLHSQA

QEGSGH
Length:406
Mass (Da):45,273
Last modified:February 2, 2004 - v2
Checksum:iAE82D1B601C2CDF4
GO
Isoform 2Curated (identifier: Q8BU27-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:306
Mass (Da):34,054
Checksum:iFA5CDCC368C624FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021I → M in AAR01612. (PubMed:14654243)Curated
Sequence conflicti102 – 1021I → M in BAC40085. (PubMed:16141072)Curated
Sequence conflicti156 – 1561S → L in BAB30649. (PubMed:16141072)Curated
Sequence conflicti223 – 2231F → L in BAB30649. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100Missing in isoform 2. 1 PublicationVSP_050658Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY332616 mRNA. Translation: AAR01612.1.
AK013149 mRNA. Translation: BAB28679.2.
AK017245 mRNA. Translation: BAB30649.1.
AK046387 mRNA. Translation: BAC32699.1.
AK087999 mRNA. Translation: BAC40085.1.
CCDSiCCDS23471.1. [Q8BU27-1]
RefSeqiNP_945149.2. NM_198931.3.
UniGeneiMm.23018.

Genome annotation databases

GeneIDi67905.
KEGGimmu:67905.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY332616 mRNA. Translation: AAR01612.1 .
AK013149 mRNA. Translation: BAB28679.2 .
AK017245 mRNA. Translation: BAB30649.1 .
AK046387 mRNA. Translation: BAC32699.1 .
AK087999 mRNA. Translation: BAC40085.1 .
CCDSi CCDS23471.1. [Q8BU27-1 ]
RefSeqi NP_945149.2. NM_198931.3.
UniGenei Mm.23018.

3D structure databases

ProteinModelPortali Q8BU27.
SMRi Q8BU27. Positions 62-396.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8BU27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 67905.
KEGGi mmu:67905.

Organism-specific databases

CTDi 132160.
MGIi MGI:1915155. Ppm1m.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000251606.
HOVERGENi HBG105802.
InParanoidi Q8BU27.
KOi K17507.
PhylomeDBi Q8BU27.

Miscellaneous databases

NextBioi 325910.
PROi Q8BU27.
SOURCEi Search...

Gene expression databases

CleanExi MM_PPM1E.
MM_PPM1M.
Genevestigatori Q8BU27.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family."
    Komaki K., Katsura K., Ohnishi M., Li M.G., Sasaki M., Watanabe M., Kobayashi T., Tamura S.
    Biochim. Biophys. Acta 1630:130-137(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: EmbryoImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina, Head and Thymus.

Entry informationi

Entry nameiPPM1M_MOUSE
AccessioniPrimary (citable) accession number: Q8BU27
Secondary accession number(s): Q9CSD6, Q9CU88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: October 1, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3