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Protein

Inactive serine protease PAMR1

Gene

Pamr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regeneration of skeletal muscle.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Serine protease homolog

Protein family/group databases

MEROPSiS01.998.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease PAMR1
Alternative name(s):
Peptidase domain-containing protein associated with muscle regeneration 1
Regeneration-associated muscle protease homolog
Gene namesi
Name:Pamr1
Synonyms:Ramp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445082. Pamr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 720699Inactive serine protease PAMR1PRO_0000287603Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi128 ↔ 150By similarity
Disulfide bondi177 ↔ 199By similarity
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi244 ↔ 260By similarity
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi280 ↔ 329By similarity
Disulfide bondi315 ↔ 342By similarity
Disulfide bondi414 ↔ 442By similarity
Disulfide bondi489 ↔ 505By similarity
Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi661 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BU25.
PaxDbiQ8BU25.
PRIDEiQ8BU25.

PTM databases

iPTMnetiQ8BU25.
PhosphoSiteiQ8BU25.

Expressioni

Tissue specificityi

Predominantly expressed in normal skeletal muscle and brain. Expression is enhanced in the regenerating area of injured skeletal muscle in mice.1 Publication

Inductioni

Down-regulated in dystrophin-mutant mdx muscle cell line.1 Publication

Gene expression databases

BgeeiQ8BU25.
CleanExiMM_E430002G05RIK.
GenevisibleiQ8BU25. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028612.

Structurei

3D structure databases

ProteinModelPortaliQ8BU25.
SMRiQ8BU25. Positions 128-258, 328-720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 236109CUBPROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27238EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini278 – 34467Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini387 – 44458Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini445 – 720276Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 9453Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 CUB domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
HOGENOMiHOG000231787.
HOVERGENiHBG055250.
InParanoidiQ8BU25.
OMAiFYRDDDR.
OrthoDBiEOG7GXP9X.
TreeFamiTF351669.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00008. EGF. 1 hit.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDRWAQLG LVFLQLLLIS SLPREYTVIN EACPGAEWNI MCRECCEYDQ
60 70 80 90 100
IECLCPGKKE VVGYTIPCCR NEDNECDSCL IHPGCTIFEN CKSCRNGSWG
110 120 130 140 150
GTLDDFYVKG FYCAECRAGW YGGDCMRCGQ VLRASKGQIL LESYPLNAHC
160 170 180 190 200
EWTIHARPGF IIQLRFGMLS LEFDYMCQYD YVEVRDGDNS DSPIIKRFCG
210 220 230 240 250
NERPAPIRST GSSLHVLFHS DGSKNFDGFH AVFEEITACS SSPCFHDGTC
260 270 280 290 300
LLDTTGSFKC ACLAGYTGQR CENLLEERNC SDLGGPVNGY KKITEGPGLL
310 320 330 340 350
NERHVKIGTV VSFFCNGSYV LSGNEKRTCQ QNGEWSGKQP VCMKACREPK
360 370 380 390 400
ISDLVRRRVL SMQVQSRETP LHQLYSTAFS KQKLQDASTK KPALPFGDLP
410 420 430 440 450
PGYQHLHTQV QYECISPFYR RLGSSRRTCL RTGKWSGRAP SCIPICGKIE
460 470 480 490 500
STPSPKTQGT RWPWQAAIYR RTSGVHDGGL HKGAWFLVCS GALVNERTVV
510 520 530 540 550
VAAHCVTELG KATIIKTADL KVVLGKFYRD DDRDEKSIQN LRVSAIILHP
560 570 580 590 600
NYDPILLDTD IAVLKLLDKA RISTRVQPIC LATTRDLSTS FQESHITVAG
610 620 630 640 650
WNILADVRSP GFKNDTLHYG MVRVVDPMLC EEQHEDHGIP VSVTDNMFCA
660 670 680 690 700
SKDPSTPSDI CTAETGGIAA LSFPGRASPE PRWHLVGLVS WSYDKTCSNG
710 720
LSTAFTKVLP FKDWIERNMK
Length:720
Mass (Da):80,320
Last modified:July 27, 2011 - v3
Checksum:i845BC9660EC4FE3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141A → E in AAH31841 (PubMed:15489334).Curated
Sequence conflicti114 – 1141A → E in AAH57685 (PubMed:15489334).Curated
Sequence conflicti303 – 3031R → H in BAC40098 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088017 mRNA. Translation: BAC40098.1.
AL845276, AL844605 Genomic DNA. Translation: CAM21810.1.
AL844605, AL845276 Genomic DNA. Translation: CAM27621.1.
CH466519 Genomic DNA. Translation: EDL27671.1.
BC031841 mRNA. Translation: AAH31841.1.
BC057685 mRNA. Translation: AAH57685.1.
CCDSiCCDS16468.1.
RefSeqiNP_776110.3. NM_173749.4.
UniGeneiMm.28649.
Mm.431895.

Genome annotation databases

EnsembliENSMUST00000028612; ENSMUSP00000028612; ENSMUSG00000027188.
GeneIDi210622.
KEGGimmu:210622.
UCSCiuc012caf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088017 mRNA. Translation: BAC40098.1.
AL845276, AL844605 Genomic DNA. Translation: CAM21810.1.
AL844605, AL845276 Genomic DNA. Translation: CAM27621.1.
CH466519 Genomic DNA. Translation: EDL27671.1.
BC031841 mRNA. Translation: AAH31841.1.
BC057685 mRNA. Translation: AAH57685.1.
CCDSiCCDS16468.1.
RefSeqiNP_776110.3. NM_173749.4.
UniGeneiMm.28649.
Mm.431895.

3D structure databases

ProteinModelPortaliQ8BU25.
SMRiQ8BU25. Positions 128-258, 328-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028612.

Protein family/group databases

MEROPSiS01.998.

PTM databases

iPTMnetiQ8BU25.
PhosphoSiteiQ8BU25.

Proteomic databases

MaxQBiQ8BU25.
PaxDbiQ8BU25.
PRIDEiQ8BU25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028612; ENSMUSP00000028612; ENSMUSG00000027188.
GeneIDi210622.
KEGGimmu:210622.
UCSCiuc012caf.1. mouse.

Organism-specific databases

CTDi25891.
MGIiMGI:2445082. Pamr1.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.
HOGENOMiHOG000231787.
HOVERGENiHBG055250.
InParanoidiQ8BU25.
OMAiFYRDDDR.
OrthoDBiEOG7GXP9X.
TreeFamiTF351669.

Miscellaneous databases

ChiTaRSiPamr1. mouse.
PROiQ8BU25.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BU25.
CleanExiMM_E430002G05RIK.
GenevisibleiQ8BU25. MM.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR000436. Sushi_SCR_CCP_dom.
IPR001254. Trypsin_dom.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
PF00008. EGF. 1 hit.
PF00084. Sushi. 2 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00032. CCP. 2 hits.
SM00042. CUB. 1 hit.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF57535. SSF57535. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
PS50240. TRYPSIN_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. "Cloning of cDNA encoding a regeneration-associated muscle protease whose expression is attenuated in cell lines derived from Duchenne muscular dystrophy patients."
    Nakayama Y., Nara N., Kawakita Y., Takeshima Y., Arakawa M., Katoh M., Morita S., Iwatsuki K., Tanaka K., Okamoto S., Kitamura T., Seki N., Matsuda R., Matsuo M., Saito K., Hara T.
    Am. J. Pathol. 164:1773-1782(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE FUNCTION, TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiPAMR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BU25
Secondary accession number(s): A2AQI2, Q8K2B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.