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Protein

Inactive serine protease PAMR1

Gene

Pamr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in regeneration of skeletal muscle.

Caution

Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity.Curated

GO - Molecular functioni

Keywordsi

Molecular functionSerine protease homolog

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive serine protease PAMR1
Alternative name(s):
Peptidase domain-containing protein associated with muscle regeneration 1
Regeneration-associated muscle protease homolog
Gene namesi
Name:Pamr1
Synonyms:Ramp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2445082 Pamr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028760322 – 720Inactive serine protease PAMR1Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi128 ↔ 150By similarity
Disulfide bondi177 ↔ 199By similarity
Disulfide bondi239 ↔ 250By similarity
Disulfide bondi244 ↔ 260By similarity
Disulfide bondi262 ↔ 271By similarity
Disulfide bondi280 ↔ 329By similarity
Disulfide bondi315 ↔ 342By similarity
Disulfide bondi414 ↔ 442By similarity
Disulfide bondi489 ↔ 505By similarity
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 649By similarity
Disulfide bondi661 ↔ 697By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BU25
PaxDbiQ8BU25
PRIDEiQ8BU25

PTM databases

iPTMnetiQ8BU25
PhosphoSitePlusiQ8BU25

Expressioni

Tissue specificityi

Predominantly expressed in normal skeletal muscle and brain. Expression is enhanced in the regenerating area of injured skeletal muscle in mice.1 Publication

Inductioni

Down-regulated in dystrophin-mutant mdx muscle cell line.1 Publication

Gene expression databases

BgeeiENSMUSG00000027188
CleanExiMM_E430002G05RIK
GenevisibleiQ8BU25 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028612

Structurei

3D structure databases

ProteinModelPortaliQ8BU25
SMRiQ8BU25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 236CUBPROSITE-ProRule annotationAdd BLAST109
Domaini235 – 272EGF-likePROSITE-ProRule annotationAdd BLAST38
Domaini278 – 344Sushi 1PROSITE-ProRule annotationAdd BLAST67
Domaini387 – 444Sushi 2PROSITE-ProRule annotationAdd BLAST58
Domaini445 – 720Peptidase S1PROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 94Cys-richAdd BLAST53

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000141096
HOGENOMiHOG000231787
HOVERGENiHBG055250
InParanoidiQ8BU25
OMAiIPCCRNE
OrthoDBiEOG091G0GHF
TreeFamiTF351669

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00041 CUB, 1 hit
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00008 EGF, 1 hit
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00042 CUB, 1 hit
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BU25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELDRWAQLG LVFLQLLLIS SLPREYTVIN EACPGAEWNI MCRECCEYDQ
60 70 80 90 100
IECLCPGKKE VVGYTIPCCR NEDNECDSCL IHPGCTIFEN CKSCRNGSWG
110 120 130 140 150
GTLDDFYVKG FYCAECRAGW YGGDCMRCGQ VLRASKGQIL LESYPLNAHC
160 170 180 190 200
EWTIHARPGF IIQLRFGMLS LEFDYMCQYD YVEVRDGDNS DSPIIKRFCG
210 220 230 240 250
NERPAPIRST GSSLHVLFHS DGSKNFDGFH AVFEEITACS SSPCFHDGTC
260 270 280 290 300
LLDTTGSFKC ACLAGYTGQR CENLLEERNC SDLGGPVNGY KKITEGPGLL
310 320 330 340 350
NERHVKIGTV VSFFCNGSYV LSGNEKRTCQ QNGEWSGKQP VCMKACREPK
360 370 380 390 400
ISDLVRRRVL SMQVQSRETP LHQLYSTAFS KQKLQDASTK KPALPFGDLP
410 420 430 440 450
PGYQHLHTQV QYECISPFYR RLGSSRRTCL RTGKWSGRAP SCIPICGKIE
460 470 480 490 500
STPSPKTQGT RWPWQAAIYR RTSGVHDGGL HKGAWFLVCS GALVNERTVV
510 520 530 540 550
VAAHCVTELG KATIIKTADL KVVLGKFYRD DDRDEKSIQN LRVSAIILHP
560 570 580 590 600
NYDPILLDTD IAVLKLLDKA RISTRVQPIC LATTRDLSTS FQESHITVAG
610 620 630 640 650
WNILADVRSP GFKNDTLHYG MVRVVDPMLC EEQHEDHGIP VSVTDNMFCA
660 670 680 690 700
SKDPSTPSDI CTAETGGIAA LSFPGRASPE PRWHLVGLVS WSYDKTCSNG
710 720
LSTAFTKVLP FKDWIERNMK
Length:720
Mass (Da):80,320
Last modified:July 27, 2011 - v3
Checksum:i845BC9660EC4FE3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114A → E in AAH31841 (PubMed:15489334).Curated1
Sequence conflicti114A → E in AAH57685 (PubMed:15489334).Curated1
Sequence conflicti303R → H in BAC40098 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088017 mRNA Translation: BAC40098.1
AL845276, AL844605 Genomic DNA Translation: CAM21810.1
AL844605, AL845276 Genomic DNA Translation: CAM27621.1
CH466519 Genomic DNA Translation: EDL27671.1
BC031841 mRNA Translation: AAH31841.1
BC057685 mRNA Translation: AAH57685.1
CCDSiCCDS16468.1
RefSeqiNP_776110.3, NM_173749.4
UniGeneiMm.28649
Mm.431895

Genome annotation databases

EnsembliENSMUST00000028612; ENSMUSP00000028612; ENSMUSG00000027188
GeneIDi210622
KEGGimmu:210622
UCSCiuc012caf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPAMR1_MOUSE
AccessioniPrimary (citable) accession number: Q8BU25
Secondary accession number(s): A2AQI2, Q8K2B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health