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Protein

Translocation protein SEC62

Gene

Sec62

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for preprotein translocation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC62
Alternative name(s):
Translocation protein 1
Short name:
TP-1
Gene namesi
Name:Sec62
Synonyms:Tloc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916526. Sec62.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 196CytoplasmicSequence analysisAdd BLAST196
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 234LumenalSequence analysisAdd BLAST17
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 398CytoplasmicSequence analysisAdd BLAST143

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066171 – 398Translocation protein SEC62Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineBy similarity1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1
Modified residuei356PhosphoserineCombined sources1
Modified residuei375PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BU14.
MaxQBiQ8BU14.
PaxDbiQ8BU14.
PeptideAtlasiQ8BU14.
PRIDEiQ8BU14.

PTM databases

iPTMnetiQ8BU14.
PhosphoSitePlusiQ8BU14.
SwissPalmiQ8BU14.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027706.
GenevisibleiQ8BU14. MM.

Interactioni

Subunit structurei

Part of a complex that contains SEC61, SEC62 and SEC63 Interacts with SEC61B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029256.

Structurei

3D structure databases

ProteinModelPortaliQ8BU14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC62 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2927. Eukaryota.
COG5232. LUCA.
GeneTreeiENSGT00390000002757.
HOGENOMiHOG000016701.
HOVERGENiHBG055550.
InParanoidiQ8BU14.
KOiK12275.
OMAiSNGNDFE.
OrthoDBiEOG091G0KPB.
PhylomeDBiQ8BU14.
TreeFamiTF314944.

Family and domain databases

InterProiIPR004728. Sec62.
[Graphical view]
PANTHERiPTHR12443. PTHR12443. 1 hit.
PfamiPF03839. Sec62. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BU14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS
60 70 80 90 100
KAVECLLDSK WAKAKKGEDA LFTTRESVVD YCNRLLKKQF FHRALKVMKM
110 120 130 140 150
KYDKDVKKEK DKGKSESGKE DDKKSKKESV KEEKTKKEKE KKKDGEKEDS
160 170 180 190 200
KKEETPGTPK KKETKKKFKL EPHDDQVFLD GNEVFVWIYD PVHIKTFVMG
210 220 230 240 250
LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL LAIARCILFL
260 270 280 290 300
IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE
310 320 330 340 350
TKKQQKSDSE EKSDSEKKED EEGKGAPADH GPEGSGGERH SDTDSDRRED
360 370 380 390
DRSQHSSGNG NDFEMITKEE LEQQTDGDCD EEDDDKDGEV PKSAHEKS
Length:398
Mass (Da):45,581
Last modified:March 1, 2003 - v1
Checksum:iF91B3E90336FFC9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85L → F in AAH67202 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088093 mRNA. Translation: BAC40140.1.
BC067202 mRNA. Translation: AAH67202.1.
CCDSiCCDS17286.1.
RefSeqiNP_081292.1. NM_027016.2.
UniGeneiMm.26017.

Genome annotation databases

EnsembliENSMUST00000029256; ENSMUSP00000029256; ENSMUSG00000027706.
GeneIDi69276.
KEGGimmu:69276.
UCSCiuc008ovh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088093 mRNA. Translation: BAC40140.1.
BC067202 mRNA. Translation: AAH67202.1.
CCDSiCCDS17286.1.
RefSeqiNP_081292.1. NM_027016.2.
UniGeneiMm.26017.

3D structure databases

ProteinModelPortaliQ8BU14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029256.

PTM databases

iPTMnetiQ8BU14.
PhosphoSitePlusiQ8BU14.
SwissPalmiQ8BU14.

Proteomic databases

EPDiQ8BU14.
MaxQBiQ8BU14.
PaxDbiQ8BU14.
PeptideAtlasiQ8BU14.
PRIDEiQ8BU14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029256; ENSMUSP00000029256; ENSMUSG00000027706.
GeneIDi69276.
KEGGimmu:69276.
UCSCiuc008ovh.1. mouse.

Organism-specific databases

CTDi7095.
MGIiMGI:1916526. Sec62.

Phylogenomic databases

eggNOGiKOG2927. Eukaryota.
COG5232. LUCA.
GeneTreeiENSGT00390000002757.
HOGENOMiHOG000016701.
HOVERGENiHBG055550.
InParanoidiQ8BU14.
KOiK12275.
OMAiSNGNDFE.
OrthoDBiEOG091G0KPB.
PhylomeDBiQ8BU14.
TreeFamiTF314944.

Enzyme and pathway databases

ReactomeiR-MMU-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSec62. mouse.
PROiQ8BU14.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027706.
GenevisibleiQ8BU14. MM.

Family and domain databases

InterProiIPR004728. Sec62.
[Graphical view]
PANTHERiPTHR12443. PTHR12443. 1 hit.
PfamiPF03839. Sec62. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEC62_MOUSE
AccessioniPrimary (citable) accession number: Q8BU14
Secondary accession number(s): Q6NX81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.