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Q8BU11

- TOX4_MOUSE

UniProt

Q8BU11 - TOX4_MOUSE

Protein

TOX high mobility group box family member 4

Gene

Tox4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi223 – 29169HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TOX high mobility group box family member 4
    Alternative name(s):
    Epidermal Langerhans cell protein LCP1
    Gene namesi
    Name:Tox4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1915389. Tox4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation
    Note: Associated with chromatin.

    GO - Cellular componenti

    1. chromatin Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell
    3. PTW/PP1 phosphatase complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619TOX high mobility group box family member 4PRO_0000048569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei178 – 1781Phosphoserine1 Publication
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei313 – 3131PhosphothreonineBy similarity
    Modified residuei315 – 3151PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8BU11.
    PRIDEiQ8BU11.

    PTM databases

    PhosphoSiteiQ8BU11.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BU11.
    BgeeiQ8BU11.
    CleanExiMM_TOX4.
    GenevestigatoriQ8BU11.

    Interactioni

    Subunit structurei

    Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS By similarity.By similarity

    Protein-protein interaction databases

    BioGridi234546. 1 interaction.
    IntActiQ8BU11. 5 interactions.
    MINTiMINT-1592006.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BU11.
    SMRiQ8BU11. Positions 219-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi213 – 2186Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi401 – 522122Gln/Pro-richAdd
    BLAST
    Compositional biasi426 – 4327Poly-Ala

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284736.
    GeneTreeiENSGT00560000076898.
    HOVERGENiHBG051013.
    InParanoidiQ3UGN7.
    OMAiPPTLKMQ.
    OrthoDBiEOG7R834J.
    TreeFamiTF106481.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BU11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL    50
    AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL 100
    SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS 150
    SQLGLSLGGG TILPPAQSPE DRLSTTPSPT NSLHEDGVDD FRRQLPAQKT 200
    VVVETGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF 250
    GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV 300
    ETVELDPVPQ SQTPSPPPVT AADPASPAPA STESPALPPC IIVNSTLSSY 350
    VANQASSGPG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL 400
    QVGQTSTATI QPSQQAQIVT RSVLQAAAAA AASMQLPPPR LQPPPLQQMP 450
    QPPTQQQVTI LQQPPPLQAM QQPPPQKVRI NLQQQPPPLQ SKIVPPPTLK 500
    IQTTVVPPTV ESSPEQPMNS SPEAHTVEAT SPETICEMIA DVVPEVESPS 550
    QMDVELVSGS PVALSPQPRC VRSGCENPPV VSKDWDNEYC SNECVVKHCR 600
    DVFLAWVASR NPNSVVFVK 619
    Length:619
    Mass (Da):65,961
    Last modified:July 27, 2011 - v3
    Checksum:i232AAF5171000D92
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31F → S in AAK00713. 1 PublicationCurated
    Sequence conflicti243 – 2431G → R in BAC40170. (PubMed:16141072)Curated
    Sequence conflicti321 – 3211A → T in AAK00713. 1 PublicationCurated
    Sequence conflicti321 – 3211A → T in BAC40170. (PubMed:16141072)Curated
    Sequence conflicti321 – 3211A → T in AAH50091. (PubMed:15489334)Curated
    Sequence conflicti365 – 3651I → T in AAH50091. (PubMed:15489334)Curated
    Sequence conflicti425 – 4251Q → R in AAH50091. (PubMed:15489334)Curated
    Sequence conflicti446 – 4461L → S in AAK00713. 1 PublicationCurated
    Sequence conflicti453 – 4531P → T in BAB31949. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228408 mRNA. Translation: AAK00713.1.
    AK019980 mRNA. Translation: BAB31949.1.
    AK088144 mRNA. Translation: BAC40170.1.
    AK147023 mRNA. Translation: BAE27616.1.
    AK147834 mRNA. Translation: BAE28170.1.
    BC050091 mRNA. Translation: AAH50091.1.
    CCDSiCCDS36920.1.
    RefSeqiNP_075923.2. NM_023434.3.
    UniGeneiMm.246237.

    Genome annotation databases

    EnsembliENSMUST00000022766; ENSMUSP00000022766; ENSMUSG00000016831.
    GeneIDi268741.
    KEGGimmu:268741.
    UCSCiuc007tpa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228408 mRNA. Translation: AAK00713.1 .
    AK019980 mRNA. Translation: BAB31949.1 .
    AK088144 mRNA. Translation: BAC40170.1 .
    AK147023 mRNA. Translation: BAE27616.1 .
    AK147834 mRNA. Translation: BAE28170.1 .
    BC050091 mRNA. Translation: AAH50091.1 .
    CCDSi CCDS36920.1.
    RefSeqi NP_075923.2. NM_023434.3.
    UniGenei Mm.246237.

    3D structure databases

    ProteinModelPortali Q8BU11.
    SMRi Q8BU11. Positions 219-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 234546. 1 interaction.
    IntActi Q8BU11. 5 interactions.
    MINTi MINT-1592006.

    PTM databases

    PhosphoSitei Q8BU11.

    Proteomic databases

    PaxDbi Q8BU11.
    PRIDEi Q8BU11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022766 ; ENSMUSP00000022766 ; ENSMUSG00000016831 .
    GeneIDi 268741.
    KEGGi mmu:268741.
    UCSCi uc007tpa.2. mouse.

    Organism-specific databases

    CTDi 9878.
    MGIi MGI:1915389. Tox4.

    Phylogenomic databases

    eggNOGi NOG284736.
    GeneTreei ENSGT00560000076898.
    HOVERGENi HBG051013.
    InParanoidi Q3UGN7.
    OMAi PPTLKMQ.
    OrthoDBi EOG7R834J.
    TreeFami TF106481.

    Miscellaneous databases

    ChiTaRSi TOX4. mouse.
    NextBioi 392465.
    PROi Q8BU11.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BU11.
    Bgeei Q8BU11.
    CleanExi MM_TOX4.
    Genevestigatori Q8BU11.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel gene expressed differentially in maturing epidermal Langerhans cells."
      Luy M.A., Reske K.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Heart and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trophoblast.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTOX4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BU11
    Secondary accession number(s): Q3UGN7
    , Q80UI2, Q99PN9, Q9CS16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3