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Q8BU11

- TOX4_MOUSE

UniProt

Q8BU11 - TOX4_MOUSE

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Protein

TOX high mobility group box family member 4

Gene
Tox4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi223 – 29169HMG boxAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 4
Alternative name(s):
Epidermal Langerhans cell protein LCP1
Gene namesi
Name:Tox4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1915389. Tox4.

Subcellular locationi

Nucleus By similarity
Note: Associated with chromatin.

GO - Cellular componenti

  1. chromatin Source: UniProtKB
  2. nucleus Source: UniProtKB-SubCell
  3. PTW/PP1 phosphatase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619TOX high mobility group box family member 4PRO_0000048569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781Phosphoserine1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei313 – 3131Phosphothreonine By similarity
Modified residuei315 – 3151Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BU11.
PRIDEiQ8BU11.

PTM databases

PhosphoSiteiQ8BU11.

Expressioni

Gene expression databases

ArrayExpressiQ8BU11.
BgeeiQ8BU11.
CleanExiMM_TOX4.
GenevestigatoriQ8BU11.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS By similarity.

Protein-protein interaction databases

BioGridi234546. 1 interaction.
IntActiQ8BU11. 5 interactions.
MINTiMINT-1592006.

Structurei

3D structure databases

ProteinModelPortaliQ8BU11.
SMRiQ8BU11. Positions 219-291.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi213 – 2186Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi401 – 522122Gln/Pro-richAdd
BLAST
Compositional biasi426 – 4327Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG284736.
GeneTreeiENSGT00560000076898.
HOVERGENiHBG051013.
InParanoidiQ3UGN7.
OMAiPPTLKMQ.
OrthoDBiEOG7R834J.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BU11-1 [UniParc]FASTAAdd to Basket

« Hide

MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL    50
AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL 100
SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS 150
SQLGLSLGGG TILPPAQSPE DRLSTTPSPT NSLHEDGVDD FRRQLPAQKT 200
VVVETGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF 250
GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV 300
ETVELDPVPQ SQTPSPPPVT AADPASPAPA STESPALPPC IIVNSTLSSY 350
VANQASSGPG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL 400
QVGQTSTATI QPSQQAQIVT RSVLQAAAAA AASMQLPPPR LQPPPLQQMP 450
QPPTQQQVTI LQQPPPLQAM QQPPPQKVRI NLQQQPPPLQ SKIVPPPTLK 500
IQTTVVPPTV ESSPEQPMNS SPEAHTVEAT SPETICEMIA DVVPEVESPS 550
QMDVELVSGS PVALSPQPRC VRSGCENPPV VSKDWDNEYC SNECVVKHCR 600
DVFLAWVASR NPNSVVFVK 619
Length:619
Mass (Da):65,961
Last modified:July 27, 2011 - v3
Checksum:i232AAF5171000D92
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31F → S in AAK00713. 1 Publication
Sequence conflicti243 – 2431G → R in BAC40170. 1 Publication
Sequence conflicti321 – 3211A → T in AAK00713. 1 Publication
Sequence conflicti321 – 3211A → T in BAC40170. 1 Publication
Sequence conflicti321 – 3211A → T in AAH50091. 1 Publication
Sequence conflicti365 – 3651I → T in AAH50091. 1 Publication
Sequence conflicti425 – 4251Q → R in AAH50091. 1 Publication
Sequence conflicti446 – 4461L → S in AAK00713. 1 Publication
Sequence conflicti453 – 4531P → T in BAB31949. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228408 mRNA. Translation: AAK00713.1.
AK019980 mRNA. Translation: BAB31949.1.
AK088144 mRNA. Translation: BAC40170.1.
AK147023 mRNA. Translation: BAE27616.1.
AK147834 mRNA. Translation: BAE28170.1.
BC050091 mRNA. Translation: AAH50091.1.
CCDSiCCDS36920.1.
RefSeqiNP_075923.2. NM_023434.3.
UniGeneiMm.246237.

Genome annotation databases

EnsembliENSMUST00000022766; ENSMUSP00000022766; ENSMUSG00000016831.
GeneIDi268741.
KEGGimmu:268741.
UCSCiuc007tpa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228408 mRNA. Translation: AAK00713.1 .
AK019980 mRNA. Translation: BAB31949.1 .
AK088144 mRNA. Translation: BAC40170.1 .
AK147023 mRNA. Translation: BAE27616.1 .
AK147834 mRNA. Translation: BAE28170.1 .
BC050091 mRNA. Translation: AAH50091.1 .
CCDSi CCDS36920.1.
RefSeqi NP_075923.2. NM_023434.3.
UniGenei Mm.246237.

3D structure databases

ProteinModelPortali Q8BU11.
SMRi Q8BU11. Positions 219-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 234546. 1 interaction.
IntActi Q8BU11. 5 interactions.
MINTi MINT-1592006.

PTM databases

PhosphoSitei Q8BU11.

Proteomic databases

PaxDbi Q8BU11.
PRIDEi Q8BU11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022766 ; ENSMUSP00000022766 ; ENSMUSG00000016831 .
GeneIDi 268741.
KEGGi mmu:268741.
UCSCi uc007tpa.2. mouse.

Organism-specific databases

CTDi 9878.
MGIi MGI:1915389. Tox4.

Phylogenomic databases

eggNOGi NOG284736.
GeneTreei ENSGT00560000076898.
HOVERGENi HBG051013.
InParanoidi Q3UGN7.
OMAi PPTLKMQ.
OrthoDBi EOG7R834J.
TreeFami TF106481.

Miscellaneous databases

ChiTaRSi TOX4. mouse.
NextBioi 392465.
PROi Q8BU11.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BU11.
Bgeei Q8BU11.
CleanExi MM_TOX4.
Genevestigatori Q8BU11.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel gene expressed differentially in maturing epidermal Langerhans cells."
    Luy M.A., Reske K.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Heart and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trophoblast.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOX4_MOUSE
AccessioniPrimary (citable) accession number: Q8BU11
Secondary accession number(s): Q3UGN7
, Q80UI2, Q99PN9, Q9CS16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi