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Protein

TOX high mobility group box family member 4

Gene

Tox4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi223 – 291HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TOX high mobility group box family member 4
Alternative name(s):
Epidermal Langerhans cell protein LCP1
Gene namesi
Name:Tox4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1915389. Tox4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

  • Note: Associated with chromatin.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485691 – 619TOX high mobility group box family member 4Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei176PhosphothreonineCombined sources1
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei313PhosphothreonineBy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei479Asymmetric dimethylarginineCombined sources1
Modified residuei531PhosphoserineBy similarity1
Modified residuei548PhosphoserineBy similarity1
Modified residuei550PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei560PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BU11.
MaxQBiQ8BU11.
PaxDbiQ8BU11.
PRIDEiQ8BU11.

PTM databases

iPTMnetiQ8BU11.
PhosphoSitePlusiQ8BU11.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016831.
CleanExiMM_TOX4.
GenevisibleiQ8BU11. MM.

Interactioni

Subunit structurei

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity).By similarity

Protein-protein interaction databases

BioGridi234546. 12 interactors.
IntActiQ8BU11. 16 interactors.
MINTiMINT-1592006.
STRINGi10090.ENSMUSP00000022766.

Structurei

3D structure databases

ProteinModelPortaliQ8BU11.
SMRiQ8BU11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi213 – 218Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi401 – 522Gln/Pro-richAdd BLAST122
Compositional biasi426 – 432Poly-Ala7

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOVERGENiHBG051013.
InParanoidiQ8BU11.
OMAiPPTLKMQ.
OrthoDBiEOG091G12A3.
TreeFamiTF106481.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BU11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL
60 70 80 90 100
AVSDVVGHFD DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL
110 120 130 140 150
SGGLTMDLDH SIGTQYSANP PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS
160 170 180 190 200
SQLGLSLGGG TILPPAQSPE DRLSTTPSPT NSLHEDGVDD FRRQLPAQKT
210 220 230 240 250
VVVETGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA IKGQNPNATF
260 270 280 290 300
GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV
310 320 330 340 350
ETVELDPVPQ SQTPSPPPVT AADPASPAPA STESPALPPC IIVNSTLSSY
360 370 380 390 400
VANQASSGPG GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL
410 420 430 440 450
QVGQTSTATI QPSQQAQIVT RSVLQAAAAA AASMQLPPPR LQPPPLQQMP
460 470 480 490 500
QPPTQQQVTI LQQPPPLQAM QQPPPQKVRI NLQQQPPPLQ SKIVPPPTLK
510 520 530 540 550
IQTTVVPPTV ESSPEQPMNS SPEAHTVEAT SPETICEMIA DVVPEVESPS
560 570 580 590 600
QMDVELVSGS PVALSPQPRC VRSGCENPPV VSKDWDNEYC SNECVVKHCR
610
DVFLAWVASR NPNSVVFVK
Length:619
Mass (Da):65,961
Last modified:July 27, 2011 - v3
Checksum:i232AAF5171000D92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → S in AAK00713 (Ref. 1) Curated1
Sequence conflicti243G → R in BAC40170 (PubMed:16141072).Curated1
Sequence conflicti321A → T in AAK00713 (Ref. 1) Curated1
Sequence conflicti321A → T in BAC40170 (PubMed:16141072).Curated1
Sequence conflicti321A → T in AAH50091 (PubMed:15489334).Curated1
Sequence conflicti365I → T in AAH50091 (PubMed:15489334).Curated1
Sequence conflicti425Q → R in AAH50091 (PubMed:15489334).Curated1
Sequence conflicti446L → S in AAK00713 (Ref. 1) Curated1
Sequence conflicti453P → T in BAB31949 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228408 mRNA. Translation: AAK00713.1.
AK019980 mRNA. Translation: BAB31949.1.
AK088144 mRNA. Translation: BAC40170.1.
AK147023 mRNA. Translation: BAE27616.1.
AK147834 mRNA. Translation: BAE28170.1.
BC050091 mRNA. Translation: AAH50091.1.
CCDSiCCDS36920.1.
RefSeqiNP_075923.2. NM_023434.3.
UniGeneiMm.246237.

Genome annotation databases

EnsembliENSMUST00000022766; ENSMUSP00000022766; ENSMUSG00000016831.
GeneIDi268741.
KEGGimmu:268741.
UCSCiuc007tpa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228408 mRNA. Translation: AAK00713.1.
AK019980 mRNA. Translation: BAB31949.1.
AK088144 mRNA. Translation: BAC40170.1.
AK147023 mRNA. Translation: BAE27616.1.
AK147834 mRNA. Translation: BAE28170.1.
BC050091 mRNA. Translation: AAH50091.1.
CCDSiCCDS36920.1.
RefSeqiNP_075923.2. NM_023434.3.
UniGeneiMm.246237.

3D structure databases

ProteinModelPortaliQ8BU11.
SMRiQ8BU11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234546. 12 interactors.
IntActiQ8BU11. 16 interactors.
MINTiMINT-1592006.
STRINGi10090.ENSMUSP00000022766.

PTM databases

iPTMnetiQ8BU11.
PhosphoSitePlusiQ8BU11.

Proteomic databases

EPDiQ8BU11.
MaxQBiQ8BU11.
PaxDbiQ8BU11.
PRIDEiQ8BU11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022766; ENSMUSP00000022766; ENSMUSG00000016831.
GeneIDi268741.
KEGGimmu:268741.
UCSCiuc007tpa.2. mouse.

Organism-specific databases

CTDi9878.
MGIiMGI:1915389. Tox4.

Phylogenomic databases

eggNOGiKOG0381. Eukaryota.
COG5648. LUCA.
GeneTreeiENSGT00560000076898.
HOVERGENiHBG051013.
InParanoidiQ8BU11.
OMAiPPTLKMQ.
OrthoDBiEOG091G12A3.
TreeFamiTF106481.

Miscellaneous databases

ChiTaRSiTox4. mouse.
PROiQ8BU11.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016831.
CleanExiMM_TOX4.
GenevisibleiQ8BU11. MM.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOX4_MOUSE
AccessioniPrimary (citable) accession number: Q8BU11
Secondary accession number(s): Q3UGN7
, Q80UI2, Q99PN9, Q9CS16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.