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Q8BU11 (TOX4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TOX high mobility group box family member 4
Alternative name(s):
Epidermal Langerhans cell protein LCP1
Gene names
Name:Tox4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase By similarity.

Subunit structure

Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS By similarity.

Subcellular location

Nucleus By similarity. Note: Associated with chromatin.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentPTW/PP1 phosphatase complex

Inferred from sequence or structural similarity. Source: UniProtKB

chromatin

Inferred from sequence or structural similarity. Source: UniProtKB

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619TOX high mobility group box family member 4
PRO_0000048569

Regions

DNA binding223 – 29169HMG box
Motif213 – 2186Nuclear localization signal Potential
Compositional bias401 – 522122Gln/Pro-rich
Compositional bias426 – 4327Poly-Ala

Amino acid modifications

Modified residue1781Phosphoserine Ref.5
Modified residue1821Phosphoserine Ref.5
Modified residue3131Phosphothreonine By similarity
Modified residue3151Phosphoserine By similarity

Experimental info

Sequence conflict31F → S in AAK00713. Ref.1
Sequence conflict2431G → R in BAC40170. Ref.2
Sequence conflict3211A → T in AAK00713. Ref.1
Sequence conflict3211A → T in BAC40170. Ref.2
Sequence conflict3211A → T in AAH50091. Ref.3
Sequence conflict3651I → T in AAH50091. Ref.3
Sequence conflict4251Q → R in AAH50091. Ref.3
Sequence conflict4461L → S in AAK00713. Ref.1
Sequence conflict4531P → T in BAB31949. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8BU11 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 232AAF5171000D92

FASTA61965,961
        10         20         30         40         50         60 
MEFPGGNDNY LTITGPSHPF LSGAETFHTP SLGDEEFEIP PISLDSDPSL AVSDVVGHFD 

        70         80         90        100        110        120 
DLADPSSSQD GSFSAQYGVQ TLDMPVGMTH GLMEQGGGLL SGGLTMDLDH SIGTQYSANP 

       130        140        150        160        170        180 
PVTIDVPMTD MTSGLMGHSQ LTTIDQSELS SQLGLSLGGG TILPPAQSPE DRLSTTPSPT 

       190        200        210        220        230        240 
NSLHEDGVDD FRRQLPAQKT VVVETGKKQK APKKRKKKDP NEPQKPVSAY ALFFRDTQAA 

       250        260        270        280        290        300 
IKGQNPNATF GEVSKIVASM WDSLGEEQKQ VYKRKTEAAK KEYLKALAAY KDNQECQATV 

       310        320        330        340        350        360 
ETVELDPVPQ SQTPSPPPVT AADPASPAPA STESPALPPC IIVNSTLSSY VANQASSGPG 

       370        380        390        400        410        420 
GQPNITKLII TKQMLPSSIT MSQGGMVTVI PATVVTSRGL QVGQTSTATI QPSQQAQIVT 

       430        440        450        460        470        480 
RSVLQAAAAA AASMQLPPPR LQPPPLQQMP QPPTQQQVTI LQQPPPLQAM QQPPPQKVRI 

       490        500        510        520        530        540 
NLQQQPPPLQ SKIVPPPTLK IQTTVVPPTV ESSPEQPMNS SPEAHTVEAT SPETICEMIA 

       550        560        570        580        590        600 
DVVPEVESPS QMDVELVSGS PVALSPQPRC VRSGCENPPV VSKDWDNEYC SNECVVKHCR 

       610 
DVFLAWVASR NPNSVVFVK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel gene expressed differentially in maturing epidermal Langerhans cells."
Luy M.A., Reske K.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Heart and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Trophoblast.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178 AND SER-182, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF228408 mRNA. Translation: AAK00713.1.
AK019980 mRNA. Translation: BAB31949.1.
AK088144 mRNA. Translation: BAC40170.1.
AK147023 mRNA. Translation: BAE27616.1.
AK147834 mRNA. Translation: BAE28170.1.
BC050091 mRNA. Translation: AAH50091.1.
CCDSCCDS36920.1.
RefSeqNP_075923.2. NM_023434.3.
UniGeneMm.246237.

3D structure databases

ProteinModelPortalQ8BU11.
SMRQ8BU11. Positions 219-291.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid234546. 1 interaction.
IntActQ8BU11. 5 interactions.
MINTMINT-1592006.

PTM databases

PhosphoSiteQ8BU11.

Proteomic databases

PaxDbQ8BU11.
PRIDEQ8BU11.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000022766; ENSMUSP00000022766; ENSMUSG00000016831.
GeneID268741.
KEGGmmu:268741.
UCSCuc007tpa.2. mouse.

Organism-specific databases

CTD9878.
MGIMGI:1915389. Tox4.

Phylogenomic databases

eggNOGNOG284736.
GeneTreeENSGT00560000076898.
HOVERGENHBG051013.
InParanoidQ3UGN7.
OMAPPTLKMQ.
OrthoDBEOG7R834J.
TreeFamTF106481.

Gene expression databases

ArrayExpressQ8BU11.
BgeeQ8BU11.
CleanExMM_TOX4.
GenevestigatorQ8BU11.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTOX4. mouse.
NextBio392465.
PROQ8BU11.
SOURCESearch...

Entry information

Entry nameTOX4_MOUSE
AccessionPrimary (citable) accession number: Q8BU11
Secondary accession number(s): Q3UGN7 expand/collapse secondary AC list , Q80UI2, Q99PN9, Q9CS16
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot