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Q8BTZ7

- GMPPB_MOUSE

UniProt

Q8BTZ7 - GMPPB_MOUSE

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Protein

Mannose-1-phosphate guanyltransferase beta

Gene
Gmppb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathwayi

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198715. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase beta (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta
Gene namesi
Name:Gmppb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2660880. Gmppb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Mannose-1-phosphate guanyltransferase betaPRO_0000307163Add
BLAST

Proteomic databases

MaxQBiQ8BTZ7.
PaxDbiQ8BTZ7.
PRIDEiQ8BTZ7.

2D gel databases

REPRODUCTION-2DPAGEQ8BTZ7.

PTM databases

PhosphoSiteiQ8BTZ7.

Expressioni

Gene expression databases

BgeeiQ8BTZ7.
CleanExiMM_GMPPB.
GenevestigatoriQ8BTZ7.

Interactioni

Subunit structurei

Associates with GMPPA By similarity.

Protein-protein interaction databases

IntActiQ8BTZ7. 2 interactions.
MINTiMINT-1866573.
STRINGi10090.ENSMUSP00000107914.

Structurei

3D structure databases

ProteinModelPortaliQ8BTZ7.
SMRiQ8BTZ7. Positions 1-333.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1208.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG107955.
InParanoidiQ8BTZ7.
KOiK00966.
OMAiKLIDECS.
OrthoDBiEOG7CRTPW.
PhylomeDBiQ8BTZ7.
TreeFamiTF300718.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTZ7-1 [UniParc]FASTAAdd to Basket

« Hide

MKALILVGGY GTRLRPLTLS TPKPLVDFCN KPILLHQVEA LAAAGVDHVI    50
LAVSYMSQML EKEMKAQEQR LGIRISMSHE EEPLGTAGPL ALARDLLSET 100
ADPFFVLNSD VICDFPFQAM VQFHRHHGQE GSILVTKVEE PSKYGVVVCE 150
ADTGRIHRFV EKPQVFVSNK INAGMYILSP AVLQRIQLKP TSIEKEIFPV 200
MAKEGQLYAM ELQGFWMDIG QPKDFLTGMC LFLQSLRQKH PERLYSGPGI 250
VGNVLVDPSA RIGQNCSIGP NVSLGPGVVV EDGVCIRRCT VLRDAHIRSH 300
SWLESCIVGW RCRVGQWVRM ENVTVLGEDV IVNDELYLNG ASVLPHKSIG 350
ESVPEPRIIM 360
Length:360
Mass (Da):39,917
Last modified:March 1, 2003 - v1
Checksum:i2AF911A12C801A1D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088295 mRNA. Translation: BAC40266.1.
AK148125 mRNA. Translation: BAE28361.1.
AK158470 mRNA. Translation: BAE34527.1.
BC061207 mRNA. Translation: AAH61207.1.
CCDSiCCDS23515.1.
RefSeqiNP_808578.1. NM_177910.3.
XP_006511822.1. XM_006511759.1.
UniGeneiMm.22554.
Mm.379272.

Genome annotation databases

EnsembliENSMUST00000047947; ENSMUSP00000036898; ENSMUSG00000070284.
ENSMUST00000112295; ENSMUSP00000107914; ENSMUSG00000070284.
GeneIDi331026.
KEGGimmu:331026.
UCSCiuc009rog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088295 mRNA. Translation: BAC40266.1 .
AK148125 mRNA. Translation: BAE28361.1 .
AK158470 mRNA. Translation: BAE34527.1 .
BC061207 mRNA. Translation: AAH61207.1 .
CCDSi CCDS23515.1.
RefSeqi NP_808578.1. NM_177910.3.
XP_006511822.1. XM_006511759.1.
UniGenei Mm.22554.
Mm.379272.

3D structure databases

ProteinModelPortali Q8BTZ7.
SMRi Q8BTZ7. Positions 1-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8BTZ7. 2 interactions.
MINTi MINT-1866573.
STRINGi 10090.ENSMUSP00000107914.

PTM databases

PhosphoSitei Q8BTZ7.

2D gel databases

REPRODUCTION-2DPAGE Q8BTZ7.

Proteomic databases

MaxQBi Q8BTZ7.
PaxDbi Q8BTZ7.
PRIDEi Q8BTZ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047947 ; ENSMUSP00000036898 ; ENSMUSG00000070284 .
ENSMUST00000112295 ; ENSMUSP00000107914 ; ENSMUSG00000070284 .
GeneIDi 331026.
KEGGi mmu:331026.
UCSCi uc009rog.1. mouse.

Organism-specific databases

CTDi 29925.
MGIi MGI:2660880. Gmppb.

Phylogenomic databases

eggNOGi COG1208.
GeneTreei ENSGT00530000063581.
HOGENOMi HOG000283479.
HOVERGENi HBG107955.
InParanoidi Q8BTZ7.
KOi K00966.
OMAi KLIDECS.
OrthoDBi EOG7CRTPW.
PhylomeDBi Q8BTZ7.
TreeFami TF300718.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00930 .
Reactomei REACT_198715. Synthesis of GDP-mannose.

Miscellaneous databases

ChiTaRSi GMPPB. mouse.
NextBioi 399690.
PROi Q8BTZ7.
SOURCEi Search...

Gene expression databases

Bgeei Q8BTZ7.
CleanExi MM_GMPPB.
Genevestigatori Q8BTZ7.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Inner ear and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiGMPPB_MOUSE
AccessioniPrimary (citable) accession number: Q8BTZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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