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Protein

Mannose-1-phosphate guanyltransferase beta

Gene

Gmppb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathway:iGDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase beta (Gmppb)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_328870. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase beta (EC:2.7.7.13)
Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta
Gene namesi
Name:Gmppb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2660880. Gmppb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: Ensembl
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Mannose-1-phosphate guanyltransferase betaPRO_0000307163Add
BLAST

Proteomic databases

MaxQBiQ8BTZ7.
PaxDbiQ8BTZ7.
PRIDEiQ8BTZ7.

2D gel databases

REPRODUCTION-2DPAGEQ8BTZ7.

PTM databases

PhosphoSiteiQ8BTZ7.

Expressioni

Gene expression databases

BgeeiQ8BTZ7.
CleanExiMM_GMPPB.
GenevisibleiQ8BTZ7. MM.

Interactioni

Subunit structurei

Associates with GMPPA.By similarity

Protein-protein interaction databases

IntActiQ8BTZ7. 2 interactions.
MINTiMINT-1866573.
STRINGi10090.ENSMUSP00000036898.

Structurei

3D structure databases

ProteinModelPortaliQ8BTZ7.
SMRiQ8BTZ7. Positions 1-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1208.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG107955.
InParanoidiQ8BTZ7.
KOiK00966.
OMAiGQWVSLW.
OrthoDBiEOG7CRTPW.
PhylomeDBiQ8BTZ7.
TreeFamiTF300718.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALILVGGY GTRLRPLTLS TPKPLVDFCN KPILLHQVEA LAAAGVDHVI
60 70 80 90 100
LAVSYMSQML EKEMKAQEQR LGIRISMSHE EEPLGTAGPL ALARDLLSET
110 120 130 140 150
ADPFFVLNSD VICDFPFQAM VQFHRHHGQE GSILVTKVEE PSKYGVVVCE
160 170 180 190 200
ADTGRIHRFV EKPQVFVSNK INAGMYILSP AVLQRIQLKP TSIEKEIFPV
210 220 230 240 250
MAKEGQLYAM ELQGFWMDIG QPKDFLTGMC LFLQSLRQKH PERLYSGPGI
260 270 280 290 300
VGNVLVDPSA RIGQNCSIGP NVSLGPGVVV EDGVCIRRCT VLRDAHIRSH
310 320 330 340 350
SWLESCIVGW RCRVGQWVRM ENVTVLGEDV IVNDELYLNG ASVLPHKSIG
360
ESVPEPRIIM
Length:360
Mass (Da):39,917
Last modified:March 1, 2003 - v1
Checksum:i2AF911A12C801A1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088295 mRNA. Translation: BAC40266.1.
AK148125 mRNA. Translation: BAE28361.1.
AK158470 mRNA. Translation: BAE34527.1.
BC061207 mRNA. Translation: AAH61207.1.
CCDSiCCDS23515.1.
RefSeqiNP_808578.1. NM_177910.3.
XP_006511822.1. XM_006511759.2.
UniGeneiMm.22554.
Mm.379272.

Genome annotation databases

EnsembliENSMUST00000047947; ENSMUSP00000036898; ENSMUSG00000070284.
ENSMUST00000112295; ENSMUSP00000107914; ENSMUSG00000070284.
GeneIDi331026.
KEGGimmu:331026.
UCSCiuc009rog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088295 mRNA. Translation: BAC40266.1.
AK148125 mRNA. Translation: BAE28361.1.
AK158470 mRNA. Translation: BAE34527.1.
BC061207 mRNA. Translation: AAH61207.1.
CCDSiCCDS23515.1.
RefSeqiNP_808578.1. NM_177910.3.
XP_006511822.1. XM_006511759.2.
UniGeneiMm.22554.
Mm.379272.

3D structure databases

ProteinModelPortaliQ8BTZ7.
SMRiQ8BTZ7. Positions 1-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BTZ7. 2 interactions.
MINTiMINT-1866573.
STRINGi10090.ENSMUSP00000036898.

PTM databases

PhosphoSiteiQ8BTZ7.

2D gel databases

REPRODUCTION-2DPAGEQ8BTZ7.

Proteomic databases

MaxQBiQ8BTZ7.
PaxDbiQ8BTZ7.
PRIDEiQ8BTZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047947; ENSMUSP00000036898; ENSMUSG00000070284.
ENSMUST00000112295; ENSMUSP00000107914; ENSMUSG00000070284.
GeneIDi331026.
KEGGimmu:331026.
UCSCiuc009rog.1. mouse.

Organism-specific databases

CTDi29925.
MGIiMGI:2660880. Gmppb.

Phylogenomic databases

eggNOGiCOG1208.
GeneTreeiENSGT00530000063581.
HOGENOMiHOG000283479.
HOVERGENiHBG107955.
InParanoidiQ8BTZ7.
KOiK00966.
OMAiGQWVSLW.
OrthoDBiEOG7CRTPW.
PhylomeDBiQ8BTZ7.
TreeFamiTF300718.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00930.
ReactomeiREACT_328870. Synthesis of GDP-mannose.

Miscellaneous databases

ChiTaRSiGmppb. mouse.
NextBioi399690.
PROiQ8BTZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTZ7.
CleanExiMM_GMPPB.
GenevisibleiQ8BTZ7. MM.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Inner ear and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiGMPPB_MOUSE
AccessioniPrimary (citable) accession number: Q8BTZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.