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Q8BTZ7

- GMPPB_MOUSE

UniProt

Q8BTZ7 - GMPPB_MOUSE

Protein

Mannose-1-phosphate guanyltransferase beta

Gene

Gmppb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. mannose-1-phosphate guanylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198715. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-1-phosphate guanyltransferase beta (EC:2.7.7.13)
    Alternative name(s):
    GDP-mannose pyrophosphorylase B
    GTP-mannose-1-phosphate guanylyltransferase beta
    Gene namesi
    Name:Gmppb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2660880. Gmppb.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Mannose-1-phosphate guanyltransferase betaPRO_0000307163Add
    BLAST

    Proteomic databases

    MaxQBiQ8BTZ7.
    PaxDbiQ8BTZ7.
    PRIDEiQ8BTZ7.

    2D gel databases

    REPRODUCTION-2DPAGEQ8BTZ7.

    PTM databases

    PhosphoSiteiQ8BTZ7.

    Expressioni

    Gene expression databases

    BgeeiQ8BTZ7.
    CleanExiMM_GMPPB.
    GenevestigatoriQ8BTZ7.

    Interactioni

    Subunit structurei

    Associates with GMPPA.By similarity

    Protein-protein interaction databases

    IntActiQ8BTZ7. 2 interactions.
    MINTiMINT-1866573.
    STRINGi10090.ENSMUSP00000107914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BTZ7.
    SMRiQ8BTZ7. Positions 1-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1208.
    GeneTreeiENSGT00530000063581.
    HOGENOMiHOG000283479.
    HOVERGENiHBG107955.
    InParanoidiQ8BTZ7.
    KOiK00966.
    OMAiKLIDECS.
    OrthoDBiEOG7CRTPW.
    PhylomeDBiQ8BTZ7.
    TreeFamiTF300718.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BTZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKALILVGGY GTRLRPLTLS TPKPLVDFCN KPILLHQVEA LAAAGVDHVI    50
    LAVSYMSQML EKEMKAQEQR LGIRISMSHE EEPLGTAGPL ALARDLLSET 100
    ADPFFVLNSD VICDFPFQAM VQFHRHHGQE GSILVTKVEE PSKYGVVVCE 150
    ADTGRIHRFV EKPQVFVSNK INAGMYILSP AVLQRIQLKP TSIEKEIFPV 200
    MAKEGQLYAM ELQGFWMDIG QPKDFLTGMC LFLQSLRQKH PERLYSGPGI 250
    VGNVLVDPSA RIGQNCSIGP NVSLGPGVVV EDGVCIRRCT VLRDAHIRSH 300
    SWLESCIVGW RCRVGQWVRM ENVTVLGEDV IVNDELYLNG ASVLPHKSIG 350
    ESVPEPRIIM 360
    Length:360
    Mass (Da):39,917
    Last modified:March 1, 2003 - v1
    Checksum:i2AF911A12C801A1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088295 mRNA. Translation: BAC40266.1.
    AK148125 mRNA. Translation: BAE28361.1.
    AK158470 mRNA. Translation: BAE34527.1.
    BC061207 mRNA. Translation: AAH61207.1.
    CCDSiCCDS23515.1.
    RefSeqiNP_808578.1. NM_177910.3.
    XP_006511822.1. XM_006511759.1.
    UniGeneiMm.22554.
    Mm.379272.

    Genome annotation databases

    EnsembliENSMUST00000047947; ENSMUSP00000036898; ENSMUSG00000070284.
    ENSMUST00000112295; ENSMUSP00000107914; ENSMUSG00000070284.
    GeneIDi331026.
    KEGGimmu:331026.
    UCSCiuc009rog.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088295 mRNA. Translation: BAC40266.1 .
    AK148125 mRNA. Translation: BAE28361.1 .
    AK158470 mRNA. Translation: BAE34527.1 .
    BC061207 mRNA. Translation: AAH61207.1 .
    CCDSi CCDS23515.1.
    RefSeqi NP_808578.1. NM_177910.3.
    XP_006511822.1. XM_006511759.1.
    UniGenei Mm.22554.
    Mm.379272.

    3D structure databases

    ProteinModelPortali Q8BTZ7.
    SMRi Q8BTZ7. Positions 1-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BTZ7. 2 interactions.
    MINTi MINT-1866573.
    STRINGi 10090.ENSMUSP00000107914.

    PTM databases

    PhosphoSitei Q8BTZ7.

    2D gel databases

    REPRODUCTION-2DPAGE Q8BTZ7.

    Proteomic databases

    MaxQBi Q8BTZ7.
    PaxDbi Q8BTZ7.
    PRIDEi Q8BTZ7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047947 ; ENSMUSP00000036898 ; ENSMUSG00000070284 .
    ENSMUST00000112295 ; ENSMUSP00000107914 ; ENSMUSG00000070284 .
    GeneIDi 331026.
    KEGGi mmu:331026.
    UCSCi uc009rog.1. mouse.

    Organism-specific databases

    CTDi 29925.
    MGIi MGI:2660880. Gmppb.

    Phylogenomic databases

    eggNOGi COG1208.
    GeneTreei ENSGT00530000063581.
    HOGENOMi HOG000283479.
    HOVERGENi HBG107955.
    InParanoidi Q8BTZ7.
    KOi K00966.
    OMAi KLIDECS.
    OrthoDBi EOG7CRTPW.
    PhylomeDBi Q8BTZ7.
    TreeFami TF300718.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00930 .
    Reactomei REACT_198715. Synthesis of GDP-mannose.

    Miscellaneous databases

    ChiTaRSi GMPPB. mouse.
    NextBioi 399690.
    PROi Q8BTZ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BTZ7.
    CleanExi MM_GMPPB.
    Genevestigatori Q8BTZ7.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Inner ear and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiGMPPB_MOUSE
    AccessioniPrimary (citable) accession number: Q8BTZ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3