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Protein

Ankyrin repeat domain-containing protein 46

Gene

Ankrd46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 46
Alternative name(s):
Ankyrin repeat small protein
Short name:
ANK-S
Gene namesi
Name:Ankrd46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916089. Ankrd46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Ankyrin repeat domain-containing protein 46PRO_0000244578Add
BLAST

Proteomic databases

EPDiQ8BTZ5.
MaxQBiQ8BTZ5.
PaxDbiQ8BTZ5.
PRIDEiQ8BTZ5.

PTM databases

iPTMnetiQ8BTZ5.
PhosphoSiteiQ8BTZ5.

Expressioni

Gene expression databases

BgeeiQ8BTZ5.
CleanExiMM_ANKRD46.
GenevisibleiQ8BTZ5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052521.

Structurei

3D structure databases

ProteinModelPortaliQ8BTZ5.
SMRiQ8BTZ5. Positions 6-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4030ANK 1Add
BLAST
Repeati44 – 7431ANK 2Add
BLAST
Repeati77 – 10327ANK 3Add
BLAST
Repeati107 – 13832ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000123078.
HOGENOMiHOG000033966.
HOVERGENiHBG080854.
InParanoidiQ8BTZ5.
OMAiATEYQGN.
OrthoDBiEOG7B5WWW.
PhylomeDBiQ8BTZ5.
TreeFamiTF330790.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYVFVNDSS QTNVPLLQAC IDGDFTYSKR LLESGFDPNI RDSRGRTGLH
60 70 80 90 100
LAAARGNVDI CQLLHKFGAD PLATDYQGNT ALHLCGHVDT IQFLVSNGLK
110 120 130 140 150
IDICNHQGAT PLVLAKRRGV NKDVIRLLES LEEQEVKGFN RGAHSKLETM
160 170 180 190 200
QTAESESAME SHSLLNPNLQ QGEGVLSSFR TTWQEFVEDL GFWRVLLLIL
210 220
VIALLSLGIA YYVSGVLPFV DNQPELVH
Length:228
Mass (Da):25,223
Last modified:March 1, 2003 - v1
Checksum:iF9BBC1CE9839483D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041C → W in AAI15843 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076382 mRNA. Translation: BAD23946.1.
AK079270 mRNA. Translation: BAC37594.1.
AK088304 mRNA. Translation: BAC40271.1.
AK148049 mRNA. Translation: BAE28312.1.
BC086659 mRNA. Translation: AAH86659.1.
BC094595 mRNA. Translation: AAH94595.1.
BC115842 mRNA. Translation: AAI15843.1.
CCDSiCCDS27429.1.
RefSeqiNP_780343.1. NM_175134.4.
XP_006520237.1. XM_006520174.2.
XP_006520238.1. XM_006520175.2.
XP_011243681.1. XM_011245379.1.
UniGeneiMm.396537.

Genome annotation databases

EnsembliENSMUST00000057486; ENSMUSP00000052521; ENSMUSG00000048307.
GeneIDi68839.
KEGGimmu:68839.
UCSCiuc007vmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076382 mRNA. Translation: BAD23946.1.
AK079270 mRNA. Translation: BAC37594.1.
AK088304 mRNA. Translation: BAC40271.1.
AK148049 mRNA. Translation: BAE28312.1.
BC086659 mRNA. Translation: AAH86659.1.
BC094595 mRNA. Translation: AAH94595.1.
BC115842 mRNA. Translation: AAI15843.1.
CCDSiCCDS27429.1.
RefSeqiNP_780343.1. NM_175134.4.
XP_006520237.1. XM_006520174.2.
XP_006520238.1. XM_006520175.2.
XP_011243681.1. XM_011245379.1.
UniGeneiMm.396537.

3D structure databases

ProteinModelPortaliQ8BTZ5.
SMRiQ8BTZ5. Positions 6-162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000052521.

PTM databases

iPTMnetiQ8BTZ5.
PhosphoSiteiQ8BTZ5.

Proteomic databases

EPDiQ8BTZ5.
MaxQBiQ8BTZ5.
PaxDbiQ8BTZ5.
PRIDEiQ8BTZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057486; ENSMUSP00000052521; ENSMUSG00000048307.
GeneIDi68839.
KEGGimmu:68839.
UCSCiuc007vmt.2. mouse.

Organism-specific databases

CTDi157567.
MGIiMGI:1916089. Ankrd46.

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00790000123078.
HOGENOMiHOG000033966.
HOVERGENiHBG080854.
InParanoidiQ8BTZ5.
OMAiATEYQGN.
OrthoDBiEOG7B5WWW.
PhylomeDBiQ8BTZ5.
TreeFamiTF330790.

Miscellaneous databases

ChiTaRSiAnkrd46. mouse.
NextBioi328027.
PROiQ8BTZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTZ5.
CleanExiMM_ANKRD46.
GenevisibleiQ8BTZ5. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel ankyrin-repeat containing gene expressed in SAMP8 hippocampus."
    Yamamura N., Koike N., Nomura Y., Sakaki Y., Tashiro T., Furihata C.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: SAMP8.
    Tissue: Hippocampus.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Eye.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiANR46_MOUSE
AccessioniPrimary (citable) accession number: Q8BTZ5
Secondary accession number(s): Q1LZK9, Q8BV97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.