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Protein

Inactive hydroxysteroid dehydrogenase-like protein 1

Gene

Hsdl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei125NADPBy similarity1
Binding sitei222NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 80NADPBy similarity7

Keywordsi

LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive hydroxysteroid dehydrogenase-like protein 1
Gene namesi
Name:Hsdl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1919802 Hsdl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136722 – 330Inactive hydroxysteroid dehydrogenase-like protein 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8BTX9
MaxQBiQ8BTX9
PaxDbiQ8BTX9
PeptideAtlasiQ8BTX9
PRIDEiQ8BTX9

PTM databases

PhosphoSitePlusiQ8BTX9
SwissPalmiQ8BTX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000034189
CleanExiMM_HSDL1
ExpressionAtlasiQ8BTX9 baseline and differential
GenevisibleiQ8BTX9 MM

Interactioni

Subunit structurei

Interacts with STYXL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044371

Structurei

3D structure databases

ProteinModelPortaliQ8BTX9
SMRiQ8BTX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 82Required for mitochondria translocationBy similarityAdd BLAST81

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1014 Eukaryota
COG0300 LUCA
GeneTreeiENSGT00390000010069
HOGENOMiHOG000039237
HOVERGENiHBG005478
InParanoidiQ8BTX9
OMAiFYPYPQY
OrthoDBiEOG091G06T2
PhylomeDBiQ8BTX9
TreeFamiTF314591

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BTX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVDSFYLL YREIARSCNC YMEALALVGA WYTARKSITV ICDFYSLVRL
60 70 80 90 100
HFIPRLGSRP DLIKQYGRWA VISGATDGIG KAYAEELASH GLNVILISQE
110 120 130 140 150
EEKLQAAAKH IADTYRVETL VLVADFSRGR EIYAPIREAL RDRDIGILVN
160 170 180 190 200
DVGAFYPYPQ YFSQVPEDTL WDIVNVNIAA ASLMVHIVLP GMVERKKGAI
210 220 230 240 250
VTVSSGSCCK PTPQLAAFSA SKAYLDHFSR ALQYEYASKG IFVQSLIPFY
260 270 280 290 300
VTSSGAAPAS FLHRCPWLAP SPRVYAQHAV STLGISKRTT GYWSHSIQFL
310 320 330
FAQYMPEWLW VWGANLLNRS LRKEALSCQA
Length:330
Mass (Da):36,868
Last modified:March 1, 2003 - v1
Checksum:iA54D0DB8546DDA00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088412 mRNA Translation: BAC40340.1
AK150638 mRNA Translation: BAE29726.1
AK152392 mRNA Translation: BAE31180.1
BC065074 mRNA Translation: AAH65074.1
CCDSiCCDS22708.1
RefSeqiNP_780394.1, NM_175185.4
XP_006531459.1, XM_006531396.1
XP_006531460.1, XM_006531397.3
UniGeneiMm.36756

Genome annotation databases

EnsembliENSMUST00000036049; ENSMUSP00000044371; ENSMUSG00000034189
GeneIDi72552
KEGGimmu:72552
UCSCiuc009npu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHSDL1_MOUSE
AccessioniPrimary (citable) accession number: Q8BTX9
Secondary accession number(s): Q3U839
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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