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Q8BTW8 (CK5P1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDK5 regulatory subunit-associated protein 1
Alternative name(s):
CDK5 activator-binding protein C42
Gene names
Name:Cdk5rap1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 By similarity. HAMAP-Rule MF_01864

Cofactor

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 By similarity.

Sequence similarities

Belongs to the methylthiotransferase family. MiaB subfamily.

Contains 1 MTTase N-terminal domain.

Contains 1 TRAM domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588CDK5 regulatory subunit-associated protein 1 HAMAP-Rule MF_01864
PRO_0000141765

Regions

Domain99 – 219121MTTase N-terminal
Domain500 – 57576TRAM

Sites

Metal binding1081Iron-sulfur (4Fe-4S) By similarity
Metal binding1441Iron-sulfur (4Fe-4S) By similarity
Metal binding1821Iron-sulfur (4Fe-4S) By similarity
Metal binding2571Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding2611Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding2641Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Experimental info

Sequence conflict5051C → Y in BAC40398. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BTW8 [UniParc].

Last modified June 16, 2003. Version 2.
Checksum: 4430C4F1A067093C

FASTA58866,110
        10         20         30         40         50         60 
MHPLRCVLQV QRLSAPFTSM CWVLLRTCRA QSSVSSTPCP SPEAKSSEAQ KDFSSRLATG 

        70         80         90        100        110        120 
PTFQHFLRSA SVPQEKPSSP EVEDPPPYLS GDELLGRQRK VYLETYGCQM NVNDTEIAWS 

       130        140        150        160        170        180 
ILQKSGYLRT SNLQEADVIL LVTCSIREKA EQTIWNRLHQ LKVLKTKRPR SRVPLRIGIL 

       190        200        210        220        230        240 
GCMAERLKGE ILNREKMVDL LAGPDAYRDL PRLLAVVESG QQAANVLLSL DETYADIMPV 

       250        260        270        280        290        300 
QTSPSATSAF VSIMRGCDNM CSYCIVPFTR GRERSRPVAS ILDEVRKLSE QGLKEVTLLG 

       310        320        330        340        350        360 
QNVNSFRDNS EVQFNNAGSA NLSRGFTTNY KPKQGGLRFS HLLDQVSRID PEMRIRFTSP 

       370        380        390        400        410        420 
HPKDFPDEVL QLIRERHNIC KQIHLPAQSG SSRVLDAMRR GYSREAYVAL VHHVRETIPG 

       430        440        450        460        470        480 
VSLSSDFITG FCGETEDDHR QTVSLLREVQ YNTGFLFAYS MRQKTRAYHR LKDDVPEEVK 

       490        500        510        520        530        540 
LRRLEELITV FREEASKANK TSVGCSQLVL VEGFSKRSTT DLCGRNDANL KVIFPDAEVE 

       550        560        570        580 
DITNPGLKVR AQPGDYVLVK ITSASSQTLK GHILCRTTMK DSLTYCTT 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Thymus and Tongue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK010097 mRNA. Translation: BAB26700.1.
AK088517 mRNA. Translation: BAC40398.1.
BC025132 mRNA. Translation: AAH25132.1.
CCDSCCDS16931.1.
RefSeqNP_080152.1. NM_025876.2.
UniGeneMm.289427.

3D structure databases

ProteinModelPortalQ8BTW8.
SMRQ8BTW8. Positions 100-513.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BTW8.

Proteomic databases

PaxDbQ8BTW8.
PRIDEQ8BTW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487.
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487.
GeneID66971.
KEGGmmu:66971.
UCSCuc008njb.1. mouse.

Organism-specific databases

CTD51654.
MGIMGI:1914221. Cdk5rap1.

Phylogenomic databases

eggNOGCOG0621.
GeneTreeENSGT00530000063447.
HOGENOMHOG000224767.
HOVERGENHBG050975.
InParanoidQ8BTW8.
OMAIEVYKDT.
OrthoDBEOG744T8N.
PhylomeDBQ8BTW8.
TreeFamTF101033.

Gene expression databases

BgeeQ8BTW8.
CleanExMM_CDK5RAP1.
GenevestigatorQ8BTW8.

Family and domain databases

Gene3D3.80.30.20. 1 hit.
HAMAPMF_01864. tRNA_metthiotr_MiaB.
InterProIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006463. MiaB_methiolase.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERPTHR11918. PTHR11918. 1 hit.
PfamPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00089. TIGR00089. 1 hit.
PROSITEPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio323171.
PROQ8BTW8.
SOURCESearch...

Entry information

Entry nameCK5P1_MOUSE
AccessionPrimary (citable) accession number: Q8BTW8
Secondary accession number(s): Q9D6Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot