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Protein

CDK5 regulatory subunit-associated protein 1

Gene

Cdk5rap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity).By similarity

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S)By similarity
Metal bindingi144 – 1441Iron-sulfur (4Fe-4S)By similarity
Metal bindingi182 – 1821Iron-sulfur (4Fe-4S)By similarity
Metal bindingi257 – 2571Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi261 – 2611Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi264 – 2641Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 1
Alternative name(s):
CDK5 activator-binding protein C42
Gene namesi
Name:Cdk5rap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914221. Cdk5rap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588CDK5 regulatory subunit-associated protein 1PRO_0000141765Add
BLAST

Proteomic databases

MaxQBiQ8BTW8.
PaxDbiQ8BTW8.
PRIDEiQ8BTW8.

PTM databases

PhosphoSiteiQ8BTW8.

Expressioni

Gene expression databases

BgeeiQ8BTW8.
CleanExiMM_CDK5RAP1.
ExpressionAtlasiQ8BTW8. baseline and differential.
GenevisibleiQ8BTW8. MM.

Interactioni

Subunit structurei

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028990.

Structurei

3D structure databases

ProteinModelPortaliQ8BTW8.
SMRiQ8BTW8. Positions 100-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 219121MTTase N-terminalAdd
BLAST
Domaini500 – 57576TRAMAdd
BLAST

Sequence similaritiesi

Contains 1 MTTase N-terminal domain.Curated
Contains 1 TRAM domain.Curated

Phylogenomic databases

eggNOGiCOG0621.
GeneTreeiENSGT00530000063447.
HOGENOMiHOG000224767.
HOVERGENiHBG050975.
InParanoidiQ8BTW8.
OMAiGCQMNKA.
OrthoDBiEOG744T8N.
PhylomeDBiQ8BTW8.
TreeFamiTF101033.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
HAMAPiMF_01864. tRNA_metthiotr_MiaB.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006463. MiaB_methiolase.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPLRCVLQV QRLSAPFTSM CWVLLRTCRA QSSVSSTPCP SPEAKSSEAQ
60 70 80 90 100
KDFSSRLATG PTFQHFLRSA SVPQEKPSSP EVEDPPPYLS GDELLGRQRK
110 120 130 140 150
VYLETYGCQM NVNDTEIAWS ILQKSGYLRT SNLQEADVIL LVTCSIREKA
160 170 180 190 200
EQTIWNRLHQ LKVLKTKRPR SRVPLRIGIL GCMAERLKGE ILNREKMVDL
210 220 230 240 250
LAGPDAYRDL PRLLAVVESG QQAANVLLSL DETYADIMPV QTSPSATSAF
260 270 280 290 300
VSIMRGCDNM CSYCIVPFTR GRERSRPVAS ILDEVRKLSE QGLKEVTLLG
310 320 330 340 350
QNVNSFRDNS EVQFNNAGSA NLSRGFTTNY KPKQGGLRFS HLLDQVSRID
360 370 380 390 400
PEMRIRFTSP HPKDFPDEVL QLIRERHNIC KQIHLPAQSG SSRVLDAMRR
410 420 430 440 450
GYSREAYVAL VHHVRETIPG VSLSSDFITG FCGETEDDHR QTVSLLREVQ
460 470 480 490 500
YNTGFLFAYS MRQKTRAYHR LKDDVPEEVK LRRLEELITV FREEASKANK
510 520 530 540 550
TSVGCSQLVL VEGFSKRSTT DLCGRNDANL KVIFPDAEVE DITNPGLKVR
560 570 580
AQPGDYVLVK ITSASSQTLK GHILCRTTMK DSLTYCTT
Length:588
Mass (Da):66,110
Last modified:June 16, 2003 - v2
Checksum:i4430C4F1A067093C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti505 – 5051C → Y in BAC40398 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010097 mRNA. Translation: BAB26700.1.
AK088517 mRNA. Translation: BAC40398.1.
BC025132 mRNA. Translation: AAH25132.1.
CCDSiCCDS16931.1.
RefSeqiNP_080152.1. NM_025876.2.
UniGeneiMm.289427.

Genome annotation databases

EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487.
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487.
GeneIDi66971.
KEGGimmu:66971.
UCSCiuc008njb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010097 mRNA. Translation: BAB26700.1.
AK088517 mRNA. Translation: BAC40398.1.
BC025132 mRNA. Translation: AAH25132.1.
CCDSiCCDS16931.1.
RefSeqiNP_080152.1. NM_025876.2.
UniGeneiMm.289427.

3D structure databases

ProteinModelPortaliQ8BTW8.
SMRiQ8BTW8. Positions 100-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028990.

PTM databases

PhosphoSiteiQ8BTW8.

Proteomic databases

MaxQBiQ8BTW8.
PaxDbiQ8BTW8.
PRIDEiQ8BTW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487.
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487.
GeneIDi66971.
KEGGimmu:66971.
UCSCiuc008njb.1. mouse.

Organism-specific databases

CTDi51654.
MGIiMGI:1914221. Cdk5rap1.

Phylogenomic databases

eggNOGiCOG0621.
GeneTreeiENSGT00530000063447.
HOGENOMiHOG000224767.
HOVERGENiHBG050975.
InParanoidiQ8BTW8.
OMAiGCQMNKA.
OrthoDBiEOG744T8N.
PhylomeDBiQ8BTW8.
TreeFamiTF101033.

Miscellaneous databases

NextBioi323171.
PROiQ8BTW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTW8.
CleanExiMM_CDK5RAP1.
ExpressionAtlasiQ8BTW8. baseline and differential.
GenevisibleiQ8BTW8. MM.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
HAMAPiMF_01864. tRNA_metthiotr_MiaB.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006463. MiaB_methiolase.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCK5P1_MOUSE
AccessioniPrimary (citable) accession number: Q8BTW8
Secondary accession number(s): Q9D6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 22, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.