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Q8BTW8

- CK5P1_MOUSE

UniProt

Q8BTW8 - CK5P1_MOUSE

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Protein

CDK5 regulatory subunit-associated protein 1

Gene
Cdk5rap1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 By similarity.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S) By similarity
Metal bindingi144 – 1441Iron-sulfur (4Fe-4S) By similarity
Metal bindingi182 – 1821Iron-sulfur (4Fe-4S) By similarity
Metal bindingi257 – 2571Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi261 – 2611Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi264 – 2641Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. transferase activity Source: InterPro

GO - Biological processi

  1. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  3. tRNA modification Source: InterPro
Complete GO annotation...

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 1
Alternative name(s):
CDK5 activator-binding protein C42
Gene namesi
Name:Cdk5rap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1914221. Cdk5rap1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588CDK5 regulatory subunit-associated protein 1UniRule annotationPRO_0000141765Add
BLAST

Proteomic databases

PaxDbiQ8BTW8.
PRIDEiQ8BTW8.

PTM databases

PhosphoSiteiQ8BTW8.

Expressioni

Gene expression databases

BgeeiQ8BTW8.
CleanExiMM_CDK5RAP1.
GenevestigatoriQ8BTW8.

Interactioni

Subunit structurei

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BTW8.
SMRiQ8BTW8. Positions 100-513.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini99 – 219121MTTase N-terminalAdd
BLAST
Domaini500 – 57576TRAMAdd
BLAST

Sequence similaritiesi

Contains 1 TRAM domain.

Phylogenomic databases

eggNOGiCOG0621.
GeneTreeiENSGT00530000063447.
HOGENOMiHOG000224767.
HOVERGENiHBG050975.
InParanoidiQ8BTW8.
OMAiIEVYKDT.
OrthoDBiEOG744T8N.
PhylomeDBiQ8BTW8.
TreeFamiTF101033.

Family and domain databases

Gene3Di3.80.30.20. 1 hit.
HAMAPiMF_01864. tRNA_metthiotr_MiaB.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006463. MiaB_methiolase.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTW8-1 [UniParc]FASTAAdd to Basket

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MHPLRCVLQV QRLSAPFTSM CWVLLRTCRA QSSVSSTPCP SPEAKSSEAQ    50
KDFSSRLATG PTFQHFLRSA SVPQEKPSSP EVEDPPPYLS GDELLGRQRK 100
VYLETYGCQM NVNDTEIAWS ILQKSGYLRT SNLQEADVIL LVTCSIREKA 150
EQTIWNRLHQ LKVLKTKRPR SRVPLRIGIL GCMAERLKGE ILNREKMVDL 200
LAGPDAYRDL PRLLAVVESG QQAANVLLSL DETYADIMPV QTSPSATSAF 250
VSIMRGCDNM CSYCIVPFTR GRERSRPVAS ILDEVRKLSE QGLKEVTLLG 300
QNVNSFRDNS EVQFNNAGSA NLSRGFTTNY KPKQGGLRFS HLLDQVSRID 350
PEMRIRFTSP HPKDFPDEVL QLIRERHNIC KQIHLPAQSG SSRVLDAMRR 400
GYSREAYVAL VHHVRETIPG VSLSSDFITG FCGETEDDHR QTVSLLREVQ 450
YNTGFLFAYS MRQKTRAYHR LKDDVPEEVK LRRLEELITV FREEASKANK 500
TSVGCSQLVL VEGFSKRSTT DLCGRNDANL KVIFPDAEVE DITNPGLKVR 550
AQPGDYVLVK ITSASSQTLK GHILCRTTMK DSLTYCTT 588
Length:588
Mass (Da):66,110
Last modified:June 16, 2003 - v2
Checksum:i4430C4F1A067093C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti505 – 5051C → Y in BAC40398. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010097 mRNA. Translation: BAB26700.1.
AK088517 mRNA. Translation: BAC40398.1.
BC025132 mRNA. Translation: AAH25132.1.
CCDSiCCDS16931.1.
RefSeqiNP_080152.1. NM_025876.2.
UniGeneiMm.289427.

Genome annotation databases

EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487.
ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487.
GeneIDi66971.
KEGGimmu:66971.
UCSCiuc008njb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010097 mRNA. Translation: BAB26700.1 .
AK088517 mRNA. Translation: BAC40398.1 .
BC025132 mRNA. Translation: AAH25132.1 .
CCDSi CCDS16931.1.
RefSeqi NP_080152.1. NM_025876.2.
UniGenei Mm.289427.

3D structure databases

ProteinModelPortali Q8BTW8.
SMRi Q8BTW8. Positions 100-513.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BTW8.

Proteomic databases

PaxDbi Q8BTW8.
PRIDEi Q8BTW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028990 ; ENSMUSP00000028990 ; ENSMUSG00000027487 .
ENSMUST00000109731 ; ENSMUSP00000105353 ; ENSMUSG00000027487 .
GeneIDi 66971.
KEGGi mmu:66971.
UCSCi uc008njb.1. mouse.

Organism-specific databases

CTDi 51654.
MGIi MGI:1914221. Cdk5rap1.

Phylogenomic databases

eggNOGi COG0621.
GeneTreei ENSGT00530000063447.
HOGENOMi HOG000224767.
HOVERGENi HBG050975.
InParanoidi Q8BTW8.
OMAi IEVYKDT.
OrthoDBi EOG744T8N.
PhylomeDBi Q8BTW8.
TreeFami TF101033.

Miscellaneous databases

NextBioi 323171.
PROi Q8BTW8.
SOURCEi Search...

Gene expression databases

Bgeei Q8BTW8.
CleanExi MM_CDK5RAP1.
Genevestigatori Q8BTW8.

Family and domain databases

Gene3Di 3.80.30.20. 1 hit.
HAMAPi MF_01864. tRNA_metthiotr_MiaB.
InterProi IPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR006463. MiaB_methiolase.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view ]
PANTHERi PTHR11918. PTHR11918. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
PF01938. TRAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
PROSITEi PS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Thymus and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCK5P1_MOUSE
AccessioniPrimary (citable) accession number: Q8BTW8
Secondary accession number(s): Q9D6Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi