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Q8BTW8

- CK5P1_MOUSE

UniProt

Q8BTW8 - CK5P1_MOUSE

Protein

CDK5 regulatory subunit-associated protein 1

Gene

Cdk5rap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (16 Jun 2003)
      Previous versions | rss
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    Functioni

    Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 By similarity.By similarity

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi108 – 1081Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi144 – 1441Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi182 – 1821Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi257 – 2571Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi261 – 2611Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi264 – 2641Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. transferase activity Source: InterPro

    GO - Biological processi

    1. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    3. tRNA modification Source: InterPro

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 regulatory subunit-associated protein 1
    Alternative name(s):
    CDK5 activator-binding protein C42
    Gene namesi
    Name:Cdk5rap1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1914221. Cdk5rap1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588CDK5 regulatory subunit-associated protein 1PRO_0000141765Add
    BLAST

    Proteomic databases

    PaxDbiQ8BTW8.
    PRIDEiQ8BTW8.

    PTM databases

    PhosphoSiteiQ8BTW8.

    Expressioni

    Gene expression databases

    BgeeiQ8BTW8.
    CleanExiMM_CDK5RAP1.
    GenevestigatoriQ8BTW8.

    Interactioni

    Subunit structurei

    Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BTW8.
    SMRiQ8BTW8. Positions 100-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini99 – 219121MTTase N-terminalAdd
    BLAST
    Domaini500 – 57576TRAMAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MTTase N-terminal domain.Curated
    Contains 1 TRAM domain.Curated

    Phylogenomic databases

    eggNOGiCOG0621.
    GeneTreeiENSGT00530000063447.
    HOGENOMiHOG000224767.
    HOVERGENiHBG050975.
    InParanoidiQ8BTW8.
    OMAiIEVYKDT.
    OrthoDBiEOG744T8N.
    PhylomeDBiQ8BTW8.
    TreeFamiTF101033.

    Family and domain databases

    Gene3Di3.80.30.20. 1 hit.
    HAMAPiMF_01864. tRNA_metthiotr_MiaB.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR006463. MiaB_methiolase.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BTW8-1 [UniParc]FASTAAdd to Basket

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    MHPLRCVLQV QRLSAPFTSM CWVLLRTCRA QSSVSSTPCP SPEAKSSEAQ    50
    KDFSSRLATG PTFQHFLRSA SVPQEKPSSP EVEDPPPYLS GDELLGRQRK 100
    VYLETYGCQM NVNDTEIAWS ILQKSGYLRT SNLQEADVIL LVTCSIREKA 150
    EQTIWNRLHQ LKVLKTKRPR SRVPLRIGIL GCMAERLKGE ILNREKMVDL 200
    LAGPDAYRDL PRLLAVVESG QQAANVLLSL DETYADIMPV QTSPSATSAF 250
    VSIMRGCDNM CSYCIVPFTR GRERSRPVAS ILDEVRKLSE QGLKEVTLLG 300
    QNVNSFRDNS EVQFNNAGSA NLSRGFTTNY KPKQGGLRFS HLLDQVSRID 350
    PEMRIRFTSP HPKDFPDEVL QLIRERHNIC KQIHLPAQSG SSRVLDAMRR 400
    GYSREAYVAL VHHVRETIPG VSLSSDFITG FCGETEDDHR QTVSLLREVQ 450
    YNTGFLFAYS MRQKTRAYHR LKDDVPEEVK LRRLEELITV FREEASKANK 500
    TSVGCSQLVL VEGFSKRSTT DLCGRNDANL KVIFPDAEVE DITNPGLKVR 550
    AQPGDYVLVK ITSASSQTLK GHILCRTTMK DSLTYCTT 588
    Length:588
    Mass (Da):66,110
    Last modified:June 16, 2003 - v2
    Checksum:i4430C4F1A067093C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti505 – 5051C → Y in BAC40398. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010097 mRNA. Translation: BAB26700.1.
    AK088517 mRNA. Translation: BAC40398.1.
    BC025132 mRNA. Translation: AAH25132.1.
    CCDSiCCDS16931.1.
    RefSeqiNP_080152.1. NM_025876.2.
    UniGeneiMm.289427.

    Genome annotation databases

    EnsembliENSMUST00000028990; ENSMUSP00000028990; ENSMUSG00000027487.
    ENSMUST00000109731; ENSMUSP00000105353; ENSMUSG00000027487.
    GeneIDi66971.
    KEGGimmu:66971.
    UCSCiuc008njb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010097 mRNA. Translation: BAB26700.1 .
    AK088517 mRNA. Translation: BAC40398.1 .
    BC025132 mRNA. Translation: AAH25132.1 .
    CCDSi CCDS16931.1.
    RefSeqi NP_080152.1. NM_025876.2.
    UniGenei Mm.289427.

    3D structure databases

    ProteinModelPortali Q8BTW8.
    SMRi Q8BTW8. Positions 100-513.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BTW8.

    Proteomic databases

    PaxDbi Q8BTW8.
    PRIDEi Q8BTW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028990 ; ENSMUSP00000028990 ; ENSMUSG00000027487 .
    ENSMUST00000109731 ; ENSMUSP00000105353 ; ENSMUSG00000027487 .
    GeneIDi 66971.
    KEGGi mmu:66971.
    UCSCi uc008njb.1. mouse.

    Organism-specific databases

    CTDi 51654.
    MGIi MGI:1914221. Cdk5rap1.

    Phylogenomic databases

    eggNOGi COG0621.
    GeneTreei ENSGT00530000063447.
    HOGENOMi HOG000224767.
    HOVERGENi HBG050975.
    InParanoidi Q8BTW8.
    OMAi IEVYKDT.
    OrthoDBi EOG744T8N.
    PhylomeDBi Q8BTW8.
    TreeFami TF101033.

    Miscellaneous databases

    NextBioi 323171.
    PROi Q8BTW8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BTW8.
    CleanExi MM_CDK5RAP1.
    Genevestigatori Q8BTW8.

    Family and domain databases

    Gene3Di 3.80.30.20. 1 hit.
    HAMAPi MF_01864. tRNA_metthiotr_MiaB.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR006463. MiaB_methiolase.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Thymus and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiCK5P1_MOUSE
    AccessioniPrimary (citable) accession number: Q8BTW8
    Secondary accession number(s): Q9D6Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3