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Protein

Cleavage and polyadenylation specificity factor subunit 7

Gene

Cpsf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylation RNA substrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72187. mRNA 3'-end processing.
R-MMU-77595. Processing of Intronless Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 7
Gene namesi
Name:Cpsf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1917826. Cpsf7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815281 – 471Cleavage and polyadenylation specificity factor subunit 7Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphothreonineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei413PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BTV2.
PeptideAtlasiQ8BTV2.
PRIDEiQ8BTV2.

PTM databases

iPTMnetiQ8BTV2.
PhosphoSitePlusiQ8BTV2.

Miscellaneous databases

PMAP-CutDBQ8BTV2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034820.
CleanExiMM_5730453I16RIK.
GenevisibleiQ8BTV2. MM.

Interactioni

Subunit structurei

Component of the cleavage factor Im (CFIm) complex, composed of, at least, NUDT21/CPSF5 and CPSF6 or CPSF7. Within the cleavage factor Im complex, the NUDT21/CPSF5 homodimer is at the core of a heterotetramer, and is clasped by two additional subunits (CPSF6 or CPSF7). Interacts with NUDT21/CPSF5 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BTV2. 1 interactor.
MINTiMINT-4115639.
STRINGi10090.ENSMUSP00000038958.

Structurei

3D structure databases

ProteinModelPortaliQ8BTV2.
SMRiQ8BTV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 162RRMPROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 54Poly-Pro4
Compositional biasi218 – 329Pro-richAdd BLAST112
Compositional biasi418 – 469Arg-richAdd BLAST52

Sequence similaritiesi

Belongs to the RRM CPSF6/7 family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4849. Eukaryota.
ENOG4111NBM. LUCA.
GeneTreeiENSGT00730000110905.
HOGENOMiHOG000111137.
HOVERGENiHBG056699.
InParanoidiQ8BTV2.
KOiK14398.
OMAiNADQMDL.
OrthoDBiEOG091G0CVC.
PhylomeDBiQ8BTV2.
TreeFamiTF316430.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BTV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEGVDLIDI YADEEFNQDS EFNNTDQIDL YDDVLTAASQ PSDDRSSSTE
60 70 80 90 100
PPPPVRQEPA PKPNNKTPAI LYTYSGLRSR RAAVYVGSFS WWTTDQQLIQ
110 120 130 140 150
VIRSIGVYDV VELKFAENRA NGQSKGYAEV VVASENSVHK LLELLPGKVL
160 170 180 190 200
NGEKVDVRPA TRQNLSQFEA QARKRECVRV PRGGIPPRAH SRDSSDSADG
210 220 230 240 250
RATPSENLVP SSARVDKPPS VLPYFNRPPS ALPLMGLPPP PIPPPPPLSS
260 270 280 290 300
SFGVPPPPPG IHYQHLMPPP PRLPPHLAVP PPGAIPPALH LNPAFFPPPN
310 320 330 340 350
ATVGPPPDTY MKASTPYNHH GSRDSGPPPS TVSEAEFEEI MKRNRAISSS
360 370 380 390 400
AISKAVSGAS AGDYSDAIET LLTAIAVIKQ SRVANDERCR VLISSLKDCL
410 420 430 440 450
HGIEAKSYSV GASGSSSRKR HRSRERSPSR SRESSRRHRD LLHNEDRHDD
460 470
YFQERNREHE RHRDRERDRH H
Length:471
Mass (Da):52,011
Last modified:February 7, 2006 - v2
Checksum:i3ACC0F1FF7224109
GO
Isoform 2 (identifier: Q8BTV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-184: Missing.

Show »
Length:462
Mass (Da):51,057
Checksum:i42D511ECC74E228E
GO
Isoform 3 (identifier: Q8BTV2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.

Show »
Length:237
Mass (Da):26,192
Checksum:iBA60549810D0C8FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262H → Q in BAC40447 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0171951 – 234Missing in isoform 3. 1 PublicationAdd BLAST234
Alternative sequenceiVSP_017196176 – 184Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053375 mRNA. Translation: BAC35368.1.
AK165330 mRNA. Translation: BAE38138.1.
AK088603 mRNA. Translation: BAC40447.1.
BC038812 mRNA. Translation: AAH38812.1.
CCDSiCCDS29579.1. [Q8BTV2-1]
RefSeqiNP_001157744.1. NM_001164272.1. [Q8BTV2-2]
NP_758506.3. NM_172302.3. [Q8BTV2-1]
XP_006527179.1. XM_006527116.3. [Q8BTV2-1]
XP_006527186.1. XM_006527123.2. [Q8BTV2-3]
UniGeneiMm.490260.

Genome annotation databases

EnsembliENSMUST00000038379; ENSMUSP00000038958; ENSMUSG00000034820. [Q8BTV2-1]
GeneIDi269061.
KEGGimmu:269061.
UCSCiuc008gpw.2. mouse. [Q8BTV2-1]
uc008gqa.2. mouse. [Q8BTV2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053375 mRNA. Translation: BAC35368.1.
AK165330 mRNA. Translation: BAE38138.1.
AK088603 mRNA. Translation: BAC40447.1.
BC038812 mRNA. Translation: AAH38812.1.
CCDSiCCDS29579.1. [Q8BTV2-1]
RefSeqiNP_001157744.1. NM_001164272.1. [Q8BTV2-2]
NP_758506.3. NM_172302.3. [Q8BTV2-1]
XP_006527179.1. XM_006527116.3. [Q8BTV2-1]
XP_006527186.1. XM_006527123.2. [Q8BTV2-3]
UniGeneiMm.490260.

3D structure databases

ProteinModelPortaliQ8BTV2.
SMRiQ8BTV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BTV2. 1 interactor.
MINTiMINT-4115639.
STRINGi10090.ENSMUSP00000038958.

PTM databases

iPTMnetiQ8BTV2.
PhosphoSitePlusiQ8BTV2.

Proteomic databases

PaxDbiQ8BTV2.
PeptideAtlasiQ8BTV2.
PRIDEiQ8BTV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038379; ENSMUSP00000038958; ENSMUSG00000034820. [Q8BTV2-1]
GeneIDi269061.
KEGGimmu:269061.
UCSCiuc008gpw.2. mouse. [Q8BTV2-1]
uc008gqa.2. mouse. [Q8BTV2-2]

Organism-specific databases

CTDi79869.
MGIiMGI:1917826. Cpsf7.

Phylogenomic databases

eggNOGiKOG4849. Eukaryota.
ENOG4111NBM. LUCA.
GeneTreeiENSGT00730000110905.
HOGENOMiHOG000111137.
HOVERGENiHBG056699.
InParanoidiQ8BTV2.
KOiK14398.
OMAiNADQMDL.
OrthoDBiEOG091G0CVC.
PhylomeDBiQ8BTV2.
TreeFamiTF316430.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72187. mRNA 3'-end processing.
R-MMU-77595. Processing of Intronless Pre-mRNAs.

Miscellaneous databases

PMAP-CutDBQ8BTV2.
PROiQ8BTV2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034820.
CleanExiMM_5730453I16RIK.
GenevisibleiQ8BTV2. MM.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPSF7_MOUSE
AccessioniPrimary (citable) accession number: Q8BTV2
Secondary accession number(s): Q3TNF1, Q8BKE7, Q8CFS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.