Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor suppressor candidate 3

Gene

Tusc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-MMU-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor suppressor candidate 3
Alternative name(s):
Magnesium uptake/transporter TUSC3
Protein N33
Gene namesi
Name:Tusc3
Synonyms:N33
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1933134. Tusc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 196155LumenalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Topological domaini218 – 2214CytoplasmicSequence analysis
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 27634LumenalSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Topological domaini298 – 31215CytoplasmicSequence analysisAdd
BLAST
Transmembranei313 – 33321HelicalSequence analysisAdd
BLAST
Topological domaini334 – 34714LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
  • oligosaccharyltransferase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence analysisAdd
BLAST
Chaini42 – 347306Tumor suppressor candidate 3PRO_0000414923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 102Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BTV1.
PaxDbiQ8BTV1.
PeptideAtlasiQ8BTV1.
PRIDEiQ8BTV1.

PTM databases

iPTMnetiQ8BTV1.
PhosphoSiteiQ8BTV1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039530.
ExpressionAtlasiQ8BTV1. baseline and differential.
GenevisibleiQ8BTV1. MM.

Interactioni

Subunit structurei

Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126080.

Structurei

3D structure databases

ProteinModelPortaliQ8BTV1.
SMRiQ8BTV1. Positions 44-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 187129ThioredoxinAdd
BLAST

Sequence similaritiesi

Belongs to the OST3/OST6 family.Curated
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
GeneTreeiENSGT00390000012030.
HOGENOMiHOG000231301.
HOVERGENiHBG002493.
InParanoidiQ8BTV1.
KOiK12669.
OMAiDLIARSW.
OrthoDBiEOG091G0ERM.
PhylomeDBiQ8BTV1.
TreeFamiTF314850.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BTV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSARAAPSRR RQAGRRLRYL PTGSFPFLLL LLLLCIQLGG GQKKKENLLA
60 70 80 90 100
EKVEQLMEWS SRRSIFRMNG DKFRKFVKAP PRNYSMIVMF TALQPQRQCS
110 120 130 140 150
VCRQANEEYQ ILANSWRYSS AFCNKLFFGM VDYDEGTDVF QQLNMNSAPT
160 170 180 190 200
FMHFPSKGRP KRADTFDLQR IGFAAEQLAK WIADRTDVHI RVFRPPNYSG
210 220 230 240 250
TIALALLVSL VGGLLYLRRN NLEFIYNKTG WAMVSLCIVF AMTSGQMWNH
260 270 280 290 300
IRGPPYAHKN PHNGQVSYIH GSSQAQFVAE SHIILVLNAA ITMGMVLLNE
310 320 330 340
AATSKGDVGK RRIICLVGLG LVVFFFSFLL SIFRSKYHGY PYSFLIK
Length:347
Mass (Da):39,548
Last modified:March 1, 2003 - v1
Checksum:iA2C6A79FA2A979C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088616 mRNA. Translation: BAC40455.1.
AK132766 mRNA. Translation: BAE21346.1.
AC168314 Genomic DNA. No translation available.
AC174643 Genomic DNA. No translation available.
CAAA01027656 Genomic DNA. No translation available.
BC069898 mRNA. Translation: AAH69898.1.
RefSeqiNP_084530.3. NM_030254.3.
UniGeneiMm.272722.

Genome annotation databases

EnsembliENSMUST00000167992; ENSMUSP00000126080; ENSMUSG00000039530.
GeneIDi80286.
KEGGimmu:80286.
UCSCiuc009lmf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088616 mRNA. Translation: BAC40455.1.
AK132766 mRNA. Translation: BAE21346.1.
AC168314 Genomic DNA. No translation available.
AC174643 Genomic DNA. No translation available.
CAAA01027656 Genomic DNA. No translation available.
BC069898 mRNA. Translation: AAH69898.1.
RefSeqiNP_084530.3. NM_030254.3.
UniGeneiMm.272722.

3D structure databases

ProteinModelPortaliQ8BTV1.
SMRiQ8BTV1. Positions 44-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126080.

PTM databases

iPTMnetiQ8BTV1.
PhosphoSiteiQ8BTV1.

Proteomic databases

MaxQBiQ8BTV1.
PaxDbiQ8BTV1.
PeptideAtlasiQ8BTV1.
PRIDEiQ8BTV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167992; ENSMUSP00000126080; ENSMUSG00000039530.
GeneIDi80286.
KEGGimmu:80286.
UCSCiuc009lmf.1. mouse.

Organism-specific databases

CTDi7991.
MGIiMGI:1933134. Tusc3.

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
GeneTreeiENSGT00390000012030.
HOGENOMiHOG000231301.
HOVERGENiHBG002493.
InParanoidiQ8BTV1.
KOiK12669.
OMAiDLIARSW.
OrthoDBiEOG091G0ERM.
PhylomeDBiQ8BTV1.
TreeFamiTF314850.

Enzyme and pathway databases

ReactomeiR-MMU-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiTusc3. mouse.
PROiQ8BTV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039530.
ExpressionAtlasiQ8BTV1. baseline and differential.
GenevisibleiQ8BTV1. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTUSC3_MOUSE
AccessioniPrimary (citable) accession number: Q8BTV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.