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Protein

Nuclear pore complex protein Nup54

Gene

Nup54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup54
Alternative name(s):
54 kDa nucleoporin
Nucleoporin Nup54
Gene namesi
Name:Nup54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1920460. Nup54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Nuclear pore complex protein Nup54PRO_0000204875Add
BLAST

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BTS4.
MaxQBiQ8BTS4.
PaxDbiQ8BTS4.
PeptideAtlasiQ8BTS4.
PRIDEiQ8BTS4.

2D gel databases

REPRODUCTION-2DPAGEQ8BTS4.

PTM databases

iPTMnetiQ8BTS4.
PhosphoSiteiQ8BTS4.

Expressioni

Gene expression databases

BgeeiQ8BTS4.
CleanExiMM_NUP54.
ExpressionAtlasiQ8BTS4. baseline and differential.
GenevisibleiQ8BTS4. MM.

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58.By similarity

Protein-protein interaction databases

IntActiQ8BTS4. 1 interaction.
MINTiMINT-4104303.
STRINGi10090.ENSMUSP00000046540.

Structurei

3D structure databases

ProteinModelPortaliQ8BTS4.
SMRiQ8BTS4. Positions 189-425, 456-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 621
Repeati25 – 2622
Repeati28 – 2923
Repeati61 – 6224
Repeati63 – 6425
Repeati67 – 6826
Repeati87 – 8827
Repeati447 – 44828

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni5 – 4484448 X 2 AA repeats of F-GAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi6 – 8984Gly-richAdd
BLAST
Compositional biasi11 – 8373Thr-richAdd
BLAST
Compositional biasi93 – 1008Poly-Gln
Compositional biasi208 – 2114Poly-Gln

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3091. Eukaryota.
ENOG410XPU5. LUCA.
GeneTreeiENSGT00390000013620.
HOGENOMiHOG000046583.
HOVERGENiHBG052698.
InParanoidiQ8BTS4.
KOiK14308.
OMAiEQANIKT.
OrthoDBiEOG7H4DV6.
PhylomeDBiQ8BTS4.
TreeFamiTF320237.

Family and domain databases

InterProiIPR024864. Nup54/Nup57/Nup44.
IPR025712. Nup54_alpha-helical_dom.
[Graphical view]
PANTHERiPTHR13000. PTHR13000. 1 hit.
PfamiPF13874. Nup54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNFGAPSG TSGTSTATAA PAGGFGGFGT TTTTAGSAFS FSAPTNTGST
60 70 80 90 100
GLLGGTQNKG FGFGTGFGTT TGTGTGLGTG LGTGLGFGGF NTQQQQQQQQ
110 120 130 140 150
TSLGGLFSQP TQAPAQSTQL INTASALSAP TLLGDERDAI LAKWNQLQAF
160 170 180 190 200
WGTGKGYFNN NIPPVEFTQE NPFCRFKAVG YSCMPNNKDE DGLVVLIFNK
210 220 230 240 250
KETDIRSQQQ QLVESLHKVL GGNQTLTVNV EGIKTLPDDQ TEVVIYVVER
260 270 280 290 300
SPNGTSRRVP ATTLYAHFEQ ANIKAQLQQL GVTLSMTRTE LSPAQIKQLL
310 320 330 340 350
QNPPAGVDPI IWEQAKVDNP DSEKLIPVPM VGFKELLRRL KVQDQMTKQH
360 370 380 390 400
QTRLDIISED ISELQKNQTT TMAKIAQYKR KLMELSHRTL QVLIKQEIQR
410 420 430 440 450
KSGYAIQADE EQLRVQLDTI QGELNAPTQF KGRLNELMSQ IRMQNHFGAV
460 470 480 490 500
KSEEKYYIDA DLLREIKQHL KQQQEGLSHL ISIIKDDLED IKLVEHGLNE
510
TIHSRGGVFS
Length:510
Mass (Da):55,732
Last modified:March 1, 2003 - v1
Checksum:iFD70E4574964BE30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087827 mRNA. Translation: BAC40018.1.
AK088855 mRNA. Translation: BAC40615.1.
AK133841 mRNA. Translation: BAE21878.1.
AK162037 mRNA. Translation: BAE36693.1.
BC068114 mRNA. Translation: AAH68114.1.
CCDSiCCDS19430.1.
RefSeqiNP_899248.1. NM_183392.2.
UniGeneiMm.275289.

Genome annotation databases

EnsembliENSMUST00000038514; ENSMUSP00000046540; ENSMUSG00000034826.
GeneIDi269113.
KEGGimmu:269113.
UCSCiuc008ydk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087827 mRNA. Translation: BAC40018.1.
AK088855 mRNA. Translation: BAC40615.1.
AK133841 mRNA. Translation: BAE21878.1.
AK162037 mRNA. Translation: BAE36693.1.
BC068114 mRNA. Translation: AAH68114.1.
CCDSiCCDS19430.1.
RefSeqiNP_899248.1. NM_183392.2.
UniGeneiMm.275289.

3D structure databases

ProteinModelPortaliQ8BTS4.
SMRiQ8BTS4. Positions 189-425, 456-494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BTS4. 1 interaction.
MINTiMINT-4104303.
STRINGi10090.ENSMUSP00000046540.

PTM databases

iPTMnetiQ8BTS4.
PhosphoSiteiQ8BTS4.

2D gel databases

REPRODUCTION-2DPAGEQ8BTS4.

Proteomic databases

EPDiQ8BTS4.
MaxQBiQ8BTS4.
PaxDbiQ8BTS4.
PeptideAtlasiQ8BTS4.
PRIDEiQ8BTS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038514; ENSMUSP00000046540; ENSMUSG00000034826.
GeneIDi269113.
KEGGimmu:269113.
UCSCiuc008ydk.1. mouse.

Organism-specific databases

CTDi53371.
MGIiMGI:1920460. Nup54.

Phylogenomic databases

eggNOGiKOG3091. Eukaryota.
ENOG410XPU5. LUCA.
GeneTreeiENSGT00390000013620.
HOGENOMiHOG000046583.
HOVERGENiHBG052698.
InParanoidiQ8BTS4.
KOiK14308.
OMAiEQANIKT.
OrthoDBiEOG7H4DV6.
PhylomeDBiQ8BTS4.
TreeFamiTF320237.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ8BTS4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTS4.
CleanExiMM_NUP54.
ExpressionAtlasiQ8BTS4. baseline and differential.
GenevisibleiQ8BTS4. MM.

Family and domain databases

InterProiIPR024864. Nup54/Nup57/Nup44.
IPR025712. Nup54_alpha-helical_dom.
[Graphical view]
PANTHERiPTHR13000. PTHR13000. 1 hit.
PfamiPF13874. Nup54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Muellerian duct, Ovary and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Lubec G., Yang J.W., Zigmond M.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 144-155.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Lung, Spleen and Testis.

Entry informationi

Entry nameiNUP54_MOUSE
AccessioniPrimary (citable) accession number: Q8BTS4
Secondary accession number(s): Q3TSI2, Q8BU42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.