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Protein

Nuclear pore complex protein Nup54

Gene

Nup54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup54
Alternative name(s):
54 kDa nucleoporin
Nucleoporin Nup54
Gene namesi
Name:Nup54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1920460. Nup54.

Subcellular locationi

  • Nucleusnuclear pore complex By similarity
  • Nucleus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  • Nucleus membrane By similarity; Peripheral membrane protein By similarity; Nucleoplasmic side By similarity

  • Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002048751 – 510Nuclear pore complex protein Nup54Add BLAST510

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8BTS4.
MaxQBiQ8BTS4.
PaxDbiQ8BTS4.
PeptideAtlasiQ8BTS4.
PRIDEiQ8BTS4.

2D gel databases

REPRODUCTION-2DPAGEQ8BTS4.

PTM databases

iPTMnetiQ8BTS4.
PhosphoSitePlusiQ8BTS4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034826.
CleanExiMM_NUP54.
ExpressionAtlasiQ8BTS4. baseline and differential.
GenevisibleiQ8BTS4. MM.

Interactioni

Subunit structurei

Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.By similarity

Protein-protein interaction databases

IntActiQ8BTS4. 1 interactor.
MINTiMINT-4104303.
STRINGi10090.ENSMUSP00000046540.

Structurei

3D structure databases

ProteinModelPortaliQ8BTS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 612
Repeati25 – 2622
Repeati28 – 2932
Repeati61 – 6242
Repeati63 – 6452
Repeati67 – 6862
Repeati87 – 8872
Repeati447 – 44882

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni5 – 4488 X 2 AA repeats of F-GAdd BLAST444

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 89Gly-richAdd BLAST84
Compositional biasi11 – 83Thr-richAdd BLAST73
Compositional biasi93 – 100Poly-Gln8
Compositional biasi208 – 211Poly-Gln4

Domaini

Contains FG repeats.

Sequence similaritiesi

Belongs to the NUP54 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3091. Eukaryota.
ENOG410XPU5. LUCA.
GeneTreeiENSGT00390000013620.
HOGENOMiHOG000046583.
HOVERGENiHBG052698.
InParanoidiQ8BTS4.
KOiK14308.
OMAiWNQLQAY.
OrthoDBiEOG091G0BAH.
PhylomeDBiQ8BTS4.
TreeFamiTF320237.

Family and domain databases

InterProiIPR024864. Nup54/Nup57/Nup44.
IPR025712. Nup54_alpha-helical_dom.
[Graphical view]
PANTHERiPTHR13000. PTHR13000. 1 hit.
PfamiPF13874. Nup54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFNFGAPSG TSGTSTATAA PAGGFGGFGT TTTTAGSAFS FSAPTNTGST
60 70 80 90 100
GLLGGTQNKG FGFGTGFGTT TGTGTGLGTG LGTGLGFGGF NTQQQQQQQQ
110 120 130 140 150
TSLGGLFSQP TQAPAQSTQL INTASALSAP TLLGDERDAI LAKWNQLQAF
160 170 180 190 200
WGTGKGYFNN NIPPVEFTQE NPFCRFKAVG YSCMPNNKDE DGLVVLIFNK
210 220 230 240 250
KETDIRSQQQ QLVESLHKVL GGNQTLTVNV EGIKTLPDDQ TEVVIYVVER
260 270 280 290 300
SPNGTSRRVP ATTLYAHFEQ ANIKAQLQQL GVTLSMTRTE LSPAQIKQLL
310 320 330 340 350
QNPPAGVDPI IWEQAKVDNP DSEKLIPVPM VGFKELLRRL KVQDQMTKQH
360 370 380 390 400
QTRLDIISED ISELQKNQTT TMAKIAQYKR KLMELSHRTL QVLIKQEIQR
410 420 430 440 450
KSGYAIQADE EQLRVQLDTI QGELNAPTQF KGRLNELMSQ IRMQNHFGAV
460 470 480 490 500
KSEEKYYIDA DLLREIKQHL KQQQEGLSHL ISIIKDDLED IKLVEHGLNE
510
TIHSRGGVFS
Length:510
Mass (Da):55,732
Last modified:March 1, 2003 - v1
Checksum:iFD70E4574964BE30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087827 mRNA. Translation: BAC40018.1.
AK088855 mRNA. Translation: BAC40615.1.
AK133841 mRNA. Translation: BAE21878.1.
AK162037 mRNA. Translation: BAE36693.1.
BC068114 mRNA. Translation: AAH68114.1.
CCDSiCCDS19430.1.
RefSeqiNP_899248.1. NM_183392.2.
UniGeneiMm.275289.

Genome annotation databases

EnsembliENSMUST00000038514; ENSMUSP00000046540; ENSMUSG00000034826.
GeneIDi269113.
KEGGimmu:269113.
UCSCiuc008ydk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK087827 mRNA. Translation: BAC40018.1.
AK088855 mRNA. Translation: BAC40615.1.
AK133841 mRNA. Translation: BAE21878.1.
AK162037 mRNA. Translation: BAE36693.1.
BC068114 mRNA. Translation: AAH68114.1.
CCDSiCCDS19430.1.
RefSeqiNP_899248.1. NM_183392.2.
UniGeneiMm.275289.

3D structure databases

ProteinModelPortaliQ8BTS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BTS4. 1 interactor.
MINTiMINT-4104303.
STRINGi10090.ENSMUSP00000046540.

PTM databases

iPTMnetiQ8BTS4.
PhosphoSitePlusiQ8BTS4.

2D gel databases

REPRODUCTION-2DPAGEQ8BTS4.

Proteomic databases

EPDiQ8BTS4.
MaxQBiQ8BTS4.
PaxDbiQ8BTS4.
PeptideAtlasiQ8BTS4.
PRIDEiQ8BTS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038514; ENSMUSP00000046540; ENSMUSG00000034826.
GeneIDi269113.
KEGGimmu:269113.
UCSCiuc008ydk.1. mouse.

Organism-specific databases

CTDi53371.
MGIiMGI:1920460. Nup54.

Phylogenomic databases

eggNOGiKOG3091. Eukaryota.
ENOG410XPU5. LUCA.
GeneTreeiENSGT00390000013620.
HOGENOMiHOG000046583.
HOVERGENiHBG052698.
InParanoidiQ8BTS4.
KOiK14308.
OMAiWNQLQAY.
OrthoDBiEOG091G0BAH.
PhylomeDBiQ8BTS4.
TreeFamiTF320237.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-191859. snRNP Assembly.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiQ8BTS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034826.
CleanExiMM_NUP54.
ExpressionAtlasiQ8BTS4. baseline and differential.
GenevisibleiQ8BTS4. MM.

Family and domain databases

InterProiIPR024864. Nup54/Nup57/Nup44.
IPR025712. Nup54_alpha-helical_dom.
[Graphical view]
PANTHERiPTHR13000. PTHR13000. 1 hit.
PfamiPF13874. Nup54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP54_MOUSE
AccessioniPrimary (citable) accession number: Q8BTS4
Secondary accession number(s): Q3TSI2, Q8BU42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.