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Q8BTR5

- DUS28_MOUSE

UniProt

Q8BTR5 - DUS28_MOUSE

Protein

Dual specificity phosphatase 28

Gene

Dusp28

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei95 – 951Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. JNK cascade Source: RefGenome
    2. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Dusp28
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914696. Dusp28.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 163163Dual specificity phosphatase 28PRO_0000302841Add
    BLAST

    Proteomic databases

    PaxDbiQ8BTR5.
    PRIDEiQ8BTR5.

    Expressioni

    Gene expression databases

    BgeeiQ8BTR5.
    CleanExiMM_DUSP28.
    GenevestigatoriQ8BTR5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000057690.

    Structurei

    Secondary structure

    1
    163
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi10 – 156
    Beta strandi18 – 225
    Helixi23 – 275
    Helixi29 – 346
    Beta strandi37 – 426
    Beta strandi44 – 463
    Beta strandi56 – 594
    Helixi71 – 8616
    Beta strandi90 – 9910
    Helixi100 – 11314
    Helixi118 – 12811
    Helixi136 – 15116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HCMX-ray2.00A2-163[»]
    ProteinModelPortaliQ8BTR5.
    SMRiQ8BTR5. Positions 1-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8BTR5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 13063Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG313004.
    GeneTreeiENSGT00750000117525.
    HOGENOMiHOG000233766.
    HOVERGENiHBG051422.
    InParanoidiQ8BTR5.
    KOiK14165.
    OMAiAKAFQMV.
    OrthoDBiEOG715Q5Z.
    PhylomeDBiQ8BTR5.
    TreeFamiTF105128.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BTR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTSEAAPPP FARVAPALFI GNARAAGATE LLVRAGITLC VNVSRQQPGP    50
    RAPGVAELRV PVFDDPAEDL LTHLEPTCAA MEAAVRDGGS CLVYCKNGRS 100
    RSAAVCTAYL MRHRGHSLDR AFQMVKSARP VAEPNLGFWA QLQKYEQTLQ 150
    AQAILPREPI DPE 163
    Length:163
    Mass (Da):17,505
    Last modified:March 1, 2003 - v1
    Checksum:i40259C4C084B0696
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088940 mRNA. Translation: BAC40664.1.
    AK163560 mRNA. Translation: BAE37397.1.
    BC119127 mRNA. Translation: AAI19128.1.
    CCDSiCCDS15179.1.
    RefSeqiNP_780327.1. NM_175118.3.
    UniGeneiMm.46179.

    Genome annotation databases

    EnsembliENSMUST00000060913; ENSMUSP00000057690; ENSMUSG00000047067.
    GeneIDi67446.
    KEGGimmu:67446.
    UCSCiuc007cbu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK088940 mRNA. Translation: BAC40664.1 .
    AK163560 mRNA. Translation: BAE37397.1 .
    BC119127 mRNA. Translation: AAI19128.1 .
    CCDSi CCDS15179.1.
    RefSeqi NP_780327.1. NM_175118.3.
    UniGenei Mm.46179.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HCM X-ray 2.00 A 2-163 [» ]
    ProteinModelPortali Q8BTR5.
    SMRi Q8BTR5. Positions 1-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000057690.

    Proteomic databases

    PaxDbi Q8BTR5.
    PRIDEi Q8BTR5.

    Protocols and materials databases

    DNASUi 67446.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060913 ; ENSMUSP00000057690 ; ENSMUSG00000047067 .
    GeneIDi 67446.
    KEGGi mmu:67446.
    UCSCi uc007cbu.1. mouse.

    Organism-specific databases

    CTDi 285193.
    MGIi MGI:1914696. Dusp28.

    Phylogenomic databases

    eggNOGi NOG313004.
    GeneTreei ENSGT00750000117525.
    HOGENOMi HOG000233766.
    HOVERGENi HBG051422.
    InParanoidi Q8BTR5.
    KOi K14165.
    OMAi AKAFQMV.
    OrthoDBi EOG715Q5Z.
    PhylomeDBi Q8BTR5.
    TreeFami TF105128.

    Miscellaneous databases

    EvolutionaryTracei Q8BTR5.
    NextBioi 324594.
    PROi Q8BTR5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BTR5.
    CleanExi MM_DUSP28.
    Genevestigatori Q8BTR5.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Corpora quadrigemina and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiDUS28_MOUSE
    AccessioniPrimary (citable) accession number: Q8BTR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3