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Protein

Dual specificity phosphatase 28

Gene

Dusp28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dusp28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914696. Dusp28.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028411 – 163Dual specificity phosphatase 28Add BLAST163

Proteomic databases

PaxDbiQ8BTR5.
PeptideAtlasiQ8BTR5.
PRIDEiQ8BTR5.

PTM databases

PhosphoSitePlusiQ8BTR5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047067.
CleanExiMM_DUSP28.
GenevisibleiQ8BTR5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057690.

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Beta strandi18 – 22Combined sources5
Helixi23 – 27Combined sources5
Helixi29 – 34Combined sources6
Beta strandi37 – 42Combined sources6
Beta strandi44 – 46Combined sources3
Beta strandi56 – 59Combined sources4
Helixi71 – 86Combined sources16
Beta strandi90 – 99Combined sources10
Helixi100 – 113Combined sources14
Helixi118 – 128Combined sources11
Helixi136 – 151Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HCMX-ray2.00A2-163[»]
ProteinModelPortaliQ8BTR5.
SMRiQ8BTR5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8BTR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 130Tyrosine-protein phosphataseAdd BLAST63

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ8BTR5.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG091G0RMR.
PhylomeDBiQ8BTR5.
TreeFamiTF105128.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSEAAPPP FARVAPALFI GNARAAGATE LLVRAGITLC VNVSRQQPGP
60 70 80 90 100
RAPGVAELRV PVFDDPAEDL LTHLEPTCAA MEAAVRDGGS CLVYCKNGRS
110 120 130 140 150
RSAAVCTAYL MRHRGHSLDR AFQMVKSARP VAEPNLGFWA QLQKYEQTLQ
160
AQAILPREPI DPE
Length:163
Mass (Da):17,505
Last modified:March 1, 2003 - v1
Checksum:i40259C4C084B0696
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088940 mRNA. Translation: BAC40664.1.
AK163560 mRNA. Translation: BAE37397.1.
BC119127 mRNA. Translation: AAI19128.1.
CCDSiCCDS15179.1.
RefSeqiNP_780327.1. NM_175118.3.
UniGeneiMm.46179.

Genome annotation databases

EnsembliENSMUST00000060913; ENSMUSP00000057690; ENSMUSG00000047067.
GeneIDi67446.
KEGGimmu:67446.
UCSCiuc007cbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088940 mRNA. Translation: BAC40664.1.
AK163560 mRNA. Translation: BAE37397.1.
BC119127 mRNA. Translation: AAI19128.1.
CCDSiCCDS15179.1.
RefSeqiNP_780327.1. NM_175118.3.
UniGeneiMm.46179.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HCMX-ray2.00A2-163[»]
ProteinModelPortaliQ8BTR5.
SMRiQ8BTR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057690.

PTM databases

PhosphoSitePlusiQ8BTR5.

Proteomic databases

PaxDbiQ8BTR5.
PeptideAtlasiQ8BTR5.
PRIDEiQ8BTR5.

Protocols and materials databases

DNASUi67446.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060913; ENSMUSP00000057690; ENSMUSG00000047067.
GeneIDi67446.
KEGGimmu:67446.
UCSCiuc007cbu.1. mouse.

Organism-specific databases

CTDi285193.
MGIiMGI:1914696. Dusp28.

Phylogenomic databases

eggNOGiKOG1718. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ8BTR5.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG091G0RMR.
PhylomeDBiQ8BTR5.
TreeFamiTF105128.

Miscellaneous databases

EvolutionaryTraceiQ8BTR5.
PROiQ8BTR5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047067.
CleanExiMM_DUSP28.
GenevisibleiQ8BTR5. MM.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS28_MOUSE
AccessioniPrimary (citable) accession number: Q8BTR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.