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Q8BTR5

- DUS28_MOUSE

UniProt

Q8BTR5 - DUS28_MOUSE

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Protein
Dual specificity phosphatase 28
Gene
Dusp28
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. JNK cascade Source: RefGenome
  2. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity phosphatase 28 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:Dusp28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914696. Dusp28.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Dual specificity phosphatase 28
PRO_0000302841Add
BLAST

Proteomic databases

PaxDbiQ8BTR5.
PRIDEiQ8BTR5.

Expressioni

Gene expression databases

BgeeiQ8BTR5.
CleanExiMM_DUSP28.
GenevestigatoriQ8BTR5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057690.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 156
Beta strandi18 – 225
Helixi23 – 275
Helixi29 – 346
Beta strandi37 – 426
Beta strandi44 – 463
Beta strandi56 – 594
Helixi71 – 8616
Beta strandi90 – 9910
Helixi100 – 11314
Helixi118 – 12811
Helixi136 – 15116

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HCMX-ray2.00A2-163[»]
ProteinModelPortaliQ8BTR5.
SMRiQ8BTR5. Positions 1-158.

Miscellaneous databases

EvolutionaryTraceiQ8BTR5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 13063Tyrosine-protein phosphatase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG313004.
GeneTreeiENSGT00750000117525.
HOGENOMiHOG000233766.
HOVERGENiHBG051422.
InParanoidiQ8BTR5.
KOiK14165.
OMAiAKAFQMV.
OrthoDBiEOG715Q5Z.
PhylomeDBiQ8BTR5.
TreeFamiTF105128.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTR5-1 [UniParc]FASTAAdd to Basket

« Hide

MGTSEAAPPP FARVAPALFI GNARAAGATE LLVRAGITLC VNVSRQQPGP    50
RAPGVAELRV PVFDDPAEDL LTHLEPTCAA MEAAVRDGGS CLVYCKNGRS 100
RSAAVCTAYL MRHRGHSLDR AFQMVKSARP VAEPNLGFWA QLQKYEQTLQ 150
AQAILPREPI DPE 163
Length:163
Mass (Da):17,505
Last modified:March 1, 2003 - v1
Checksum:i40259C4C084B0696
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088940 mRNA. Translation: BAC40664.1.
AK163560 mRNA. Translation: BAE37397.1.
BC119127 mRNA. Translation: AAI19128.1.
CCDSiCCDS15179.1.
RefSeqiNP_780327.1. NM_175118.3.
UniGeneiMm.46179.

Genome annotation databases

EnsembliENSMUST00000060913; ENSMUSP00000057690; ENSMUSG00000047067.
GeneIDi67446.
KEGGimmu:67446.
UCSCiuc007cbu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK088940 mRNA. Translation: BAC40664.1 .
AK163560 mRNA. Translation: BAE37397.1 .
BC119127 mRNA. Translation: AAI19128.1 .
CCDSi CCDS15179.1.
RefSeqi NP_780327.1. NM_175118.3.
UniGenei Mm.46179.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HCM X-ray 2.00 A 2-163 [» ]
ProteinModelPortali Q8BTR5.
SMRi Q8BTR5. Positions 1-158.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057690.

Proteomic databases

PaxDbi Q8BTR5.
PRIDEi Q8BTR5.

Protocols and materials databases

DNASUi 67446.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000060913 ; ENSMUSP00000057690 ; ENSMUSG00000047067 .
GeneIDi 67446.
KEGGi mmu:67446.
UCSCi uc007cbu.1. mouse.

Organism-specific databases

CTDi 285193.
MGIi MGI:1914696. Dusp28.

Phylogenomic databases

eggNOGi NOG313004.
GeneTreei ENSGT00750000117525.
HOGENOMi HOG000233766.
HOVERGENi HBG051422.
InParanoidi Q8BTR5.
KOi K14165.
OMAi AKAFQMV.
OrthoDBi EOG715Q5Z.
PhylomeDBi Q8BTR5.
TreeFami TF105128.

Miscellaneous databases

EvolutionaryTracei Q8BTR5.
NextBioi 324594.
PROi Q8BTR5.
SOURCEi Search...

Gene expression databases

Bgeei Q8BTR5.
CleanExi MM_DUSP28.
Genevestigatori Q8BTR5.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiDUS28_MOUSE
AccessioniPrimary (citable) accession number: Q8BTR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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