Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Polycomb group RING finger protein 3

Gene

PcgF3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 5640RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 3
Alternative name(s):
RING finger protein 3A
Gene namesi
Name:PcgF3
Synonyms:Rnf3, Rnf3a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1916837. Pcgf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Polycomb group RING finger protein 3PRO_0000277865Add
BLAST

Proteomic databases

MaxQBiQ8BTQ0.
PaxDbiQ8BTQ0.
PRIDEiQ8BTQ0.

PTM databases

PhosphoSiteiQ8BTQ0.

Expressioni

Gene expression databases

BgeeiQ8BTQ0.
CleanExiMM_PCGF3.
ExpressionAtlasiQ8BTQ0. baseline and differential.
GenevisibleiQ8BTQ0. MM.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213553. 1 interaction.
IntActiQ8BTQ0. 1 interaction.
STRINGi10090.ENSMUSP00000041790.

Structurei

3D structure databases

ProteinModelPortaliQ8BTQ0.
SMRiQ8BTQ0. Positions 5-97, 152-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 5640RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ8BTQ0.
KOiK11488.
OMAiYRPRIDI.
OrthoDBiEOG754HQ5.
PhylomeDBiQ8BTQ0.
TreeFamiTF324206.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BTQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN
60 70 80 90 100
TCPTCRIVIH QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL
110 120 130 140 150
GMEVPGDIKG EACSAKQHLD PRNGETKADD NSNKETAEEK QEEDNDYHRS
160 170 180 190 200
DEQVSICLEC NSSKLRGLKR KWIRCSAQAT VLHLKKFIAK KLNLSSFNEL
210 220 230 240
DILCNEEILG KDHTLKFVVV TRWRFKKAPL LLHYRPKMDL L
Length:241
Mass (Da):28,046
Last modified:March 1, 2003 - v1
Checksum:i1F4645C6E7A3DEA5
GO
Isoform 2 (identifier: Q8BTQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-178: SICLECNSSKLRGLKRKWIRCSAQ → NTRPLWIFWHQFIPCLRTSFENVT
     179-241: Missing.

Show »
Length:178
Mass (Da):20,843
Checksum:i792FB74D2F0938A1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei155 – 17824SICLE…RCSAQ → NTRPLWIFWHQFIPCLRTSF ENVT in isoform 2. 1 PublicationVSP_023116Add
BLAST
Alternative sequencei179 – 24163Missing in isoform 2. 1 PublicationVSP_023117Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033609 mRNA. Translation: BAC28388.1.
AK089091 mRNA. Translation: BAC40745.1.
BC049266 mRNA. Translation: AAH49266.1.
CCDSiCCDS19512.1. [Q8BTQ0-1]
RefSeqiNP_766304.2. NM_172716.4. [Q8BTQ0-1]
UniGeneiMm.261218.
Mm.486543.

Genome annotation databases

EnsembliENSMUST00000046975; ENSMUSP00000041790; ENSMUSG00000033623. [Q8BTQ0-1]
ENSMUST00000112597; ENSMUSP00000108216; ENSMUSG00000033623. [Q8BTQ0-2]
GeneIDi69587.
KEGGimmu:69587.
UCSCiuc008yod.1. mouse. [Q8BTQ0-2]
uc008yoe.1. mouse. [Q8BTQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK033609 mRNA. Translation: BAC28388.1.
AK089091 mRNA. Translation: BAC40745.1.
BC049266 mRNA. Translation: AAH49266.1.
CCDSiCCDS19512.1. [Q8BTQ0-1]
RefSeqiNP_766304.2. NM_172716.4. [Q8BTQ0-1]
UniGeneiMm.261218.
Mm.486543.

3D structure databases

ProteinModelPortaliQ8BTQ0.
SMRiQ8BTQ0. Positions 5-97, 152-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213553. 1 interaction.
IntActiQ8BTQ0. 1 interaction.
STRINGi10090.ENSMUSP00000041790.

PTM databases

PhosphoSiteiQ8BTQ0.

Proteomic databases

MaxQBiQ8BTQ0.
PaxDbiQ8BTQ0.
PRIDEiQ8BTQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046975; ENSMUSP00000041790; ENSMUSG00000033623. [Q8BTQ0-1]
ENSMUST00000112597; ENSMUSP00000108216; ENSMUSG00000033623. [Q8BTQ0-2]
GeneIDi69587.
KEGGimmu:69587.
UCSCiuc008yod.1. mouse. [Q8BTQ0-2]
uc008yoe.1. mouse. [Q8BTQ0-1]

Organism-specific databases

CTDi10336.
MGIiMGI:1916837. Pcgf3.

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
GeneTreeiENSGT00550000074463.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ8BTQ0.
KOiK11488.
OMAiYRPRIDI.
OrthoDBiEOG754HQ5.
PhylomeDBiQ8BTQ0.
TreeFamiTF324206.

Miscellaneous databases

PROiQ8BTQ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTQ0.
CleanExiMM_PCGF3.
ExpressionAtlasiQ8BTQ0. baseline and differential.
GenevisibleiQ8BTQ0. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: NOD.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPCGF3_MOUSE
AccessioniPrimary (citable) accession number: Q8BTQ0
Secondary accession number(s): Q8BZT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.