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Protein

GPI mannosyltransferase 4

Gene

Pigz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 4 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase IV
Short name:
GPI-MT-IV
Phosphatidylinositol-glycan biosynthesis class Z protein
Short name:
PIG-Z
Gene namesi
Name:Pigz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443822. Pigz.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei126 – 143HelicalSequence analysisAdd BLAST18
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462691 – 560GPI mannosyltransferase 4Add BLAST560

Proteomic databases

PaxDbiQ8BTP0.
PRIDEiQ8BTP0.

PTM databases

iPTMnetiQ8BTP0.
PhosphoSitePlusiQ8BTP0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045625.
GenevisibleiQ8BTP0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057509.

Structurei

3D structure databases

ProteinModelPortaliQ8BTP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4123. Eukaryota.
ENOG410XTCB. LUCA.
GeneTreeiENSGT00390000003227.
HOGENOMiHOG000121777.
HOVERGENiHBG082141.
InParanoidiQ8BTP0.
KOiK08098.
OMAiSTFWLLR.
OrthoDBiEOG091G04TT.
TreeFamiTF324461.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 2 hits.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVAAQVIWG SFSLLRVLWC LLPQTGYIHP DEFFQSPEVM AEDILGVQAT
60 70 80 90 100
RPWEFYPSSS CRTVVFPLLT SGSTFWLLRL WEELGLWPGL VSGYMLLVGP
110 120 130 140 150
RFLLTALSFA LDWAVYDLAP LWGADRWNAL CLLSGSYVTL VFYTRTFSNT
160 170 180 190 200
IEGLLFTWLL VLVSPGVVRS PTSKKPTPGP RWHRYLLGVI LAAGFFNRPT
210 220 230 240 250
FLAFALAPLS LWGIHRASEL GGIRALIQEA LVLLPGAALA AVLCVATDSW
260 270 280 290 300
YFSSLSRSTG VFLTPANFLY YNLDPQNLAR HGTHARLTHL AVNGFLLFGV
310 320 330 340 350
LHAQALQAAW QQLHACLRAS PQTGLSRVRG ARGLLSSSKS YLLLFYFTPL
360 370 380 390 400
LLLSAFSHQE ARFLIPLLVP LVLLCSPQTQ PIPWKGTLVL FNILGALIFG
410 420 430 440 450
CLHQGGLVPG LKYLEQIVHT PDLSGTTTHY TLLFTHTYMP PQHLLHLSGL
460 470 480 490 500
GSPVEVVDMG GAEDRVLCQA LNNFSRQPAC QLAGEPWPCR LFVVTPGTNR
510 520 530 540 550
HALEKCRFPL KNETLLFPHL TLEDPPALSS LLSGAWRKHL SLHVIELETP
560
VVTKQPKAQP
Length:560
Mass (Da):62,043
Last modified:July 27, 2011 - v2
Checksum:iE7CAD2634D9AA159
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti472N → D in BAC40783 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089183 mRNA. Translation: BAC40783.1.
BC117748 mRNA. Translation: AAI17749.1.
CCDSiCCDS28109.1.
RefSeqiNP_766410.2. NM_172822.3.
XP_006522181.1. XM_006522118.3.
XP_006522182.1. XM_006522119.3.
XP_006522183.1. XM_006522120.3.
UniGeneiMm.440388.

Genome annotation databases

EnsembliENSMUST00000052174; ENSMUSP00000057509; ENSMUSG00000045625.
GeneIDi239827.
KEGGimmu:239827.
UCSCiuc007yxx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089183 mRNA. Translation: BAC40783.1.
BC117748 mRNA. Translation: AAI17749.1.
CCDSiCCDS28109.1.
RefSeqiNP_766410.2. NM_172822.3.
XP_006522181.1. XM_006522118.3.
XP_006522182.1. XM_006522119.3.
XP_006522183.1. XM_006522120.3.
UniGeneiMm.440388.

3D structure databases

ProteinModelPortaliQ8BTP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057509.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

PTM databases

iPTMnetiQ8BTP0.
PhosphoSitePlusiQ8BTP0.

Proteomic databases

PaxDbiQ8BTP0.
PRIDEiQ8BTP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052174; ENSMUSP00000057509; ENSMUSG00000045625.
GeneIDi239827.
KEGGimmu:239827.
UCSCiuc007yxx.2. mouse.

Organism-specific databases

CTDi80235.
MGIiMGI:2443822. Pigz.

Phylogenomic databases

eggNOGiKOG4123. Eukaryota.
ENOG410XTCB. LUCA.
GeneTreeiENSGT00390000003227.
HOGENOMiHOG000121777.
HOVERGENiHBG082141.
InParanoidiQ8BTP0.
KOiK08098.
OMAiSTFWLLR.
OrthoDBiEOG091G04TT.
TreeFamiTF324461.

Enzyme and pathway databases

UniPathwayiUPA00196.

Miscellaneous databases

PROiQ8BTP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045625.
GenevisibleiQ8BTP0. MM.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 2 hits.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGZ_MOUSE
AccessioniPrimary (citable) accession number: Q8BTP0
Secondary accession number(s): Q149K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.