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Q8BTL4 (Q8BTL4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Rela MGI 103290
OrganismMus musculus (Mouse) EMBL BAC40904.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 RHD (Rel-like) domain. RuleBase RU003997

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU003998
Gene Ontology (GO)
   Biological_processdefense response

Inferred from mutant phenotype PubMed 9120401. Source: MGI

hair follicle development

Inferred from mutant phenotype PubMed 16481354. Source: MGI

negative regulation of extrinsic apoptotic signaling pathway

Inferred from direct assay PubMed 22244329. Source: MGI

negative regulation of protein catabolic process

Inferred from mutant phenotype PubMed 15923614. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 9120401. Source: MGI

positive regulation of NF-kappaB transcription factor activity

Inferred from sequence orthology PubMed 15790681. Source: MGI

positive regulation of interleukin-12 biosynthetic process

Inferred from direct assay PubMed 14568984. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 14568984. Source: MGI

response to bacterium

Inferred from direct assay PubMed 15661922. Source: MGI

response to muramyl dipeptide

Inferred from direct assay PubMed 12527755. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 11567019PubMed 12527755PubMed 14961764PubMed 16249387PubMed 16643855PubMed 19404405PubMed 22227519. Source: MGI

cytosol

Inferred from direct assay PubMed 11931770. Source: MGI

nucleus

Inferred from direct assay PubMed 10227969PubMed 11567019PubMed 11931770PubMed 12527755PubMed 14961764PubMed 15220916PubMed 15661922PubMed 15817708PubMed 16249387PubMed 16643855PubMed 19404405PubMed 21874024. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 10227969PubMed 14961764PubMed 15684432PubMed 15845452PubMed 15944286PubMed 16207754PubMed 16260493PubMed 18505784. Source: MGI

chromatin binding

Inferred from direct assay PubMed 19619491. Source: MGI

protein binding

Inferred from physical interaction PubMed 11567019PubMed 15661756. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 14568984. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BTL4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: BAF6174A2F939DEC

FASTA54960,226
        10         20         30         40         50         60 
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER STDTTKTHPT 

        70         80         90        100        110        120 
IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGYY EADLCPDRSI HSFQNLGIQC 

       130        140        150        160        170        180 
VKKRDLEQAI SQRIQTNNNP FHVPIEEQRG DYDLNAVRLC FQVTVRDPAG RPLLLTPVLS 

       190        200        210        220        230        240 
HPIFDNRAPN TAELKICRVN RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS 

       250        260        270        280        290        300 
QADVHRQVAI VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE 

       310        320        330        340        350        360 
KRKRTYETFK SIMKKSPFNG PTEPRPPTRR IAVPTRNSTS VPKPAPQPYT FPASLSTINF 

       370        380        390        400        410        420 
DEFSPMLLPS GQISNQALAL APSSAPVLAQ TMVPSSAMVP LAQPPAPAPV LTPGPPQSLS 

       430        440        450        460        470        480 
APVPKSTQAG EGTLSEALLH LQFDADEDLG ALLGKSTDPG VFTDLASVDN SEFQQLLNQG 

       490        500        510        520        530        540 
VSMSHSTAEP MLMEYPEAIT RLVTGSQRPP DPAPTPLGTS GLPNGLSGDE DFSSIADMDF 


SALLSQISS 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC40904.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK089489 mRNA. Translation: BAC40904.1.
UniGeneMm.249966.

3D structure databases

ProteinModelPortalQ8BTL4.
SMRQ8BTL4. Positions 20-325.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:103290. Rela.

Phylogenomic databases

HOVERGENHBG017916.
InParanoidQ8BTL4.

Gene expression databases

GenevestigatorQ8BTL4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NF_Rel_Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR011539. RHD.
[Graphical view]
PfamPF00554. RHD. 1 hit.
[Graphical view]
PRINTSPR00057. NFKBTNSCPFCT.
SMARTSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRELA. mouse.
SOURCESearch...

Entry information

Entry nameQ8BTL4_MOUSE
AccessionPrimary (citable) accession number: Q8BTL4
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)