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Protein
Submitted name:

Putative uncharacterized protein

Gene

Rela

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. activating transcription factor binding Source: MGI
  2. chromatin binding Source: MGI
  3. DNA binding Source: MGI
  4. identical protein binding Source: MGI
  5. NF-kappaB binding Source: MGI
  6. phosphate ion binding Source: MGI
  7. protein heterodimerization activity Source: MGI
  8. protein kinase binding Source: MGI
  9. protein N-terminus binding Source: MGI
  10. repressing transcription factor binding Source: MGI
  11. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  12. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  13. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  14. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  15. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: MGI
  16. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  17. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  18. sequence-specific DNA binding Source: MGI
  19. sequence-specific DNA binding transcription factor activity Source: MGI
  20. transcription factor binding Source: MGI
  21. transcription regulatory region DNA binding Source: MGI
  22. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. cellular response to hydrogen peroxide Source: MGI
  2. cellular response to interleukin-1 Source: MGI
  3. cellular response to interleukin-6 Source: MGI
  4. cellular response to nicotine Source: MGI
  5. cellular response to peptide hormone stimulus Source: MGI
  6. cellular response to tumor necrosis factor Source: MGI
  7. cytokine-mediated signaling pathway Source: MGI
  8. defense response Source: MGI
  9. hair follicle development Source: MGI
  10. inflammatory response Source: MGI
  11. innate immune response Source: GO_Central
  12. negative regulation of apoptotic process Source: MGI
  13. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  14. negative regulation of protein catabolic process Source: MGI
  15. negative regulation of transcription, DNA-templated Source: MGI
  16. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  17. NIK/NF-kappaB signaling Source: GO_Central
  18. nucleotide-binding oligomerization domain containing 2 signaling pathway Source: MGI
  19. organ morphogenesis Source: MGI
  20. positive regulation of cell proliferation Source: MGI
  21. positive regulation of interleukin-12 biosynthetic process Source: MGI
  22. positive regulation of miRNA metabolic process Source: MGI
  23. positive regulation of NF-kappaB transcription factor activity Source: MGI
  24. positive regulation of transcription, DNA-templated Source: MGI
  25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  26. response to bacterium Source: MGI
  27. response to cytokine Source: GO_Central
  28. response to interleukin-1 Source: MGI
  29. response to muramyl dipeptide Source: MGI
  30. response to muscle stretch Source: MGI
  31. response to organic substance Source: MGI
  32. response to UV-B Source: MGI
  33. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:RelaImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:103290. Rela.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. I-kappaB/NF-kappaB complex Source: GO_Central
  4. nucleoplasm Source: GO_Central
  5. nucleus Source: MGI
  6. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ8BTL4.

Structurei

3D structure databases

ProteinModelPortaliQ8BTL4.
SMRiQ8BTL4. Positions 20-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG017916.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030495. RelA.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF1. PTHR24169:SF1. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLFPLIFP SEPAQASGPY VEIIEQPKQR GMRFRYKCEG RSAGSIPGER
60 70 80 90 100
STDTTKTHPT IKINGYTGPG TVRISLVTKD PPHRPHPHEL VGKDCRDGYY
110 120 130 140 150
EADLCPDRSI HSFQNLGIQC VKKRDLEQAI SQRIQTNNNP FHVPIEEQRG
160 170 180 190 200
DYDLNAVRLC FQVTVRDPAG RPLLLTPVLS HPIFDNRAPN TAELKICRVN
210 220 230 240 250
RNSGSCLGGD EIFLLCDKVQ KEDIEVYFTG PGWEARGSFS QADVHRQVAI
260 270 280 290 300
VFRTPPYADP SLQAPVRVSM QLRRPSDREL SEPMEFQYLP DTDDRHRIEE
310 320 330 340 350
KRKRTYETFK SIMKKSPFNG PTEPRPPTRR IAVPTRNSTS VPKPAPQPYT
360 370 380 390 400
FPASLSTINF DEFSPMLLPS GQISNQALAL APSSAPVLAQ TMVPSSAMVP
410 420 430 440 450
LAQPPAPAPV LTPGPPQSLS APVPKSTQAG EGTLSEALLH LQFDADEDLG
460 470 480 490 500
ALLGKSTDPG VFTDLASVDN SEFQQLLNQG VSMSHSTAEP MLMEYPEAIT
510 520 530 540
RLVTGSQRPP DPAPTPLGTS GLPNGLSGDE DFSSIADMDF SALLSQISS
Length:549
Mass (Da):60,226
Last modified:March 1, 2003 - v1
Checksum:iBAF6174A2F939DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089489 mRNA. Translation: BAC40904.1.
UniGeneiMm.249966.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089489 mRNA. Translation: BAC40904.1.
UniGeneiMm.249966.

3D structure databases

ProteinModelPortaliQ8BTL4.
SMRiQ8BTL4. Positions 20-325.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103290. Rela.

Phylogenomic databases

HOVERGENiHBG017916.

Miscellaneous databases

ChiTaRSiRela. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8BTL4.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000451. NFkB/Dor.
IPR008967. p53-like_TF_DNA-bd.
IPR030495. RelA.
IPR011539. RHD.
IPR030492. RHD_CS.
[Graphical view]
PANTHERiPTHR24169. PTHR24169. 1 hit.
PTHR24169:SF1. PTHR24169:SF1. 1 hit.
PfamiPF00554. RHD. 1 hit.
[Graphical view]
PRINTSiPR00057. NFKBTNSCPFCT.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS01204. REL_1. 1 hit.
PS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8BTL4_MOUSE
AccessioniPrimary (citable) accession number: Q8BTL4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.