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Protein

Serine/arginine repetitive matrix protein 2

Gene

Srrm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 2
Gene namesi
Name:Srrm2
Synonyms:Kiaa0324
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1923206. Srrm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002481551 – 2703Serine/arginine repetitive matrix protein 2Add BLAST2703

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei101N6-acetyllysineCombined sources1
Modified residuei145PhosphotyrosineBy similarity1
Modified residuei169N6-acetyllysineBy similarity1
Modified residuei220PhosphoserineBy similarity1
Modified residuei222PhosphoserineBy similarity1
Modified residuei295PhosphoserineCombined sources1
Modified residuei300PhosphoserineBy similarity1
Modified residuei310PhosphoserineCombined sources1
Modified residuei322PhosphoserineBy similarity1
Modified residuei323PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei355PhosphoserineBy similarity1
Modified residuei356PhosphoserineBy similarity1
Modified residuei357PhosphothreonineBy similarity1
Modified residuei365PhosphothreonineBy similarity1
Modified residuei375PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei402PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei452PhosphoserineBy similarity1
Modified residuei482PhosphoserineBy similarity1
Modified residuei484PhosphoserineBy similarity1
Modified residuei503PhosphoserineBy similarity1
Modified residuei505PhosphoserineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei531PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei540PhosphoserineBy similarity1
Modified residuei700PhosphoserineBy similarity1
Modified residuei702PhosphoserineBy similarity1
Modified residuei704PhosphoserineBy similarity1
Modified residuei773PhosphoserineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei821PhosphoserineBy similarity1
Modified residuei829PhosphoserineCombined sources1
Modified residuei831PhosphothreonineCombined sources1
Modified residuei841PhosphothreonineCombined sources1
Modified residuei846PhosphoserineBy similarity1
Modified residuei850PhosphoserineBy similarity1
Modified residuei851PhosphoserineBy similarity1
Modified residuei882PhosphoserineCombined sources1
Modified residuei909PhosphoserineBy similarity1
Modified residuei924PhosphoserineBy similarity1
Modified residuei926PhosphoserineBy similarity1
Modified residuei928PhosphoserineBy similarity1
Modified residuei940PhosphoserineBy similarity1
Modified residuei942PhosphoserineBy similarity1
Modified residuei944PhosphoserineBy similarity1
Modified residuei945PhosphoserineBy similarity1
Modified residuei946PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei955PhosphothreonineCombined sources1
Modified residuei962PhosphoserineBy similarity1
Modified residuei964PhosphoserineBy similarity1
Modified residuei966PhosphotyrosineBy similarity1
Modified residuei973PhosphothreonineCombined sources1
Modified residuei980PhosphoserineBy similarity1
Modified residuei984PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
Modified residuei995PhosphothreonineCombined sources1
Modified residuei997PhosphoserineBy similarity1
Modified residuei1000PhosphoserineBy similarity1
Modified residuei1011PhosphoserineCombined sources1
Modified residuei1037PhosphoserineBy similarity1
Modified residuei1038PhosphoserineCombined sources1
Modified residuei1044PhosphothreonineCombined sources1
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1064PhosphoserineBy similarity1
Modified residuei1066PhosphoserineBy similarity1
Modified residuei1067PhosphoserineCombined sources1
Modified residuei1068PhosphoserineCombined sources1
Modified residuei1071PhosphothreonineCombined sources1
Modified residuei1077PhosphoserineCombined sources1
Modified residuei1087PhosphoserineBy similarity1
Modified residuei1094PhosphoserineBy similarity1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1117PhosphoserineBy similarity1
Modified residuei1151PhosphoserineCombined sources1
Modified residuei1159PhosphoserineBy similarity1
Modified residuei1175PhosphoserineBy similarity1
Modified residuei1188PhosphoserineBy similarity1
Modified residuei1216PhosphoserineCombined sources1
Modified residuei1225PhosphoserineCombined sources1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1230PhosphoserineCombined sources1
Modified residuei1269PhosphoserineCombined sources1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1278PhosphoserineBy similarity1
Modified residuei1284PhosphoserineBy similarity1
Modified residuei1287PhosphoserineBy similarity1
Modified residuei1294PhosphoserineBy similarity1
Modified residuei1305PhosphoserineCombined sources1
Modified residuei1325PhosphoserineBy similarity1
Modified residuei1338PhosphoserineCombined sources1
Modified residuei1339PhosphoserineCombined sources1
Modified residuei1340PhosphoserineCombined sources1
Modified residuei1343PhosphoserineCombined sources1
Modified residuei1359PhosphoserineBy similarity1
Modified residuei1360PhosphoserineCombined sources1
Modified residuei1370PhosphothreonineBy similarity1
Modified residuei1372PhosphoserineBy similarity1
Modified residuei1378PhosphoserineBy similarity1
Modified residuei1380PhosphoserineCombined sources1
Modified residuei1390PhosphothreonineBy similarity1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1407PhosphoserineBy similarity1
Modified residuei1409PhosphothreonineBy similarity1
Modified residuei1414PhosphoserineBy similarity1
Modified residuei1416PhosphoserineBy similarity1
Modified residuei1418PhosphoserineBy similarity1
Modified residuei1419PhosphoserineBy similarity1
Modified residuei1428PhosphothreonineCombined sources1
Modified residuei1438PhosphoserineBy similarity1
Modified residuei1439PhosphoserineBy similarity1
Modified residuei1448PhosphothreonineBy similarity1
Modified residuei1453PhosphoserineBy similarity1
Modified residuei1455PhosphoserineBy similarity1
Modified residuei1457PhosphoserineBy similarity1
Modified residuei1458PhosphoserineBy similarity1
Modified residuei1465PhosphoserineCombined sources1
Modified residuei1467PhosphothreonineCombined sources1
Modified residuei1473PhosphoserineBy similarity1
Modified residuei1475PhosphoserineBy similarity1
Modified residuei1477PhosphoserineBy similarity1
Modified residuei1478PhosphoserineBy similarity1
Modified residuei1487PhosphothreonineBy similarity1
Modified residuei1493PhosphoserineBy similarity1
Modified residuei1495PhosphoserineBy similarity1
Modified residuei1497PhosphoserineBy similarity1
Modified residuei1498PhosphoserineBy similarity1
Modified residuei1508PhosphoserineCombined sources1
Modified residuei1533PhosphoserineBy similarity1
Modified residuei1535PhosphoserineBy similarity1
Modified residuei1537PhosphoserineBy similarity1
Modified residuei1538PhosphoserineBy similarity1
Modified residuei1554PhosphoserineBy similarity1
Modified residuei1556PhosphoserineBy similarity1
Modified residuei1557PhosphoserineBy similarity1
Modified residuei1572PhosphoserineCombined sources1
Modified residuei1576PhosphoserineCombined sources1
Modified residuei1577PhosphoserineCombined sources1
Modified residuei1604PhosphoserineBy similarity1
Modified residuei1614PhosphoserineBy similarity1
Modified residuei1647PhosphoserineBy similarity1
Modified residuei1649PhosphoserineBy similarity1
Modified residuei1650PhosphoserineBy similarity1
Modified residuei1654PhosphothreonineBy similarity1
Modified residuei1683PhosphoserineBy similarity1
Modified residuei1685PhosphoserineBy similarity1
Modified residuei1687PhosphoserineBy similarity1
Modified residuei1688PhosphoserineBy similarity1
Modified residuei1718PhosphoserineBy similarity1
Modified residuei1720PhosphoserineBy similarity1
Modified residuei1774PhosphoserineBy similarity1
Modified residuei1778PhosphoserineBy similarity1
Modified residuei1810PhosphoserineBy similarity1
Modified residuei1813PhosphoserineCombined sources1
Modified residuei1832PhosphoserineBy similarity1
Modified residuei1834PhosphoserineBy similarity1
Modified residuei1836PhosphothreonineBy similarity1
Modified residuei1840PhosphoserineBy similarity1
Modified residuei1846PhosphoserineBy similarity1
Modified residuei1848PhosphothreonineBy similarity1
Modified residuei1849PhosphoserineBy similarity1
Modified residuei1869PhosphoserineBy similarity1
Modified residuei1872PhosphoserineBy similarity1
Modified residuei1876PhosphoserineBy similarity1
Modified residuei1878PhosphoserineBy similarity1
Modified residuei1880PhosphothreonineBy similarity1
Modified residuei1884PhosphothreonineBy similarity1
Modified residuei1898PhosphoserineBy similarity1
Modified residuei1900PhosphoserineBy similarity1
Modified residuei1902PhosphothreonineBy similarity1
Modified residuei1906PhosphothreonineBy similarity1
Modified residuei1910PhosphoserineBy similarity1
Modified residuei1912PhosphoserineBy similarity1
Modified residuei1914PhosphothreonineBy similarity1
Modified residuei1918PhosphothreonineBy similarity1
Modified residuei1922PhosphoserineBy similarity1
Modified residuei1924PhosphoserineBy similarity1
Modified residuei1927PhosphoserineBy similarity1
Modified residuei1930PhosphothreonineBy similarity1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei1939PhosphoserineBy similarity1
Modified residuei1948PhosphoserineBy similarity1
Modified residuei1951PhosphoserineBy similarity1
Modified residuei1960PhosphoserineBy similarity1
Modified residuei1963PhosphoserineBy similarity1
Modified residuei1970PhosphoserineBy similarity1
Modified residuei1972PhosphoserineBy similarity1
Modified residuei1974PhosphothreonineBy similarity1
Modified residuei1982PhosphoserineCombined sources1
Modified residuei1984PhosphoserineCombined sources1
Modified residuei1986PhosphothreonineCombined sources1
Modified residuei1994PhosphoserineBy similarity1
Modified residuei1996PhosphoserineBy similarity1
Modified residuei1998PhosphoserineBy similarity1
Modified residuei2019PhosphoserineBy similarity1
Modified residuei2021PhosphothreonineBy similarity1
Modified residuei2023PhosphoserineBy similarity1
Modified residuei2042PhosphoserineBy similarity1
Modified residuei2044PhosphothreonineBy similarity1
Modified residuei2052PhosphoserineCombined sources1
Modified residuei2054PhosphoserineCombined sources1
Modified residuei2056PhosphothreonineCombined sources1
Modified residuei2070PhosphoserineCombined sources1
Modified residuei2073PhosphoserineCombined sources1
Modified residuei2075PhosphoserineCombined sources1
Modified residuei2084PhosphoserineCombined sources1
Modified residuei2096PhosphothreonineBy similarity1
Modified residuei2146Omega-N-methylarginineCombined sources1
Modified residuei2159Omega-N-methylarginineCombined sources1
Modified residuei2183Omega-N-methylarginineBy similarity1
Modified residuei2198Omega-N-methylarginineBy similarity1
Modified residuei2224PhosphoserineCombined sources1
Modified residuei2226Omega-N-methylarginineBy similarity1
Modified residuei2240Omega-N-methylarginineBy similarity1
Modified residuei2241PhosphothreonineBy similarity1
Modified residuei2254PhosphothreonineBy similarity1
Modified residuei2262PhosphoserineBy similarity1
Modified residuei2268PhosphothreonineBy similarity1
Modified residuei2281PhosphothreonineBy similarity1
Modified residuei2295Omega-N-methylarginineCombined sources1
Modified residuei2296PhosphoserineBy similarity1
Modified residuei2321PhosphoserineBy similarity1
Modified residuei2329PhosphoserineBy similarity1
Modified residuei2334PhosphothreonineBy similarity1
Modified residuei2335PhosphoserineCombined sources1
Modified residuei2337Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei2337Omega-N-methylarginine; alternateBy similarity1
Modified residuei2347PhosphoserineBy similarity1
Modified residuei2351PhosphoserineCombined sources1
Modified residuei2360PhosphoserineBy similarity1
Modified residuei2362PhosphothreonineBy similarity1
Modified residuei2365PhosphoserineBy similarity1
Modified residuei2368PhosphoserineBy similarity1
Modified residuei2381PhosphoserineCombined sources1
Modified residuei2384PhosphoserineBy similarity1
Modified residuei2404PhosphoserineCombined sources1
Modified residuei2408PhosphoserineBy similarity1
Modified residuei2535PhosphoserineCombined sources1
Modified residuei2537PhosphothreonineBy similarity1
Modified residuei2553PhosphothreonineBy similarity1
Modified residuei2618PhosphoserineBy similarity1
Modified residuei2629PhosphoserineBy similarity1
Modified residuei2631PhosphoserineBy similarity1
Modified residuei2638PhosphoserineBy similarity1
Modified residuei2642PhosphoserineBy similarity1
Modified residuei2644PhosphoserineBy similarity1
Modified residuei2646PhosphoserineCombined sources1
Modified residuei2648PhosphoserineCombined sources1
Modified residuei2656PhosphoserineCombined sources1
Modified residuei2660PhosphoserineCombined sources1
Modified residuei2689PhosphothreonineBy similarity1
Modified residuei2691PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8BTI8.
PaxDbiQ8BTI8.
PeptideAtlasiQ8BTI8.
PRIDEiQ8BTI8.

2D gel databases

REPRODUCTION-2DPAGEIPI00225062.
IPI00785240.

PTM databases

iPTMnetiQ8BTI8.
PhosphoSitePlusiQ8BTI8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039218.
CleanExiMM_SRRM2.
ExpressionAtlasiQ8BTI8. baseline and differential.
GenevisibleiQ8BTI8. MM.

Interactioni

Subunit structurei

Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex (By similarity).By similarity

Protein-protein interaction databases

BioGridi217871. 4 interactors.
IntActiQ8BTI8. 2 interactors.
MINTiMINT-4112373.
STRINGi10090.ENSMUSP00000085993.

Structurei

3D structure databases

ProteinModelPortaliQ8BTI8.
SMRiQ8BTI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 259Sufficient for RNA-bindingBy similarityAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 92Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 246Lys-richAdd BLAST61
Compositional biasi200 – 2702Ser-richAdd BLAST2503
Compositional biasi348 – 445Pro-richAdd BLAST98
Compositional biasi478 – 772Arg-richAdd BLAST295
Compositional biasi1622 – 2041Arg-richAdd BLAST420
Compositional biasi2134 – 2260Ala-richAdd BLAST127

Sequence similaritiesi

Belongs to the CWC21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1869. Eukaryota.
ENOG4111F3M. LUCA.
GeneTreeiENSGT00730000110977.
HOGENOMiHOG000154424.
HOVERGENiHBG093999.
InParanoidiQ8BTI8.
KOiK13172.
OMAiPEMKKSH.
OrthoDBiEOG091G0NRZ.
TreeFamiTF335721.

Family and domain databases

InterProiIPR013170. mRNA_splic_Cwf21_dom.
IPR024945. Spt5_C_dom.
[Graphical view]
PfamiPF08312. cwf21. 1 hit.
[Graphical view]
SMARTiSM01104. CTD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BTI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRHLEAALV
60 70 80 90 100
KRPNPDILDH ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE
110 120 130 140 150
KDVNPGAKEE TPGQRPVVTE THQLAELNEK KNERLRAAFG ISDSYVDGSS
160 170 180 190 200
FDPQRRAREA KQIAPEPPKP YSLVRETSSS RSPTPKQKKK KKKKDRGRRS
210 220 230 240 250
ESSSPRRERK KSSKKKKHRS ESESKKRKHR SPTPKSKRKS KDKKRKRSRS
260 270 280 290 300
TTPAPKSRRA HRSTSADSAS SSDTSRSRSR SAAAKIHTTA LTGQSPPLAS
310 320 330 340 350
GHQGEGDAPS VEPGATNIQQ PSSPAPSTKQ SSSPYEDKDK KEKSAVRPSP
360 370 380 390 400
SPERSSTGPE LPAPTPLLVE QHVDSPRPLA AIPSSQEPVN PSSEASPTRG
410 420 430 440 450
CSPPKSPEKP PQSTSSESCP PSPQPTKGSR HASSSPESLK PTPAPGSRRE
460 470 480 490 500
ISSSPTSKNR SHGRAKRDKS HSHTPSHRAG RSRSPATKRG RSRSRTPTKR
510 520 530 540 550
GHSRSRSPQW RRSRSAQRWG KSRSPQRRGR SRSPQRPGWS RSRNTQRRGR
560 570 580 590 600
SRSARRGRSH SRSPATRGRS RSRTPARRGR SRSRTPARRR SRSRTPARRR
610 620 630 640 650
SRSRTPARRG RSRSRTPARR RSRTRSPVRR RSRSRSQARR SGRSRSRTPA
660 670 680 690 700
RRSGRSRSRT PARRGRSRSR TPARRSARSR SRTPARRGRS RSRTPARRRS
710 720 730 740 750
RSRSLVRRGR SHSRTPQRRG RSGSSSERKN KSRTSQRRSR SNSSPEMKKS
760 770 780 790 800
HVSSRRSRSL SSPRSKAKSL RRSLSGSSPC PKQKSQTPTR RSRSGSSPPK
810 820 830 840 850
QKSKTPPRQS RSNSPQPKVK SGTPPRPGSV TNMQADECTA TPQRQSHSES
860 870 880 890 900
SPDGEVKSRT PSRQSCSGSS PRVKSSTPPR QSPSRSSSPQ PKVKTVISPR
910 920 930 940 950
GRSHSSSSSP SPSRVTSRTP QRKSRSISPC PKVDSRLRHS RSRSSSPDSK
960 970 980 990 1000
MELGTPLRHS GSTSPYLKSM LQTPPDQNLS GSKSPCPQKS RDSPTGSSGS
1010 1020 1030 1040 1050
FHLCPGVTPS SIVPGESCFS ASFVQQKGHT QTWPDTSSPE VMQTQVESPL
1060 1070 1080 1090 1100
LQSKSQTSPK GSLSRSSSPV TELTARSPVK QDKSEISTDP KLKSGMSPEQ
1110 1120 1130 1140 1150
SKTKPDSSIY PLVDSKSFLV QSRLEPSELK ERLGLIQEDV ASSCIPRDKF
1160 1170 1180 1190 1200
SPTQDRPESS TVLKVTPRVL LKERSGAGSP PGKRDQKSLL PNSSQDELME
1210 1220 1230 1240 1250
VEKSEQPLSQ VLPSLSPEHK EMPGSNIESS PEVEERPAVL SALDQSQSQP
1260 1270 1280 1290 1300
SKAAETPAVA SCWSGPQVSP EHKELSHSPP RENSFESSLE FKNSGPVSEV
1310 1320 1330 1340 1350
NTGFSPEVKE ELNGSFLNQT EADPSVDMKE QSRSSRRSSS ELSPEVVEKV
1360 1370 1380 1390 1400
GLFSSQKVSS PVLETVQQRT PSRERSSSAS PELKDGLPRT PSRRSRSGSS
1410 1420 1430 1440 1450
PGLRDGSGTP SRHSLSGSSP GMKDTPQTPS RGRSECDSSP EPKALPQTPR
1460 1470 1480 1490 1500
ARSHSPSSPE RNNKSVTPQR ERSGSESSVE QKNLARTSPG QRSRSGSSQE
1510 1520 1530 1540 1550
LDGKPSASPQ ERSESDSSPD SKPKTRTPLR QRSHSGSSPE VDSKSRHSPR
1560 1570 1580 1590 1600
LSRSGSSPEM KDKPRVLQRA QSGTDSSPEH KIPAPRALPR HSRSGSSSKE
1610 1620 1630 1640 1650
RGPSPEGSSS SESSPEHAPK SRTARRGSRS SIEPKTKSHT PPRRRSSRSS
1660 1670 1680 1690 1700
PELTRKARVS RRSRSASSSP EIRSRTPPRR RRSPSVSSPE PTEKSRSSRR
1710 1720 1730 1740 1750
RRSVSSPRTK TTSRRGRSPS PKPRGLQRSR SRSRREKTRT TRRRDRSGSS
1760 1770 1780 1790 1800
QSTSRRRQRS RSRSRVTRRR RGGSGYHSRS PTRQESSRTS SRRRRGRSRT
1810 1820 1830 1840 1850
PLTSRKRSRS RTSPAPWKRS RSRASPATHR RSRSRTPLIS RRRSRSRTSP
1860 1870 1880 1890 1900
VSRRRSRSVN RRRSRSRASP VSRRRSRSRT PPVTRRRSRS RTPTRRRSRS
1910 1920 1930 1940 1950
RTPPVTRRRS RSRTPPVTRR RSRSRTSPVT RRRSRSRTSP VTRRRSRSRT
1960 1970 1980 1990 2000
SPVTRRRSRS RTSPVTRRRS RSRTPPAIRR RSRSRTPLLP RKRSRSRSPL
2010 2020 2030 2040 2050
AIRRRSRSRT PRAARGKRSL TRSPPAIRRR SASGSSSDRS RSATPPATRN
2060 2070 2080 2090 2100
HSGSRTPPVA LSSSRMSCFS RPSMSPTPLD RCRSPGMLEP LGSARTPMSV
2110 2120 2130 2140 2150
LQQTGGSMMD GPGPRIPDHP RSSVPENHAQ SRIALALTAI SLGTARPPPS
2160 2170 2180 2190 2200
MSAAGLAARM SQVPAPVPLM SLRTAPAANL ASRIPAASAA AMNLASARTS
2210 2220 2230 2240 2250
AIPASVNLAD SRTPAAAAAM NLASPRTAVA PSAVNLADPR TPAASAVNLA
2260 2270 2280 2290 2300
GARTPAALAA LSLTGSGTPP TAANYPSSSR TPQAPTPANL VVGPRSAHGT
2310 2320 2330 2340 2350
APVNIAGSRT PAGLAPTNLS SSRMAPALSG ANLTSPRVPL SAYDRVSGRT
2360 2370 2380 2390 2400
SPLMLDRARS RTPPSAPSQS RMTSERERAP SPASRMVQAS SQSLLPPAQD
2410 2420 2430 2440 2450
RPRSPVPSAF SDQSRSVVQT TPVAGSQSLS SGTVAKSTSS ASDHNGMLSG
2460 2470 2480 2490 2500
PAPGISHAEG GEPPASTGAQ QPSTLAALQP AKERRSSSSS SSSSSSSSSS
2510 2520 2530 2540 2550
SSSSSSSSSS GSSSSDSEGS SLPAQPEVAL KRVPSPTPVP KEAIREGRPQ
2560 2570 2580 2590 2600
EPTPAKRKRR SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS
2610 2620 2630 2640 2650
SSPSPAKPGP QALPKPASPK KPPPGERRSR SPRKPIDSLR DSRSLSYSPV
2660 2670 2680 2690 2700
ERRQPSPQPS PRDLQSSERV SWRGQRGDSH SPGHKRKETP SPRSNRHRSS

RSP
Length:2,703
Mass (Da):294,840
Last modified:July 27, 2011 - v3
Checksum:iF144CB3EB1E8DF5B
GO
Isoform 2 (identifier: Q8BTI8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:2,607
Mass (Da):283,578
Checksum:iFBC77BF091726AA3
GO
Isoform 3 (identifier: Q8BTI8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2486-2585: Missing.

Show »
Length:2,603
Mass (Da):285,154
Checksum:iA1D8F0A13CFD5BE3
GO

Sequence cautioni

The sequence AAH27781 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti373V → D in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti373V → D in BAE42172 (PubMed:16141072).Curated1
Sequence conflicti428G → V in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti428G → V in BAE42172 (PubMed:16141072).Curated1
Sequence conflicti618A → T in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti618A → T in BAE42172 (PubMed:16141072).Curated1
Sequence conflicti927I → V in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti967L → P in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti967L → P in BAC65530 (PubMed:12693553).Curated1
Sequence conflicti1255E → G in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti1639H → R in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti1639H → R in BAC65530 (PubMed:12693553).Curated1
Sequence conflicti1835R → I in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti2418V → A in BAC41104 (PubMed:16141072).Curated1
Sequence conflicti2418V → A in AAH27781 (PubMed:15489334).Curated1
Sequence conflicti2418V → A in BAC65530 (PubMed:12693553).Curated1
Sequence conflicti2628R → G in BAC41104 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0201881 – 96Missing in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_0201892486 – 2585Missing in isoform 3. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090123 mRNA. Translation: BAC41104.1.
AK171001 mRNA. Translation: BAE42172.1.
AC122821 Genomic DNA. No translation available.
BC027781 mRNA. Translation: AAH27781.1. Different initiation.
BC092355 mRNA. Translation: AAH92355.1.
AK122248 mRNA. Translation: BAC65530.1.
CCDSiCCDS37475.1. [Q8BTI8-2]
RefSeqiNP_780438.2. NM_175229.3. [Q8BTI8-2]
XP_006525139.1. XM_006525076.3. [Q8BTI8-1]
XP_006525140.1. XM_006525077.3. [Q8BTI8-1]
UniGeneiMm.436876.
Mm.5222.

Genome annotation databases

EnsembliENSMUST00000088621; ENSMUSP00000085993; ENSMUSG00000039218. [Q8BTI8-2]
ENSMUST00000190686; ENSMUSP00000139842; ENSMUSG00000039218. [Q8BTI8-1]
GeneIDi75956.
KEGGimmu:75956.
UCSCiuc008atn.1. mouse. [Q8BTI8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090123 mRNA. Translation: BAC41104.1.
AK171001 mRNA. Translation: BAE42172.1.
AC122821 Genomic DNA. No translation available.
BC027781 mRNA. Translation: AAH27781.1. Different initiation.
BC092355 mRNA. Translation: AAH92355.1.
AK122248 mRNA. Translation: BAC65530.1.
CCDSiCCDS37475.1. [Q8BTI8-2]
RefSeqiNP_780438.2. NM_175229.3. [Q8BTI8-2]
XP_006525139.1. XM_006525076.3. [Q8BTI8-1]
XP_006525140.1. XM_006525077.3. [Q8BTI8-1]
UniGeneiMm.436876.
Mm.5222.

3D structure databases

ProteinModelPortaliQ8BTI8.
SMRiQ8BTI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217871. 4 interactors.
IntActiQ8BTI8. 2 interactors.
MINTiMINT-4112373.
STRINGi10090.ENSMUSP00000085993.

PTM databases

iPTMnetiQ8BTI8.
PhosphoSitePlusiQ8BTI8.

2D gel databases

REPRODUCTION-2DPAGEIPI00225062.
IPI00785240.

Proteomic databases

EPDiQ8BTI8.
PaxDbiQ8BTI8.
PeptideAtlasiQ8BTI8.
PRIDEiQ8BTI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088621; ENSMUSP00000085993; ENSMUSG00000039218. [Q8BTI8-2]
ENSMUST00000190686; ENSMUSP00000139842; ENSMUSG00000039218. [Q8BTI8-1]
GeneIDi75956.
KEGGimmu:75956.
UCSCiuc008atn.1. mouse. [Q8BTI8-1]

Organism-specific databases

CTDi23524.
MGIiMGI:1923206. Srrm2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1869. Eukaryota.
ENOG4111F3M. LUCA.
GeneTreeiENSGT00730000110977.
HOGENOMiHOG000154424.
HOVERGENiHBG093999.
InParanoidiQ8BTI8.
KOiK13172.
OMAiPEMKKSH.
OrthoDBiEOG091G0NRZ.
TreeFamiTF335721.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiSrrm2. mouse.
PROiQ8BTI8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039218.
CleanExiMM_SRRM2.
ExpressionAtlasiQ8BTI8. baseline and differential.
GenevisibleiQ8BTI8. MM.

Family and domain databases

InterProiIPR013170. mRNA_splic_Cwf21_dom.
IPR024945. Spt5_C_dom.
[Graphical view]
PfamiPF08312. cwf21. 1 hit.
[Graphical view]
SMARTiSM01104. CTD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRRM2_MOUSE
AccessioniPrimary (citable) accession number: Q8BTI8
Secondary accession number(s): E9QNB0
, Q3TBY5, Q569P9, Q80U37, Q8K383
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.