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Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

Gene

Ankrd52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
Short name:
PP6-ARS-C
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C
Gene namesi
Name:Ankrd52
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2444029. Ankrd52.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445881 – 1076Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit CAdd BLAST1076

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1028PhosphoserineBy similarity1
Modified residuei1075PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BTI7.
MaxQBiQ8BTI7.
PaxDbiQ8BTI7.
PeptideAtlasiQ8BTI7.
PRIDEiQ8BTI7.

PTM databases

iPTMnetiQ8BTI7.
PhosphoSitePlusiQ8BTI7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000014498.
CleanExiMM_ANKRD52.
ExpressionAtlasiQ8BTI7. baseline and differential.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ8BTI7. 1 interactor.
STRINGi10090.ENSMUSP00000014642.

Structurei

3D structure databases

ProteinModelPortaliQ8BTI7.
SMRiQ8BTI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati422 – 451ANK 13Add BLAST30
Repeati455 – 484ANK 14Add BLAST30
Repeati488 – 545ANK 15Add BLAST58
Repeati549 – 579ANK 16Add BLAST31
Repeati584 – 613ANK 17Add BLAST30
Repeati617 – 646ANK 18Add BLAST30
Repeati651 – 680ANK 19Add BLAST30
Repeati687 – 716ANK 20Add BLAST30
Repeati720 – 749ANK 21Add BLAST30
Repeati753 – 782ANK 22Add BLAST30
Repeati790 – 819ANK 23Add BLAST30
Repeati822 – 852ANK 24Add BLAST31
Repeati857 – 886ANK 25Add BLAST30
Repeati890 – 920ANK 26Add BLAST31
Repeati924 – 953ANK 27Add BLAST30
Repeati960 – 989ANK 28Add BLAST30

Sequence similaritiesi

Contains 28 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8BTI7.
KOiK15504.
OMAiKNCGIAA.
OrthoDBiEOG091G02S4.
PhylomeDBiQ8BTI7.
TreeFamiTF312824.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 9 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY
60 70 80 90 100
VGDVPILQLL LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV
110 120 130 140 150
NARDKLWQTP LHVAAANRAT KCAEALAPLL SSLNVADRSG RSALHHAVHS
160 170 180 190 200
GHLETVNLLL NKGASLNVCD KKERQPLHWA AFLGHLEVLK LLVARGADLS
210 220 230 240 250
CKDRKGYGLL HTAAASGQIE VVKHLLRMGA EIDEPNAFGN TALHIACYLG
260 270 280 290 300
QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
310 320 330 340 350
YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG
360 370 380 390 400
HELLISTLMT NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI
410 420 430 440 450
VSSLSNEHVL SAGFDINTPD SLGRTCLHAA ASGGNVECLN LLLSSGADLR
460 470 480 490 500
RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA GVNEADCKGC SPLHYAAASD
510 520 530 540 550
TYRRAEPHTA SSHDAEEDEL LKESRRKEAF FCLEFLLDNG ADPSLRDRQG
560 570 580 590 600
YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTVPVSPLH LAAYNGHCEA
610 620 630 640 650
LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK
660 670 680 690 700
RKWTPLHAAA ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH
710 720 730 740 750
VDCVHLLLEK GSTADAADLR GRTALHRGAV TGCEDCLAAL LDHDAFVLCR
760 770 780 790 800
DFKGRTPIHL ASACGHTAVL RTLLQAALST DPLDAGVDYS GYSPMHWASY
810 820 830 840 850
TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE MLLGALGAKI
860 870 880 890 900
VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
910 920 930 940 950
SGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD
960 970 980 990 1000
LGLINATNSA LQMPLHIAAR NGLASVVQAL LSRGATVLAV DEEGHTPALA
1010 1020 1030 1040 1050
CAPNKDVADC LALILSTMKP FPPKDAVSPF SFSLLKNCGI AAAKTVGGCG
1060 1070
ALPHGASCPY SQERHGAIGL DGCYSE
Length:1,076
Mass (Da):115,032
Last modified:March 1, 2003 - v1
Checksum:i058FE2C95E1A5682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090124 mRNA. Translation: BAC41105.1.
BC117907 mRNA. Translation: AAI17908.1.
BC117908 mRNA. Translation: AAI17909.1.
CCDSiCCDS24274.1.
RefSeqiNP_766378.1. NM_172790.2.
UniGeneiMm.440177.

Genome annotation databases

EnsembliENSMUST00000014642; ENSMUSP00000014642; ENSMUSG00000014498.
GeneIDi237615.
KEGGimmu:237615.
UCSCiuc007hmm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090124 mRNA. Translation: BAC41105.1.
BC117907 mRNA. Translation: AAI17908.1.
BC117908 mRNA. Translation: AAI17909.1.
CCDSiCCDS24274.1.
RefSeqiNP_766378.1. NM_172790.2.
UniGeneiMm.440177.

3D structure databases

ProteinModelPortaliQ8BTI7.
SMRiQ8BTI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BTI7. 1 interactor.
STRINGi10090.ENSMUSP00000014642.

PTM databases

iPTMnetiQ8BTI7.
PhosphoSitePlusiQ8BTI7.

Proteomic databases

EPDiQ8BTI7.
MaxQBiQ8BTI7.
PaxDbiQ8BTI7.
PeptideAtlasiQ8BTI7.
PRIDEiQ8BTI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014642; ENSMUSP00000014642; ENSMUSG00000014498.
GeneIDi237615.
KEGGimmu:237615.
UCSCiuc007hmm.1. mouse.

Organism-specific databases

CTDi283373.
MGIiMGI:2444029. Ankrd52.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8BTI7.
KOiK15504.
OMAiKNCGIAA.
OrthoDBiEOG091G02S4.
PhylomeDBiQ8BTI7.
TreeFamiTF312824.

Miscellaneous databases

PROiQ8BTI7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014498.
CleanExiMM_ANKRD52.
ExpressionAtlasiQ8BTI7. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 2 hits.
PF12796. Ank_2. 9 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR52_MOUSE
AccessioniPrimary (citable) accession number: Q8BTI7
Secondary accession number(s): Q148Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.