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Protein

Casein kinase I isoform gamma-1

Gene

Csnk1g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi50 – 58ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-1 (EC:2.7.11.1)
Short name:
CKI-gamma 1
Gene namesi
Name:Csnk1g1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2660884. Csnk1g1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001928401 – 459Casein kinase I isoform gamma-1Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BTH8.
MaxQBiQ8BTH8.
PaxDbiQ8BTH8.
PeptideAtlasiQ8BTH8.
PRIDEiQ8BTH8.

PTM databases

iPTMnetiQ8BTH8.
PhosphoSitePlusiQ8BTH8.
SwissPalmiQ8BTH8.

Expressioni

Tissue specificityi

Expressed in both the striatum and the neocortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000032384.
CleanExiMM_CSNK1G1.
ExpressionAtlasiQ8BTH8. baseline and differential.
GenevisibleiQ8BTH8. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034949.

Structurei

3D structure databases

ProteinModelPortaliQ8BTH8.
SMRiQ8BTH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 315Protein kinasePROSITE-ProRule annotationAdd BLAST272

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1165. Eukaryota.
ENOG410XNXP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiQ8BTH8.
KOiK08958.
OrthoDBiEOG091G0F3Z.
TreeFamiTF313349.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSNREKDD RQRTTKTMAQ RNTHCSRPSG TSTSSGVLMV GPNFRVGKKI
60 70 80 90 100
GCGNFGELRL GKNLYTNEYV AIKLEPIKSR APQLHLEYRF YKQLGSAGEG
110 120 130 140 150
LPQVYYFGPC GKYNAMVLEL LGPSLEDLFD LCDRTFTLKT VLMIAIQLLS
160 170 180 190 200
RMEYVHSKNL IYRDVKPENF LIGRQGNKKE HVIHIIDFGL AKEYVDPETK
210 220 230 240 250
KHIPYREHKS LTGTARYMSI NTHLGKEQSR RDDLEALGHM FMYFLRGSLP
260 270 280 290 300
WQGLKADTLK ERYQKIGDTK RNTPIEALCE NFPEEMATYL RYVRRLDFFE
310 320 330 340 350
KPDYEYLRTL FTDLFERKGY TFDYAYDWVG RPIPTPVGSV HVDSGASAIT
360 370 380 390 400
RESHTHRDRP SQQQPLRNQT TSSERRGEWE IQPSRQTNTS YLTSHLAADR
410 420 430 440 450
HGGSVQVVSS TNGELNVDDP TGAHSNAPIT AHAEVEVVEE AKCCCFFKRK

RKKTAQRHK
Length:459
Mass (Da):52,744
Last modified:July 27, 2011 - v2
Checksum:i90ECD4C491A37E38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38L → H in BAC41152 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090262 mRNA. Translation: BAC41152.1.
AC112676 Genomic DNA. No translation available.
AC151906 Genomic DNA. No translation available.
CCDSiCCDS23300.1.
RefSeqiNP_775277.2. NM_173185.2.
XP_011241010.1. XM_011242708.1.
UniGeneiMm.325816.

Genome annotation databases

EnsembliENSMUST00000034949; ENSMUSP00000034949; ENSMUSG00000032384.
ENSMUST00000206594; ENSMUSP00000145947; ENSMUSG00000032384.
GeneIDi214897.
KEGGimmu:214897.
UCSCiuc009qeg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090262 mRNA. Translation: BAC41152.1.
AC112676 Genomic DNA. No translation available.
AC151906 Genomic DNA. No translation available.
CCDSiCCDS23300.1.
RefSeqiNP_775277.2. NM_173185.2.
XP_011241010.1. XM_011242708.1.
UniGeneiMm.325816.

3D structure databases

ProteinModelPortaliQ8BTH8.
SMRiQ8BTH8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034949.

PTM databases

iPTMnetiQ8BTH8.
PhosphoSitePlusiQ8BTH8.
SwissPalmiQ8BTH8.

Proteomic databases

EPDiQ8BTH8.
MaxQBiQ8BTH8.
PaxDbiQ8BTH8.
PeptideAtlasiQ8BTH8.
PRIDEiQ8BTH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034949; ENSMUSP00000034949; ENSMUSG00000032384.
ENSMUST00000206594; ENSMUSP00000145947; ENSMUSG00000032384.
GeneIDi214897.
KEGGimmu:214897.
UCSCiuc009qeg.1. mouse.

Organism-specific databases

CTDi53944.
MGIiMGI:2660884. Csnk1g1.

Phylogenomic databases

eggNOGiKOG1165. Eukaryota.
ENOG410XNXP. LUCA.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiQ8BTH8.
KOiK08958.
OrthoDBiEOG091G0F3Z.
TreeFamiTF313349.

Miscellaneous databases

ChiTaRSiCsnk1g1. mouse.
PROiQ8BTH8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032384.
CleanExiMM_CSNK1G1.
ExpressionAtlasiQ8BTH8. baseline and differential.
GenevisibleiQ8BTH8. MM.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKC1G1_MOUSE
AccessioniPrimary (citable) accession number: Q8BTH8
Secondary accession number(s): E9QPK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.