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Q8BTH7

- Q8BTH7_MOUSE

UniProt

Q8BTH7 - Q8BTH7_MOUSE

Protein
Submitted name:

Putative uncharacterized protein

Gene

Isl1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. protein binding Source: MGI
    4. RNA polymerase II transcription coactivator activity Source: MGI
    5. sequence-specific DNA binding Source: InterPro
    6. sequence-specific DNA binding transcription factor activity Source: InterPro
    7. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cardiac cell fate determination Source: MGI
    2. cardiac muscle cell myoblast differentiation Source: MGI
    3. heart development Source: MGI
    4. heart morphogenesis Source: MGI
    5. mesenchymal cell differentiation Source: MGI
    6. negative regulation of canonical Wnt signaling pathway Source: MGI
    7. negative regulation of neuron differentiation Source: MGI
    8. neural crest cell migration Source: MGI
    9. neuron differentiation Source: MGI
    10. neuron fate commitment Source: MGI
    11. pancreas development Source: MGI
    12. peripheral nervous system neuron development Source: MGI
    13. pituitary gland development Source: MGI
    14. positive regulation of cell proliferation Source: MGI
    15. positive regulation of DNA binding Source: MGI
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
    18. regulation of gene expression Source: MGI
    19. regulation of secondary heart field cardioblast proliferation Source: MGI
    20. retinal ganglion cell axon guidance Source: MGI
    21. spinal cord motor neuron cell fate specification Source: MGI
    22. spinal cord motor neuron differentiation Source: MGI
    23. visceral motor neuron differentiation Source: MGI

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative uncharacterized proteinImported
    Gene namesi
    Name:Isl1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:101791. Isl1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. intracellular Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8BTH7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044879.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BTH7.
    SMRiQ8BTH7. Positions 180-244, 254-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.UniRule annotation
    Contains LIM zinc-binding domains.SAAS annotation
    Contains homeobox DNA-binding domain.SAAS annotation

    Keywords - Domaini

    HomeoboxUniRule annotationSAAS annotation, LIM domainUniRule annotationSAAS annotation, RepeatSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG004671.
    InParanoidiQ8BTH7.
    KOiK09370.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BTH7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ    50
    YLDESCTCLV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY 100
    HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL 150
    HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTWY 200
    AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ 250
    PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 300
    SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA 349
    Length:349
    Mass (Da):39,085
    Last modified:March 1, 2003 - v1
    Checksum:iF2001865094EC9B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090263 mRNA. Translation: BAC41153.1.
    RefSeqiNP_067434.3. NM_021459.4.
    UniGeneiMm.42242.

    Genome annotation databases

    GeneIDi16392.
    KEGGimmu:16392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090263 mRNA. Translation: BAC41153.1 .
    RefSeqi NP_067434.3. NM_021459.4.
    UniGenei Mm.42242.

    3D structure databases

    ProteinModelPortali Q8BTH7.
    SMRi Q8BTH7. Positions 180-244, 254-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000044879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16392.
    KEGGi mmu:16392.

    Organism-specific databases

    CTDi 3670.
    MGIi MGI:101791. Isl1.

    Phylogenomic databases

    HOVERGENi HBG004671.
    InParanoidi Q8BTH7.
    KOi K09370.

    Miscellaneous databases

    NextBioi 289537.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8BTH7.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    2.10.110.10. 2 hits.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    SM00132. LIM. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    4. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    6. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Spinal cordImported.

    Entry informationi

    Entry nameiQ8BTH7_MOUSE
    AccessioniPrimary (citable) accession number: Q8BTH7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)