Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8BTH7

- Q8BTH7_MOUSE

UniProt

Q8BTH7 - Q8BTH7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Putative uncharacterized protein

Gene

Isl1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. RNA polymerase II transcription coactivator activity Source: MGI
  4. sequence-specific DNA binding Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cardiac cell fate determination Source: MGI
  2. cardiac muscle cell myoblast differentiation Source: MGI
  3. heart development Source: MGI
  4. heart morphogenesis Source: MGI
  5. mesenchymal cell differentiation Source: MGI
  6. negative regulation of canonical Wnt signaling pathway Source: MGI
  7. negative regulation of neuron differentiation Source: MGI
  8. neural crest cell migration Source: MGI
  9. neuron differentiation Source: MGI
  10. neuron fate commitment Source: MGI
  11. pancreas development Source: MGI
  12. peripheral nervous system neuron development Source: MGI
  13. pituitary gland development Source: MGI
  14. positive regulation of cell proliferation Source: MGI
  15. positive regulation of DNA binding Source: MGI
  16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  17. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  18. regulation of gene expression Source: MGI
  19. regulation of secondary heart field cardioblast proliferation Source: MGI
  20. retinal ganglion cell axon guidance Source: MGI
  21. spinal cord motor neuron cell fate specification Source: MGI
  22. spinal cord motor neuron differentiation Source: MGI
  23. visceral motor neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Isl1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:101791. Isl1.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. intracellular Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8BTH7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044879.

Structurei

3D structure databases

ProteinModelPortaliQ8BTH7.
SMRiQ8BTH7. Positions 180-244, 254-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.UniRule annotation
Contains LIM zinc-binding domains.SAAS annotation
Contains homeobox DNA-binding domain.SAAS annotation

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation, LIM domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOVERGENiHBG004671.
KOiK09370.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ
60 70 80 90 100
YLDESCTCLV RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY
110 120 130 140 150
HIECFRCVAC SRQLIPGDEF ALREDGLFCR ADHDVVERAS LGAGDPLSPL
160 170 180 190 200
HPARPLQMAA EPISARQPAL RPHVHKQPEK TTRVRTVLNE KQLHTLRTWY
210 220 230 240 250
AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS IMMKQLQQQQ
260 270 280 290 300
PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ
310 320 330 340
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA
Length:349
Mass (Da):39,085
Last modified:March 1, 2003 - v1
Checksum:iF2001865094EC9B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090263 mRNA. Translation: BAC41153.1.
RefSeqiNP_067434.3. NM_021459.4.
UniGeneiMm.42242.

Genome annotation databases

GeneIDi16392.
KEGGimmu:16392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090263 mRNA. Translation: BAC41153.1 .
RefSeqi NP_067434.3. NM_021459.4.
UniGenei Mm.42242.

3D structure databases

ProteinModelPortali Q8BTH7.
SMRi Q8BTH7. Positions 180-244, 254-288.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 16392.
KEGGi mmu:16392.

Organism-specific databases

CTDi 3670.
MGIi MGI:101791. Isl1.

Phylogenomic databases

HOVERGENi HBG004671.
KOi K09370.

Miscellaneous databases

NextBioi 289537.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8BTH7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  5. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Spinal cordImported.

Entry informationi

Entry nameiQ8BTH7_MOUSE
AccessioniPrimary (citable) accession number: Q8BTH7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)