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Q8BTH7 (Q8BTH7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Isl1 MGI 101791
OrganismMus musculus (Mouse) EMBL BAC41153.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS001781.

Sequence similarities

Contains 2 LIM zinc-binding domains. RuleBase RU000350

Contains LIM zinc-binding domains.

Contains homeobox DNA-binding domain. SAAS SAAS001781

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU000682 SAAS SAAS001781
   DomainHomeobox SAAS SAAS001781 RuleBase RU000682
LIM domain RuleBase RU000350 SAAS SAAS001781
Repeat SAAS SAAS001781
   LigandDNA-binding RuleBase RU000682 SAAS SAAS001781
Metal-binding
Zinc
Gene Ontology (GO)
   Biological_processcardiac cell fate determination

Inferred from mutant phenotype PubMed 19620969. Source: MGI

cardiac muscle cell myoblast differentiation

Inferred from mutant phenotype PubMed 19620969. Source: MGI

heart morphogenesis

Inferred from genetic interaction PubMed 16687132. Source: MGI

negative regulation of canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 19620969. Source: MGI

negative regulation of neuron differentiation

Inferred from genetic interaction PubMed 14766174. Source: MGI

neural crest cell migration

Inferred from genetic interaction PubMed 16687132. Source: MGI

pancreas development

Inferred from mutant phenotype PubMed 9000074. Source: MGI

peripheral nervous system neuron development

Inferred from genetic interaction PubMed 21734270. Source: MGI

pituitary gland development

Inferred from mutant phenotype PubMed 9806931. Source: MGI

positive regulation of DNA binding

Inferred from direct assay PubMed 15659653. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 15659653. Source: MGI

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 15659653. Source: MGI

regulation of secondary heart field cardioblast proliferation

Inferred from mutant phenotype PubMed 19620969. Source: MGI

retinal ganglion cell axon guidance

Inferred from mutant phenotype PubMed 18434421. Source: MGI

spinal cord motor neuron cell fate specification

Inferred from genetic interaction PubMed 19666821. Source: MGI

visceral motor neuron differentiation

Inferred from genetic interaction PubMed 14766174. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 10536059PubMed 12900460PubMed 14702043PubMed 15659653PubMed 18434421PubMed 19666821PubMed 23610558. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 19620969. Source: MGI

RNA polymerase II transcription coactivator activity

Inferred from direct assay PubMed 15659653. Source: MGI

chromatin binding

Inferred from direct assay PubMed 18434421PubMed 19620969PubMed 21734270. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BTH7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F2001865094EC9B9

FASTA34939,085
        10         20         30         40         50         60 
MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCLV 

        70         80         90        100        110        120 
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 

       130        140        150        160        170        180 
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 

       190        200        210        220        230        240 
TTRVRTVLNE KQLHTLRTWY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 

       250        260        270        280        290        300 
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 

       310        320        330        340 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[5]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[6]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC41153.1.
Tissue: Spinal cord EMBL BAC41153.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090263 mRNA. Translation: BAC41153.1.
RefSeqNP_067434.3. NM_021459.4.
UniGeneMm.42242.

3D structure databases

ProteinModelPortalQ8BTH7.
SMRQ8BTH7. Positions 180-244, 254-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16392.
KEGGmmu:16392.

Organism-specific databases

CTD3670.
MGIMGI:101791. Isl1.

Phylogenomic databases

HOVERGENHBG004671.
InParanoidQ8BTH7.
KOK09370.

Gene expression databases

GenevestigatorQ8BTH7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
2.10.110.10. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001781. Znf_LIM.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
SM00132. LIM. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio289537.
SOURCESearch...

Entry information

Entry nameQ8BTH7_MOUSE
AccessionPrimary (citable) accession number: Q8BTH7
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)