Q8BTH7 (Q8BTH7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC41153.1

Gene names

Name:

Isl1 MGI 101791

Organism

Mus musculus (Mouse) EMBL BAC41153.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000682.
Sequence similarities	Contains 1 homeobox DNA-binding domain. SAAS SAAS001781 Contains 2 LIM zinc-binding domains. SAAS SAAS001781 RuleBase RU000350

Ontologies

Keywords
Cellular component	Nucleus RuleBase RU000682 SAAS SAAS001781
Domain	Homeobox RuleBase RU000682 SAAS SAAS001781 LIM domain RuleBase RU000350 SAAS SAAS001781 Repeat SAAS SAAS001781
Ligand	DNA-binding RuleBase RU000682 SAAS SAAS001781 Metal-binding Zinc
Gene Ontology (GO)
Biological_process	cardiac cell fate determination Inferred from mutant phenotype PubMed 19620969. Source: MGI cardiac muscle cell myoblast differentiation Inferred from mutant phenotype PubMed 19620969. Source: MGI heart morphogenesis Inferred from genetic interaction PubMed 16687132. Source: MGI negative regulation of canonical Wnt receptor signaling pathway Inferred from genetic interaction PubMed 19620969. Source: MGI negative regulation of neuron differentiation Inferred from genetic interaction PubMed 14766174. Source: MGI neural crest cell migration Inferred from genetic interaction PubMed 16687132. Source: MGI pancreas development Inferred from mutant phenotype PubMed 9000074. Source: MGI pituitary gland development Inferred from mutant phenotype PubMed 9806931. Source: MGI positive regulation of DNA binding Inferred from direct assay PubMed 15659653. Source: MGI positive regulation of cell proliferation Inferred from direct assay PubMed 15659653. Source: MGI positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from direct assay PubMed 15659653. Source: MGI regulation of secondary heart field cardioblast proliferation Inferred from mutant phenotype PubMed 19620969. Source: MGI retinal ganglion cell axon guidance Inferred from mutant phenotype PubMed 18434421. Source: MGI spinal cord motor neuron cell fate specification Inferred from genetic interaction PubMed 19666821. Source: MGI visceral motor neuron differentiation Inferred from genetic interaction PubMed 14766174. Source: MGI
Cellular_component	nucleus Inferred from direct assay PubMed 10536059PubMed 12900460PubMed 14702043PubMed 15659653PubMed 18434421PubMed 19666821. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 19620969. Source: MGI RNA polymerase II transcription coactivator activity Inferred from direct assay PubMed 15659653. Source: MGI chromatin binding Inferred from direct assay PubMed 18434421PubMed 19620969. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BTH7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F2001865094EC9B9	FASTA	349	39,085
	10 20 30 40 50 60 MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCLV 70 80 90 100 110 120 RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 130 140 150 160 170 180 ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 190 200 210 220 230 240 TTRVRTVLNE KQLHTLRTWY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 250 260 270 280 290 300 IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 310 320 330 340 SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[5]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[6]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC41153.1. Tissue: Spinal cord EMBL BAC41153.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090263 mRNA. Translation: BAC41153.1.
IPI	IPI00121604.
RefSeq	NP_067434.3. NM_021459.4.
UniGene	Mm.42242.
3D structure databases
ProteinModelPortal	Q8BTH7.
SMR	Q8BTH7. Positions 180-244, 254-288.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000044879.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	16392.
KEGG	mmu:16392.
Organism-specific databases
CTD	3670.
MGI	MGI:101791. Isl1.
Phylogenomic databases
HOVERGEN	HBG004671.
InParanoid	Q8BTH7.
KO	K09370.
Gene expression databases
Genevestigator	Q8BTH7.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 2.10.110.10. 2 hits.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001781. Znf_LIM. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00412. LIM. 2 hits. [Graphical view]
SMART	SM00389. HOX. 1 hit. SM00132. LIM. 2 hits. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00478. LIM_DOMAIN_1. 2 hits. PS50023. LIM_DOMAIN_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	289537.
SOURCE	Search...

Entry information

Entry name

Q8BTH7_MOUSE

Accession

Primary (citable) accession number: Q8BTH7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)