Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional repressor scratch 2

Gene

Scrt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of neuron migration Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 2
Alternative name(s):
Scratch homolog 2 zinc finger protein
Gene namesi
Name:Scrt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139287. Scrt2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Transcriptional repressor scratch 2PRO_0000047039Add
BLAST

Proteomic databases

MaxQBiQ8BTH6.
PaxDbiQ8BTH6.
PRIDEiQ8BTH6.

PTM databases

iPTMnetiQ8BTH6.
PhosphoSiteiQ8BTH6.

Expressioni

Gene expression databases

BgeeiQ8BTH6.
GenevisibleiQ8BTH6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066280.

Structurei

3D structure databases

ProteinModelPortaliQ8BTH6.
SMRiQ8BTH6. Positions 150-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri192 – 21423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri218 – 24023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri246 – 26823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri274 – 29724C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ8BTH6.
KOiK09219.
OMAiPGDNGYV.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ8BTH6.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BTH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKKI KADGFQCSGV SAPTYHPLET AYVLPGTRGP PGDNGYVAHC
60 70 80 90 100
LPPSGYDGEQ KPGLELAPAE PAYPAAASEE YSDPESPQSS LSARYFRGEA
110 120 130 140 150
AVTDSYSMDA FFISDGRSRR RRAGAGGDAA GAGDAGGGGG GGGGGERAGR
160 170 180 190 200
SGATAGGGHR HACAECGKTY ATSSNLSRHK QTHRSLDSQL ARKCPTCGKA
210 220 230 240 250
YVSMPALAMH VLTHNLRHKC GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH
260 270 280 290 300
CGKAFADRSN LRAHMQTHSA FKHYRCRQCD KSFALKSYLH KHCEAACVKA
310
AEPPPSAGPA S
Length:311
Mass (Da):32,722
Last modified:April 13, 2004 - v2
Checksum:i3AF3745DA0B19B2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845161 Genomic DNA. Translation: CAM17706.1.
AK090280 mRNA. Translation: BAC41156.1.
CCDSiCCDS50750.1.
RefSeqiNP_001153882.1. NM_001160410.1.
UniGeneiMm.214317.

Genome annotation databases

EnsembliENSMUST00000064061; ENSMUSP00000066280; ENSMUSG00000060257.
GeneIDi545474.
KEGGimmu:545474.
UCSCiuc012cgb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845161 Genomic DNA. Translation: CAM17706.1.
AK090280 mRNA. Translation: BAC41156.1.
CCDSiCCDS50750.1.
RefSeqiNP_001153882.1. NM_001160410.1.
UniGeneiMm.214317.

3D structure databases

ProteinModelPortaliQ8BTH6.
SMRiQ8BTH6. Positions 150-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066280.

PTM databases

iPTMnetiQ8BTH6.
PhosphoSiteiQ8BTH6.

Proteomic databases

MaxQBiQ8BTH6.
PaxDbiQ8BTH6.
PRIDEiQ8BTH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064061; ENSMUSP00000066280; ENSMUSG00000060257.
GeneIDi545474.
KEGGimmu:545474.
UCSCiuc012cgb.1. mouse.

Organism-specific databases

CTDi85508.
MGIiMGI:2139287. Scrt2.

Phylogenomic databases

eggNOGiKOG2462. Eukaryota.
ENOG41106JS. LUCA.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiQ8BTH6.
KOiK09219.
OMAiPGDNGYV.
OrthoDBiEOG7P2XSG.
PhylomeDBiQ8BTH6.
TreeFamiTF315515.

Miscellaneous databases

PROiQ8BTH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BTH6.
GenevisibleiQ8BTH6. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-311.
    Strain: C57BL/6J.
    Tissue: Spinal cord.

Entry informationi

Entry nameiSCRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BTH6
Secondary accession number(s): A2AQU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: June 8, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.