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Protein

Transcriptional repressor scratch 2

Gene

Scrt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of neuron migration Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor scratch 2
Alternative name(s):
Scratch homolog 2 zinc finger protein
Gene namesi
Name:Scrt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2139287 Scrt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470391 – 311Transcriptional repressor scratch 2Add BLAST311

Proteomic databases

MaxQBiQ8BTH6
PaxDbiQ8BTH6
PRIDEiQ8BTH6

PTM databases

iPTMnetiQ8BTH6
PhosphoSitePlusiQ8BTH6

Expressioni

Gene expression databases

BgeeiENSMUSG00000060257
GenevisibleiQ8BTH6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066280

Structurei

3D structure databases

ProteinModelPortaliQ8BTH6
SMRiQ8BTH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri161 – 183C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri192 – 214C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 297C2H2-type 5; atypicalPROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2462 Eukaryota
ENOG41106JS LUCA
GeneTreeiENSGT00390000011027
HOGENOMiHOG000261665
HOVERGENiHBG007477
InParanoidiQ8BTH6
KOiK09219
OMAiAFFIMDG
OrthoDBiEOG091G0Q0V
PhylomeDBiQ8BTH6
TreeFamiTF315515

Family and domain databases

InterProiView protein in InterPro
IPR029794 SCRATCH1/2
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44270 PTHR44270, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q8BTH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKKI KADGFQCSGV SAPTYHPLET AYVLPGTRGP PGDNGYVAHC
60 70 80 90 100
LPPSGYDGEQ KPGLELAPAE PAYPAAASEE YSDPESPQSS LSARYFRGEA
110 120 130 140 150
AVTDSYSMDA FFISDGRSRR RRAGAGGDAA GAGDAGGGGG GGGGGERAGR
160 170 180 190 200
SGATAGGGHR HACAECGKTY ATSSNLSRHK QTHRSLDSQL ARKCPTCGKA
210 220 230 240 250
YVSMPALAMH VLTHNLRHKC GVCGKAFSRP WLLQGHMRSH TGEKPFGCAH
260 270 280 290 300
CGKAFADRSN LRAHMQTHSA FKHYRCRQCD KSFALKSYLH KHCEAACVKA
310
AEPPPSAGPA S
Length:311
Mass (Da):32,722
Last modified:April 13, 2004 - v2
Checksum:i3AF3745DA0B19B2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845161 Genomic DNA No translation available.
AK090280 mRNA Translation: BAC41156.1
CCDSiCCDS50750.1
RefSeqiNP_001153882.1, NM_001160410.1
UniGeneiMm.214317

Genome annotation databases

EnsembliENSMUST00000064061; ENSMUSP00000066280; ENSMUSG00000060257
GeneIDi545474
KEGGimmu:545474
UCSCiuc012cgb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSCRT2_MOUSE
AccessioniPrimary (citable) accession number: Q8BTH6
Secondary accession number(s): A2AQU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health