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Protein

Copine-3

Gene

Cpne3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1483206 Glycerophospholipid biosynthesis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-3Curated
Alternative name(s):
Copine IIIBy similarityImported
Gene namesi
Name:Cpne3Imported
Synonyms:Kiaa0636
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917818 Cpne3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001448391 – 533Copine-3Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei243PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BT60
MaxQBiQ8BT60
PaxDbiQ8BT60
PeptideAtlasiQ8BT60
PRIDEiQ8BT60

PTM databases

iPTMnetiQ8BT60
PhosphoSitePlusiQ8BT60

Expressioni

Gene expression databases

BgeeiENSMUSG00000028228
CleanExiMM_CPNE3
GenevisibleiQ8BT60 MM

Interactioni

Subunit structurei

Monomer. Interacts with ERBB2 (preferentially with the tyrosine phosphorylated form); this interaction occurs at the cell membrane and is increased in a growth factor heregulin-dependent manner. Interacts with SHC1; this interaction may mediate the binding of CPNE3 with ERBB2. Interacts with RACK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8BT60, 2 interactors
MINTiQ8BT60
STRINGi10090.ENSMUSP00000029885

Structurei

3D structure databases

ProteinModelPortaliQ8BT60
SMRiQ8BT60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 99C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini125 – 230C2 2PROSITE-ProRule annotationAdd BLAST106
Domaini291 – 513VWFAPROSITE-ProRule annotationAdd BLAST223

Sequence similaritiesi

Belongs to the copine family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327 Eukaryota
ENOG410XPC8 LUCA
GeneTreeiENSGT00760000119085
HOGENOMiHOG000220898
HOVERGENiHBG066841
InParanoidiQ8BT60
OMAiGQQWYEV
OrthoDBiEOG091G05IT
PhylomeDBiQ8BT60
TreeFamiTF316419

Family and domain databases

CDDicd04047 C2B_Copine, 1 hit
cd01459 vWA_copine_like, 1 hit
Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037768 C2B_Copine
IPR010734 Copine
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF07002 Copine, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

Q8BT60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQCVTKVE LNVSCNNLLD ADVTSKSDPL CVLFLNTSGH QWYEVERTER
60 70 80 90 100
IKNSLNPKFS KTFVIDYYFE VVQKLKFGIY DIDNKTIELS DDDFLGECEV
110 120 130 140 150
TLGQIVSSKK LTRPLVLKNG KPAGKGSITI SAEEIKDNRV VLFEMEARKL
160 170 180 190 200
DNKDLFGKSD PYLEFHKQTS DGHWLMVHRT EVIKNNLNPM WKPFKISLNS
210 220 230 240 250
LCYGDMDKTI KVECYDYDND GSHDLIGTFQ TTMTKLKEAS RSSPVEYECI
260 270 280 290 300
NEKKRQKKKS YKNSGVISVK HCEITVECTF LDYIMGGCQL NFTVGVDFTG
310 320 330 340 350
SNGDPSSPDS LHYISPNGVN EYLTAIWSVG LVIQDYDADK MFPAFGFGAQ
360 370 380 390 400
VPPQWQVSHE FPMNFNPSNP YCNGIQGIVE AYRTCLPQIR LYGPTNFSPI
410 420 430 440 450
INHVARFAAA ATQQQTASQY FVLLIITDGV ITDLDETRQA IVNAAKLPMS
460 470 480 490 500
IIIVGVGGAD FSAMEFLDGD GGSLRAPSGE VAIRDIVQFV PFRQFQNAPK
510 520 530
EALAQCVLAE IPQQVVGYFN TYKLLPPKNP AVK
Length:533
Mass (Da):59,585
Last modified:June 7, 2005 - v2
Checksum:iF76A4BDCA11C7F2E
GO

Sequence cautioni

The sequence BAD90244 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37T → A in BAC25524 (PubMed:16141072).Curated1
Sequence conflicti471 – 533GGSLR…NPAVK → EWKSPCPFRRGGHKRYCSVC AFQTVPECSKRSACSVCLGR DSPAGGGLLQHIQTPSSQKP SCEVEEPGQLQDFKSCVEQR HLSHRMMYLPSALLTPGYMM in BAC25524 (PubMed:16141072).CuratedAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220348 mRNA Translation: BAD90244.1 Different initiation.
AK017651 mRNA Translation: BAC25524.1
BC090632 mRNA Translation: AAH90632.1
CCDSiCCDS17991.1
RefSeqiNP_082045.1, NM_027769.2
UniGeneiMm.38390

Genome annotation databases

EnsembliENSMUST00000029885; ENSMUSP00000029885; ENSMUSG00000028228
GeneIDi70568
KEGGimmu:70568
UCSCiuc008sby.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCPNE3_MOUSE
AccessioniPrimary (citable) accession number: Q8BT60
Secondary accession number(s): Q5CZX9, Q5DU22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 7, 2005
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health