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Protein
Submitted name:

Putative uncharacterized protein

Gene

Npm1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: UniProtKB
  • cell growth Source: MGI
  • cell volume homeostasis Source: MGI
  • centrosome cycle Source: UniProtKB
  • DNA repair Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of centrosome duplication Source: MGI
  • negative regulation of mRNA splicing, via spliceosome Source: MGI
  • negative regulation of protein kinase activity by regulation of protein phosphorylation Source: MGI
  • nucleocytoplasmic transport Source: MGI
  • nucleosome assembly Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cellular biosynthetic process Source: MGI
  • positive regulation of centrosome duplication Source: MGI
  • positive regulation of NF-kappaB transcription factor activity Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of translation Source: MGI
  • protein homooligomerization Source: MGI
  • protein localization Source: MGI
  • protein oligomerization Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of centriole replication Source: MGI
  • regulation of centrosome duplication Source: MGI
  • regulation of DNA damage response, signal transduction by p53 class mediator Source: MGI
  • regulation of eIF2 alpha phosphorylation by dsRNA Source: MGI
  • regulation of endodeoxyribonuclease activity Source: MGI
  • regulation of endoribonuclease activity Source: MGI
  • ribosomal large subunit biogenesis Source: MGI
  • ribosomal large subunit export from nucleus Source: MGI
  • ribosomal small subunit biogenesis Source: MGI
  • ribosomal small subunit export from nucleus Source: MGI
  • rRNA export from nucleus Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Npm1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106184. Npm1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: MGI
  • focal adhesion Source: MGI
  • granular component Source: MGI
  • large ribosomal subunit Source: MGI
  • membrane Source: MGI
  • nuclear speck Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • ribonucleoprotein complex Source: MGI
  • small ribosomal subunit Source: MGI
  • spindle pole centrosome Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8BSZ3.
ExpressionAtlasiQ8BSZ3. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075067.

Structurei

3D structure databases

ProteinModelPortaliQ8BSZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG001860.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8BSZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG
60 70 80 90 100
AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL
110 120 130 140 150
RLKCGSGPVH ISGQHLVAVE EDAESEDEDE EDVKLLGMSG KRSAPGGGNK
160 170 180 190 200
VPQKKVKLDE DDEDDDEDDE DDEDDDDDDF DEEETEEKVP VKKSVRDTPA
210 220
KNAQKSNQNG KDLKPSTPRS KGQESF
Length:226
Mass (Da):24,982
Last modified:March 1, 2003 - v1
Checksum:i9F5306D0ACDFAEF6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei226 – 2261Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028370 mRNA. Translation: BAC25910.1.
UniGeneiMm.485384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028370 mRNA. Translation: BAC25910.1.
UniGeneiMm.485384.

3D structure databases

ProteinModelPortaliQ8BSZ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106184. Npm1.

Phylogenomic databases

HOVERGENiHBG001860.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ8BSZ3.
ExpressionAtlasiQ8BSZ3. baseline.

Family and domain databases

Gene3Di2.60.120.340. 1 hit.
InterProiIPR004301. Nucleoplasmin.
IPR024057. Nucleoplasmin_core_dom.
[Graphical view]
PANTHERiPTHR22747. PTHR22747. 1 hit.
SUPFAMiSSF69203. SSF69203. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Placenta and extra embryonic tissueImported.

Entry informationi

Entry nameiQ8BSZ3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.