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Q8BSZ2

- AP3S2_MOUSE

UniProt

Q8BSZ2 - AP3S2_MOUSE

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Protein

AP-3 complex subunit sigma-2

Gene
Ap3s2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  1. protein transporter activity Source: InterPro

GO - Biological processi

  1. anterograde axon cargo transport Source: UniProtKB
  2. anterograde synaptic vesicle transport Source: UniProtKB
  3. intracellular protein transport Source: MGI
  4. vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-2
Alternative name(s):
AP-3 complex subunit sigma-3B
Adaptor-related protein complex 3 subunit sigma-2
Sigma-3B-adaptin
Short name:
Sigma3B-adaptin
Sigma-adaptin 3b
Gene namesi
Name:Ap3s2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1337060. Ap3s2.

Subcellular locationi

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex By similarity.

GO - Cellular componenti

  1. AP-3 adaptor complex Source: Ensembl
  2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  3. trans-Golgi network Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193AP-3 complex subunit sigma-2PRO_0000193818Add
BLAST

Proteomic databases

MaxQBiQ8BSZ2.
PaxDbiQ8BSZ2.
PRIDEiQ8BSZ2.

PTM databases

PhosphoSiteiQ8BSZ2.

Expressioni

Tissue specificityi

Present in all adult tissues examined.

Gene expression databases

ArrayExpressiQ8BSZ2.
BgeeiQ8BSZ2.
GenevestigatoriQ8BSZ2.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) By similarity. AP-3 associates with the BLOC-1 complex. Interacts with AGAP1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8BSZ2.
SMRiQ8BSZ2. Positions 1-148.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5030.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ8BSZ2.
KOiK12399.
OMAiNRMEKSE.
OrthoDBiEOG7W41CZ.
PhylomeDBiQ8BSZ2.
TreeFamiTF300189.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BSZ2-1 [UniParc]FASTAAdd to Basket

« Hide

MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL    50
EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC 100
FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS 150
EGGLSAAPAR AVSAVKNINL PEIPRNINIG DLNIKVPNLS QFV 193
Length:193
Mass (Da):22,017
Last modified:March 1, 2003 - v1
Checksum:iD219EF4A989316EA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311E → A in BAC29788. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91933 mRNA. Translation: AAD03780.1.
AK028372 mRNA. Translation: BAC25912.1.
AK037336 mRNA. Translation: BAC29788.1.
AK150085 mRNA. Translation: BAE29294.1.
CCDSiCCDS21389.1.
RefSeqiNP_033812.3. NM_009682.3.
UniGeneiMm.220173.

Genome annotation databases

EnsembliENSMUST00000075657; ENSMUSP00000075082; ENSMUSG00000063801.
GeneIDi11778.
KEGGimmu:11778.
UCSCiuc009hzf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U91933 mRNA. Translation: AAD03780.1 .
AK028372 mRNA. Translation: BAC25912.1 .
AK037336 mRNA. Translation: BAC29788.1 .
AK150085 mRNA. Translation: BAE29294.1 .
CCDSi CCDS21389.1.
RefSeqi NP_033812.3. NM_009682.3.
UniGenei Mm.220173.

3D structure databases

ProteinModelPortali Q8BSZ2.
SMRi Q8BSZ2. Positions 1-148.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BSZ2.

Proteomic databases

MaxQBi Q8BSZ2.
PaxDbi Q8BSZ2.
PRIDEi Q8BSZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075657 ; ENSMUSP00000075082 ; ENSMUSG00000063801 .
GeneIDi 11778.
KEGGi mmu:11778.
UCSCi uc009hzf.2. mouse.

Organism-specific databases

CTDi 10239.
MGIi MGI:1337060. Ap3s2.

Phylogenomic databases

eggNOGi COG5030.
GeneTreei ENSGT00550000074761.
HOVERGENi HBG050517.
InParanoidi Q8BSZ2.
KOi K12399.
OMAi NRMEKSE.
OrthoDBi EOG7W41CZ.
PhylomeDBi Q8BSZ2.
TreeFami TF300189.

Miscellaneous databases

ChiTaRSi AP3S2. mouse.
NextBioi 279579.
PROi Q8BSZ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BSZ2.
Bgeei Q8BSZ2.
Genevestigatori Q8BSZ2.

Family and domain databases

InterProi IPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view ]
PANTHERi PTHR11753. PTHR11753. 1 hit.
Pfami PF01217. Clat_adaptor_s. 1 hit.
[Graphical view ]
PIRSFi PIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMi SSF64356. SSF64356. 1 hit.
PROSITEi PS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the adaptor-related protein complex, AP-3."
    Simpson F., Peden A.A., Christopoulou L., Robinson M.S.
    J. Cell Biol. 137:835-845(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Placenta and Thymus.
  3. "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1."
    Nie Z., Boehm M., Boja E.S., Vass W.C., Bonifacino J.S., Fales H.M., Randazzo P.A.
    Dev. Cell 5:513-521(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AGAP1.
  4. "The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse."
    Larimore J., Tornieri K., Ryder P.V., Gokhale A., Zlatic S.A., Craige B., Lee J.D., Talbot K., Pare J.F., Smith Y., Faundez V.
    Mol. Biol. Cell 22:4854-4867(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ASSOCIATION WITH THE BLOC-1 COMPLEX.

Entry informationi

Entry nameiAP3S2_MOUSE
AccessioniPrimary (citable) accession number: Q8BSZ2
Secondary accession number(s): O09077
, O09149, Q3UDG7, Q8CAY1, Q99589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi