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Protein

AP-3 complex subunit sigma-2

Gene

Ap3s2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-2
Alternative name(s):
AP-3 complex subunit sigma-3B
Adaptor-related protein complex 3 subunit sigma-2
Sigma-3B-adaptin
Short name:
Sigma3B-adaptin
Sigma-adaptin 3b
Gene namesi
Name:Ap3s2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1337060. Ap3s2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193AP-3 complex subunit sigma-2PRO_0000193818Add
BLAST

Proteomic databases

EPDiQ8BSZ2.
MaxQBiQ8BSZ2.
PaxDbiQ8BSZ2.
PRIDEiQ8BSZ2.

PTM databases

iPTMnetiQ8BSZ2.
PhosphoSiteiQ8BSZ2.

Expressioni

Tissue specificityi

Present in all adult tissues examined.

Gene expression databases

BgeeiENSMUSG00000063801.
GenevisibleiQ8BSZ2. MM.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex. Interacts with AGAP1.By similarity1 Publication

Protein-protein interaction databases

IntActiQ8BSZ2. 1 interaction.
STRINGi10090.ENSMUSP00000075082.

Structurei

3D structure databases

ProteinModelPortaliQ8BSZ2.
SMRiQ8BSZ2. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ8BSZ2.
KOiK12399.
OMAiIPRNINL.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ8BSZ2.
TreeFamiTF300189.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BSZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL
60 70 80 90 100
EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS
160 170 180 190
EGGLSAAPAR AVSAVKNINL PEIPRNINIG DLNIKVPNLS QFV
Length:193
Mass (Da):22,017
Last modified:March 1, 2003 - v1
Checksum:iD219EF4A989316EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311E → A in BAC29788 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91933 mRNA. Translation: AAD03780.1.
AK028372 mRNA. Translation: BAC25912.1.
AK037336 mRNA. Translation: BAC29788.1.
AK150085 mRNA. Translation: BAE29294.1.
CCDSiCCDS21389.1.
RefSeqiNP_033812.3. NM_009682.3.
UniGeneiMm.220173.

Genome annotation databases

EnsembliENSMUST00000075657; ENSMUSP00000075082; ENSMUSG00000063801.
GeneIDi11778.
KEGGimmu:11778.
UCSCiuc009hzf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91933 mRNA. Translation: AAD03780.1.
AK028372 mRNA. Translation: BAC25912.1.
AK037336 mRNA. Translation: BAC29788.1.
AK150085 mRNA. Translation: BAE29294.1.
CCDSiCCDS21389.1.
RefSeqiNP_033812.3. NM_009682.3.
UniGeneiMm.220173.

3D structure databases

ProteinModelPortaliQ8BSZ2.
SMRiQ8BSZ2. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BSZ2. 1 interaction.
STRINGi10090.ENSMUSP00000075082.

PTM databases

iPTMnetiQ8BSZ2.
PhosphoSiteiQ8BSZ2.

Proteomic databases

EPDiQ8BSZ2.
MaxQBiQ8BSZ2.
PaxDbiQ8BSZ2.
PRIDEiQ8BSZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075657; ENSMUSP00000075082; ENSMUSG00000063801.
GeneIDi11778.
KEGGimmu:11778.
UCSCiuc009hzf.2. mouse.

Organism-specific databases

CTDi10239.
MGIiMGI:1337060. Ap3s2.

Phylogenomic databases

eggNOGiKOG0936. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00550000074761.
HOVERGENiHBG050517.
InParanoidiQ8BSZ2.
KOiK12399.
OMAiIPRNINL.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ8BSZ2.
TreeFamiTF300189.

Miscellaneous databases

ChiTaRSiAp3s2. mouse.
PROiQ8BSZ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063801.
GenevisibleiQ8BSZ2. MM.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3S2_MOUSE
AccessioniPrimary (citable) accession number: Q8BSZ2
Secondary accession number(s): O09077
, O09149, Q3UDG7, Q8CAY1, Q99589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.