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Protein

C-X-C motif chemokine 16

Gene

Cxcl16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.1 Publication

GO - Molecular functioni

  • chemokine activity Source: MGI
  • chemokine receptor binding Source: UniProtKB
  • low-density lipoprotein receptor activity Source: MGI
  • scavenger receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:Cxcl16
Synonyms:Srpsox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1932682. Cxcl16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 201ExtracellularSequence analysisAdd BLAST175
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 246CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000511927 – 246C-X-C motif chemokine 16Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 65By similarity
Disulfide bondi37 ↔ 79By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8BSU2.
PRIDEiQ8BSU2.

PTM databases

PhosphoSitePlusiQ8BSU2.

Expressioni

Tissue specificityi

Widely expressed. Not detected in purified B- and T-cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000018920.
CleanExiMM_CXCL16.
ExpressionAtlasiQ8BSU2. baseline and differential.
GenevisibleiQ8BSU2. MM.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: MGI
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019064.

Structurei

3D structure databases

ProteinModelPortaliQ8BSU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
GeneTreeiENSGT00390000002148.
HOGENOMiHOG000112116.
HOVERGENiHBG107790.
InParanoidiQ8BSU2.
KOiK10035.
OMAiVLCKRRR.
OrthoDBiEOG091G0P40.
PhylomeDBiQ8BSU2.
TreeFamiTF337941.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BSU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGFGPLSL AFFLFLLALL TLPGDGNQGS VAGSCSCDRT ISSGTQIPQG
60 70 80 90 100
TLDHIRKYLK AFHRCPFFIR FQLQSKSVCG GSQDQWVREL VDCFERKECG
110 120 130 140 150
TGHGKSFHHQ KHLPQASTQT PEAAEGTPSD TSTPAHSQST QHSTLPSGAL
160 170 180 190 200
SLNKEHTQPW EMTTLPSGYG LEARPEAEAN EKQQDDRQQE APGAGASTPA
210 220 230 240
WVPVLSLLAI VFFLTAAMAY VLCNRRATQQ NSAGLQLWYT PVEPRP
Length:246
Mass (Da):26,896
Last modified:September 26, 2003 - v2
Checksum:i2B3047AD695219FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129S → P in AAH19961 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277001 mRNA. Translation: AAG31754.1.
AF301017 mRNA. Translation: AAG34366.1.
AK009599 mRNA. Translation: BAB26384.1.
AK028875 mRNA. Translation: BAC26166.1.
AK030515 mRNA. Translation: BAC27000.1.
AK150224 mRNA. Translation: BAE29391.1.
AK151330 mRNA. Translation: BAE30309.1.
AK152102 mRNA. Translation: BAE30949.1.
AK152547 mRNA. Translation: BAE31302.1.
AK153192 mRNA. Translation: BAE31792.1.
AL596096 Genomic DNA. Translation: CAI51990.1.
CH466596 Genomic DNA. Translation: EDL12565.1.
CH466596 Genomic DNA. Translation: EDL12566.1.
BC019961 mRNA. Translation: AAH19961.1.
CCDSiCCDS24948.1.
RefSeqiNP_075647.3. NM_023158.6.
UniGeneiMm.425692.

Genome annotation databases

EnsembliENSMUST00000019064; ENSMUSP00000019064; ENSMUSG00000018920.
GeneIDi66102.
KEGGimmu:66102.
UCSCiuc007juw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277001 mRNA. Translation: AAG31754.1.
AF301017 mRNA. Translation: AAG34366.1.
AK009599 mRNA. Translation: BAB26384.1.
AK028875 mRNA. Translation: BAC26166.1.
AK030515 mRNA. Translation: BAC27000.1.
AK150224 mRNA. Translation: BAE29391.1.
AK151330 mRNA. Translation: BAE30309.1.
AK152102 mRNA. Translation: BAE30949.1.
AK152547 mRNA. Translation: BAE31302.1.
AK153192 mRNA. Translation: BAE31792.1.
AL596096 Genomic DNA. Translation: CAI51990.1.
CH466596 Genomic DNA. Translation: EDL12565.1.
CH466596 Genomic DNA. Translation: EDL12566.1.
BC019961 mRNA. Translation: AAH19961.1.
CCDSiCCDS24948.1.
RefSeqiNP_075647.3. NM_023158.6.
UniGeneiMm.425692.

3D structure databases

ProteinModelPortaliQ8BSU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019064.

PTM databases

PhosphoSitePlusiQ8BSU2.

Proteomic databases

PaxDbiQ8BSU2.
PRIDEiQ8BSU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019064; ENSMUSP00000019064; ENSMUSG00000018920.
GeneIDi66102.
KEGGimmu:66102.
UCSCiuc007juw.1. mouse.

Organism-specific databases

CTDi58191.
MGIiMGI:1932682. Cxcl16.

Phylogenomic databases

eggNOGiENOG410J8A5. Eukaryota.
ENOG4111D6H. LUCA.
GeneTreeiENSGT00390000002148.
HOGENOMiHOG000112116.
HOVERGENiHBG107790.
InParanoidiQ8BSU2.
KOiK10035.
OMAiVLCKRRR.
OrthoDBiEOG091G0P40.
PhylomeDBiQ8BSU2.
TreeFamiTF337941.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8BSU2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018920.
CleanExiMM_CXCL16.
ExpressionAtlasiQ8BSU2. baseline and differential.
GenevisibleiQ8BSU2. MM.

Family and domain databases

InterProiIPR026296. CXCL16.
[Graphical view]
PANTHERiPTHR14385. PTHR14385. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCXL16_MOUSE
AccessioniPrimary (citable) accession number: Q8BSU2
Secondary accession number(s): Q3UD70
, Q5F2D5, Q8VE25, Q9EPB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.