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Protein

C-X-C motif chemokine 16

Gene

Cxcl16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis.1 Publication

GO - Molecular functioni

  • chemokine activity Source: MGI
  • chemokine receptor binding Source: UniProtKB
  • low-density lipoprotein particle receptor activity Source: MGI
  • scavenger receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 16
Alternative name(s):
Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
Short name:
SR-PSOX
Small-inducible cytokine B16
Transmembrane chemokine CXCL16
Gene namesi
Name:Cxcl16
Synonyms:Srpsox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1932682 Cxcl16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 201ExtracellularSequence analysisAdd BLAST175
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 246CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000511927 – 246C-X-C motif chemokine 16Add BLAST220

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 65By similarity
Disulfide bondi37 ↔ 79By similarity

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8BSU2
PaxDbiQ8BSU2
PRIDEiQ8BSU2

PTM databases

PhosphoSitePlusiQ8BSU2

Expressioni

Tissue specificityi

Widely expressed. Not detected in purified B- and T-cells.2 Publications

Gene expression databases

BgeeiENSMUSG00000018920
CleanExiMM_CXCL16
ExpressionAtlasiQ8BSU2 baseline and differential
GenevisibleiQ8BSU2 MM

Interactioni

GO - Molecular functioni

  • chemokine activity Source: MGI
  • chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019064

Structurei

3D structure databases

ProteinModelPortaliQ8BSU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8A5 Eukaryota
ENOG4111D6H LUCA
GeneTreeiENSGT00390000002148
HOGENOMiHOG000112116
HOVERGENiHBG107790
InParanoidiQ8BSU2
KOiK10035
OMAiVLCKRRR
OrthoDBiEOG091G0P40
PhylomeDBiQ8BSU2
TreeFamiTF337941

Family and domain databases

InterProiView protein in InterPro
IPR026296 CXCL16
PANTHERiPTHR14385 PTHR14385, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8BSU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGFGPLSL AFFLFLLALL TLPGDGNQGS VAGSCSCDRT ISSGTQIPQG
60 70 80 90 100
TLDHIRKYLK AFHRCPFFIR FQLQSKSVCG GSQDQWVREL VDCFERKECG
110 120 130 140 150
TGHGKSFHHQ KHLPQASTQT PEAAEGTPSD TSTPAHSQST QHSTLPSGAL
160 170 180 190 200
SLNKEHTQPW EMTTLPSGYG LEARPEAEAN EKQQDDRQQE APGAGASTPA
210 220 230 240
WVPVLSLLAI VFFLTAAMAY VLCNRRATQQ NSAGLQLWYT PVEPRP
Length:246
Mass (Da):26,896
Last modified:September 26, 2003 - v2
Checksum:i2B3047AD695219FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129S → P in AAH19961 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277001 mRNA Translation: AAG31754.1
AF301017 mRNA Translation: AAG34366.1
AK009599 mRNA Translation: BAB26384.1
AK028875 mRNA Translation: BAC26166.1
AK030515 mRNA Translation: BAC27000.1
AK150224 mRNA Translation: BAE29391.1
AK151330 mRNA Translation: BAE30309.1
AK152102 mRNA Translation: BAE30949.1
AK152547 mRNA Translation: BAE31302.1
AK153192 mRNA Translation: BAE31792.1
AL596096 Genomic DNA Translation: CAI51990.1
CH466596 Genomic DNA Translation: EDL12565.1
CH466596 Genomic DNA Translation: EDL12566.1
BC019961 mRNA Translation: AAH19961.1
CCDSiCCDS24948.1
RefSeqiNP_075647.3, NM_023158.6
UniGeneiMm.425692

Genome annotation databases

EnsembliENSMUST00000019064; ENSMUSP00000019064; ENSMUSG00000018920
GeneIDi66102
KEGGimmu:66102
UCSCiuc007juw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCXL16_MOUSE
AccessioniPrimary (citable) accession number: Q8BSU2
Secondary accession number(s): Q3UD70
, Q5F2D5, Q8VE25, Q9EPB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: April 25, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health