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Protein

Large neutral amino acids transporter small subunit 3

Gene

Slc43a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • L-amino acid transport Source: MGI
  • neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Solute carrier family 43 member 1
Gene namesi
Name:Slc43a1Imported
Synonyms:Lat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1931352. Slc43a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei105 – 124HelicalSequence analysisAdd BLAST20
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186411 – 564Large neutral amino acids transporter small subunit 3Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi57N-linked (GlcNAc...)1 Publication1
Modified residuei262PhosphoserineBy similarity1
Modified residuei267PhosphoserineBy similarity1
Glycosylationi396N-linked (GlcNAc...)Sequence analysis1
Modified residuei398PhosphoserineCombined sources1
Glycosylationi558N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BSM7.
PaxDbiQ8BSM7.
PRIDEiQ8BSM7.

PTM databases

iPTMnetiQ8BSM7.
PhosphoSitePlusiQ8BSM7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027075.
CleanExiMM_SLC43A1.
ExpressionAtlasiQ8BSM7. baseline and differential.
GenevisibleiQ8BSM7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028469.

Structurei

3D structure databases

ProteinModelPortaliQ8BSM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDRV. Eukaryota.
ENOG410Y95V. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8BSM7.
KOiK08228.
PhylomeDBiQ8BSM7.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8BSM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTLKQAYR RRWWMACTAV VENLFFSAVL LGWASLLIML KKEGFYSSLC
60 70 80 90 100
PAENRTNTTQ DEQHQWTSCD QQEKMLNLGF TIGSFLLSAT TLPLGILMDR
110 120 130 140 150
FGPRPLRLVG SACFAASCTL MALASRDTEV LSPLIFLALS LNGFAGICLT
160 170 180 190 200
FTSLTLPNMF GNLRSTFMAL MIGSYASSAI TFPGIKLIYD AGVPFTVIMF
210 220 230 240 250
TWSGLACLIF LNCALNWPAE AFPAPEEVDY TKKIKLIGLA LDHKVTGDRF
260 270 280 290 300
YTHVTIVGQR LSQKSPSLEE GADAFISSPD IPGTSEETPE KSVPFRKSLC
310 320 330 340 350
SPIFLWSLVT MGMTQLRVIF YMGAMNKILE FIVTGGKERE TNEQRQKVEE
360 370 380 390 400
TVEFYSSIFG VMQLLCLLTC PLIGYIMDWR IKDCVDAPTE GTLNENASFG
410 420 430 440 450
DARDGASTKF TRPRYRKVQK LTNAINAFTL TNILLVGFGI ACLIKNLHLQ
460 470 480 490 500
LLAFVLHTIV RGFFHSACGG LYAAVFPSNH FGTLTGLQSL ISAVFALLQQ
510 520 530 540 550
LLFMAMVGPL HGDPFWVNLG LLLLSFLGFL LPSYLYYYRS RLQREYATNL
560
VDPQKVLNTS KVAT
Length:564
Mass (Da):62,644
Last modified:March 1, 2003 - v1
Checksum:iAEC14BF1F3438BB8
GO

Sequence cautioni

The sequence BAC27305 differs from that shown. Reason: Frameshift at position 11.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSiCCDS38163.1.
RefSeqiNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.3.
UniGeneiMm.22716.

Genome annotation databases

EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneIDi72401.
KEGGimmu:72401.
UCSCiuc008kjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSiCCDS38163.1.
RefSeqiNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.3.
UniGeneiMm.22716.

3D structure databases

ProteinModelPortaliQ8BSM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028469.

PTM databases

iPTMnetiQ8BSM7.
PhosphoSitePlusiQ8BSM7.

Proteomic databases

MaxQBiQ8BSM7.
PaxDbiQ8BSM7.
PRIDEiQ8BSM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneIDi72401.
KEGGimmu:72401.
UCSCiuc008kjk.1. mouse.

Organism-specific databases

CTDi8501.
MGIiMGI:1931352. Slc43a1.

Phylogenomic databases

eggNOGiENOG410KDRV. Eukaryota.
ENOG410Y95V. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8BSM7.
KOiK08228.
PhylomeDBiQ8BSM7.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ8BSM7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027075.
CleanExiMM_SLC43A1.
ExpressionAtlasiQ8BSM7. baseline and differential.
GenevisibleiQ8BSM7. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiLAT3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSM7
Secondary accession number(s): A2ATS3, Q9D0H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.