Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8BSM7

- LAT3_MOUSE

UniProt

Q8BSM7 - LAT3_MOUSE

Protein

Large neutral amino acids transporter small subunit 3

Gene

Slc43a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine By similarity.By similarity

    GO - Molecular functioni

    1. L-amino acid transmembrane transporter activity Source: MGI
    2. neutral amino acid transmembrane transporter activity Source: UniProtKB

    GO - Biological processi

    1. L-alpha-amino acid transmembrane transport Source: GOC
    2. L-amino acid transport Source: MGI
    3. neutral amino acid transport Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large neutral amino acids transporter small subunit 3
    Alternative name(s):
    L-type amino acid transporter 3
    Solute carrier family 43 member 1
    Gene namesi
    Name:Slc43a1Imported
    Synonyms:Lat3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1931352. Slc43a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Large neutral amino acids transporter small subunit 3PRO_0000218641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
    Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
    Modified residuei398 – 3981Phosphoserine1 Publication
    Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8BSM7.
    PaxDbiQ8BSM7.
    PRIDEiQ8BSM7.

    PTM databases

    PhosphoSiteiQ8BSM7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BSM7.
    BgeeiQ8BSM7.
    CleanExiMM_SLC43A1.
    GenevestigatoriQ8BSM7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BSM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei191 – 21121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei357 – 37721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei424 – 44421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei490 – 51021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei515 – 53521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71084.
    GeneTreeiENSGT00530000063043.
    HOGENOMiHOG000231937.
    HOVERGENiHBG072879.
    InParanoidiA2ATS3.
    KOiK08228.
    OrthoDBiEOG712TWX.
    PhylomeDBiQ8BSM7.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8BSM7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPTLKQAYR RRWWMACTAV VENLFFSAVL LGWASLLIML KKEGFYSSLC    50
    PAENRTNTTQ DEQHQWTSCD QQEKMLNLGF TIGSFLLSAT TLPLGILMDR 100
    FGPRPLRLVG SACFAASCTL MALASRDTEV LSPLIFLALS LNGFAGICLT 150
    FTSLTLPNMF GNLRSTFMAL MIGSYASSAI TFPGIKLIYD AGVPFTVIMF 200
    TWSGLACLIF LNCALNWPAE AFPAPEEVDY TKKIKLIGLA LDHKVTGDRF 250
    YTHVTIVGQR LSQKSPSLEE GADAFISSPD IPGTSEETPE KSVPFRKSLC 300
    SPIFLWSLVT MGMTQLRVIF YMGAMNKILE FIVTGGKERE TNEQRQKVEE 350
    TVEFYSSIFG VMQLLCLLTC PLIGYIMDWR IKDCVDAPTE GTLNENASFG 400
    DARDGASTKF TRPRYRKVQK LTNAINAFTL TNILLVGFGI ACLIKNLHLQ 450
    LLAFVLHTIV RGFFHSACGG LYAAVFPSNH FGTLTGLQSL ISAVFALLQQ 500
    LLFMAMVGPL HGDPFWVNLG LLLLSFLGFL LPSYLYYYRS RLQREYATNL 550
    VDPQKVLNTS KVAT 564
    Length:564
    Mass (Da):62,644
    Last modified:March 1, 2003 - v1
    Checksum:iAEC14BF1F3438BB8
    GO

    Sequence cautioni

    The sequence BAC27305.1 differs from that shown. Reason: Frameshift at position 11.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB103034 mRNA. Translation: BAD10947.1.
    AK011417 mRNA. Translation: BAB27605.1. Frameshift.
    AK031215 mRNA. Translation: BAC27305.1. Frameshift.
    AL928914 Genomic DNA. Translation: CAM23317.2.
    BC053747 mRNA. Translation: AAH53747.1.
    CCDSiCCDS38163.1.
    RefSeqiNP_001077278.1. NM_001083809.1.
    NP_078773.1. NM_024497.1.
    XP_006500293.1. XM_006500230.1.
    UniGeneiMm.22716.

    Genome annotation databases

    EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
    ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
    GeneIDi72401.
    KEGGimmu:72401.
    UCSCiuc008kjk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB103034 mRNA. Translation: BAD10947.1 .
    AK011417 mRNA. Translation: BAB27605.1 . Frameshift.
    AK031215 mRNA. Translation: BAC27305.1 . Frameshift.
    AL928914 Genomic DNA. Translation: CAM23317.2 .
    BC053747 mRNA. Translation: AAH53747.1 .
    CCDSi CCDS38163.1.
    RefSeqi NP_001077278.1. NM_001083809.1.
    NP_078773.1. NM_024497.1.
    XP_006500293.1. XM_006500230.1.
    UniGenei Mm.22716.

    3D structure databases

    ProteinModelPortali Q8BSM7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BSM7.

    Proteomic databases

    MaxQBi Q8BSM7.
    PaxDbi Q8BSM7.
    PRIDEi Q8BSM7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111624 ; ENSMUSP00000107251 ; ENSMUSG00000027075 .
    ENSMUST00000121114 ; ENSMUSP00000112642 ; ENSMUSG00000027075 .
    GeneIDi 72401.
    KEGGi mmu:72401.
    UCSCi uc008kjk.1. mouse.

    Organism-specific databases

    CTDi 8501.
    MGIi MGI:1931352. Slc43a1.

    Phylogenomic databases

    eggNOGi NOG71084.
    GeneTreei ENSGT00530000063043.
    HOGENOMi HOG000231937.
    HOVERGENi HBG072879.
    InParanoidi A2ATS3.
    KOi K08228.
    OrthoDBi EOG712TWX.
    PhylomeDBi Q8BSM7.

    Miscellaneous databases

    NextBioi 336198.
    PROi Q8BSM7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BSM7.
    Bgeei Q8BSM7.
    CleanExi MM_SLC43A1.
    Genevestigatori Q8BSM7.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of mouse LAT3 system L amino acid transporter."
      Babu E., Kanai Y., Chairoungdua A., Li Y., Anzai N., Endou H.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/NImported.
      Tissue: Salivary glandImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Forelimb.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/61 Publication.
      Tissue: EmbryoImported.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.

    Entry informationi

    Entry nameiLAT3_MOUSE
    AccessioniPrimary (citable) accession number: Q8BSM7
    Secondary accession number(s): A2ATS3, Q9D0H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3