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Q8BSM7 (LAT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Solute carrier family 43 member 1
Gene names
Name:Slc43a1
Synonyms:Lat3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length564 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine By similarity. UniProtKB O75387

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the SLC43A transporter (TC 2.A.1.44) family. [View classification]

Sequence caution

The sequence BAC27305.1 differs from that shown. Reason: Frameshift at position 11.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 564564Large neutral amino acids transporter small subunit 3
PRO_0000218641

Regions

Transmembrane20 – 4021Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane105 – 12420Helical; Potential
Transmembrane131 – 15121Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane303 – 32321Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane424 – 44421Helical; Potential
Transmembrane451 – 47121Helical; Potential
Transmembrane490 – 51021Helical; Potential
Transmembrane515 – 53521Helical; Potential

Amino acid modifications

Modified residue3981Phosphoserine Ref.5
Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Ref.6
Glycosylation3961N-linked (GlcNAc...) Potential
Glycosylation5581N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8BSM7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: AEC14BF1F3438BB8

FASTA56462,644
        10         20         30         40         50         60 
MAPTLKQAYR RRWWMACTAV VENLFFSAVL LGWASLLIML KKEGFYSSLC PAENRTNTTQ 

        70         80         90        100        110        120 
DEQHQWTSCD QQEKMLNLGF TIGSFLLSAT TLPLGILMDR FGPRPLRLVG SACFAASCTL 

       130        140        150        160        170        180 
MALASRDTEV LSPLIFLALS LNGFAGICLT FTSLTLPNMF GNLRSTFMAL MIGSYASSAI 

       190        200        210        220        230        240 
TFPGIKLIYD AGVPFTVIMF TWSGLACLIF LNCALNWPAE AFPAPEEVDY TKKIKLIGLA 

       250        260        270        280        290        300 
LDHKVTGDRF YTHVTIVGQR LSQKSPSLEE GADAFISSPD IPGTSEETPE KSVPFRKSLC 

       310        320        330        340        350        360 
SPIFLWSLVT MGMTQLRVIF YMGAMNKILE FIVTGGKERE TNEQRQKVEE TVEFYSSIFG 

       370        380        390        400        410        420 
VMQLLCLLTC PLIGYIMDWR IKDCVDAPTE GTLNENASFG DARDGASTKF TRPRYRKVQK 

       430        440        450        460        470        480 
LTNAINAFTL TNILLVGFGI ACLIKNLHLQ LLAFVLHTIV RGFFHSACGG LYAAVFPSNH 

       490        500        510        520        530        540 
FGTLTGLQSL ISAVFALLQQ LLFMAMVGPL HGDPFWVNLG LLLLSFLGFL LPSYLYYYRS 

       550        560 
RLQREYATNL VDPQKVLNTS KVAT 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of mouse LAT3 system L amino acid transporter."
Babu E., Kanai Y., Chairoungdua A., Li Y., Anzai N., Endou H.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Forelimb.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Embryo.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSCCDS38163.1.
RefSeqNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.1.
UniGeneMm.22716.

3D structure databases

ProteinModelPortalQ8BSM7.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BSM7.

Proteomic databases

MaxQBQ8BSM7.
PaxDbQ8BSM7.
PRIDEQ8BSM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneID72401.
KEGGmmu:72401.
UCSCuc008kjk.1. mouse.

Organism-specific databases

CTD8501.
MGIMGI:1931352. Slc43a1.

Phylogenomic databases

eggNOGNOG71084.
GeneTreeENSGT00530000063043.
HOGENOMHOG000231937.
HOVERGENHBG072879.
InParanoidA2ATS3.
KOK08228.
OrthoDBEOG712TWX.
PhylomeDBQ8BSM7.

Gene expression databases

ArrayExpressQ8BSM7.
BgeeQ8BSM7.
CleanExMM_SLC43A1.
GenevestigatorQ8BSM7.

Family and domain databases

InterProIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

NextBio336198.
PROQ8BSM7.
SOURCESearch...

Entry information

Entry nameLAT3_MOUSE
AccessionPrimary (citable) accession number: Q8BSM7
Secondary accession number(s): A2ATS3, Q9D0H7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot