Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Large neutral amino acids transporter small subunit 3

Gene

Slc43a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity).By similarity

GO - Molecular functioni

  1. L-amino acid transmembrane transporter activity Source: MGI
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. L-alpha-amino acid transmembrane transport Source: GOC
  2. L-amino acid transport Source: MGI
  3. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Solute carrier family 43 member 1
Gene namesi
Name:Slc43a1Imported
Synonyms:Lat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1931352. Slc43a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12420HelicalSequence AnalysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence AnalysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST
Transmembranei490 – 51021HelicalSequence AnalysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Large neutral amino acids transporter small subunit 3PRO_0000218641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
Modified residuei267 – 2671PhosphoserineBy similarity
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Modified residuei398 – 3981Phosphoserine1 Publication
Glycosylationi558 – 5581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BSM7.
PaxDbiQ8BSM7.
PRIDEiQ8BSM7.

PTM databases

PhosphoSiteiQ8BSM7.

Expressioni

Gene expression databases

BgeeiQ8BSM7.
CleanExiMM_SLC43A1.
ExpressionAtlasiQ8BSM7. baseline and differential.
GenevestigatoriQ8BSM7.

Structurei

3D structure databases

ProteinModelPortaliQ8BSM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71084.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8BSM7.
KOiK08228.
OrthoDBiEOG712TWX.
PhylomeDBiQ8BSM7.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8BSM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTLKQAYR RRWWMACTAV VENLFFSAVL LGWASLLIML KKEGFYSSLC
60 70 80 90 100
PAENRTNTTQ DEQHQWTSCD QQEKMLNLGF TIGSFLLSAT TLPLGILMDR
110 120 130 140 150
FGPRPLRLVG SACFAASCTL MALASRDTEV LSPLIFLALS LNGFAGICLT
160 170 180 190 200
FTSLTLPNMF GNLRSTFMAL MIGSYASSAI TFPGIKLIYD AGVPFTVIMF
210 220 230 240 250
TWSGLACLIF LNCALNWPAE AFPAPEEVDY TKKIKLIGLA LDHKVTGDRF
260 270 280 290 300
YTHVTIVGQR LSQKSPSLEE GADAFISSPD IPGTSEETPE KSVPFRKSLC
310 320 330 340 350
SPIFLWSLVT MGMTQLRVIF YMGAMNKILE FIVTGGKERE TNEQRQKVEE
360 370 380 390 400
TVEFYSSIFG VMQLLCLLTC PLIGYIMDWR IKDCVDAPTE GTLNENASFG
410 420 430 440 450
DARDGASTKF TRPRYRKVQK LTNAINAFTL TNILLVGFGI ACLIKNLHLQ
460 470 480 490 500
LLAFVLHTIV RGFFHSACGG LYAAVFPSNH FGTLTGLQSL ISAVFALLQQ
510 520 530 540 550
LLFMAMVGPL HGDPFWVNLG LLLLSFLGFL LPSYLYYYRS RLQREYATNL
560
VDPQKVLNTS KVAT
Length:564
Mass (Da):62,644
Last modified:March 1, 2003 - v1
Checksum:iAEC14BF1F3438BB8
GO

Sequence cautioni

The sequence BAC27305.1 differs from that shown. Reason: Frameshift at position 11. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSiCCDS38163.1.
RefSeqiNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.2.
UniGeneiMm.22716.

Genome annotation databases

EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneIDi72401.
KEGGimmu:72401.
UCSCiuc008kjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSiCCDS38163.1.
RefSeqiNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.2.
UniGeneiMm.22716.

3D structure databases

ProteinModelPortaliQ8BSM7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BSM7.

Proteomic databases

MaxQBiQ8BSM7.
PaxDbiQ8BSM7.
PRIDEiQ8BSM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneIDi72401.
KEGGimmu:72401.
UCSCiuc008kjk.1. mouse.

Organism-specific databases

CTDi8501.
MGIiMGI:1931352. Slc43a1.

Phylogenomic databases

eggNOGiNOG71084.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiQ8BSM7.
KOiK08228.
OrthoDBiEOG712TWX.
PhylomeDBiQ8BSM7.

Enzyme and pathway databases

ReactomeiREACT_301178. Amino acid transport across the plasma membrane.

Miscellaneous databases

NextBioi336198.
PROiQ8BSM7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BSM7.
CleanExiMM_SLC43A1.
ExpressionAtlasiQ8BSM7. baseline and differential.
GenevestigatoriQ8BSM7.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of mouse LAT3 system L amino acid transporter."
    Babu E., Kanai Y., Chairoungdua A., Li Y., Anzai N., Endou H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/61 Publication.
    Tissue: EmbryoImported.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.

Entry informationi

Entry nameiLAT3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSM7
Secondary accession number(s): A2ATS3, Q9D0H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.