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Q8BSM7

- LAT3_MOUSE

UniProt

Q8BSM7 - LAT3_MOUSE

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Protein

Large neutral amino acids transporter small subunit 3

Gene
Slc43a1, Lat3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine By similarity.By similarity

GO - Molecular functioni

  1. L-amino acid transmembrane transporter activity Source: MGI
  2. neutral amino acid transmembrane transporter activity Source: UniProtKB

GO - Biological processi

  1. L-alpha-amino acid transmembrane transport Source: GOC
  2. L-amino acid transport Source: MGI
  3. neutral amino acid transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large neutral amino acids transporter small subunit 3
Alternative name(s):
L-type amino acid transporter 3
Solute carrier family 43 member 1
Gene namesi
Name:Slc43a1
Synonyms:Lat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1931352. Slc43a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Transmembranei105 – 12420Helical; Reviewed predictionAdd
BLAST
Transmembranei131 – 15121Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Transmembranei303 – 32321Helical; Reviewed predictionAdd
BLAST
Transmembranei357 – 37721Helical; Reviewed predictionAdd
BLAST
Transmembranei424 – 44421Helical; Reviewed predictionAdd
BLAST
Transmembranei451 – 47121Helical; Reviewed predictionAdd
BLAST
Transmembranei490 – 51021Helical; Reviewed predictionAdd
BLAST
Transmembranei515 – 53521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Large neutral amino acids transporter small subunit 3PRO_0000218641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Modified residuei398 – 3981Phosphoserine1 Publication
Glycosylationi558 – 5581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8BSM7.
PaxDbiQ8BSM7.
PRIDEiQ8BSM7.

PTM databases

PhosphoSiteiQ8BSM7.

Expressioni

Gene expression databases

ArrayExpressiQ8BSM7.
BgeeiQ8BSM7.
CleanExiMM_SLC43A1.
GenevestigatoriQ8BSM7.

Structurei

3D structure databases

ProteinModelPortaliQ8BSM7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71084.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000231937.
HOVERGENiHBG072879.
InParanoidiA2ATS3.
KOiK08228.
OrthoDBiEOG712TWX.
PhylomeDBiQ8BSM7.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8BSM7-1 [UniParc]FASTAAdd to Basket

« Hide

MAPTLKQAYR RRWWMACTAV VENLFFSAVL LGWASLLIML KKEGFYSSLC    50
PAENRTNTTQ DEQHQWTSCD QQEKMLNLGF TIGSFLLSAT TLPLGILMDR 100
FGPRPLRLVG SACFAASCTL MALASRDTEV LSPLIFLALS LNGFAGICLT 150
FTSLTLPNMF GNLRSTFMAL MIGSYASSAI TFPGIKLIYD AGVPFTVIMF 200
TWSGLACLIF LNCALNWPAE AFPAPEEVDY TKKIKLIGLA LDHKVTGDRF 250
YTHVTIVGQR LSQKSPSLEE GADAFISSPD IPGTSEETPE KSVPFRKSLC 300
SPIFLWSLVT MGMTQLRVIF YMGAMNKILE FIVTGGKERE TNEQRQKVEE 350
TVEFYSSIFG VMQLLCLLTC PLIGYIMDWR IKDCVDAPTE GTLNENASFG 400
DARDGASTKF TRPRYRKVQK LTNAINAFTL TNILLVGFGI ACLIKNLHLQ 450
LLAFVLHTIV RGFFHSACGG LYAAVFPSNH FGTLTGLQSL ISAVFALLQQ 500
LLFMAMVGPL HGDPFWVNLG LLLLSFLGFL LPSYLYYYRS RLQREYATNL 550
VDPQKVLNTS KVAT 564
Length:564
Mass (Da):62,644
Last modified:March 1, 2003 - v1
Checksum:iAEC14BF1F3438BB8
GO

Sequence cautioni

The sequence BAC27305.1 differs from that shown. Reason: Frameshift at position 11.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB103034 mRNA. Translation: BAD10947.1.
AK011417 mRNA. Translation: BAB27605.1. Frameshift.
AK031215 mRNA. Translation: BAC27305.1. Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2.
BC053747 mRNA. Translation: AAH53747.1.
CCDSiCCDS38163.1.
RefSeqiNP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.1.
UniGeneiMm.22716.

Genome annotation databases

EnsembliENSMUST00000111624; ENSMUSP00000107251; ENSMUSG00000027075.
ENSMUST00000121114; ENSMUSP00000112642; ENSMUSG00000027075.
GeneIDi72401.
KEGGimmu:72401.
UCSCiuc008kjk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB103034 mRNA. Translation: BAD10947.1 .
AK011417 mRNA. Translation: BAB27605.1 . Frameshift.
AK031215 mRNA. Translation: BAC27305.1 . Frameshift.
AL928914 Genomic DNA. Translation: CAM23317.2 .
BC053747 mRNA. Translation: AAH53747.1 .
CCDSi CCDS38163.1.
RefSeqi NP_001077278.1. NM_001083809.1.
NP_078773.1. NM_024497.1.
XP_006500293.1. XM_006500230.1.
UniGenei Mm.22716.

3D structure databases

ProteinModelPortali Q8BSM7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8BSM7.

Proteomic databases

MaxQBi Q8BSM7.
PaxDbi Q8BSM7.
PRIDEi Q8BSM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111624 ; ENSMUSP00000107251 ; ENSMUSG00000027075 .
ENSMUST00000121114 ; ENSMUSP00000112642 ; ENSMUSG00000027075 .
GeneIDi 72401.
KEGGi mmu:72401.
UCSCi uc008kjk.1. mouse.

Organism-specific databases

CTDi 8501.
MGIi MGI:1931352. Slc43a1.

Phylogenomic databases

eggNOGi NOG71084.
GeneTreei ENSGT00530000063043.
HOGENOMi HOG000231937.
HOVERGENi HBG072879.
InParanoidi A2ATS3.
KOi K08228.
OrthoDBi EOG712TWX.
PhylomeDBi Q8BSM7.

Miscellaneous databases

NextBioi 336198.
PROi Q8BSM7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8BSM7.
Bgeei Q8BSM7.
CleanExi MM_SLC43A1.
Genevestigatori Q8BSM7.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of mouse LAT3 system L amino acid transporter."
    Babu E., Kanai Y., Chairoungdua A., Li Y., Anzai N., Endou H.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Forelimb.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryo.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-398, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.

Entry informationi

Entry nameiLAT3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSM7
Secondary accession number(s): A2ATS3, Q9D0H7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi