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Protein

GRB2-associated-binding protein 3

Gene

Gab3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • macrophage differentiation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
GRB2-associated-binding protein 3
Alternative name(s):
GRB2-associated binder 3
Growth factor receptor bound protein 2-associated protein 3
Gene namesi
Name:Gab3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2387324 Gab3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189401 – 595GRB2-associated-binding protein 3Add BLAST595

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei346PhosphoserineBy similarity1
Modified residuei480PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residue(s) after macrophage colony-stimulating factor (M-CSF) receptor stimulation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8BSM5
PRIDEiQ8BSM5

PTM databases

iPTMnetiQ8BSM5
PhosphoSitePlusiQ8BSM5

Expressioni

Tissue specificityi

Highly expressed in spleen and thymus and weakly in brain, heart, lung, kidney, uterus, and embryonic stem cells. Also expressed in myeloid and macrophage cell lines.

Gene expression databases

BgeeiENSMUSG00000032750
ExpressionAtlasiQ8BSM5 baseline and differential
GenevisibleiQ8BSM5 MM

Interactioni

Subunit structurei

Interacts with PIK3R/p85, SHP2 and GRAP2/MONA. May interact with Grb2.2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041951

Structurei

3D structure databases

ProteinModelPortaliQ8BSM5
SMRiQ8BSM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 117PHPROSITE-ProRule annotationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi497 – 520Glu-richAdd BLAST24

Sequence similaritiesi

Belongs to the GAB family.Curated

Phylogenomic databases

eggNOGiENOG410IEG0 Eukaryota
ENOG4111RDE LUCA
GeneTreeiENSGT00510000046662
HOVERGENiHBG107126
InParanoidiQ8BSM5
OMAiEFQNNFV
OrthoDBiEOG091G03BY
TreeFamiTF329487

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8BSM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGDTVCMG WLIKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN
60 70 80 90 100
KHSNKPIRVI DLSECTVWKH AGPGFIRKEF QKNFVFIVKT TSRTFYLVAK
110 120 130 140 150
TEEEMQVWVH SISQVCNFSH LEDGADSMES LSHMPSSFQP SPASSLHTVH
160 170 180 190 200
VANSALLKDD RNTNSVVTEE TRRESEFLFL PDYLILSNCE TGRLHHASLP
210 220 230 240 250
TRCDSWSNSN HSLAQTSFDD VFLDGLQPFI SNNLVHPLHH GKVSQDFPSI
260 270 280 290 300
RPQASLIWNR EINGPSRNLM SSSPLLESSL NPTVHVEEKQ VSLPSGVKEL
310 320 330 340 350
NIMSNTPPPR PPKPSYLSEQ RQDQPLLTGH SSNKKPGYTM VPRRISLSGL
360 370 380 390 400
DHVGSWKGDV QSQSLRHRDK RLSLNLPCKF SPIYPTASPS AEDSYVPMSP
410 420 430 440 450
KGTASELRPH CSQDDYIPMS SSMLPELPAD LEPPPVNRNL KPQRKSRPPP
460 470 480 490 500
LDSRNLSTIQ EHTSLTRTYT VPCNRTSFLS PQRNGINCAR LFSTPSEEEE
510 520 530 540 550
EEEEEEEEEE EEEKYIQMEE YGTVSSLSRS ALSWTKKFSL DYLALDFNST
560 570 580 590
SPAPVQKKLL LSEEQRVDYV QVDEQKTQAL RSTKQEWTDE RQSKV
Length:595
Mass (Da):67,840
Last modified:March 1, 2003 - v1
Checksum:i59850B7B55276F30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161R → G in AAL25824 (PubMed:11739737).Curated1
Sequence conflicti306T → I in AAL25824 (PubMed:11739737).Curated1
Sequence conflicti586E → A in AAL25824 (PubMed:11739737).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057988 mRNA Translation: AAL25824.1
AK031227 mRNA Translation: BAC27308.1
AL845304, AL808110 Genomic DNA Translation: CAM16813.1
AL808110, AL845304 Genomic DNA Translation: CAM26483.1
AJ748654 mRNA Translation: CAG38688.1
CCDSiCCDS30235.1
RefSeqiNP_853615.1, NM_181584.4
UniGeneiMm.267056

Genome annotation databases

EnsembliENSMUST00000037374; ENSMUSP00000041951; ENSMUSG00000032750
GeneIDi210710
KEGGimmu:210710
UCSCiuc009tpn.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGAB3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSM5
Secondary accession number(s): Q684I9, Q8VH53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health