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Q8BSL7

- ARF2_MOUSE

UniProt

Q8BSL7 - ARF2_MOUSE

Protein

ADP-ribosylation factor 2

Gene

Arf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi67 – 715GTPBy similarity
    Nucleotide bindingi126 – 1294GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: MGI

    GO - Biological processi

    1. protein transport Source: MGI
    2. small GTPase mediated signal transduction Source: InterPro
    3. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor 2
    Gene namesi
    Name:Arf2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:99595. Arf2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 181180ADP-ribosylation factor 2PRO_0000207384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    PaxDbiQ8BSL7.
    PRIDEiQ8BSL7.

    PTM databases

    PhosphoSiteiQ8BSL7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BSL7.
    BgeeiQ8BSL7.
    CleanExiMM_ARF2.
    GenevestigatoriQ8BSL7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8BSL7. 1 interaction.

    Structurei

    Secondary structure

    1
    181
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi18 – 236
    Helixi30 – 3910
    Beta strandi49 – 5810
    Beta strandi61 – 688
    Helixi72 – 8110
    Beta strandi87 – 937
    Helixi97 – 993
    Helixi100 – 11112
    Helixi114 – 1163
    Beta strandi120 – 1267
    Helixi136 – 1438
    Helixi145 – 1473
    Beta strandi153 – 1575
    Turni160 – 1634
    Helixi166 – 17813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J2JX-ray1.60A18-181[»]
    ProteinModelPortaliQ8BSL7.
    SMRiQ8BSL7. Positions 18-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8BSL7.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00720000108501.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    InParanoidiQ8BSL7.
    KOiK06883.
    OMAiWLANILK.
    OrthoDBiEOG77WWDV.
    PhylomeDBiQ8BSL7.
    TreeFamiTF300808.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8BSL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNVFEKLFK SLFGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG    50
    FNVETVEYKN ISFTVWDVGG QDKIRPLWRH YFQNTQGLIF VVDSNDRERV 100
    NEAREELTRM LAEDELRDAV LLVFVNKQDL PNAMNAAEIT DKLGLHSLRQ 150
    RNWYIQATCA TSGDGLYEGL DWLSNQLKNQ K 181
    Length:181
    Mass (Da):20,746
    Last modified:August 16, 2004 - v2
    Checksum:i95BE17A962B83016
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 552ET → GH in AAH10487. (PubMed:15489334)Curated
    Sequence conflicti154 – 1541Y → N in BAC27325. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87899 mRNA. Translation: BAA13491.1.
    AK031259 mRNA. Translation: BAC27325.1.
    AK042977 mRNA. Translation: BAC31426.1.
    AK053123 mRNA. Translation: BAC35273.1.
    AK077591 mRNA. Translation: BAC36882.1.
    AK167133 mRNA. Translation: BAE39279.1.
    AK167601 mRNA. Translation: BAE39658.1.
    AK167653 mRNA. Translation: BAE39704.1.
    AK169094 mRNA. Translation: BAE40877.1.
    AK169412 mRNA. Translation: BAE41158.1.
    BC010487 mRNA. Translation: AAH10487.1.
    CCDSiCCDS25525.1.
    PIRiJC4946.
    RefSeqiNP_031503.1. NM_007477.4.
    XP_006532106.1. XM_006532043.1.
    UniGeneiMm.5061.

    Genome annotation databases

    EnsembliENSMUST00000057921; ENSMUSP00000051814; ENSMUSG00000062421.
    ENSMUST00000063347; ENSMUSP00000102622; ENSMUSG00000062421.
    GeneIDi11841.
    KEGGimmu:11841.
    UCSCiuc007lvx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87899 mRNA. Translation: BAA13491.1 .
    AK031259 mRNA. Translation: BAC27325.1 .
    AK042977 mRNA. Translation: BAC31426.1 .
    AK053123 mRNA. Translation: BAC35273.1 .
    AK077591 mRNA. Translation: BAC36882.1 .
    AK167133 mRNA. Translation: BAE39279.1 .
    AK167601 mRNA. Translation: BAE39658.1 .
    AK167653 mRNA. Translation: BAE39704.1 .
    AK169094 mRNA. Translation: BAE40877.1 .
    AK169412 mRNA. Translation: BAE41158.1 .
    BC010487 mRNA. Translation: AAH10487.1 .
    CCDSi CCDS25525.1.
    PIRi JC4946.
    RefSeqi NP_031503.1. NM_007477.4.
    XP_006532106.1. XM_006532043.1.
    UniGenei Mm.5061.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J2J X-ray 1.60 A 18-181 [» ]
    ProteinModelPortali Q8BSL7.
    SMRi Q8BSL7. Positions 18-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8BSL7. 1 interaction.

    PTM databases

    PhosphoSitei Q8BSL7.

    Proteomic databases

    PaxDbi Q8BSL7.
    PRIDEi Q8BSL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057921 ; ENSMUSP00000051814 ; ENSMUSG00000062421 .
    ENSMUST00000063347 ; ENSMUSP00000102622 ; ENSMUSG00000062421 .
    GeneIDi 11841.
    KEGGi mmu:11841.
    UCSCi uc007lvx.1. mouse.

    Organism-specific databases

    CTDi 11841.
    MGIi MGI:99595. Arf2.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00720000108501.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    InParanoidi Q8BSL7.
    KOi K06883.
    OMAi WLANILK.
    OrthoDBi EOG77WWDV.
    PhylomeDBi Q8BSL7.
    TreeFami TF300808.

    Miscellaneous databases

    ChiTaRSi ARF2. mouse.
    EvolutionaryTracei Q8BSL7.
    NextBioi 20806307.
    PROi Q8BSL7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BSL7.
    Bgeei Q8BSL7.
    CleanExi MM_ARF2.
    Genevestigatori Q8BSL7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)."
      Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K.
      J. Biochem. 120:813-819(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Cerebellum, Embryo, Forelimb, Heart, Lung and Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    4. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 39-59 AND 80-97, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiARF2_MOUSE
    AccessioniPrimary (citable) accession number: Q8BSL7
    Secondary accession number(s): P10947
    , P16500, Q3TJ37, Q91VR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3