Reviewed, UniProtKB/Swiss-Prot Q8BSF4 (PISD_MOUSE)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:

Pisd

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2.
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.
Subunit structure	Heterodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Phosphatidylserine decarboxylase beta chain		PRO_0000029837
	Chain	375 – 406	32	Phosphatidylserine decarboxylase alpha chain		PRO_0000029838
Sites
	Site	374 – 375	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	375	1	Pyruvic acid (Ser) By similarity
Experimental info
	Sequence conflict	338 – 340	3	SPR → KPK in BAC28786. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8BSF4-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6614312FA8BA9704	FASTA	406	45,927
	10 20 30 40 50 60 MAASGGRACV RSLRGGVLWR SSPCHYESTA TRHFLGTLQK LPLQAGVRNF HTAPVRSLFL 70 80 90 100 110 120 LRPVPILLAT GGGYAGYRQY EKYRERKLEK LGLEIPPKLA SHWEVSLYKS VPTRLLSRAC 130 140 150 160 170 180 GRLNQVELPY WLRRPVYSLY IWTFGVNMTE AAVEDLHHYR NLSEFFRRKL KPQARPVCGL 190 200 210 220 230 240 HCVTSPSDGK ILTFGQVKNS EVEQVKGVTY SLESFLGPRA NTEDLPFPPA SSSDSFRNQL 250 260 270 280 290 300 VTREGNELYH CVIYLAPGDY HCFHSPTDWT ISHRRHFPGS LMSVNPGMAR WIKELFCHNE 310 320 330 340 350 360 RVVLTGDWKH GFFSLTAVGA TNVGSIRIHF DRDLHTNSPR YSKGSYNDLS FVTHANKEGI 370 380 390 400 PMRKGEPLGE FNLGSTIVLI FEAPKDFNFR LKAGQKIRFG EALGSL

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Colon.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK033483 mRNA. Translation: BAC28313.1. AK034656 mRNA. Translation: BAC28786.1. BC070408 mRNA. Translation: AAH70408.1.
IPI	IPI00310099.
RefSeq	NP_796272.2.
UniGene	Mm.273765
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BSF4.
Proteomic databases
PRIDE	Q8BSF4.
Genome annotation databases
Ensembl	ENSMUST00000061895; ENSMUSP00000051438; ENSMUSG00000023452; Mus musculus. [Genome view]
GeneID	320951.
KEGG	mmu:320951.
UCSC	uc008wzv.1. mouse.
Organism-specific databases
CTD	320951.
MGI	MGI:2445114. Pisd.
Phylogenomic databases
HOGENOM	Q8BSF4.
HOVERGEN	Q8BSF4.
OMA	CLNERVV.
Enzyme and pathway databases
BRENDA	4.1.1.65. 244.
Gene expression databases
ArrayExpress	Q8BSF4.
Bgee	Q8BSF4.
CleanEx	MM_PISD.
Genevestigator	Q8BSF4.
GermOnline	ENSMUSG00000023452. Mus musculus.
Family and domain databases
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	397752.
SOURCE	Search...

Entry information

Entry name

PISD_MOUSE

Accession

Primary (citable) accession number: Q8BSF4
Secondary accession number(s): Q8BSD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)