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Q8BSD4

- CXD4_MOUSE

UniProt

Q8BSD4 - CXD4_MOUSE

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Protein
Gap junction delta-4 protein
Gene
Gjd4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

GO - Biological processi

  1. cell communication Source: InterPro
  2. regulation of satellite cell activation involved in skeletal muscle regeneration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-39
Short name:
Cx39
Gene namesi
Name:Gjd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2444990. Gjd4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei20 – 4021Helical; Reviewed prediction
Add
BLAST
Topological domaini41 – 7636Extracellular Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 12831Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Reviewed prediction
Add
BLAST
Topological domaini150 – 17324Extracellular Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Topological domaini195 – 364170Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Gap junction delta-4 protein
PRO_0000313011Add
BLAST

Proteomic databases

PaxDbiQ8BSD4.
PRIDEiQ8BSD4.

PTM databases

PhosphoSiteiQ8BSD4.

Expressioni

Gene expression databases

BgeeiQ8BSD4.
CleanExiMM_GJD4.
GenevestigatoriQ8BSD4.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8BSD4.
SMRiQ8BSD4. Positions 14-200.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39258.
GeneTreeiENSGT00640000091490.
HOGENOMiHOG000112113.
HOVERGENiHBG062544.
InParanoidiB2RQL7.
KOiK07630.
OMAiPIYEDEQ.
OrthoDBiEOG78PV9Q.
PhylomeDBiQ8BSD4.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BSD4-1 [UniParc]FASTAAdd to Basket

« Hide

MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE    50
RFICNTLQPG CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG 100
AKLAAVGGAC RPQVPDLSTA YLVHLLLRML LEAGLAFLHY FLFGFSVPAR 150
VSCSHVPCSG AVDCYVSRPT EKSLLILFFW AVSALSFLLS LADLLWILPR 200
RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV DQEDRQEEQV 250
VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT 300
AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS 350
GSAPHLRTKK SEWV 364
Length:364
Mass (Da):40,042
Last modified:March 1, 2003 - v1
Checksum:iFA58BCCFB1E6B758
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981L → P in BAC35240. 1 Publication
Sequence conflicti222 – 2221A → T in BAC35240. 1 Publication
Sequence conflicti345 – 3451C → G in CAC93844. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSiCCDS29049.1.
RefSeqiNP_694726.2. NM_153086.5.
XP_006525871.1. XM_006525808.1.
UniGeneiMm.119273.

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneIDi225152.
KEGGimmu:225152.
UCSCiuc008eah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414562 mRNA. Translation: CAC93844.1 .
AK034663 mRNA. Translation: BAC28788.1 .
AK053016 mRNA. Translation: BAC35240.1 .
BC137984 mRNA. Translation: AAI37985.1 .
CCDSi CCDS29049.1.
RefSeqi NP_694726.2. NM_153086.5.
XP_006525871.1. XM_006525808.1.
UniGenei Mm.119273.

3D structure databases

ProteinModelPortali Q8BSD4.
SMRi Q8BSD4. Positions 14-200.
ModBasei Search...

PTM databases

PhosphoSitei Q8BSD4.

Proteomic databases

PaxDbi Q8BSD4.
PRIDEi Q8BSD4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000041007 ; ENSMUSP00000035472 ; ENSMUSG00000036855 .
GeneIDi 225152.
KEGGi mmu:225152.
UCSCi uc008eah.1. mouse.

Organism-specific databases

CTDi 219770.
MGIi MGI:2444990. Gjd4.

Phylogenomic databases

eggNOGi NOG39258.
GeneTreei ENSGT00640000091490.
HOGENOMi HOG000112113.
HOVERGENi HBG062544.
InParanoidi B2RQL7.
KOi K07630.
OMAi PIYEDEQ.
OrthoDBi EOG78PV9Q.
PhylomeDBi Q8BSD4.
TreeFami TF329606.

Miscellaneous databases

NextBioi 377549.
PROi Q8BSD4.
SOURCEi Search...

Gene expression databases

Bgeei Q8BSD4.
CleanExi MM_GJD4.
Genevestigatori Q8BSD4.

Family and domain databases

InterProi IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional diversity of connexin genes in the mouse and human genome."
    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
    Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCXD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BSD4
Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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