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Q8BSD4

- CXD4_MOUSE

UniProt

Q8BSD4 - CXD4_MOUSE

Protein

Gap junction delta-4 protein

Gene

Gjd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

    GO - Biological processi

    1. cell communication Source: InterPro
    2. regulation of satellite cell activation involved in skeletal muscle regeneration Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction delta-4 protein
    Alternative name(s):
    Connexin-39
    Short name:
    Cx39
    Gene namesi
    Name:Gjd4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2444990. Gjd4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Gap junction delta-4 proteinPRO_0000313011Add
    BLAST

    Proteomic databases

    PaxDbiQ8BSD4.
    PRIDEiQ8BSD4.

    PTM databases

    PhosphoSiteiQ8BSD4.

    Expressioni

    Gene expression databases

    BgeeiQ8BSD4.
    CleanExiMM_GJD4.
    GenevestigatoriQ8BSD4.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BSD4.
    SMRiQ8BSD4. Positions 14-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 12831CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 17324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini195 – 364170CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Delta-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39258.
    GeneTreeiENSGT00640000091490.
    HOGENOMiHOG000112113.
    HOVERGENiHBG062544.
    InParanoidiB2RQL7.
    KOiK07630.
    OMAiPIYEDEQ.
    OrthoDBiEOG78PV9Q.
    PhylomeDBiQ8BSD4.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BSD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE    50
    RFICNTLQPG CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG 100
    AKLAAVGGAC RPQVPDLSTA YLVHLLLRML LEAGLAFLHY FLFGFSVPAR 150
    VSCSHVPCSG AVDCYVSRPT EKSLLILFFW AVSALSFLLS LADLLWILPR 200
    RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV DQEDRQEEQV 250
    VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT 300
    AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS 350
    GSAPHLRTKK SEWV 364
    Length:364
    Mass (Da):40,042
    Last modified:March 1, 2003 - v1
    Checksum:iFA58BCCFB1E6B758
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981L → P in BAC35240. (PubMed:16141072)Curated
    Sequence conflicti222 – 2221A → T in BAC35240. (PubMed:16141072)Curated
    Sequence conflicti345 – 3451C → G in CAC93844. (PubMed:12108537)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ414562 mRNA. Translation: CAC93844.1.
    AK034663 mRNA. Translation: BAC28788.1.
    AK053016 mRNA. Translation: BAC35240.1.
    BC137984 mRNA. Translation: AAI37985.1.
    CCDSiCCDS29049.1.
    RefSeqiNP_694726.2. NM_153086.5.
    XP_006525871.1. XM_006525808.1.
    UniGeneiMm.119273.

    Genome annotation databases

    EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
    GeneIDi225152.
    KEGGimmu:225152.
    UCSCiuc008eah.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ414562 mRNA. Translation: CAC93844.1 .
    AK034663 mRNA. Translation: BAC28788.1 .
    AK053016 mRNA. Translation: BAC35240.1 .
    BC137984 mRNA. Translation: AAI37985.1 .
    CCDSi CCDS29049.1.
    RefSeqi NP_694726.2. NM_153086.5.
    XP_006525871.1. XM_006525808.1.
    UniGenei Mm.119273.

    3D structure databases

    ProteinModelPortali Q8BSD4.
    SMRi Q8BSD4. Positions 14-200.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BSD4.

    Proteomic databases

    PaxDbi Q8BSD4.
    PRIDEi Q8BSD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041007 ; ENSMUSP00000035472 ; ENSMUSG00000036855 .
    GeneIDi 225152.
    KEGGi mmu:225152.
    UCSCi uc008eah.1. mouse.

    Organism-specific databases

    CTDi 219770.
    MGIi MGI:2444990. Gjd4.

    Phylogenomic databases

    eggNOGi NOG39258.
    GeneTreei ENSGT00640000091490.
    HOGENOMi HOG000112113.
    HOVERGENi HBG062544.
    InParanoidi B2RQL7.
    KOi K07630.
    OMAi PIYEDEQ.
    OrthoDBi EOG78PV9Q.
    PhylomeDBi Q8BSD4.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 377549.
    PROi Q8BSD4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8BSD4.
    CleanExi MM_GJD4.
    Genevestigatori Q8BSD4.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional diversity of connexin genes in the mouse and human genome."
      Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
      Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCXD4_MOUSE
    AccessioniPrimary (citable) accession number: Q8BSD4
    Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3