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Protein

Gap junction delta-4 protein

Gene

Gjd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

  • cell communication Source: InterPro
  • regulation of satellite cell activation involved in skeletal muscle regeneration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-39
Short name:
Cx39
Gene namesi
Name:Gjd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444990. Gjd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 128CytoplasmicSequence analysisAdd BLAST31
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 173ExtracellularSequence analysisAdd BLAST24
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 364CytoplasmicSequence analysisAdd BLAST170

GO - Cellular componenti

  • connexin complex Source: InterPro
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130111 – 364Gap junction delta-4 proteinAdd BLAST364

Proteomic databases

PaxDbiQ8BSD4.
PRIDEiQ8BSD4.

PTM databases

PhosphoSitePlusiQ8BSD4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036855.
CleanExiMM_GJD4.
GenevisibleiQ8BSD4. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035472.

Structurei

3D structure databases

ProteinModelPortaliQ8BSD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEKW. Eukaryota.
ENOG4111ING. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000112113.
HOVERGENiHBG062544.
InParanoidiQ8BSD4.
KOiK07630.
OMAiLRTTQWV.
OrthoDBiEOG091G0GK6.
PhylomeDBiQ8BSD4.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 2 hits.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BSD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE
60 70 80 90 100
RFICNTLQPG CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG
110 120 130 140 150
AKLAAVGGAC RPQVPDLSTA YLVHLLLRML LEAGLAFLHY FLFGFSVPAR
160 170 180 190 200
VSCSHVPCSG AVDCYVSRPT EKSLLILFFW AVSALSFLLS LADLLWILPR
210 220 230 240 250
RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV DQEDRQEEQV
260 270 280 290 300
VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT
310 320 330 340 350
AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS
360
GSAPHLRTKK SEWV
Length:364
Mass (Da):40,042
Last modified:March 1, 2003 - v1
Checksum:iFA58BCCFB1E6B758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → P in BAC35240 (PubMed:16141072).Curated1
Sequence conflicti222A → T in BAC35240 (PubMed:16141072).Curated1
Sequence conflicti345C → G in CAC93844 (PubMed:12108537).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSiCCDS29049.1.
RefSeqiNP_694726.2. NM_153086.5.
UniGeneiMm.119273.

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneIDi225152.
KEGGimmu:225152.
UCSCiuc008eah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSiCCDS29049.1.
RefSeqiNP_694726.2. NM_153086.5.
UniGeneiMm.119273.

3D structure databases

ProteinModelPortaliQ8BSD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035472.

PTM databases

PhosphoSitePlusiQ8BSD4.

Proteomic databases

PaxDbiQ8BSD4.
PRIDEiQ8BSD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneIDi225152.
KEGGimmu:225152.
UCSCiuc008eah.1. mouse.

Organism-specific databases

CTDi219770.
MGIiMGI:2444990. Gjd4.

Phylogenomic databases

eggNOGiENOG410IEKW. Eukaryota.
ENOG4111ING. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000112113.
HOVERGENiHBG062544.
InParanoidiQ8BSD4.
KOiK07630.
OMAiLRTTQWV.
OrthoDBiEOG091G0GK6.
PhylomeDBiQ8BSD4.
TreeFamiTF329606.

Miscellaneous databases

PROiQ8BSD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036855.
CleanExiMM_GJD4.
GenevisibleiQ8BSD4. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 2 hits.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BSD4
Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.