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Protein

Gap junction delta-4 protein

Gene

Gjd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

  1. cell communication Source: InterPro
  2. regulation of satellite cell activation involved in skeletal muscle regeneration Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-39
Short name:
Cx39
Gene namesi
Name:Gjd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2444990. Gjd4.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 12831CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Topological domaini150 – 17324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Topological domaini195 – 364170CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Gap junction delta-4 proteinPRO_0000313011Add
BLAST

Proteomic databases

PaxDbiQ8BSD4.
PRIDEiQ8BSD4.

PTM databases

PhosphoSiteiQ8BSD4.

Expressioni

Gene expression databases

BgeeiQ8BSD4.
CleanExiMM_GJD4.
GenevestigatoriQ8BSD4.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BSD4.
SMRiQ8BSD4. Positions 14-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39258.
GeneTreeiENSGT00780000121881.
HOGENOMiHOG000112113.
HOVERGENiHBG062544.
InParanoidiQ8BSD4.
KOiK07630.
OMAiLRTTQWV.
OrthoDBiEOG78PV9Q.
PhylomeDBiQ8BSD4.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BSD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE
60 70 80 90 100
RFICNTLQPG CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG
110 120 130 140 150
AKLAAVGGAC RPQVPDLSTA YLVHLLLRML LEAGLAFLHY FLFGFSVPAR
160 170 180 190 200
VSCSHVPCSG AVDCYVSRPT EKSLLILFFW AVSALSFLLS LADLLWILPR
210 220 230 240 250
RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV DQEDRQEEQV
260 270 280 290 300
VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT
310 320 330 340 350
AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS
360
GSAPHLRTKK SEWV
Length:364
Mass (Da):40,042
Last modified:February 28, 2003 - v1
Checksum:iFA58BCCFB1E6B758
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981L → P in BAC35240 (PubMed:16141072).Curated
Sequence conflicti222 – 2221A → T in BAC35240 (PubMed:16141072).Curated
Sequence conflicti345 – 3451C → G in CAC93844 (PubMed:12108537).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSiCCDS29049.1.
RefSeqiNP_694726.2. NM_153086.5.
UniGeneiMm.119273.

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneIDi225152.
KEGGimmu:225152.
UCSCiuc008eah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSiCCDS29049.1.
RefSeqiNP_694726.2. NM_153086.5.
UniGeneiMm.119273.

3D structure databases

ProteinModelPortaliQ8BSD4.
SMRiQ8BSD4. Positions 14-200.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BSD4.

Proteomic databases

PaxDbiQ8BSD4.
PRIDEiQ8BSD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneIDi225152.
KEGGimmu:225152.
UCSCiuc008eah.1. mouse.

Organism-specific databases

CTDi219770.
MGIiMGI:2444990. Gjd4.

Phylogenomic databases

eggNOGiNOG39258.
GeneTreeiENSGT00780000121881.
HOGENOMiHOG000112113.
HOVERGENiHBG062544.
InParanoidiQ8BSD4.
KOiK07630.
OMAiLRTTQWV.
OrthoDBiEOG78PV9Q.
PhylomeDBiQ8BSD4.
TreeFamiTF329606.

Miscellaneous databases

NextBioi377549.
PROiQ8BSD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BSD4.
CleanExiMM_GJD4.
GenevestigatoriQ8BSD4.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional diversity of connexin genes in the mouse and human genome."
    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
    Biol. Chem. 383:725-737(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCXD4_MOUSE
AccessioniPrimary (citable) accession number: Q8BSD4
Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 14, 2008
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.