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Q8BSD4 (CXD4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction delta-4 protein
Alternative name(s):
Connexin-39
Short name=Cx39
Gene names
Name:Gjd4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

Subunit structure

A connexon is composed of a hexamer of connexins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity.

Sequence similarities

Belongs to the connexin family. Delta-type subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Gap junction delta-4 protein
PRO_0000313011

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 7636Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 12831Cytoplasmic Potential
Transmembrane129 – 14921Helical; Potential
Topological domain150 – 17324Extracellular Potential
Transmembrane174 – 19421Helical; Potential
Topological domain195 – 364170Cytoplasmic Potential

Experimental info

Sequence conflict1981L → P in BAC35240. Ref.2
Sequence conflict2221A → T in BAC35240. Ref.2
Sequence conflict3451C → G in CAC93844. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BSD4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: FA58BCCFB1E6B758

FASTA36440,042
        10         20         30         40         50         60 
MEKLNLLGFL IITLNCNVTI MGMIWLIVEV LLRMLVVVLA GSPIYEDEQE RFICNTLQPG 

        70         80         90        100        110        120 
CANVCYDLFS PVSPLRFWLV QSLALLLPSV VFGTYTLHRG AKLAAVGGAC RPQVPDLSTA 

       130        140        150        160        170        180 
YLVHLLLRML LEAGLAFLHY FLFGFSVPAR VSCSHVPCSG AVDCYVSRPT EKSLLILFFW 

       190        200        210        220        230        240 
AVSALSFLLS LADLLWILPR RKTLRTTQWV NGEARPVCEV PAPPPCLLQN PQGYLSQGQV 

       250        260        270        280        290        300 
DQEDRQEEQV VPEFPCMWTA GQSDNSNVGQ ACVSGLLEHS DQDASEATSS AGDRLTVAHT 

       310        320        330        340        350        360 
AHELRFHRET SLDLGGKNTQ ADELSLATQS HLARHSSASK PQAPCRLTTS GSAPHLRTKK 


SEWV 

« Hide

References

« Hide 'large scale' references
[1]"Structural and functional diversity of connexin genes in the mouse and human genome."
Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ414562 mRNA. Translation: CAC93844.1.
AK034663 mRNA. Translation: BAC28788.1.
AK053016 mRNA. Translation: BAC35240.1.
BC137984 mRNA. Translation: AAI37985.1.
CCDSCCDS29049.1.
RefSeqNP_694726.2. NM_153086.5.
XP_006525871.1. XM_006525808.1.
UniGeneMm.119273.

3D structure databases

ProteinModelPortalQ8BSD4.
SMRQ8BSD4. Positions 14-200.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BSD4.

Proteomic databases

PaxDbQ8BSD4.
PRIDEQ8BSD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041007; ENSMUSP00000035472; ENSMUSG00000036855.
GeneID225152.
KEGGmmu:225152.
UCSCuc008eah.1. mouse.

Organism-specific databases

CTD219770.
MGIMGI:2444990. Gjd4.

Phylogenomic databases

eggNOGNOG39258.
GeneTreeENSGT00640000091490.
HOGENOMHOG000112113.
HOVERGENHBG062544.
InParanoidB2RQL7.
KOK07630.
OMAPIYEDEQ.
OrthoDBEOG78PV9Q.
PhylomeDBQ8BSD4.
TreeFamTF329606.

Gene expression databases

BgeeQ8BSD4.
CleanExMM_GJD4.
GenevestigatorQ8BSD4.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio377549.
PROQ8BSD4.
SOURCESearch...

Entry information

Entry nameCXD4_MOUSE
AccessionPrimary (citable) accession number: Q8BSD4
Secondary accession number(s): B2RQL7, Q8C6W6, Q91YD0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot