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Protein

tRNA wybutosine-synthesizing protein 3 homolog

Gene

Tyw3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + 7-((3S)-(3-amino-3-carboxypropyl))-4-demethylwyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-(3-amino-3-carboxypropyl))wyosine(37) in tRNA(Phe).

Pathwayi: wybutosine-tRNA(Phe) biosynthesis

This protein is involved in the pathway wybutosine-tRNA(Phe) biosynthesis, which is part of tRNA modification.
View all proteins of this organism that are known to be involved in the pathway wybutosine-tRNA(Phe) biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00375.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA wybutosine-synthesizing protein 3 homolog (EC:2.1.1.282)
Short name:
tRNA-yW-synthesizing protein 3
Alternative name(s):
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
Gene namesi
Name:Tyw3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2445040. Tyw3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818431 – 257tRNA wybutosine-synthesizing protein 3 homologAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BSA9.
MaxQBiQ8BSA9.
PaxDbiQ8BSA9.
PRIDEiQ8BSA9.

PTM databases

iPTMnetiQ8BSA9.
PhosphoSitePlusiQ8BSA9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047583.
ExpressionAtlasiQ8BSA9. baseline and differential.
GenevisibleiQ8BSA9. MM.

Interactioni

Protein-protein interaction databases

BioGridi229093. 9 interactors.
IntActiQ8BSA9. 9 interactors.
STRINGi10090.ENSMUSP00000057828.

Structurei

3D structure databases

ProteinModelPortaliQ8BSA9.
SMRiQ8BSA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TYW3 family.Curated

Phylogenomic databases

eggNOGiKOG1228. Eukaryota.
COG1590. LUCA.
GeneTreeiENSGT00390000018149.
HOGENOMiHOG000007205.
HOVERGENiHBG106708.
InParanoidiQ8BSA9.
KOiK15450.
OMAiGKWHHYA.
OrthoDBiEOG091G0KHY.
PhylomeDBiQ8BSA9.
TreeFamiTF329327.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
InterProiIPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BSA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAEFGRW KAQSLSKADL SRKGSVDEDA VEVVELLNSR EEFFTTSSCA
60 70 80 90 100
GRILLLDGST EGSGVQKQHC CWLLVTHKPC ARDDVMAALK GATSEAVLKF
110 120 130 140 150
EPFILHVQCR TLQDAQTLHS VAIDSGFRNS GITVGKRGKT MLAVRGTHGL
160 170 180 190 200
EVPLTHKGKL MVTEEYIEFL LTIANQKMEE NKRRIGRFYN YLQHALKRET
210 220 230 240 250
ISNSHSKIKE RNNPLCTHKN RRSQGKAQGP STTEDNGREL EDGDGLEISA

ALFLGDD
Length:257
Mass (Da):28,575
Last modified:March 1, 2003 - v1
Checksum:i03A9EEC6296F19D3
GO

Sequence cautioni

The sequence BAC26913 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030344 mRNA. Translation: BAC26913.1. Different initiation.
AK034820 mRNA. Translation: BAC28842.1.
BC086686 mRNA. Translation: AAH86686.1.
BC087879 mRNA. Translation: AAH87879.1.
CCDSiCCDS38680.1.
RefSeqiNP_766062.1. NM_172474.5.
UniGeneiMm.347513.

Genome annotation databases

EnsembliENSMUST00000052774; ENSMUSP00000057828; ENSMUSG00000047583.
GeneIDi209584.
KEGGimmu:209584.
UCSCiuc008ruo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK030344 mRNA. Translation: BAC26913.1. Different initiation.
AK034820 mRNA. Translation: BAC28842.1.
BC086686 mRNA. Translation: AAH86686.1.
BC087879 mRNA. Translation: AAH87879.1.
CCDSiCCDS38680.1.
RefSeqiNP_766062.1. NM_172474.5.
UniGeneiMm.347513.

3D structure databases

ProteinModelPortaliQ8BSA9.
SMRiQ8BSA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229093. 9 interactors.
IntActiQ8BSA9. 9 interactors.
STRINGi10090.ENSMUSP00000057828.

PTM databases

iPTMnetiQ8BSA9.
PhosphoSitePlusiQ8BSA9.

Proteomic databases

EPDiQ8BSA9.
MaxQBiQ8BSA9.
PaxDbiQ8BSA9.
PRIDEiQ8BSA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052774; ENSMUSP00000057828; ENSMUSG00000047583.
GeneIDi209584.
KEGGimmu:209584.
UCSCiuc008ruo.2. mouse.

Organism-specific databases

CTDi127253.
MGIiMGI:2445040. Tyw3.

Phylogenomic databases

eggNOGiKOG1228. Eukaryota.
COG1590. LUCA.
GeneTreeiENSGT00390000018149.
HOGENOMiHOG000007205.
HOVERGENiHBG106708.
InParanoidiQ8BSA9.
KOiK15450.
OMAiGKWHHYA.
OrthoDBiEOG091G0KHY.
PhylomeDBiQ8BSA9.
TreeFamiTF329327.

Enzyme and pathway databases

UniPathwayiUPA00375.

Miscellaneous databases

PROiQ8BSA9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047583.
ExpressionAtlasiQ8BSA9. baseline and differential.
GenevisibleiQ8BSA9. MM.

Family and domain databases

Gene3Di3.30.1960.10. 1 hit.
InterProiIPR003827. tRNA_yW-synthesising.
[Graphical view]
PfamiPF02676. TYW3. 1 hit.
[Graphical view]
SUPFAMiSSF111278. SSF111278. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTYW3_MOUSE
AccessioniPrimary (citable) accession number: Q8BSA9
Secondary accession number(s): Q8BSX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.