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Q8BS95

- GPHR_MOUSE

UniProt

Q8BS95 - GPHR_MOUSE

Protein

Golgi pH regulator

Gene

Gpr89a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

    GO - Molecular functioni

    1. voltage-gated anion channel activity Source: UniProtKB

    GO - Biological processi

    1. intracellular pH reduction Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. regulation of anion transport Source: GOC
    4. skin development Source: MGI

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi pH regulator
    Alternative name(s):
    Protein GPR89
    Gene namesi
    Name:Gpr89a
    Synonyms:Gphr, Gpr89
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1914799. Gpr89.

    Subcellular locationi

    Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
    Note: Detected at low levels in lysosomes and endosomes.By similarity

    GO - Cellular componenti

    1. Golgi-associated vesicle membrane Source: UniProtKB
    2. Golgi cisterna membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Golgi pH regulatorPRO_0000223261Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8BS95.
    PRIDEiQ8BS95.

    PTM databases

    PhosphoSiteiQ8BS95.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8BS95.
    BgeeiQ8BS95.
    CleanExiMM_GPR89.
    GenevestigatoriQ8BS95.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8BS95.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295277.
    GeneTreeiENSGT00390000000684.
    HOGENOMiHOG000240999.
    HOVERGENiHBG054909.
    InParanoidiQ8BS95.
    OMAiLLMRMSM.
    OrthoDBiEOG7HHWRV.
    PhylomeDBiQ8BS95.
    TreeFamiTF313484.

    Family and domain databases

    InterProiIPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view]
    PANTHERiPTHR15948. PTHR15948. 1 hit.
    PfamiPF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8BS95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEVRQYVV QVIFSVTFAF    50
    SCTMFELIIF EILGVLNSSS RYFHWKLNLC VILLILVFMV PFYIGYFIVS 100
    NIQLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV 150
    GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI 200
    ISKKKRMAVA RRTMFQRGDV QNKPSGLWGM LKSVTASAPG SENLTLIQQE 250
    VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 300
    IFMATINIVL DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI 350
    IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM 400
    SMPPEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE 450
    KHMAP 455
    Length:455
    Mass (Da):52,735
    Last modified:February 7, 2006 - v2
    Checksum:iCAE9B93C64262252
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431N → H in BAC28872. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034895 mRNA. Translation: BAC28872.1.
    AK016787 mRNA. Translation: BAB30430.1.
    BC010729 mRNA. Translation: AAH10729.1.
    CCDSiCCDS17650.1.
    RefSeqiNP_080505.1. NM_026229.4.
    UniGeneiMm.46722.

    Genome annotation databases

    EnsembliENSMUST00000029738; ENSMUSP00000029738; ENSMUSG00000028096.
    GeneIDi67549.
    KEGGimmu:67549.
    UCSCiuc008qom.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK034895 mRNA. Translation: BAC28872.1 .
    AK016787 mRNA. Translation: BAB30430.1 .
    BC010729 mRNA. Translation: AAH10729.1 .
    CCDSi CCDS17650.1.
    RefSeqi NP_080505.1. NM_026229.4.
    UniGenei Mm.46722.

    3D structure databases

    ProteinModelPortali Q8BS95.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8BS95.

    Proteomic databases

    PaxDbi Q8BS95.
    PRIDEi Q8BS95.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029738 ; ENSMUSP00000029738 ; ENSMUSG00000028096 .
    GeneIDi 67549.
    KEGGi mmu:67549.
    UCSCi uc008qom.1. mouse.

    Organism-specific databases

    CTDi 67549.
    MGIi MGI:1914799. Gpr89.

    Phylogenomic databases

    eggNOGi NOG295277.
    GeneTreei ENSGT00390000000684.
    HOGENOMi HOG000240999.
    HOVERGENi HBG054909.
    InParanoidi Q8BS95.
    OMAi LLMRMSM.
    OrthoDBi EOG7HHWRV.
    PhylomeDBi Q8BS95.
    TreeFami TF313484.

    Miscellaneous databases

    NextBioi 324888.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8BS95.
    Bgeei Q8BS95.
    CleanExi MM_GPR89.
    Genevestigatori Q8BS95.

    Family and domain databases

    InterProi IPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view ]
    PANTHERi PTHR15948. PTHR15948. 1 hit.
    Pfami PF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiGPHR_MOUSE
    AccessioniPrimary (citable) accession number: Q8BS95
    Secondary accession number(s): Q9D455
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3