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Q8BS95 (GPHR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgi pH regulator
Alternative name(s):
Protein GPR89
Gene names
Name:Gpr89a
Synonyms:Gphr, Gpr89
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance By similarity.

Subunit structure

Homotrimer By similarity.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity. Note: Detected at low levels in lysosomes and endosomes By similarity.

Sequence similarities

Belongs to the Golgi pH regulator (TC 1.A.38) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Golgi pH regulator
PRO_0000223261

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane343 – 36321Helical; Potential
Transmembrane378 – 39821Helical; Potential
Transmembrane425 – 44521Helical; Potential

Amino acid modifications

Glycosylation1801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2431N → H in BAC28872. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8BS95 [UniParc].

Last modified February 7, 2006. Version 2.
Checksum: CAE9B93C64262252

FASTA45552,735
        10         20         30         40         50         60 
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEVRQYVV QVIFSVTFAF SCTMFELIIF 

        70         80         90        100        110        120 
EILGVLNSSS RYFHWKLNLC VILLILVFMV PFYIGYFIVS NIQLLHKQRL LFSCLLWLTF 

       130        140        150        160        170        180 
MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN 

       190        200        210        220        230        240 
VTDTDILALE RRLLQTMDMI ISKKKRMAVA RRTMFQRGDV QNKPSGLWGM LKSVTASAPG 

       250        260        270        280        290        300 
SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 

       310        320        330        340        350        360 
IFMATINIVL DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL 

       370        380        390        400        410        420 
ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPPEYRTII TEVLGELQFN 

       430        440        450 
FYHRWFDVIF LVSALSSILF LYLAHKQAPE KHMAP 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK034895 mRNA. Translation: BAC28872.1.
AK016787 mRNA. Translation: BAB30430.1.
BC010729 mRNA. Translation: AAH10729.1.
CCDSCCDS17650.1.
RefSeqNP_080505.1. NM_026229.4.
UniGeneMm.46722.

3D structure databases

ProteinModelPortalQ8BS95.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8BS95.

Proteomic databases

PaxDbQ8BS95.
PRIDEQ8BS95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029738; ENSMUSP00000029738; ENSMUSG00000028096.
GeneID67549.
KEGGmmu:67549.
UCSCuc008qom.1. mouse.

Organism-specific databases

CTD67549.
MGIMGI:1914799. Gpr89.

Phylogenomic databases

eggNOGNOG295277.
GeneTreeENSGT00390000000684.
HOGENOMHOG000240999.
HOVERGENHBG054909.
InParanoidQ8BS95.
OMALLMRMSM.
OrthoDBEOG7HHWRV.
PhylomeDBQ8BS95.
TreeFamTF313484.

Gene expression databases

ArrayExpressQ8BS95.
BgeeQ8BS95.
CleanExMM_GPR89.
GenevestigatorQ8BS95.

Family and domain databases

InterProIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERPTHR15948. PTHR15948. 1 hit.
PfamPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio324888.
SOURCESearch...

Entry information

Entry nameGPHR_MOUSE
AccessionPrimary (citable) accession number: Q8BS95
Secondary accession number(s): Q9D455
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot