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Protein

Golgi pH regulator

Gene

Gpr89a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

GO - Molecular functioni

  1. signal transducer activity Source: MGI
  2. voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  1. intracellular pH reduction Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. regulation of anion transport Source: GOC
  4. signal transduction Source: GOC
  5. skin development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator
Alternative name(s):
Protein GPR89
Gene namesi
Name:Gpr89a
Synonyms:Gphr, Gpr89
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914799. Gpr89.

Subcellular locationi

Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Note: Detected at low levels in lysosomes and endosomes.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi-associated vesicle membrane Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Golgi pH regulatorPRO_0000223261Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8BS95.
PaxDbiQ8BS95.
PRIDEiQ8BS95.

PTM databases

PhosphoSiteiQ8BS95.

Expressioni

Gene expression databases

BgeeiQ8BS95.
CleanExiMM_GPR89.
ExpressionAtlasiQ8BS95. baseline and differential.
GenevestigatoriQ8BS95.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8BS95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295277.
GeneTreeiENSGT00390000000684.
HOGENOMiHOG000240999.
HOVERGENiHBG054909.
InParanoidiQ8BS95.
OMAiFLYGFWR.
OrthoDBiEOG7HHWRV.
PhylomeDBiQ8BS95.
TreeFamiTF313484.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BS95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEVRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKLNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIQLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAVA RRTMFQRGDV QNKPSGLWGM LKSVTASAPG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVL DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPPEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KHMAP
Length:455
Mass (Da):52,735
Last modified:February 7, 2006 - v2
Checksum:iCAE9B93C64262252
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431N → H in BAC28872 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034895 mRNA. Translation: BAC28872.1.
AK016787 mRNA. Translation: BAB30430.1.
BC010729 mRNA. Translation: AAH10729.1.
CCDSiCCDS17650.1.
RefSeqiNP_080505.1. NM_026229.4.
UniGeneiMm.46722.

Genome annotation databases

EnsembliENSMUST00000029738; ENSMUSP00000029738; ENSMUSG00000028096.
GeneIDi67549.
KEGGimmu:67549.
UCSCiuc008qom.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034895 mRNA. Translation: BAC28872.1.
AK016787 mRNA. Translation: BAB30430.1.
BC010729 mRNA. Translation: AAH10729.1.
CCDSiCCDS17650.1.
RefSeqiNP_080505.1. NM_026229.4.
UniGeneiMm.46722.

3D structure databases

ProteinModelPortaliQ8BS95.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8BS95.

Proteomic databases

MaxQBiQ8BS95.
PaxDbiQ8BS95.
PRIDEiQ8BS95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029738; ENSMUSP00000029738; ENSMUSG00000028096.
GeneIDi67549.
KEGGimmu:67549.
UCSCiuc008qom.1. mouse.

Organism-specific databases

CTDi67549.
MGIiMGI:1914799. Gpr89.

Phylogenomic databases

eggNOGiNOG295277.
GeneTreeiENSGT00390000000684.
HOGENOMiHOG000240999.
HOVERGENiHBG054909.
InParanoidiQ8BS95.
OMAiFLYGFWR.
OrthoDBiEOG7HHWRV.
PhylomeDBiQ8BS95.
TreeFamiTF313484.

Miscellaneous databases

NextBioi324888.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BS95.
CleanExiMM_GPR89.
ExpressionAtlasiQ8BS95. baseline and differential.
GenevestigatoriQ8BS95.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiGPHR_MOUSE
AccessioniPrimary (citable) accession number: Q8BS95
Secondary accession number(s): Q9D455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: March 4, 2015
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.