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Protein

Intraflagellar transport protein 56

Gene

Ttc26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.2 Publications

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • intraciliary transport Source: UniProtKB
  • photoreceptor cell differentiation Source: MGI
  • photoreceptor cell morphogenesis Source: MGI
  • smoothened signaling pathway Source: UniProtKB
  • spermatid development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 561 Publication
Alternative name(s):
Protein hop-sterile1 Publication
Tetratricopeptide repeat protein 26Imported
Short name:
TPR repeat protein 26Imported
Gene namesi
Name:Ttc26Imported
Synonyms:Hop1 Publication, Ift561 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444853. Ttc26.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • ciliary basal body Source: UniProtKB
  • cilium Source: MGI
  • intraciliary transport particle B Source: UniProtKB
  • primary cilium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Partial embryonic lethality and patterning defects. Surviving mice show hopping gait, polydactyly, hydrocephalus, and male sterility. Impaired hedgehog signaling. Primary cilia are not reduced in number and their length is normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Intraflagellar transport protein 56PRO_0000289084Add
BLAST

Proteomic databases

MaxQBiQ8BS45.
PaxDbiQ8BS45.
PRIDEiQ8BS45.

PTM databases

iPTMnetiQ8BS45.
PhosphoSiteiQ8BS45.

Expressioni

Tissue specificityi

High expression detected in testis. Detected also retina, kidney, lung and brain tissue. The expression level is low in liver and spleen (PubMed:22718903). Present in the airway epithelial cells and the testes (at protein level) (PubMed:25340710).2 Publications

Gene expression databases

BgeeiQ8BS45.
CleanExiMM_TTC26.
ExpressionAtlasiQ8BS45. baseline and differential.
GenevisibleiQ8BS45. MM.

Interactioni

Subunit structurei

Component of the IFT complex B. Interacts with IFT46; the interaction is direct.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124369.

Structurei

3D structure databases

ProteinModelPortaliQ8BS45.
SMRiQ8BS45. Positions 285-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati57 – 9034TPR 1Add
BLAST
Repeati92 – 12534TPR 2Add
BLAST
Repeati151 – 18434TPR 3Add
BLAST
Repeati468 – 50134TPR 4Add
BLAST

Sequence similaritiesi

Belongs to the IFT56 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3785. Eukaryota.
ENOG410XRMP. LUCA.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiQ8BS45.
KOiK19685.
OMAiVEYMIRI.
OrthoDBiEOG76MK86.
PhylomeDBiQ8BS45.
TreeFamiTF105816.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BS45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSRAKPAV GGESPHTDKR KKKGRKIPKL EDLLSQRDFT GAITLLEFKR
60 70 80 90 100
HVGEQEDDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN PEVWVNLACT
110 120 130 140 150
YFFLGMYKQA EAAGFKAPKS RLQNRLLFHL AHKFNDEKKL MNFHQNLQDI
160 170 180 190 200
KEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY
210 220 230 240 250
YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGKAAEA ELKSLMDNAS
260 270 280 290 300
SPFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
310 320 330 340 350
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG
360 370 380 390 400
GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA
410 420 430 440 450
QAKAATGNTS EGEEVFLLIQ SEKLKNDYIY LSWLARCYIM NKKPRLAWEL
460 470 480 490 500
YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK
510 520 530 540 550
RGACVGIFQM ILAGREPKET LREVLHLLRS TGNTQVEYII RIMKKWAKEN

RVPI
Length:554
Mass (Da):64,151
Last modified:March 1, 2003 - v1
Checksum:iC126B8B129EA1306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035185 mRNA. Translation: BAC28974.1.
BC066060 mRNA. Translation: AAH66060.1.
CCDSiCCDS51750.1.
RefSeqiNP_705828.2. NM_153600.2.
UniGeneiMm.253446.

Genome annotation databases

EnsembliENSMUST00000162554; ENSMUSP00000124369; ENSMUSG00000056832.
GeneIDi264134.
KEGGimmu:264134.
UCSCiuc009bkc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035185 mRNA. Translation: BAC28974.1.
BC066060 mRNA. Translation: AAH66060.1.
CCDSiCCDS51750.1.
RefSeqiNP_705828.2. NM_153600.2.
UniGeneiMm.253446.

3D structure databases

ProteinModelPortaliQ8BS45.
SMRiQ8BS45. Positions 285-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124369.

PTM databases

iPTMnetiQ8BS45.
PhosphoSiteiQ8BS45.

Proteomic databases

MaxQBiQ8BS45.
PaxDbiQ8BS45.
PRIDEiQ8BS45.

Protocols and materials databases

DNASUi264134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162554; ENSMUSP00000124369; ENSMUSG00000056832.
GeneIDi264134.
KEGGimmu:264134.
UCSCiuc009bkc.1. mouse.

Organism-specific databases

CTDi79989.
MGIiMGI:2444853. Ttc26.

Phylogenomic databases

eggNOGiKOG3785. Eukaryota.
ENOG410XRMP. LUCA.
GeneTreeiENSGT00390000000159.
HOGENOMiHOG000258854.
HOVERGENiHBG108610.
InParanoidiQ8BS45.
KOiK19685.
OMAiVEYMIRI.
OrthoDBiEOG76MK86.
PhylomeDBiQ8BS45.
TreeFamiTF105816.

Enzyme and pathway databases

ReactomeiR-MMU-5620924. Intraflagellar transport.

Miscellaneous databases

PROiQ8BS45.
SOURCEiSearch...

Gene expression databases

BgeeiQ8BS45.
CleanExiMM_TTC26.
ExpressionAtlasiQ8BS45. baseline and differential.
GenevisibleiQ8BS45. MM.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR030511. TTC26.
[Graphical view]
PANTHERiPTHR14781:SF0. PTHR14781:SF0. 1 hit.
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas and Testis.
  4. "Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells and the pronephros in zebrafish."
    Zhang Q., Liu Q., Austin C., Drummond I., Pierce E.A.
    Mol. Biol. Cell 23:3069-3078(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.
  5. "TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella."
    Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H., Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R., Marshall W.F.
    Elife 3:E01566-E01566(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE IFT COMPLEX B.
  6. "A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling."
    Swiderski R.E., Nakano Y., Mullins R.F., Seo S., Banfi B.
    PLoS Genet. 10:E1004689-E1004689(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, IDENTIFICATION IN THE IFT COMPLEX B, INTERACTION WITH IFT46.

Entry informationi

Entry nameiIFT56_MOUSE
AccessioniPrimary (citable) accession number: Q8BS45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.