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Protein

Intraflagellar transport protein 56

Gene

Ttc26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU.2 Publications

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • intraciliary transport Source: UniProtKB
  • photoreceptor cell differentiation Source: MGI
  • photoreceptor cell morphogenesis Source: MGI
  • protein transport Source: UniProtKB-KW
  • smoothened signaling pathway Source: UniProtKB
  • spermatid development Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 561 Publication
Alternative name(s):
Protein hop-sterile1 Publication
Tetratricopeptide repeat protein 26Imported
Short name:
TPR repeat protein 26Imported
Gene namesi
Name:Ttc26Imported
Synonyms:Hop1 Publication, Ift561 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2444853 Ttc26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Disruption phenotypei

Partial embryonic lethality and patterning defects. Surviving mice show hopping gait, polydactyly, hydrocephalus, and male sterility. Impaired hedgehog signaling. Primary cilia are not reduced in number and their length is normal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002890841 – 554Intraflagellar transport protein 56Add BLAST554

Proteomic databases

MaxQBiQ8BS45
PaxDbiQ8BS45
PRIDEiQ8BS45

PTM databases

iPTMnetiQ8BS45
PhosphoSitePlusiQ8BS45

Expressioni

Tissue specificityi

High expression detected in testis. Detected also retina, kidney, lung and brain tissue. The expression level is low in liver and spleen (PubMed:22718903). Present in the airway epithelial cells and the testes (at protein level) (PubMed:25340710).2 Publications

Gene expression databases

BgeeiENSMUSG00000056832
CleanExiMM_TTC26
ExpressionAtlasiQ8BS45 baseline and differential
GenevisibleiQ8BS45 MM

Interactioni

Subunit structurei

Component of the IFT complex B. Interacts with IFT46; the interaction is direct.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124369

Structurei

3D structure databases

ProteinModelPortaliQ8BS45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 90TPR 1Add BLAST34
Repeati92 – 125TPR 2Add BLAST34
Repeati151 – 184TPR 3Add BLAST34
Repeati468 – 501TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the IFT56 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG3785 Eukaryota
ENOG410XRMP LUCA
GeneTreeiENSGT00390000000159
HOGENOMiHOG000258854
HOVERGENiHBG108610
InParanoidiQ8BS45
KOiK19685
OMAiKKLMSFH
OrthoDBiEOG091G04RS
PhylomeDBiQ8BS45
TreeFamiTF105816

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR030511 TTC26
PANTHERiPTHR14781 PTHR14781, 1 hit
SUPFAMiSSF48452 SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q8BS45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSRAKPAV GGESPHTDKR KKKGRKIPKL EDLLSQRDFT GAITLLEFKR
60 70 80 90 100
HVGEQEDDTN LWIGYCAFHL GDYKRALEEY ENATKEENCN PEVWVNLACT
110 120 130 140 150
YFFLGMYKQA EAAGFKAPKS RLQNRLLFHL AHKFNDEKKL MNFHQNLQDI
160 170 180 190 200
KEDQLSLASI HYMRSHYQEA IDIYKRILLD NREYLALNVY VALCYYKLDY
210 220 230 240 250
YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGKAAEA ELKSLMDNAS
260 270 280 290 300
SPFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
310 320 330 340 350
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG
360 370 380 390 400
GSASECDTIP GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA
410 420 430 440 450
QAKAATGNTS EGEEVFLLIQ SEKLKNDYIY LSWLARCYIM NKKPRLAWEL
460 470 480 490 500
YLKMETSGES FSLLQLIAND CYKMGQFYYS AKAFDVLERL DPNPEYWEGK
510 520 530 540 550
RGACVGIFQM ILAGREPKET LREVLHLLRS TGNTQVEYII RIMKKWAKEN

RVPI
Length:554
Mass (Da):64,151
Last modified:March 1, 2003 - v1
Checksum:iC126B8B129EA1306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035185 mRNA Translation: BAC28974.1
BC066060 mRNA Translation: AAH66060.1
CCDSiCCDS51750.1
RefSeqiNP_705828.2, NM_153600.2
UniGeneiMm.253446

Genome annotation databases

EnsembliENSMUST00000162554; ENSMUSP00000124369; ENSMUSG00000056832
GeneIDi264134
KEGGimmu:264134
UCSCiuc009bkc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFT56_MOUSE
AccessioniPrimary (citable) accession number: Q8BS45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health