Q8BS14 (Q8BS14_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC30725.1

Gene names

Name:

Pik3cd MGI 1098211

Organism

Mus musculus (Mouse) EMBL BAC30725.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1047 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 PI3K/PI4K domain. SAAS SAAS018936 Contains 1 PIK helical domain. SAAS SAAS015433

Ontologies

Keywords
Molecular function	Kinase SAAS SAAS018936 Transferase
Gene Ontology (GO)
Biological process	B cell activation Inferred from mutant phenotype. Source: MGI B cell homeostasis Inferred from mutant phenotype. Source: MGI cell surface receptor linked signaling pathway Inferred from mutant phenotype. Source: MGI phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular component	phosphatidylinositol 3-kinase complex Inferred from electronic annotation. Source: InterPro
Molecular function	1-phosphatidylinositol-3-kinase activity Inferred from electronic annotation. Source: InterPro binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol-4,5-bisphosphate 3-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BS14 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 73654D27449A30B2	FASTA	1,047	120,187
	10 20 30 40 50 60 MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW HRAQYEPLFH 70 80 90 100 110 120 MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR LVAREGDRVK KLINSQISLL 130 140 150 160 170 180 IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA AAHRQQLGWV EWLQYSFPMQ LEPSARGWRA 190 200 210 220 230 240 GLLRVSNRAL LVNVKFEGSE ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA 250 260 270 280 290 300 LQVNGRHEYL YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR 310 320 330 340 350 360 AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG NEMLCKTVSS 370 380 390 400 410 420 SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK AKKARSTKKK SKKADCPIAW 430 440 450 460 470 480 ANLMLFDYKD QLKTGERCLY MWPSVPDEKG ELLNPAGTVR GNPNTESAAA LVIYLPEVAP 490 500 510 520 530 540 HPVYFPALEK ILELGRHGER GRITEEEQLQ LREILERRGS GELYEHEKDL VWKMRHEVQE 550 560 570 580 590 600 HFPEALARLL LVTKWNKHED VAQLSQMLYL LCSWPELPVL SALELLDFSF PDCYVGSFAI 610 620 630 640 650 660 KSLRKLTDDE LFQYLLQLVQ VLKYESYLDC ELTKFLLGRA LANRKIGHFL FWHLRSEMHV 670 680 690 700 710 720 PSVALRFGLI MEAYCRGSTH HMKVLMKQGE ALSKLKALND FVKVSSQKTT KPQTKEMMHM 730 740 750 760 770 780 CMRQETYMEA LSHLQSPLDP STLLEEVCVE QCTFMDSKMK PLWIMYSSEE AGSAGNVGII 790 800 810 820 830 840 FKNGDDLRQD MLTLQMIQLM DVLWKQEGLD LRMTPYGCLP TGDRTGLIEV VLHSDTIANI 850 860 870 880 890 900 QLNKSNMAAT AAFNKDALLN WLKSKNPGEA LDRAIEEFTL SCAGYCVATY VLGIGDRHSD 910 920 930 940 950 960 NIMIRESGQL FHIDFGHFLG NFKTKFGINR ERVPFILTYD FVHVIQQGKT NNSEKFERFR 970 980 990 1000 1010 1020 GYCERAYTIL RRHGLLFLHL FALMRAAGLP ELSCSKDIQY LKDSLALGKT EEEALKHFRV 1030 1040 KFNEALRESW KTKVNWLAHN VSKDNRQ

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed: 10349636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[2]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed: 16141073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[3]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[4]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[6]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed: 11042159] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[7]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed: 11076861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
[8]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30725.1. Tissue: Aorta and vein EMBL BAC30725.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK040867 mRNA. Translation: BAC30725.1.
IPI	IPI00316677.
RefSeq	NP_001025008.2. NM_001029837.2. NP_032866.2. NM_008840.3.
UniGene	Mm.229108.
3D structure databases
HSSP	HSSP built from PDB template 1E8Y based on UniProtKB P48736.
ProteinModelPortal	Q8BS14.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8BS14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	18707.
KEGG	mmu:18707.
Organism-specific databases
CTD	5293.
MGI	MGI:1098211. Pik3cd.
Phylogenomic databases
GeneTree	ENSGT00550000074176.
HOVERGEN	HBG052721.
InParanoid	Q8BS14.
Gene expression databases
ArrayExpress	Q8BS14.
Genevestigator	Q8BS14.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR002420. PI3K_C2. IPR003113. PI3K_p85-bd. IPR000341. PI3K_ras-bd. IPR015433. PI_Kinase. IPR001263. PInositide-3_kin_accessory_dom. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit. G3DSA:1.25.40.70. PI3Ka. 1 hit.
KO	K00922.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. PF00792. PI3K_C2. 1 hit. PF02192. PI3K_p85B. 1 hit. PF00794. PI3K_rbd. 1 hit. PF00613. PI3Ka. 1 hit. [Graphical view]
SMART	SM00142. PI3K_C2. 1 hit. SM00143. PI3K_p85B. 1 hit. SM00144. PI3K_rbd. 1 hit. SM00145. PI3Ka. 1 hit. SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF49562. C2_CaLB. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	294773.
SOURCE	Search...

Entry information

Entry name

Q8BS14_MOUSE

Accession

Primary (citable) accession number: Q8BS14

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)