Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Putative uncharacterized protein

Gene

Pik3cd

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: GO_Central
  • B cell activation Source: MGI
  • B cell homeostasis Source: MGI
  • cell chemotaxis Source: GO_Central
  • cell surface receptor signaling pathway Source: MGI
  • defense response to fungus Source: MGI
  • homeostasis of number of cells Source: MGI
  • inflammatory response Source: GO_Central
  • innate immune response Source: GO_Central
  • phosphatidylinositol 3-kinase signaling Source: GO_Central
  • phosphatidylinositol-3-phosphate biosynthetic process Source: GO_Central
  • phosphatidylinositol phosphorylation Source: GO_Central
  • platelet activation Source: GO_Central
  • positive regulation of cell migration Source: MGI
  • positive regulation of gene expression Source: MGI
  • protein phosphorylation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:Pik3cdImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1098211. Pik3cd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ8BS14.

Expressioni

Gene expression databases

GenevisibleiQ8BS14. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101315.

Structurei

3D structure databases

ProteinModelPortaliQ8BS14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PI3K/PI4K domain.SAAS annotation
Contains PIK helical domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG052721.
KOiK00922.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BS14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPGVDCPME FWTKEESQSV VVDFLLPTGV YLNFPVSRNA NLSTIKQVLW
60 70 80 90 100
HRAQYEPLFH MLSDPEAYVF TCVNQTAEQQ ELEDEQRRLC DIQPFLPVLR
110 120 130 140 150
LVAREGDRVK KLINSQISLL IGKGLHEFDS LRDPEVNDFR TKMRQFCEEA
160 170 180 190 200
AAHRQQLGWV EWLQYSFPMQ LEPSARGWRA GLLRVSNRAL LVNVKFEGSE
210 220 230 240 250
ESFTFQVSTK DMPLALMACA LRKKATVFRQ PLVEQPEEYA LQVNGRHEYL
260 270 280 290 300
YGNYPLCHFQ YICSCLHSGL TPHLTMVHSS SILAMRDEQS NPAPQVQKPR
310 320 330 340 350
AKPPPIPAKK PSSVSLWSLE QPFSIELIEG RKVNADERMK LVVQAGLFHG
360 370 380 390 400
NEMLCKTVSS SEVNVCSEPV WKQRLEFDIS VCDLPRMARL CFALYAVVEK
410 420 430 440 450
AKKARSTKKK SKKADCPIAW ANLMLFDYKD QLKTGERCLY MWPSVPDEKG
460 470 480 490 500
ELLNPAGTVR GNPNTESAAA LVIYLPEVAP HPVYFPALEK ILELGRHGER
510 520 530 540 550
GRITEEEQLQ LREILERRGS GELYEHEKDL VWKMRHEVQE HFPEALARLL
560 570 580 590 600
LVTKWNKHED VAQLSQMLYL LCSWPELPVL SALELLDFSF PDCYVGSFAI
610 620 630 640 650
KSLRKLTDDE LFQYLLQLVQ VLKYESYLDC ELTKFLLGRA LANRKIGHFL
660 670 680 690 700
FWHLRSEMHV PSVALRFGLI MEAYCRGSTH HMKVLMKQGE ALSKLKALND
710 720 730 740 750
FVKVSSQKTT KPQTKEMMHM CMRQETYMEA LSHLQSPLDP STLLEEVCVE
760 770 780 790 800
QCTFMDSKMK PLWIMYSSEE AGSAGNVGII FKNGDDLRQD MLTLQMIQLM
810 820 830 840 850
DVLWKQEGLD LRMTPYGCLP TGDRTGLIEV VLHSDTIANI QLNKSNMAAT
860 870 880 890 900
AAFNKDALLN WLKSKNPGEA LDRAIEEFTL SCAGYCVATY VLGIGDRHSD
910 920 930 940 950
NIMIRESGQL FHIDFGHFLG NFKTKFGINR ERVPFILTYD FVHVIQQGKT
960 970 980 990 1000
NNSEKFERFR GYCERAYTIL RRHGLLFLHL FALMRAAGLP ELSCSKDIQY
1010 1020 1030 1040
LKDSLALGKT EEEALKHFRV KFNEALRESW KTKVNWLAHN VSKDNRQ
Length:1,047
Mass (Da):120,187
Last modified:March 1, 2003 - v1
Checksum:i73654D27449A30B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040867 mRNA. Translation: BAC30725.1.
RefSeqiNP_001025008.2. NM_001029837.2.
NP_032866.2. NM_008840.3.
UniGeneiMm.229108.

Genome annotation databases

GeneIDi18707.
KEGGimmu:18707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040867 mRNA. Translation: BAC30725.1.
RefSeqiNP_001025008.2. NM_001029837.2.
NP_032866.2. NM_008840.3.
UniGeneiMm.229108.

3D structure databases

ProteinModelPortaliQ8BS14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101315.

Proteomic databases

PRIDEiQ8BS14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi18707.
KEGGimmu:18707.

Organism-specific databases

CTDi5293.
MGIiMGI:1098211. Pik3cd.

Phylogenomic databases

HOVERGENiHBG052721.
KOiK00922.

Miscellaneous databases

ChiTaRSiPik3cd. mouse.
NextBioi294773.
SOURCEiSearch...

Gene expression databases

GenevisibleiQ8BS14. MM.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
1.25.40.70. 1 hit.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR003113. PI3K_adapt-bd_dom.
IPR002420. PI3K_C2_dom.
IPR000341. PI3K_Ras-bd_dom.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF02192. PI3K_p85B. 1 hit.
PF00794. PI3K_rbd. 1 hit.
PF00613. PI3Ka. 1 hit.
[Graphical view]
SMARTiSM00142. PI3K_C2. 1 hit.
SM00143. PI3K_p85B. 1 hit.
SM00144. PI3K_rbd. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51544. PI3K_ABD. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51546. PI3K_RBD. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.

Entry informationi

Entry nameiQ8BS14_MOUSE
AccessioniPrimary (citable) accession number: Q8BS14
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.