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Protein

E3 ubiquitin-protein ligase MARCH3

Gene

March3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 123RING-CH-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Endocytosis, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH3 (EC:6.3.2.-)
Alternative name(s):
Membrane-associated RING finger protein 3
Membrane-associated RING-CH protein III
Short name:
MARCH-III
Gene namesi
Name:March3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2443667. March3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559281 – 218E3 ubiquitin-protein ligase MARCH3Add BLAST218

Proteomic databases

PaxDbiQ8BRX9.
PRIDEiQ8BRX9.

PTM databases

iPTMnetiQ8BRX9.
PhosphoSitePlusiQ8BRX9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032656.
CleanExiMM_MARCH3.
ExpressionAtlasiQ8BRX9. baseline and differential.

Interactioni

Subunit structurei

Interacts with MARCH2 and STX6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099976.

Structurei

3D structure databases

ProteinModelPortaliQ8BRX9.
SMRiQ8BRX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.PROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 RING-CH-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 123RING-CH-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110355.
HOGENOMiHOG000293394.
HOVERGENiHBG052411.
InParanoidiQ8BRX9.
KOiK10658.
TreeFamiTF319557.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 1 hit.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BRX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSRCSHLP EVLPDCTSSA APVVKTVEDC GSLVNGQPQY VMQVSAKDGQ
60 70 80 90 100
LLSTVVRTLA TQSPFNDRPM CRICHEGSSQ EDLLSPCECT GTLGTIHRSC
110 120 130 140 150
LEHWLSSSNT SYCELCHFRF AVERKPRPLV EWLRNPGPQH EKRTLFGDMV
160 170 180 190 200
CFLFITPLAT ISGWLCLRGA VDHLHFSSRL EAVGLIALTV ALFTIYLFWT
210
LRRYGHQSKP FWNQSSRS
Length:218
Mass (Da):24,491
Last modified:March 1, 2003 - v1
Checksum:i098C2028247ECE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041088 mRNA. Translation: BAC30814.1.
BC107233 mRNA. Translation: AAI07234.1.
BC107232 mRNA. Translation: AAI07233.1.
CCDSiCCDS29262.1.
RefSeqiNP_796089.1. NM_177115.2.
UniGeneiMm.312623.

Genome annotation databases

EnsembliENSMUST00000102912; ENSMUSP00000099976; ENSMUSG00000032656.
GeneIDi320253.
KEGGimmu:320253.
UCSCiuc008eyv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041088 mRNA. Translation: BAC30814.1.
BC107233 mRNA. Translation: AAI07234.1.
BC107232 mRNA. Translation: AAI07233.1.
CCDSiCCDS29262.1.
RefSeqiNP_796089.1. NM_177115.2.
UniGeneiMm.312623.

3D structure databases

ProteinModelPortaliQ8BRX9.
SMRiQ8BRX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099976.

PTM databases

iPTMnetiQ8BRX9.
PhosphoSitePlusiQ8BRX9.

Proteomic databases

PaxDbiQ8BRX9.
PRIDEiQ8BRX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102912; ENSMUSP00000099976; ENSMUSG00000032656.
GeneIDi320253.
KEGGimmu:320253.
UCSCiuc008eyv.1. mouse.

Organism-specific databases

CTDi115123.
MGIiMGI:2443667. March3.

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110355.
HOGENOMiHOG000293394.
HOVERGENiHBG052411.
InParanoidiQ8BRX9.
KOiK10658.
TreeFamiTF319557.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8BRX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032656.
CleanExiMM_MARCH3.
ExpressionAtlasiQ8BRX9. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 1 hit.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARH3_MOUSE
AccessioniPrimary (citable) accession number: Q8BRX9
Secondary accession number(s): Q3KNK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.