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Unreviewed, UniProtKB/TrEMBL Q8BRW2 (Q8BRW2_MOUSE)

Last modified January 19, 2010. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Putative uncharacterized protein EMBL BAC30866.1
Gene names
Name: Adipoq MGI 106675
Synonyms: Acdc MGI 106675
OrganismMus musculus (Mouse) EMBL BAC30866.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 C1q domain.

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Ontologies

Keywords
   DomainCollagen Spearmint SPM001073
Gene Ontology (GO)
   Biological processadiponectin-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

brown fat cell differentiation

Inferred from direct assay. Source: MGI

fatty acid beta-oxidation

Inferred from mutant phenotype. Source: MGI

glucose homeostasis

Inferred from direct assay. Source: MGI

glucose metabolic process

Inferred from direct assay. Source: MGI

low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Compara

membrane depolarization

Inferred from electronic annotation. Source: Compara

membrane hyperpolarization

Inferred from electronic annotation. Source: Compara

negative regulation of I-kappaB kinase/NF-kappaB cascade

Inferred from electronic annotation. Source: Compara

negative regulation of fat cell differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of gluconeogenesis

Inferred from direct assay. Source: MGI

negative regulation of granulocyte differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Compara

negative regulation of hormone secretion

Inferred from electronic annotation. Source: Compara

negative regulation of low-density lipoprotein receptor biosynthetic process

Inferred from electronic annotation. Source: Compara

negative regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Compara

negative regulation of phagocytosis

Inferred from electronic annotation. Source: Compara

negative regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Compara

negative regulation of tumor necrosis factor-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

positive regulation of I-kappaB kinase/NF-kappaB cascade

Inferred from direct assay. Source: MGI

positive regulation of blood pressure

Inferred from electronic annotation. Source: Compara

positive regulation of cholesterol efflux

Inferred from electronic annotation. Source: Compara

positive regulation of fatty acid metabolic process

Inferred from mutant phenotype. Source: MGI

positive regulation of glucose import

Inferred from direct assay. Source: MGI

positive regulation of myeloid cell apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Compara

positive regulation of protein kinase A signaling cascade

Inferred from electronic annotation. Source: Compara

protein homooligomerization

Inferred from direct assay. Source: MGI

response to drug

Inferred from electronic annotation. Source: Compara

response to ethanol

Inferred from electronic annotation. Source: Compara

response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Compara

response to glucose stimulus

Inferred from direct assay. Source: MGI

response to hypoxia

Inferred from electronic annotation. Source: Compara

response to nutrient

Inferred from electronic annotation. Source: Compara

response to sucrose stimulus

Inferred from electronic annotation. Source: Compara

response to tumor necrosis factor

Inferred from electronic annotation. Source: Compara

   Cellular componentendoplasmic reticulum

Inferred from direct assay. Source: MGI

extracellular space

Inferred from direct assay. Source: MGI

   Molecular functioneukaryotic cell surface binding

Inferred from electronic annotation. Source: Compara

hormone activity

Inferred from direct assay. Source: MGI

protein homodimerization activity

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q8BRW2-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0D3FA64C789CAEF3

FASTA24726,751
        10         20         30         40         50         60 
MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG 

        70         80         90        100        110        120 
RDGTPGEKGE KGDAGLLGPK GETGGVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV 

       130        140        150        160        170        180 
GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK 

       190        200        210        220        230        240 
KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF 


LLYHDTN

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK041214 mRNA. Translation: BAC30866.1.
IPIIPI00742301.
UniGeneMm.3969

3D structure databases

HSSPHSSP built from PDB template 1C28 based on UniProtKB Q60994.
SMRQ8BRW2. Positions 111-247.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8BRW2.

Genome annotation databases

EnsemblENSMUST00000023593; ENSMUSP00000023593; ENSMUSG00000022878; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:106675. Adipoq.

Phylogenomic databases

HOVERGENQ8BRW2.
InParanoidQ8BRW2.

Gene expression databases

ArrayExpressQ8BRW2.
BgeeQ8BRW2.
GenevestigatorQ8BRW2.

Family and domain databases

InterProIPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like.
[Graphical view]
Gene3DG3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit.
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ8BRW2_MOUSE
AccessionPrimary (citable) accession number: Q8BRW2
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 19, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information