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Q8BRW2 (Q8BRW2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Adipoq MGI 106675
Synonyms:Acdc MGI 106675
OrganismMus musculus (Mouse) EMBL BAC30866.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length247 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains C1q domain. SAAS SAAS001073

Ontologies

Keywords
   Cellular componentSecreted SAAS SAAS001073
   DomainCollagen SAAS SAAS001073
Gene Ontology (GO)
   Biological_processbrown fat cell differentiation

Inferred from direct assay PubMed 18492766. Source: MGI

cellular response to insulin stimulus

Inferred from genetic interaction PubMed 17693256. Source: MGI

fatty acid beta-oxidation

Inferred from mutant phenotype PubMed 12151381. Source: MGI

fatty acid oxidation

Inferred from direct assay PubMed 12802337. Source: MGI

glucose homeostasis

Inferred from direct assay PubMed 11479628PubMed 12068289. Source: MGI

glucose metabolic process

Inferred from direct assay PubMed 11479628PubMed 12068289PubMed 12802337. Source: MGI

negative regulation of gluconeogenesis

Inferred from direct assay PubMed 11479628. Source: MGI

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from direct assay PubMed 12087086PubMed 14522956. Source: MGI

positive regulation of fatty acid metabolic process

Inferred from mutant phenotype PubMed 12068289. Source: MGI

positive regulation of glucose import

Inferred from direct assay PubMed 12068289. Source: MGI

positive regulation of signal transduction

Inferred from direct assay PubMed 12087086PubMed 14522956. Source: MGI

protein heterotrimerization

Inferred from physical interaction PubMed 18783346. Source: MGI

protein homooligomerization

Inferred from direct assay PubMed 12087086PubMed 14522956PubMed 15210937PubMed 7592907. Source: MGI

response to glucose

Inferred from direct assay PubMed 12068289. Source: MGI

   Cellular_componentcollagen trimer

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum

Inferred from direct assay PubMed 10444069. Source: MGI

extracellular space

Inferred from direct assay PubMed 10444069PubMed 11479628PubMed 12087086PubMed 14522956PubMed 14578283PubMed 15210937PubMed 15231994PubMed 17693256PubMed 7592907. Source: MGI

   Molecular_functionhormone activity

Inferred from direct assay PubMed 11479628. Source: MGI

protein binding

Inferred from physical interaction PubMed 12802337PubMed 15210937. Source: MGI

receptor binding

Inferred from direct assay PubMed 12087086PubMed 12802337PubMed 14522956. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BRW2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0D3FA64C789CAEF3

FASTA24726,751
        10         20         30         40         50         60 
MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG 

        70         80         90        100        110        120 
RDGTPGEKGE KGDAGLLGPK GETGGVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV 

       130        140        150        160        170        180 
GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK 

       190        200        210        220        230        240 
KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF 


LLYHDTN 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30866.1.
Tissue: Aorta and vein EMBL BAC30866.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK041214 mRNA. Translation: BAC30866.1.
UniGeneMm.3969.

3D structure databases

ProteinModelPortalQ8BRW2.
SMRQ8BRW2. Positions 111-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8BRW2. 1 interaction.
MINTMINT-4112137.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:106675. Adipoq.

Phylogenomic databases

HOVERGENHBG108220.
InParanoidQ8BRW2.

Gene expression databases

GenevestigatorQ8BRW2.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR028572. Adiponectin.
IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERPTHR24022:SF81. PTHR24022:SF81. 1 hit.
PfamPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8BRW2_MOUSE
AccessionPrimary (citable) accession number: Q8BRW2
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)