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Protein
Submitted name:

Putative uncharacterized protein

Gene

Adipoq

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. hormone activity Source: MGI
  2. protein homodimerization activity Source: MGI
  3. receptor binding Source: MGI
  4. sialic acid binding Source: MGI

GO - Biological processi

  1. adiponectin-activated signaling pathway Source: InterPro
  2. brown fat cell differentiation Source: MGI
  3. cellular response to insulin stimulus Source: MGI
  4. fatty acid beta-oxidation Source: MGI
  5. fatty acid oxidation Source: MGI
  6. glucose homeostasis Source: MGI
  7. glucose metabolic process Source: MGI
  8. low-density lipoprotein particle clearance Source: MGI
  9. negative regulation of blood pressure Source: MGI
  10. negative regulation of DNA biosynthetic process Source: MGI
  11. negative regulation of ERK1 and ERK2 cascade Source: MGI
  12. negative regulation of fat cell differentiation Source: MGI
  13. negative regulation of gluconeogenesis Source: MGI
  14. negative regulation of granulocyte differentiation Source: MGI
  15. negative regulation of heterotypic cell-cell adhesion Source: MGI
  16. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  17. negative regulation of intracellular protein transport Source: MGI
  18. negative regulation of low-density lipoprotein particle receptor biosynthetic process Source: MGI
  19. negative regulation of macrophage derived foam cell differentiation Source: MGI
  20. negative regulation of macrophage differentiation Source: MGI
  21. negative regulation of phagocytosis Source: MGI
  22. negative regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
  23. negative regulation of protein autophosphorylation Source: MGI
  24. negative regulation of receptor binding Source: MGI
  25. negative regulation of smooth muscle cell migration Source: MGI
  26. negative regulation of smooth muscle cell proliferation Source: MGI
  27. negative regulation of synaptic transmission Source: MGI
  28. negative regulation of transcription, DNA-templated Source: MGI
  29. negative regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
  30. negative regulation of tumor necrosis factor production Source: MGI
  31. positive regulation of cAMP-dependent protein kinase activity Source: MGI
  32. positive regulation of cellular protein metabolic process Source: MGI
  33. positive regulation of cholesterol efflux Source: MGI
  34. positive regulation of fatty acid metabolic process Source: MGI
  35. positive regulation of glucose import Source: MGI
  36. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  37. positive regulation of interleukin-8 production Source: MGI
  38. positive regulation of monocyte chemotactic protein-1 production Source: MGI
  39. positive regulation of myeloid cell apoptotic process Source: MGI
  40. positive regulation of protein kinase A signaling Source: MGI
  41. positive regulation of protein phosphorylation Source: MGI
  42. positive regulation of renal albumin absorption Source: MGI
  43. positive regulation of signal transduction Source: MGI
  44. protein heterotrimerization Source: MGI
  45. protein homooligomerization Source: MGI
  46. protein localization to plasma membrane Source: MGI
  47. regulation of glucose metabolic process Source: MGI
  48. response to glucose Source: MGI
  49. response to tumor necrosis factor Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
Gene namesi
Name:AdipoqImported
Synonyms:AcdcImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106675. Adipoq.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: MGI
  2. collagen trimer Source: UniProtKB-KW
  3. endoplasmic reticulum Source: MGI
  4. extracellular space Source: MGI
  5. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8BRW2.

Interactioni

Protein-protein interaction databases

IntActiQ8BRW2. 1 interaction.
MINTiMINT-4112137.

Structurei

3D structure databases

ProteinModelPortaliQ8BRW2.
SMRiQ8BRW2. Positions 111-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains C1q domain.SAAS annotation

Keywords - Domaini

CollagenSAAS annotation

Phylogenomic databases

HOVERGENiHBG108220.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR028572. Adiponectin.
IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR24022:SF81. PTHR24022:SF81. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8BRW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP
60 70 80 90 100
GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGGVGMTG AEGPRGFPGT
110 120 130 140 150
PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST
160 170 180 190 200
GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA
210 220 230 240
SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN
Length:247
Mass (Da):26,751
Last modified:March 1, 2003 - v1
Checksum:i0D3FA64C789CAEF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041214 mRNA. Translation: BAC30866.1.
UniGeneiMm.3969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041214 mRNA. Translation: BAC30866.1.
UniGeneiMm.3969.

3D structure databases

ProteinModelPortaliQ8BRW2.
SMRiQ8BRW2. Positions 111-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BRW2. 1 interaction.
MINTiMINT-4112137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106675. Adipoq.

Phylogenomic databases

HOVERGENiHBG108220.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8BRW2.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR028572. Adiponectin.
IPR001073. C1q.
IPR008160. Collagen.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR24022:SF81. PTHR24022:SF81. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF01391. Collagen. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  4. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Aorta and veinImported.

Entry informationi

Entry nameiQ8BRW2_MOUSE
AccessioniPrimary (citable) accession number: Q8BRW2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.