Q8BRW2 (Q8BRW2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAC30866.1

Gene names

Name:	Adipoq MGI 106675
Synonyms:	Acdc MGI 106675

Organism

Mus musculus (Mouse) EMBL BAC30866.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C1q domain. SAAS SAAS008160

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS008160
Domain	Collagen SAAS SAAS008160
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from direct assay PubMed 18492766. Source: MGI cellular response to insulin stimulus Inferred from genetic interaction PubMed 17693256. Source: MGI fatty acid beta-oxidation Inferred from mutant phenotype PubMed 12151381. Source: MGI glucose homeostasis Inferred from direct assay PubMed 11479628PubMed 12068289. Source: MGI glucose metabolic process Inferred from direct assay PubMed 11479628PubMed 12068289PubMed 12802337. Source: MGI negative regulation of gluconeogenesis Inferred from direct assay PubMed 11479628. Source: MGI positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 12087086PubMed 14522956. Source: MGI positive regulation of fatty acid metabolic process Inferred from mutant phenotype PubMed 12068289. Source: MGI positive regulation of glucose import Inferred from direct assay PubMed 12068289. Source: MGI protein heterotrimerization Inferred from physical interaction PubMed 18783346. Source: MGI protein homooligomerization Inferred from direct assay PubMed 12087086PubMed 14522956PubMed 15210937PubMed 7592907. Source: MGI response to glucose stimulus Inferred from direct assay PubMed 12068289. Source: MGI
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum Inferred from direct assay PubMed 10444069. Source: MGI extracellular space Inferred from direct assay PubMed 10444069PubMed 11479628PubMed 12087086PubMed 14522956PubMed 14578283PubMed 15210937PubMed 15231994PubMed 17693256PubMed 7592907. Source: MGI
Molecular_function	hormone activity Inferred from direct assay PubMed 11479628. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8BRW2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0D3FA64C789CAEF3	FASTA	247	26,751
	10 20 30 40 50 60 MLLLQALLFL LILPSHAEDD VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG 70 80 90 100 110 120 RDGTPGEKGE KGDAGLLGPK GETGGVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV 130 140 150 160 170 180 GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK 190 200 210 220 230 240 KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[4]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[5]	Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAC30866.1. Tissue: Aorta and vein EMBL BAC30866.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK041214 mRNA. Translation: BAC30866.1.
IPI	IPI00742301.
UniGene	Mm.3969.
3D structure databases
HSSP	HSSP built from PDB template 1C28 based on UniProtKB Q60994.
ProteinModelPortal	Q8BRW2.
SMR	Q8BRW2. Positions 111-247.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:106675. Adipoq.
Phylogenomic databases
HOVERGEN	HBG108220.
InParanoid	Q8BRW2.
Gene expression databases
Genevestigator	Q8BRW2.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR001073. C1q. IPR008160. Collagen. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00386. C1q. 1 hit. PF01391. Collagen. 1 hit. [Graphical view]
PRINTS	PR00007. COMPLEMNTC1Q.
SMART	SM00110. C1Q. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50871. C1Q. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8BRW2_MOUSE

Accession

Primary (citable) accession number: Q8BRW2

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)