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Q8BRU2 (Q8BRU2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Trpc2 MGI 109527 EMBL AAH67003.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Gene Ontology (GO)
   Biological_processacrosome reaction

Inferred from mutant phenotype PubMed 11331878. Source: MGI

calcium ion transmembrane transport

Inferred from direct assay PubMed 10051594. Source: GOC

calcium ion transport

Inferred from mutant phenotype PubMed 11331878. Source: MGI

female courtship behavior

Inferred from mutant phenotype PubMed 17676034. Source: MGI

inter-male aggressive behavior

Inferred from mutant phenotype PubMed 11823606. Source: MGI

mating behavior, sex discrimination

Inferred from mutant phenotype PubMed 11823606PubMed 11972034. Source: MGI

negative regulation of male mating behavior

Inferred from genetic interaction PubMed 24089208. Source: MGI

positive regulation of cytosolic calcium ion concentration

Inferred from physical interaction PubMed 10051594. Source: MGI

response to pheromone

Inferred from mutant phenotype PubMed 11823606PubMed 11972034PubMed 24089208. Source: MGI

single strand break repair

Inferred from electronic annotation. Source: InterPro

territorial aggressive behavior

Inferred from mutant phenotype PubMed 11972034PubMed 17676034. Source: MGI

   Cellular_componentGolgi membrane

Inferred from direct assay PubMed 10998353. Source: MGI

dendrite membrane

Inferred from mutant phenotype PubMed 14642279. Source: MGI

endomembrane system

Inferred from direct assay PubMed 10998353. Source: MGI

endoplasmic reticulum membrane

Inferred from direct assay PubMed 10998353. Source: MGI

nuclear envelope

Inferred from direct assay PubMed 10998353. Source: MGI

plasma membrane

Inferred from direct assay PubMed 14699131. Source: MGI

   Molecular_functioncalmodulin binding

Inferred from direct assay PubMed 12601176. Source: MGI

damaged DNA binding

Inferred from electronic annotation. Source: InterPro

diacylglycerol binding

Inferred from mutant phenotype PubMed 14642279. Source: MGI

store-operated calcium channel activity

Inferred from direct assay PubMed 10051594. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8BRU2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B033588998BC4F39

FASTA31333,898
        10         20         30         40         50         60 
MLMSRTDSKS GKNRSGVRMF KDGDFLTPAS GESWDRLRLT CSQPFTRHQS FGLAFLRVRS 

        70         80         90        100        110        120 
SLGSLADPVV DPSAPGSSGL NQNSTDVLES DPRPWLTNPS IRRTFFPDPQ TSTKEISELK 

       130        140        150        160        170        180 
GMLKQLQPGP LGRAARMVLS AARKAPPASV VSPNNSHGEP GPSRAESAEP RAEEPNRKTA 

       190        200        210        220        230        240 
VGRRKRRKVQ EPRRSLSNSS SQPNRRTGRT RQRQHRPQTK SDDGGVQAAG QCPICAGFFS 

       250        260        270        280        290        300 
IETLPQHAAT CGESPPPQPA SPASLSSSES VLWVSSPESS PPPSWVQCPI CELQFSAREI 

       310 
EEHASVCGEV LPA 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[4]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[5]Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K. expand/collapse author list , Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH67003.1.
Tissue: Mouse EMBL AAH67003.1.
[8]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
[9]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAC30894.1.
Tissue: Aorta and vein EMBL BAC30894.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC067003 mRNA. Translation: AAH67003.1.
AK041300 mRNA. Translation: BAC30894.1.
RefSeqNP_001273618.1. NM_001286689.1.
NP_001273619.1. NM_001286690.1.
UniGeneMm.292904.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102443350.

Organism-specific databases

MGIMGI:109527. Trpc2.

Phylogenomic databases

HOGENOMHOG000072714.
HOVERGENHBG061894.

Gene expression databases

GenevestigatorQ8BRU2.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR002706. Xrcc1_N.
[Graphical view]
PfamPF01834. XRCC1_N. 1 hit.
[Graphical view]
SUPFAMSSF49785. SSF49785. 1 hit.
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ8BRU2_MOUSE
AccessionPrimary (citable) accession number: Q8BRU2
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)