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Protein

Coiled-coil and C2 domain-containing protein 1B

Gene

Cc2d1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil and C2 domain-containing protein 1B
Alternative name(s):
Five prime repressor element under dual repression-binding protein 2
Short name:
FRE under dual repression-binding protein 2
Short name:
Freud-2
Gene namesi
Name:Cc2d1b
Synonyms:Kiaa1836
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2443076. Cc2d1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884271 – 848Coiled-coil and C2 domain-containing protein 1BAdd BLAST848

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei455PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei586PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8BRN9.
MaxQBiQ8BRN9.
PaxDbiQ8BRN9.
PeptideAtlasiQ8BRN9.
PRIDEiQ8BRN9.

PTM databases

iPTMnetiQ8BRN9.
PhosphoSitePlusiQ8BRN9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028582.
CleanExiMM_CC2D1B.
ExpressionAtlasiQ8BRN9. baseline and differential.
GenevisibleiQ8BRN9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8BRN9. 1 interactor.
MINTiMINT-4112084.
STRINGi10090.ENSMUSP00000030320.

Structurei

3D structure databases

ProteinModelPortaliQ8BRN9.
SMRiQ8BRN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 789C2Add BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 193Sequence analysisAdd BLAST29
Coiled coili600 – 626Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 96Poly-Glu7

Sequence similaritiesi

Belongs to the CC2D1 family.Curated
Contains 1 C2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ8BRN9.
KOiK18260.
OMAiMVTENWL.
OrthoDBiEOG091G02GK.
PhylomeDBiQ8BRN9.
TreeFamiTF314229.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8BRN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGPRPRKGP KTSGQGAETA KQLGLFVEFN PEDMLLGVDE TEDDGDLEAE
60 70 80 90 100
LLALTGETAS RSRKPAPKGQ APLPMAHIEK LAADCMRDVE EDEEEEGLED
110 120 130 140 150
DADLLTELQE VLGEDEEAGL LDGSEAASPD LCEEKTWDNT ELPVEQAACQ
160 170 180 190 200
QAVPAAAQAG GPRGLQALLE ERIRNYREAA ASAKEAGEAA KARRCERGLK
210 220 230 240 250
TLQSQLATVR KGGKICEDEI PPPVALGKRP PAPQERAIKN PEIDSPGPCA
260 270 280 290 300
MEPGNLSQPE SSLPAIAPLP DSDPDPQALL LARQREYKAA ALDAKRAGDL
310 320 330 340 350
DRARELMRIG KRFGTVLEAL EKGQPVDLSG MPPAPADLKA LPQASKASSA
360 370 380 390 400
TQGLSPAVEQ MQPVMASDLP ATPVAPAEPT TVLDALQQRL NKYREAGIQA
410 420 430 440 450
RANGDERKAR MHDRIAKQYQ DAVRAHQAGQ KVDFAELPVP PGFPPIPGLE
460 470 480 490 500
PRKGSEQDSV AATLATAQKL ASEDAALVDD DEESDTPAQA PLAKKPAQTL
510 520 530 540 550
VSPSHLLTEP KASSSKESLS PSVREQVTLL EARKLQYQRA ALQAKRRQDL
560 570 580 590 600
EQAKSHLRVA KSLEAQIIQA RAGQPIDLSK VPSPLTDEEG DFILIHHEDL
610 620 630 640 650
RLSQKAEEVY AQLQKMLQEQ QAKCLLFSKQ YMHQGNVAET TRFERLAEDR
660 670 680 690 700
KKQLEILQLA QAQGLDPPSH HFELKTFQTV RIFSELNSTE MHLIIVRGMN
710 720 730 740 750
LPAPPGVTPD DLDAFVRFEF HYPNSDQAQK SKTAVVKNTN SPEFEQVFKL
760 770 780 790 800
NINRNHRGFR RVIQSKGIKF EIFHKGSFFR SDKLVGTAHL KLERLEKECE
810 820 830 840
IREIMEVLDG RKPTGGKLEV KVRLREPLSS QDVQTVTENW LVLEPRGL
Length:848
Mass (Da):93,091
Last modified:March 1, 2003 - v1
Checksum:i32F781AF50CA8297
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25L → F in BAE27295 (PubMed:16141072).Curated1
Sequence conflicti388Q → L in BAE27295 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043839 mRNA. Translation: BAC31675.1.
AK146601 mRNA. Translation: BAE27295.1.
AL626783 Genomic DNA. Translation: CAM23502.1.
BC125517 mRNA. Translation: AAI25518.1.
BC137743 mRNA. Translation: AAI37744.1.
AK173271 mRNA. Translation: BAD32549.1.
CCDSiCCDS18454.1.
RefSeqiNP_796019.1. NM_177045.3.
UniGeneiMm.151129.

Genome annotation databases

EnsembliENSMUST00000030320; ENSMUSP00000030320; ENSMUSG00000028582.
GeneIDi319965.
KEGGimmu:319965.
UCSCiuc008ubl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK043839 mRNA. Translation: BAC31675.1.
AK146601 mRNA. Translation: BAE27295.1.
AL626783 Genomic DNA. Translation: CAM23502.1.
BC125517 mRNA. Translation: AAI25518.1.
BC137743 mRNA. Translation: AAI37744.1.
AK173271 mRNA. Translation: BAD32549.1.
CCDSiCCDS18454.1.
RefSeqiNP_796019.1. NM_177045.3.
UniGeneiMm.151129.

3D structure databases

ProteinModelPortaliQ8BRN9.
SMRiQ8BRN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8BRN9. 1 interactor.
MINTiMINT-4112084.
STRINGi10090.ENSMUSP00000030320.

PTM databases

iPTMnetiQ8BRN9.
PhosphoSitePlusiQ8BRN9.

Proteomic databases

EPDiQ8BRN9.
MaxQBiQ8BRN9.
PaxDbiQ8BRN9.
PeptideAtlasiQ8BRN9.
PRIDEiQ8BRN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030320; ENSMUSP00000030320; ENSMUSG00000028582.
GeneIDi319965.
KEGGimmu:319965.
UCSCiuc008ubl.1. mouse.

Organism-specific databases

CTDi200014.
MGIiMGI:2443076. Cc2d1b.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3837. Eukaryota.
ENOG410XPM7. LUCA.
GeneTreeiENSGT00390000009595.
HOGENOMiHOG000285993.
HOVERGENiHBG100866.
InParanoidiQ8BRN9.
KOiK18260.
OMAiMVTENWL.
OrthoDBiEOG091G02GK.
PhylomeDBiQ8BRN9.
TreeFamiTF314229.

Miscellaneous databases

PROiQ8BRN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028582.
CleanExiMM_CC2D1B.
ExpressionAtlasiQ8BRN9. baseline and differential.
GenevisibleiQ8BRN9. MM.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR006608. DM14.
[Graphical view]
PfamiPF00168. C2. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00685. DM14. 4 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC2D1B_MOUSE
AccessioniPrimary (citable) accession number: Q8BRN9
Secondary accession number(s): B2RQ40, Q3UJ60, Q69Z95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.