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Protein

RAB6-interacting golgin

Gene

Gorab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
RAB6-interacting golgin
Alternative name(s):
N-terminal kinase-like-binding protein 1
Short name:
NTKL-BP1
Short name:
NTKL-binding protein 1
Short name:
mNTKL-BP1
SCY1-like 1-binding protein 1
Short name:
SCYL1-BP1
Short name:
SCYL1-binding protein 1
Gene namesi
Name:Gorab
Synonyms:Ntklbp1, Scyl1bp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2138271. Gorab.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • Golgi apparatus Source: MGI
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368RAB6-interacting golginPRO_0000252445Add
BLAST

Proteomic databases

MaxQBiQ8BRM2.
PaxDbiQ8BRM2.
PeptideAtlasiQ8BRM2.
PRIDEiQ8BRM2.

PTM databases

iPTMnetiQ8BRM2.
PhosphoSiteiQ8BRM2.

Expressioni

Tissue specificityi

Expressed in small intestine, kidney, skeletal muscle, lung, spleen, brain and heart. High expression is observed in osteoblasts and skin; also expressed in osteoclasts albeit at lower levels.2 Publications

Gene expression databases

BgeeiENSMUSG00000040124.
CleanExiMM_SCYL1BP1.
ExpressionAtlasiQ8BRM2. baseline and differential.
GenevisibleiQ8BRM2. MM.

Interactioni

Subunit structurei

Interacts with RCHY1 (By similarity). Interacts with SCYL1 and RAB6A/RAB6.By similarity2 Publications

Protein-protein interaction databases

BioGridi221044. 1 interaction.
STRINGi10090.ENSMUSP00000036253.

Structurei

3D structure databases

ProteinModelPortaliQ8BRM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni188 – 368181Necessary for interaction with RCHY1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili145 – 310166Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GORAB family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJC7. Eukaryota.
ENOG4111VTM. LUCA.
GeneTreeiENSGT00390000014886.
HOGENOMiHOG000112758.
InParanoidiQ8BRM2.
KOiK19748.
OMAiHLTEHLC.
OrthoDBiEOG091G0NTU.
PhylomeDBiQ8BRM2.
TreeFamiTF324839.

Family and domain databases

InterProiIPR007033. GORAB.
[Graphical view]
PANTHERiPTHR21470:SF2. PTHR21470:SF2. 1 hit.
PfamiPF04949. Transcrip_act. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8BRM2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQDWAGFSE EELRRLKQNK DPFEPQRRIP VKKTRQQLQR EKALLEQSQK
60 70 80 90 100
LGLQDGSASL LPEQLLSAPK QRANSQKPRS PSPVAPSPLT PTSSSGDGKL
110 120 130 140 150
PGVGSQPQEP GLENSHHGHK SAEVRAPKPD CKVEKKKMEL QEKSRWEVLQ
160 170 180 190 200
QEQRLMEEKN KRKKALLAQA IAERSKKTQA ETIKLKRIQK ELQALDDMVS
210 220 230 240 250
ADIGILRNRI DQASLEYSYA RKRFDRAEAE YITAKLDLQR KTETKEQLTE
260 270 280 290 300
HLCTIIQQNE LRKAKKLEEL MQQLDVQADE EALQLEVEVE QLLREQEAEA
310 320 330 340 350
AKQMASVERL CPPDGESVSS ELAEENNEPQ KQAPSPETDK PGKCCSSSPH
360
RLDCPDPGAK NFSAAVAT
Length:368
Mass (Da):41,487
Last modified:March 1, 2003 - v1
Checksum:i5204B23BE1E0C196
GO
Isoform 2 (identifier: Q8BRM2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-155: Missing.

Show »
Length:213
Mass (Da):24,078
Checksum:i3F50A0D2724C3378
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 155155Missing in isoform 2. 1 PublicationVSP_020979Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039170 mRNA. Translation: BAC30263.1.
AK043953 mRNA. Translation: BAC31712.1.
AK165909 mRNA. Translation: BAE38454.1.
AK169151 mRNA. Translation: BAE40930.1.
BC119132 mRNA. Translation: AAI19133.1.
BC119134 mRNA. Translation: AAI19135.1.
CCDSiCCDS15429.1. [Q8BRM2-1]
RefSeqiNP_001300667.1. NM_001313738.1. [Q8BRM2-2]
NP_849214.2. NM_178883.6. [Q8BRM2-1]
UniGeneiMm.32901.

Genome annotation databases

EnsembliENSMUST00000045138; ENSMUSP00000036253; ENSMUSG00000040124. [Q8BRM2-1]
GeneIDi98376.
KEGGimmu:98376.
UCSCiuc007dhl.1. mouse. [Q8BRM2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039170 mRNA. Translation: BAC30263.1.
AK043953 mRNA. Translation: BAC31712.1.
AK165909 mRNA. Translation: BAE38454.1.
AK169151 mRNA. Translation: BAE40930.1.
BC119132 mRNA. Translation: AAI19133.1.
BC119134 mRNA. Translation: AAI19135.1.
CCDSiCCDS15429.1. [Q8BRM2-1]
RefSeqiNP_001300667.1. NM_001313738.1. [Q8BRM2-2]
NP_849214.2. NM_178883.6. [Q8BRM2-1]
UniGeneiMm.32901.

3D structure databases

ProteinModelPortaliQ8BRM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221044. 1 interaction.
STRINGi10090.ENSMUSP00000036253.

PTM databases

iPTMnetiQ8BRM2.
PhosphoSiteiQ8BRM2.

Proteomic databases

MaxQBiQ8BRM2.
PaxDbiQ8BRM2.
PeptideAtlasiQ8BRM2.
PRIDEiQ8BRM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045138; ENSMUSP00000036253; ENSMUSG00000040124. [Q8BRM2-1]
GeneIDi98376.
KEGGimmu:98376.
UCSCiuc007dhl.1. mouse. [Q8BRM2-1]

Organism-specific databases

CTDi92344.
MGIiMGI:2138271. Gorab.

Phylogenomic databases

eggNOGiENOG410IJC7. Eukaryota.
ENOG4111VTM. LUCA.
GeneTreeiENSGT00390000014886.
HOGENOMiHOG000112758.
InParanoidiQ8BRM2.
KOiK19748.
OMAiHLTEHLC.
OrthoDBiEOG091G0NTU.
PhylomeDBiQ8BRM2.
TreeFamiTF324839.

Miscellaneous databases

PROiQ8BRM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040124.
CleanExiMM_SCYL1BP1.
ExpressionAtlasiQ8BRM2. baseline and differential.
GenevisibleiQ8BRM2. MM.

Family and domain databases

InterProiIPR007033. GORAB.
[Graphical view]
PANTHERiPTHR21470:SF2. PTHR21470:SF2. 1 hit.
PfamiPF04949. Transcrip_act. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGORAB_MOUSE
AccessioniPrimary (citable) accession number: Q8BRM2
Secondary accession number(s): Q8CAA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.